mutLBSgeneDB

mutLBSgeneDB
mutated Ligand Binding Site gene DataBase

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Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for MPST
Gene summary
Basic gene Info.Gene symbolMPST
Gene namemercaptopyruvate sulfurtransferase
SynonymsMST|TST2|TUM1
CytomapUCSC genome browser: 22q13.1
Type of geneprotein-coding
RefGenesNM_001013436.2,
NM_001130517.2,NM_021126.5,NM_001013440.1,NR_024038.1,
Description3-mercaptopyruvate sulfurtransferasehuman liver rhodanesetRNA thiouridin modification protein 1
Modification date20141215
dbXrefs MIM : 602496
HGNC : HGNC
Ensembl : ENSG00000128309
HPRD : 11896
Vega : OTTHUMG00000150543
ProteinUniProt: P25325
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_MPST
BioGPS: 4357
PathwayNCI Pathway Interaction Database: MPST
KEGG: MPST
REACTOME: MPST
Pathway Commons: MPST
ContextiHOP: MPST
ligand binding site mutation search in PubMed: MPST
UCL Cancer Institute: MPST
Assigned class in mutLBSgeneDBC: This gene just belongs to mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO TermPubMed ID


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Ligand binding site mutations for MPST

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
P196P194LSKCM1
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.


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Protein structure related information for MPST
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
P196P194L-0.50565327
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for MPST from PDB

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Differential gene expression and gene-gene network for MPST
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of MPST and the right PPI network was created from samples without mutations in the LBS of MPST. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


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Phenotype information for MPST
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

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Pharmacological information for MPST
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of MPST go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS
PYRPYRUVIC ACID4jgtBP196


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Conservation information for LBS of MPST
Multiple alignments for P25325 in multiple species
LBSAA sequence# speciesSpecies
C248PLVATCGSGVT2Homo sapiens, Rattus norvegicus
C248PTICSCGTGVS1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
C248PIITSCGSGVT1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
C248PIMASCGTGVT1Arabidopsis thaliana
C248PIAASCGTGVT1Arabidopsis thaliana
G249LVATCGSGVTA2Homo sapiens, Rattus norvegicus
G249TICSCGTGVSG1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
G249IITSCGSGVTA1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G249IMASCGTGVTA1Arabidopsis thaliana
G249IAASCGTGVTA1Arabidopsis thaliana
L38DASWYLPKLGR2Homo sapiens, Rattus norvegicus
L38DATWYLPSWKL1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
L38DATWYLPTDTK1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
L38DASWYMPDEQR1Arabidopsis thaliana
L38DASWYMAHEQR1Arabidopsis thaliana
P196GTEPEPRDGIE1Homo sapiens
P196GTEPEPRSDIP1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
P196GNVPESRPGLA1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
P196GTQPEPRDGIE1Rattus norvegicus
P196GTAPEPRKGIR1Arabidopsis thaliana
P196GIAPEPWKGLP1Arabidopsis thaliana
R188SRATGRFRGTE1Homo sapiens
R188ARSLGRFEGTE1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
R188ARAHERFLGNV1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
R188ARAAGRFQGTQ1Rattus norvegicus
R188ARSKARFDGTA1Arabidopsis thaliana
R188ARSKARFDGIA1Arabidopsis thaliana
R197TEPEPRDGIEP1Homo sapiens
R197TEPEPRSDIPS1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
R197NVPESRPGLAS1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
R197TQPEPRDGIEP1Rattus norvegicus
R197TAPEPRKGIRS1Arabidopsis thaliana
R197IAPEPWKGLPS1Arabidopsis thaliana
S250VATCGSGVTAC2Homo sapiens, Rattus norvegicus
S250ICSCGTGVSGV1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
S250ITSCGSGVTAS1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
S250MASCGTGVTAC1Arabidopsis thaliana
S250AASCGTGVTAC1Arabidopsis thaliana
V252TCGSGVTACHV2Homo sapiens, Rattus norvegicus
V252SCGTGVTACIL2Arabidopsis thaliana, Arabidopsis thaliana
V252SCGTGVSGVII1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
V252SCGSGVTASVL1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
W36LLDASWYLPKL2Homo sapiens, Rattus norvegicus
W36PVDATWYLPSW1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
W36LLDATWYLPTD1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
W36ILDASWYMPDE1Arabidopsis thaliana
W36VLDASWYMAHE1Arabidopsis thaliana
Y108SDQGLYSAPRV2Homo sapiens, Rattus norvegicus
Y108--VGNFSSPRC1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Y108--KGFFSSPRV1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Y108--KGIFSAARV1Arabidopsis thaliana
Y108--MGLFSAARV1Arabidopsis thaliana


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