mutLBSgeneDB

mutLBSgeneDB
mutated Ligand Binding Site gene DataBase

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	Gene Summary
	Ligand Binding Site Mutation Information
	Protein Structure Related Information
	Gene Expression and Gene-Gene Network
	Phenotype Information
	Pharmacological Information
	Conservation Information for LBS

Gene summary for MSH2

Gene summary

Basic gene Info.	Gene symbol	MSH2
	Gene name	mutS homolog 2
	Synonyms	COCA1\|FCC1\|HNPCC\|HNPCC1\|LCFS2
	Cytomap	UCSC genome browser: 2p21
	Type of gene	protein-coding
	RefGenes	NM_000251.2, NM_001258281.1,
	Description	DNA mismatch repair protein Msh2hMSH2mutS homolog 2, colon cancer, nonpolyposis type 1
	Modification date	20141222
dbXrefs	MIM : 609309
	HGNC : HGNC
	Ensembl : ENSG00000095002
	HPRD : 00389
	Vega : OTTHUMG00000128861
Protein	UniProt: P43246 go to UniProt's Cross Reference DB Table
Expression	CleanEX: HS_MSH2
	BioGPS: 4436
Pathway	NCI Pathway Interaction Database: MSH2
	KEGG: MSH2
	REACTOME: MSH2
	Pathway Commons: MSH2
Context	iHOP: MSH2
	ligand binding site mutation search in PubMed: MSH2
	UCL Cancer Institute: MSH2
Assigned class in mutLBSgeneDB	C: This gene just belongs to mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez

GO ID	GO Term	PubMed ID
GO:0006200	ATP catabolic process	16403449
GO:0006281	DNA repair	8942985
GO:0006298	mismatch repair	11555625
GO:0006301	postreplication repair	7923193
GO:0045910	negative regulation of DNA recombination	17715146
GO:0051096	positive regulation of helicase activity	17715146

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Ligand binding site mutations for MSH2

Lollipop-style diagram of mutations at LBS in amino-acid sequence.
We represented ligand binding site mutations only. (You can see big image via clicking.)

: non-synonymous mutation on LBS, Circle size denotes number of samples.

Cancer type specific mutLBS sorted by frequency

LBS	AAchange of nsSNV	Cancer type	# samples
Q545	D543N	BLCA	1
K509	Q510H	BRCA	1
G548	K550T	COAD	1

cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.

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Protein structure related information for MSH2

Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
(ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)

: nsSNV at non-LBS

: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.

LBS	AAchange of nsSNV	Relative stability change
Q545	D543N	-0.66001273
K509	Q510H	-0.40087828
G548	K550T	-0.36902396

(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for MSH2 from PDB

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Differential gene expression and gene-gene network for MSH2

Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)

* Left PPI network was created from samples with mutations in the LBS of MSH2 and the right PPI network was created from samples without mutations in the LBS of MSH2. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.

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Phenotype information for MSH2

Gene level disease information (DisGeNet)

Disease ID	Disease name	# PubMed	Association type
umls:C0009405	Colorectal Neoplasms, Hereditary Nonpolyposis	53	AlteredExpression, Biomarker, GeneticVariation
umls:C0009404	Colorectal Neoplasms	40	AlteredExpression, Biomarker, GeneticVariation
umls:C1321489	Muir-Torre Syndrome	35	Biomarker, GeneticVariation
umls:C2936783	Colorectal cancer, hereditary nonpolyposis, type 1	30	Biomarker, GeneticVariation
umls:C0265325	Turcot syndrome	18	Biomarker, GeneticVariation
umls:C0919267	Ovarian Neoplasms	5	Biomarker, GeneticVariation
umls:C0027831	Neurofibromatosis 1	4	Biomarker, GeneticVariation
umls:C0017638	Glioma	3	Biomarker, GeneticVariation
umls:C0027672	Neoplastic Syndromes, Hereditary	2	Biomarker, GeneticVariation
umls:C1861975	Cafe au lait spots, multiple	1	Biomarker
umls:C2931459	Lynch syndrome I (site-specific colonic cancer)	1	Biomarker

Mutation level pathogenic information (ClinVar annotation)

Allele ID	AA change	Clinical significance	Origin	Phenotype IDs
151993	Q510H	Uncertain significance	Germline	MedGen:C0027672 SNOMED CT:699346009
180014	Q510H	Uncertain significance	Germline	MedGen:C0027672 SNOMED CT:699346009

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Pharmacological information for MSH2

Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.

