mutLBSgeneDB |
Gene summary for MMP8 |
Gene summary |
Basic gene Info. | Gene symbol | MMP8 |
Gene name | matrix metallopeptidase 8 (neutrophil collagenase) | |
Synonyms | CLG1|HNC|MMP-8|PMNL-CL | |
Cytomap | UCSC genome browser: 11q22.3 | |
Type of gene | protein-coding | |
RefGenes | NM_002424.2, | |
Description | PMNL collagenasematrix metalloproteinase 8 (neutrophil collagenase)matrix metalloproteinase-8neutrophil collagenase | |
Modification date | 20141207 | |
dbXrefs | MIM : 120355 | |
HGNC : HGNC | ||
Ensembl : ENSG00000118113 | ||
HPRD : 00385 | ||
Vega : OTTHUMG00000167587 | ||
Protein | UniProt: P22894 go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_MMP8 | |
BioGPS: 4317 | ||
Pathway | NCI Pathway Interaction Database: MMP8 | |
KEGG: MMP8 | ||
REACTOME: MMP8 | ||
Pathway Commons: MMP8 | ||
Context | iHOP: MMP8 | |
ligand binding site mutation search in PubMed: MMP8 | ||
UCL Cancer Institute: MMP8 | ||
Assigned class in mutLBSgeneDB | B: This gene belongs to targetable_mutLBSgenes. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO Term | PubMed ID | GO:0006508 | proteolysis | 2164002 |
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Ligand binding site mutations for MMP8 |
Lollipop-style diagram of mutations at LBS in amino-acid sequence. We represented ligand binding site mutations only. (You can see big image via clicking.) : non-synonymous mutation on LBS, Circle size denotes number of samples. |
Cancer type specific mutLBS sorted by frequency |
LBS | AAchange of nsSNV | Cancer type | # samples | H221 | H221N | BRCA | 1 | Y236 | Y236S | COAD | 1 | H221 | S222Y | COAD | 1 | E200 | W202C | LUSC | 1 | S171 | P172S | SKCM | 1 | D197 | A198V | STAD | 1 |
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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Protein structure related information for MMP8 |
Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
: nsSNV at non-LBS: nsSNV at LBS |
nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
LBS | AAchange of nsSNV | Relative stability change | H221 | S222Y | 0.19889657 | Y236 | Y236S | -1.2121629 | S171 | P172S | -0.89865571 | E200 | W202C | -0.80210513 | H221 | H221N | -0.49623362 | D197 | A198V | -0.34271174 |
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
Structure image for MMP8 from PDB |
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Differential gene expression and gene-gene network for MMP8 |
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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Phenotype information for MMP8 |
Gene level disease information (DisGeNet) |
Disease ID | Disease name | # PubMed | Association type |
umls:C0025202 | Melanoma | 7 | AlteredExpression, Biomarker, GeneticVariation, Therapeutic |
umls:C0023893 | Liver Cirrhosis, Experimental | 1 | Therapeutic |
umls:C0024115 | Lung Diseases | 1 | Biomarker |
umls:C0043251 | Wounds and Injuries | 1 | Biomarker |
Mutation level pathogenic information (ClinVar annotation) |
Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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Pharmacological information for MMP8 |
Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
