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mutLBSgeneDB |
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| Gene summary for MMP14 |
 Gene summary |
| Basic gene Info. | Gene symbol | MMP14 |
| Gene name | matrix metallopeptidase 14 (membrane-inserted) | |
| Synonyms | MMP-14|MMP-X1|MT-MMP|MT-MMP 1|MT1-MMP|MT1MMP|MTMMP1|WNCHRS | |
| Cytomap | UCSC genome browser: 14q11.2 | |
| Type of gene | protein-coding | |
| RefGenes | NM_004995.3, | |
| Description | matrix metalloproteinase-14membrane type 1 metalloproteasemembrane-type-1 matrix metalloproteinase | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 600754 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000157227 | ||
| HPRD : 02856 | ||
| Vega : OTTHUMG00000028704 | ||
| Protein | UniProt: P50281 go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_MMP14 | |
| BioGPS: 4323 | ||
| Pathway | NCI Pathway Interaction Database: MMP14 | |
| KEGG: MMP14 | ||
| REACTOME: MMP14 | ||
| Pathway Commons: MMP14 | ||
| Context | iHOP: MMP14 | |
| ligand binding site mutation search in PubMed: MMP14 | ||
| UCL Cancer Institute: MMP14 | ||
| Assigned class in mutLBSgeneDB | B: This gene belongs to targetable_mutLBSgenes. | |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO Term | PubMed ID | GO:0006508 | proteolysis | 15863497 | GO:0030307 | positive regulation of cell growth | 22065321 | GO:0030335 | positive regulation of cell migration | 22065321 |
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| Ligand binding site mutations for MMP14 |
| Lollipop-style diagram of mutations at LBS in amino-acid sequence. We represented ligand binding site mutations only. (You can see big image via clicking.)  : non-synonymous mutation on LBS, Circle size denotes number of samples. |
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| Cancer type specific mutLBS sorted by frequency |
| LBS | AAchange of nsSNV | Cancer type | # samples | G206 | G206C | LUSC | 1 |
| cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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| Protein structure related information for MMP14 |
| Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
 : nsSNV at non-LBS : nsSNV at LBS |
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| nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
| LBS | AAchange of nsSNV | Relative stability change | G206 | G206C | -0.76486005 |
| (MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
| Structure image for MMP14 from PDB |
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| Differential gene expression and gene-gene network for MMP14 |
| Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
| Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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| Phenotype information for MMP14 |
| Gene level disease information (DisGeNet) |
| Disease ID | Disease name | # PubMed | Association type |
| umls:C0001418 | Adenocarcinoma | 6 | Biomarker |
| umls:C0014859 | Esophageal Neoplasms | 4 | Biomarker |
| umls:C0162871 | Aortic Aneurysm, Abdominal | 3 | Biomarker |
| umls:C0024117 | Pulmonary Disease, Chronic Obstructive | 2 | Biomarker, GeneticVariation |
| umls:C0432289 | Winchester syndrome | 1 | GeneticVariation |
| Mutation level pathogenic information (ClinVar annotation) |
| Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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| Pharmacological information for MMP14 |
| Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
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| Gene-centered drug-gene interaction network |
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| Drug information targeting mutLBSgene (Approved drugs only) |
| Drug status | DrugBank ID | Name | Type | Drug structure |
| Approved|investigational | DB00786 | Marimastat | Small molecule |  |
| Gene-centered ligand-gene interaction network |
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| Ligands binding to mutated ligand binding site of MMP14 go to BioLip |
| Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | CA | CALCIUM(2+) | 1bqq | M | G206 | CA | CALCIUM(2+) | 1buv | M | G206 |
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| Conservation information for LBS of MMP14 |
| Multiple alignments for P50281 in multiple species |
| LBS | AA sequence | # species | Species | D176 | HEKQADIMIFF | 2 | Homo sapiens, Bos taurus | D176 | HEKQADIMILF | 2 | Mus musculus, Rattus norvegicus | D188 | EGFHGDSTPFD | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | D193 | DSTPFDGEGGF | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | D212 | PNIGGDTHFDS | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | D216 | GDTHFDSAEPW | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | E195 | TPFDGEGGFLA | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | E219 | HFDSAEPWTVR | 2 | Homo sapiens, Bos taurus | E219 | HFDSAEPWTVQ | 2 | Mus musculus, Rattus norvegicus | F198 | DGEGGFLAHAY | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | G194 | STPFDGEGGFL | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | G196 | PFDGEGGFLAH | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | G206 | HAYFPGPNIGG | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | G210 | PGPNIGGDTHF | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | H186 | FAEGFHGDSTP | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | H201 | GGFLAHAYFPG | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | H214 | IGGDTHFDSAE | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | H239 | FLVAVHELGHA | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | H243 | VHELGHALGLE | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | H249 | ALGLEHSNDPS | 3 | Bos taurus, Mus musculus, Rattus norvegicus | H249 | ALGLEHSSDPS | 1 | Homo sapiens | I209 | FPGPNIGGDTH | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | L199 | GEGGFLAHAYF | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | N208 | YFPGPNIGGDT | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus |
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