Drug information targeting mutLBSgene (Approved drugs only)

Drug status

DrugBank ID

Name

Type

Drug structure

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of MSH2 go to BioLip

Ligand ID	Ligand short name	Ligand long name	PDB ID	PDB name	mutLBS
NUC		Nucleic Acids	3thx	A	G548
NUC		Nucleic Acids	3thz	A	K509
NUC		Nucleic Acids	2o8f	A	K509 Q545
NUC		Nucleic Acids	2o8b	A	Q545
NUC		Nucleic Acids	2o8c	A	Q545
NUC		Nucleic Acids	2o8d	A	Q545
NUC		Nucleic Acids	2o8e	A	Q545

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Conservation information for LBS of MSH2

Multiple alignments for P43246 in multiple species

LBS	AA sequence	# species	Species
A649	VQDEVAFIPND	2	Bos taurus, Mus musculus
A649	VQDEIAFIPND	1	Homo sapiens
A649	LQEHVNFIANS	1	Drosophila melanogaster
A649	AQDWVNFIPND	1	Arabidopsis thaliana
A649	VQHDVAFIPND	1	Rattus norvegicus
A649	AQDDVKFIPND	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
A649	MQDDISFISND	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
A649	VQDDVTFITND	1	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
C527	YFRVTCKEEKV	4	Homo sapiens, Bos taurus, Rattus norvegicus, Mus musculus
C527	HFRITVKDDSV	1	Drosophila melanogaster
C527	VFRITKKEEPK	1	Arabidopsis thaliana
C527	CLRLTRTEAGC	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
C527	CMRLTRNDAKE	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
C527	CMRLTRTEAGC	1	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
D41	LFDRGDFYTAH	4	Homo sapiens, Bos taurus, Rattus norvegicus, Mus musculus
D41	FFDHTDRYTVH	1	Drosophila melanogaster
D41	FFDRKDYYTAH	1	Arabidopsis thaliana
D41	VFDRGEFYVAI	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
D41	LVDKGDYYTVI	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
D41	IFDRGDWYTAH	1	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
F42	FDRGDFYTAHG	3	Homo sapiens, Rattus norvegicus, Mus musculus
F42	FDHTDRYTVHG	1	Drosophila melanogaster
F42	FDRKDYYTAHG	1	Arabidopsis thaliana
F42	FDRGDFYTAHR	1	Bos taurus
F42	FDRGEFYVAIG	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
F42	VDKGDYYTVIG	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
F42	FDRGDWYTAHG	1	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
F650	QDEVAFIPNDV	2	Bos taurus, Mus musculus
F650	QDEIAFIPNDV	1	Homo sapiens
F650	QEHVNFIANSV	1	Drosophila melanogaster
F650	QDWVNFIPNDC	1	Arabidopsis thaliana
F650	QHDVAFIPNDV	1	Rattus norvegicus
F650	QDDVKFIPNDV	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
F650	QDDISFISNDV	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
F650	QDDVTFITNDV	1	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
G508	LGLDPGKQIKL	4	Homo sapiens, Bos taurus, Rattus norvegicus, Mus musculus
G508	LNLDGKNQVKL	1	Drosophila melanogaster
G508	LDLQVDKALKL	1	Arabidopsis thaliana
G508	LHQDTEKKLHL	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G508	LGFDPDKKLKL	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
G508	LGQEREKKIFL	1	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
G548	DIQKNGVKFTN	4	Homo sapiens, Bos taurus, Rattus norvegicus, Mus musculus
G548	STQKNGVYFTT	2	Schizosaccharomyces pombe (strain 972 / ATCC 24843), Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
G548	DVIKGGVRFTS	1	Drosophila melanogaster
G548	ETRKDGVKFTN	1	Arabidopsis thaliana
G548	STVKAGIFFST	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
G673	TGPNMGGKSTY	8	Homo sapiens, Drosophila melanogaster, Bos taurus, Rattus norvegicus, Mus musculus, Schizosaccharomyces pombe (strain 972 / ATCC 24843), Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71
G673	TGPNMGGKSTF	1	Arabidopsis thaliana
G674	GPNMGGKSTYI	8	Homo sapiens, Drosophila melanogaster, Bos taurus, Rattus norvegicus, Mus musculus, Schizosaccharomyces pombe (strain 972 / ATCC 24843), Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71
G674	GPNMGGKSTFI	1	Arabidopsis thaliana
I648	EVQDEVAFIPN	2	Bos taurus, Mus musculus
