mutLBSgeneDB |
Gene summary for MPST |
Gene summary |
Basic gene Info. | Gene symbol | MPST |
Gene name | mercaptopyruvate sulfurtransferase | |
Synonyms | MST|TST2|TUM1 | |
Cytomap | UCSC genome browser: 22q13.1 | |
Type of gene | protein-coding | |
RefGenes | NM_001013436.2, NM_001130517.2,NM_021126.5,NM_001013440.1,NR_024038.1, | |
Description | 3-mercaptopyruvate sulfurtransferasehuman liver rhodanesetRNA thiouridin modification protein 1 | |
Modification date | 20141215 | |
dbXrefs | MIM : 602496 | |
HGNC : HGNC | ||
Ensembl : ENSG00000128309 | ||
HPRD : 11896 | ||
Vega : OTTHUMG00000150543 | ||
Protein | UniProt: P25325 go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_MPST | |
BioGPS: 4357 | ||
Pathway | NCI Pathway Interaction Database: MPST | |
KEGG: MPST | ||
REACTOME: MPST | ||
Pathway Commons: MPST | ||
Context | iHOP: MPST | |
ligand binding site mutation search in PubMed: MPST | ||
UCL Cancer Institute: MPST | ||
Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO Term | PubMed ID |
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Ligand binding site mutations for MPST |
Cancer type specific mutLBS sorted by frequency |
LBS | AAchange of nsSNV | Cancer type | # samples | P196 | P194L | SKCM | 1 |
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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Protein structure related information for MPST |
Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
: nsSNV at non-LBS: nsSNV at LBS |
nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
LBS | AAchange of nsSNV | Relative stability change | P196 | P194L | -0.50565327 |
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
Structure image for MPST from PDB |
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Differential gene expression and gene-gene network for MPST |
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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Phenotype information for MPST |
Gene level disease information (DisGeNet) |
Disease ID | Disease name | # PubMed | Association type |
Mutation level pathogenic information (ClinVar annotation) |
Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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Pharmacological information for MPST |
Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
Drug information targeting mutLBSgene (Approved drugs only) |
Drug status | DrugBank ID | Name | Type | Drug structure |
Gene-centered ligand-gene interaction network |
Ligands binding to mutated ligand binding site of MPST go to BioLip |
Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | PYR | PYRUVIC ACID | 4jgt | B | P196 |
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Conservation information for LBS of MPST |
Multiple alignments for P25325 in multiple species |
LBS | AA sequence | # species | Species | C248 | PLVATCGSGVT | 2 | Homo sapiens, Rattus norvegicus | C248 | PTICSCGTGVS | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | C248 | PIITSCGSGVT | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | C248 | PIMASCGTGVT | 1 | Arabidopsis thaliana | C248 | PIAASCGTGVT | 1 | Arabidopsis thaliana | G249 | LVATCGSGVTA | 2 | Homo sapiens, Rattus norvegicus | G249 | TICSCGTGVSG | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | G249 | IITSCGSGVTA | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | G249 | IMASCGTGVTA | 1 | Arabidopsis thaliana | G249 | IAASCGTGVTA | 1 | Arabidopsis thaliana | L38 | DASWYLPKLGR | 2 | Homo sapiens, Rattus norvegicus | L38 | DATWYLPSWKL | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | L38 | DATWYLPTDTK | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | L38 | DASWYMPDEQR | 1 | Arabidopsis thaliana | L38 | DASWYMAHEQR | 1 | Arabidopsis thaliana | P196 | GTEPEPRDGIE | 1 | Homo sapiens | P196 | GTEPEPRSDIP | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | P196 | GNVPESRPGLA | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | P196 | GTQPEPRDGIE | 1 | Rattus norvegicus | P196 | GTAPEPRKGIR | 1 | Arabidopsis thaliana | P196 | GIAPEPWKGLP | 1 | Arabidopsis thaliana | R188 | SRATGRFRGTE | 1 | Homo sapiens | R188 | ARSLGRFEGTE | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | R188 | ARAHERFLGNV | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | R188 | ARAAGRFQGTQ | 1 | Rattus norvegicus | R188 | ARSKARFDGTA | 1 | Arabidopsis thaliana | R188 | ARSKARFDGIA | 1 | Arabidopsis thaliana | R197 | TEPEPRDGIEP | 1 | Homo sapiens | R197 | TEPEPRSDIPS | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | R197 | NVPESRPGLAS | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | R197 | TQPEPRDGIEP | 1 | Rattus norvegicus | R197 | TAPEPRKGIRS | 1 | Arabidopsis thaliana | R197 | IAPEPWKGLPS | 1 | Arabidopsis thaliana | S250 | VATCGSGVTAC | 2 | Homo sapiens, Rattus norvegicus | S250 | ICSCGTGVSGV | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | S250 | ITSCGSGVTAS | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | S250 | MASCGTGVTAC | 1 | Arabidopsis thaliana | S250 | AASCGTGVTAC | 1 | Arabidopsis thaliana | V252 | TCGSGVTACHV | 2 | Homo sapiens, Rattus norvegicus | V252 | SCGTGVTACIL | 2 | Arabidopsis thaliana, Arabidopsis thaliana | V252 | SCGTGVSGVII | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | V252 | SCGSGVTASVL | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | W36 | LLDASWYLPKL | 2 | Homo sapiens, Rattus norvegicus | W36 | PVDATWYLPSW | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | W36 | LLDATWYLPTD | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | W36 | ILDASWYMPDE | 1 | Arabidopsis thaliana | W36 | VLDASWYMAHE | 1 | Arabidopsis thaliana | Y108 | SDQGLYSAPRV | 2 | Homo sapiens, Rattus norvegicus | Y108 | --VGNFSSPRC | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | Y108 | --KGFFSSPRV | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | Y108 | --KGIFSAARV | 1 | Arabidopsis thaliana | Y108 | --MGLFSAARV | 1 | Arabidopsis thaliana |
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