Gene-centered drug-gene interaction network |
Drug information targeting mutLBSgene (Approved drugs only) |
Drug status | DrugBank ID | Name | Type | Drug structure |
Approved|investigational | DB00786 | Marimastat | Small molecule | |
Experimental | DB02326 | 1-Hydroxyamine-2-Isobutylmalonic Acid | Small molecule | |
Experimental | DB02953 | 2-Thiomethyl-3-Phenylpropanoic Acid | Small molecule | |
Experimental | DB03207 | 2-(Biphenyl-4-Sulfonyl)-1,2,3,4-Tetrahydro-Isoquinoline-3-Carboxylic Acid | Small molecule | |
Experimental | DB03622 | 2-Hydroxy-5-[4-(2-Hydroxy-Ethyl)-Piperidin-1-Yl]-5-Phenyl-1h-Pyrimidine-4,6-Dione | Small molecule | |
Experimental | DB03636 | Glycinamid | Small molecule | |
Experimental | DB03880 | Batimastat | Small molecule | |
Experimental | DB06971 | N-{2-[(4'-CYANO-1,1'-BIPHENYL-4-YL)OXY]ETHYL}-N'-HYDROXY-N-METHYLUREA | Small molecule | |
Experimental | DB07397 | (5S)-5-(2-amino-2-oxoethyl)-4-oxo-N-[(3-oxo-3,4-dihydro-2H-1,4-benzoxazin-6-yl)methyl]-3,4,5,6,7,8-hexahydro[1]benzothieno[2,3-d]pyrimidine-2-carboxamide | Small molecule | |
Experimental | DB07713 | (1S)-1-{[(4'-METHOXY-1,1'-BIPHENYL-4-YL)SULFONYL]AMINO}-2-METHYLPROPYLPHOSPHONIC ACID | Small molecule | |
Experimental | DB07772 | (1R)-1-{[(4'-METHOXY-1,1'-BIPHENYL-4-YL)SULFONYL]AMINO}-2-METHYLPROPYLPHOSPHONIC ACID | Small molecule | |
Experimental | DB07900 | 3-FORMYL-2-HYDROXY-5-METHYL-HEXANOIC ACID HYDROXYAMIDE | Small molecule | |
Experimental | DB08028 | BUT-3-ENYL-[5-(4-CHLORO-PHENYL)-3,6-DIHYDRO-[1,3,4]THIADIAZIN-2-YLIDENE]-AMINE | Small molecule | |
Experimental | DB08403 | METHYLAMINO-PHENYLALANYL-LEUCYL-HYDROXAMIC ACID | Small molecule | |
Experimental | DB08476 | 3-AMINO-AZACYCLOTRIDECAN-2-ONE | Small molecule |
Gene-centered ligand-gene interaction network |
Ligands binding to mutated ligand binding site of MMP8 go to BioLip |
Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS |
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Conservation information for LBS of MMP8 |
Multiple alignments for P22894 in multiple species |
LBS | AA sequence | # species | Species | A181 | PNGILAHAFQP | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | A183 | GILAHAFQPGQ | 2 | Homo sapiens, Mus musculus | A183 | GILAHAFQPGR | 1 | Rattus norvegicus | A233 | STDPGALMYPN | 2 | Mus musculus, Rattus norvegicus | A233 | SSDPGALMYPN | 1 | Homo sapiens | A240 | MYPNYAYREPS | 2 | Mus musculus, Rattus norvegicus | A240 | MYPNYAFRETS | 1 | Homo sapiens | D157 | SQGEADINIAF | 1 | Homo sapiens | D157 | LQGEADINIAF | 1 | Mus musculus | D157 | LEGEADINIAF | 1 | Rattus norvegicus | D169 | SRDHGDNSPFD | 2 | Mus musculus, Rattus norvegicus | D169 | QRDHGDNSPFD | 1 | Homo sapiens | D174 | DNSPFDGPNGI | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | D193 | QGIGGDAHFDA | 1 | Homo sapiens | D193 | QGIGGDAHFDS | 1 | Mus musculus | D193 | RGIGGDAHFDS | 1 | Rattus norvegicus | D197 | GDAHFDSEETW | 2 | Mus musculus, Rattus norvegicus | D197 | GDAHFDAEETW | 1 | Homo sapiens | E200 | HFDSEETWTQD | 2 | Mus musculus, Rattus norvegicus | E200 | HFDAEETWTNT | 1 | Homo sapiens | E218 | LVAAHEFGHSL | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | F184 | ILAHAFQPGQG | 2 | Homo sapiens, Mus musculus | F184 | ILAHAFQPGRG | 1 | Rattus norvegicus | F212 | KNYNLFLVAAH | 2 | Mus musculus, Rattus norvegicus | F212 | ANYNLFLVAAH | 1 | Homo sapiens | F241 | YPNYAYREPST | 2 | Mus musculus, Rattus norvegicus | F241 | YPNYAFRETSN | 1 | Homo sapiens | G175 | NSPFDGPNGIL | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | G178 | FDGPNGILAHA | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | G189 | FQPGQGIGGDA | 2 | Homo sapiens, Mus musculus | G189 | FQPGRGIGGDA | 1 | Rattus norvegicus | G191 | PGQGIGGDAHF | 2 | Homo sapiens, Mus musculus | G191 | PGRGIGGDAHF | 1 | Rattus norvegicus | H167 | FVSRDHGDNSP | 2 | Mus musculus, Rattus norvegicus | H167 | FYQRDHGDNSP | 1 | Homo sapiens | H182 | NGILAHAFQPG | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | H195 | IGGDAHFDSEE | 2 | Mus musculus, Rattus norvegicus | H195 | IGGDAHFDAEE | 1 | Homo sapiens | H217 | FLVAAHEFGHS | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | H221 | AHEFGHSLGLS | 2 | Mus musculus, Rattus norvegicus | H221 | AHEFGHSLGLA | 1 | Homo sapiens | H227 | SLGLSHSTDPG | 2 | Mus musculus, Rattus norvegicus | H227 | SLGLAHSSDPG | 1 | Homo sapiens | I179 | DGPNGILAHAF | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | I190 | QPGQGIGGDAH | 2 | Homo sapiens, Mus musculus | I190 | QPGRGIGGDAH | 1 | Rattus norvegicus | L180 | GPNGILAHAFQ | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | L213 | NYNLFLVAAHE | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | L234 | TDPGALMYPNY | 2 | Mus musculus, Rattus norvegicus | L234 | SDPGALMYPNY | 1 | Homo sapiens | N177 | PFDGPNGILAH | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | N238 | ALMYPNYAYRE | 2 | Mus musculus, Rattus norvegicus | N238 | ALMYPNYAFRE | 1 | Homo sapiens | N246 | YREPSTYSLPQ | 2 | Mus musculus, Rattus norvegicus | N246 | FRETSNYSLPQ | 1 | Homo sapiens | P176 | SPFDGPNGILA | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | P237 | GALMYPNYAYR | 2 | Mus musculus, Rattus norvegicus | P237 | GALMYPNYAFR | 1 | Homo sapiens | P250 | STYSLPQDDIN | 2 | Mus musculus, Rattus norvegicus | P250 | SNYSLPQDDID | 1 | Homo sapiens | Q185 | LAHAFQPGQGI | 2 | Homo sapiens, Mus musculus | Q185 | LAHAFQPGRGI | 1 | Rattus norvegicus | R242 | PNYAYREPSTY | 2 | Mus musculus, Rattus norvegicus | R242 | PNYAFRETSNY | 1 | Homo sapiens | S171 | DHGDNSPFDGP | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | S248 | EPSTYSLPQDD | 2 | Mus musculus, Rattus norvegicus | S248 | ETSNYSLPQDD | 1 | Homo sapiens | T244 | YAYREPSTYSL | 2 | Mus musculus, Rattus norvegicus | T244 | YAFRETSNYSL | 1 | Homo sapiens | V214 | YNLFLVAAHEF | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | Y209 | QDSKNYNLFLV | 2 | Mus musculus, Rattus norvegicus | Y209 | NTSANYNLFLV | 1 | Homo sapiens | Y236 | PGALMYPNYAY | 2 | Mus musculus, Rattus norvegicus | Y236 | PGALMYPNYAF | 1 | Homo sapiens | Y239 | LMYPNYAYREP | 2 | Mus musculus, Rattus norvegicus | Y239 | LMYPNYAFRET | 1 | Homo sapiens | Y247 | REPSTYSLPQD | 2 | Mus musculus, Rattus norvegicus | Y247 | RETSNYSLPQD | 1 | Homo sapiens |
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