I648	EVQDEIAFIPN	1	Homo sapiens
I648	ELQEHVNFIAN	1	Drosophila melanogaster
I648	EAQDWVNFIPN	1	Arabidopsis thaliana
I648	EVQHDVAFIPN	1	Rattus norvegicus
I648	EAQDDVKFIPN	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
I648	EMQDDISFISN	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
I648	EVQDDVTFITN	1	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
I651	DEVAFIPNDVH	2	Bos taurus, Mus musculus
I651	DEIAFIPNDVY	1	Homo sapiens
I651	EHVNFIANSVD	1	Drosophila melanogaster
I651	DWVNFIPNDCR	1	Arabidopsis thaliana
I651	HDVAFIPNDVH	1	Rattus norvegicus
I651	DDVKFIPNDVN	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
I651	DDISFISNDVT	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
I651	DDVTFITNDVT	1	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
K509	GLDPGKQIKLD	4	Homo sapiens, Bos taurus, Rattus norvegicus, Mus musculus
K509	NLDGKNQVKLE	1	Drosophila melanogaster
K509	DLQVDKALKLD	1	Arabidopsis thaliana
K509	HQDTEKKLHLE	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
K509	GFDPDKKLKLE	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
K509	GQEREKKIFLE	1	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
K512	PGKQIKLDSSA	3	Homo sapiens, Rattus norvegicus, Mus musculus
K512	GKNQVKLESVA	1	Drosophila melanogaster
K512	VDKALKLDKAA	1	Arabidopsis thaliana
K512	PGKQIKLDSST	1	Bos taurus
K512	TEKKLHLEQHH	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
K512	PDKKLKLENHH	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
K512	REKKIFLENHK	1	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
K528	FRVTCKEEKVL	4	Homo sapiens, Bos taurus, Rattus norvegicus, Mus musculus
K528	FRITVKDDSVL	1	Drosophila melanogaster
K528	FRITKKEEPKI	1	Arabidopsis thaliana
K528	LRLTRTEAGCL	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
K528	MRLTRNDAKEL	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
K528	MRLTRTEAGCI	1	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
K546	TVDIQKNGVKF	4	Homo sapiens, Bos taurus, Rattus norvegicus, Mus musculus
K546	IVDVIKGGVRF	1	Drosophila melanogaster
K546	VLETRKDGVKF	1	Arabidopsis thaliana
K546	ELSTQKNGVYF	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
K546	ELSTVKAGIFF	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
K546	ECSTQKNGVYF	1	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
K6	MAVQPKETLQL	3	Homo sapiens, Rattus norvegicus, Mus musculus
K6	TDSRQEPTLNM	1	Drosophila melanogaster
K6	EEQNKLPELKL	1	Arabidopsis thaliana
K6	MAVQPKDTLQL	1	Bos taurus
K6	-MSSRNASIAN	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
K6	MSSTRPELKFS	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
K6	MSSRPE----L	1	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
K675	PNMGGKSTYIR	8	Homo sapiens, Drosophila melanogaster, Bos taurus, Rattus norvegicus, Mus musculus, Schizosaccharomyces pombe (strain 972 / ATCC 24843), Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71
K675	PNMGGKSTFIR	1	Arabidopsis thaliana
M672	ITGPNMGGKST	8	Homo sapiens, Drosophila melanogaster, Bos taurus, Rattus norvegicus, Mus musculus, Schizosaccharomyces pombe (strain 972 / ATCC 24843), Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71
M672	VTGPNMGGKST	1	Arabidopsis thaliana
N547	VDIQKNGVKFT	4	Homo sapiens, Bos taurus, Rattus norvegicus, Mus musculus
N547	VDVIKGGVRFT	1	Drosophila melanogaster
N547	LETRKDGVKFT	1	Arabidopsis thaliana
N547	LSTQKNGVYFT	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
N547	LSTVKAGIFFS	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
N547	CSTQKNGVYFT	1	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
N653	VAFIPNDVHFE	3	Bos taurus, Rattus norvegicus, Mus musculus
N653	IAFIPNDVYFE	1	Homo sapiens
N653	VNFIANSVDFK	1	Drosophila melanogaster
N653	VNFIPNDCRLM	1	Arabidopsis thaliana
N653	VKFIPNDVNLE	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
N653	ISFISNDVTLE	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
N653	VTFITNDVTLT	1	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
N671	IITGPNMGGKS	8	Homo sapiens, Drosophila melanogaster, Bos taurus, Rattus norvegicus, Mus musculus, Schizosaccharomyces pombe (strain 972 / ATCC 24843), Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71
N671	IVTGPNMGGKS	1	Arabidopsis thaliana
P670	HIITGPNMGGK	4	Homo sapiens, Bos taurus, Rattus norvegicus, Mus musculus
P670	LIITGPNMGGK	3	Schizosaccharomyces pombe (strain 972 / ATCC 24843), Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
P670	FIITGPNMGGK	1	Drosophila melanogaster
P670	QIVTGPNMGGK	1	Arabidopsis thaliana
Q518	LDSSAQFGYYF	3	Homo sapiens, Rattus norvegicus, Mus musculus
Q518	LESVAKLGHHF	1	Drosophila melanogaster
Q518	LDKAAQFGHVF	1	Arabidopsis thaliana
Q518	LDSSTQFGYYF	1	Bos taurus
Q518	LEQHHLYGWCL	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Q518	LENHHLHGWCM	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Q518	LENHKVHGWCM	1	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Q545	STVDIQKNGVK	4	Homo sapiens, Bos taurus, Rattus norvegicus, Mus musculus
Q545	RIVDVIKGGVR	1	Drosophila melanogaster
Q545	IVLETRKDGVK	1	Arabidopsis thaliana
Q545	TELSTQKNGVY	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Q545	IELSTVKAGIF	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Q545	LECSTQKNGVY	1	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
R524	FGYYFRVTCKE	4	Homo sapiens, Bos taurus, Rattus norvegicus, Mus musculus
R524	LGHHFRITVKD	1	Drosophila melanogaster
R524	FGHVFRITKKE	1	Arabidopsis thaliana
R524	YGWCLRLTRTE	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
R524	HGWCMRLTRND	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
R524	HGWCMRLTRTE	1	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
S676	NMGGKSTYIRQ	7	Homo sapiens, Bos taurus, Rattus norvegicus, Mus musculus, Schizosaccharomyces pombe (strain 972 / ATCC 24843), Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
S676	NMGGKSTYIRS	1	Drosophila melanogaster
S676	NMGGKSTFIRQ	1	Arabidopsis thaliana
T526	YYFRVTCKEEK	4	Homo sapiens, Bos taurus, Rattus norvegicus, Mus musculus
T526	HHFRITVKDDS	1	Drosophila melanogaster
T526	HVFRITKKEEP	1	Arabidopsis thaliana
T526	WCLRLTRTEAG	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
T526	WCMRLTRNDAK	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
T526	WCMRLTRTEAG	1	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
T677	MGGKSTYIRQT	4	Homo sapiens, Bos taurus, Rattus norvegicus, Mus musculus
T677	MGGKSTYIRQV	2	Schizosaccharomyces pombe (strain 972 / ATCC 24843), Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
T677	MGGKSTYIRSV	1	Drosophila melanogaster
T677	MGGKSTFIRQV	1	Arabidopsis thaliana
T677	MGGKSTYIRQI	1	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
V642	SRHACVEVQDE	3	Homo sapiens, Bos taurus, Mus musculus
V642	VRHPCLELQEH	1	Drosophila melanogaster
V642	SRHPCVEAQDW	1	Arabidopsis thaliana
V642	SRHACVEVQHD	1	Rattus norvegicus
V642	ARHPCLEAQDD	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
V642	SRHPVLEMQDD	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
V642	ARHPCMEVQDD	1	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
V79	--QSVVLSKMN	2	Homo sapiens, Mus musculus
V79	--QFVSMSKGN	1	Drosophila melanogaster
V79	--SSVSISRNM	1	Arabidopsis thaliana
V79	--ESVVLSKMN	1	Bos taurus
V79	--QTVVLSKMN	1	Rattus norvegicus
V79	--SYCNLSPSL	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
V79	PTKYVTVSLQV	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
V79	--PSVTMTVTV	1	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Y815	TLTMLYQVKKG	3	Homo sapiens, Bos taurus, Mus musculus
Y815	DFTLLYQVRSG	1	Drosophila melanogaster
Y815	KLTMLYKVEPG	1	Arabidopsis thaliana
Y815	TLTMLYQVKTG	1	Rattus norvegicus
Y815	DVALLYNVCEG	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Y815	DITLLYKVEPG	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Y815	EVTLLYKVEPG	1	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)