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mutLBSgeneDB |
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| Gene summary for NCBP1 |
 Gene summary |
| Basic gene Info. | Gene symbol | NCBP1 |
| Gene name | nuclear cap binding protein subunit 1, 80kDa | |
| Synonyms | CBP80|NCBP|Sto1 | |
| Cytomap | UCSC genome browser: 9q34.1 | |
| Type of gene | protein-coding | |
| RefGenes | NM_002486.4, | |
| Description | 80 kDa nuclear cap-binding proteinNCBP 80 kDa subunitnuclear cap binding protein subunit 1, 80kDnuclear cap-binding protein subunit 1 | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 600469 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000136937 | ||
| HPRD : 02717 | ||
| Vega : OTTHUMG00000020332 | ||
| Protein | UniProt: Q09161 go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_NCBP1 | |
| BioGPS: 4686 | ||
| Pathway | NCI Pathway Interaction Database: NCBP1 | |
| KEGG: NCBP1 | ||
| REACTOME: NCBP1 | ||
| Pathway Commons: NCBP1 | ||
| Context | iHOP: NCBP1 | |
| ligand binding site mutation search in PubMed: NCBP1 | ||
| UCL Cancer Institute: NCBP1 | ||
| Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. | |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO Term | PubMed ID | GO:0000184 | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay | 11551508 | GO:0006370 | 7-methylguanosine mRNA capping | 12434151 | GO:0006379 | mRNA cleavage | 9342333 | GO:0006446 | regulation of translational initiation | 11551508 | GO:0031442 | positive regulation of mRNA 3'-end processing | 9342333 |
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| Ligand binding site mutations for NCBP1 |
| Lollipop-style diagram of mutations at LBS in amino-acid sequence. We represented ligand binding site mutations only. (You can see big image via clicking.)  : non-synonymous mutation on LBS, Circle size denotes number of samples. |
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| Cancer type specific mutLBS sorted by frequency |
| LBS | AAchange of nsSNV | Cancer type | # samples | Y761 | Q760H | LUAD | 1 |
| cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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| Protein structure related information for NCBP1 |
| Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
 : nsSNV at non-LBS : nsSNV at LBS |
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| nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
| LBS | AAchange of nsSNV | Relative stability change | Y761 | Q760H | -1.2705908 |
| (MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
| Structure image for NCBP1 from PDB |
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| Differential gene expression and gene-gene network for NCBP1 |
| Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
| Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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| Phenotype information for NCBP1 |
| Gene level disease information (DisGeNet) |
| Disease ID | Disease name | # PubMed | Association type |
| Mutation level pathogenic information (ClinVar annotation) |
| Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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| Pharmacological information for NCBP1 |
| Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
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| Drug information targeting mutLBSgene (Approved drugs only) |
| Drug status | DrugBank ID | Name | Type | Drug structure |
| Gene-centered ligand-gene interaction network |
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| Ligands binding to mutated ligand binding site of NCBP1 go to BioLip |
| Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | MG | MAGNESIUM(2+) | 1n52 | A | Y761 |
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| Conservation information for LBS of NCBP1 |
| Multiple alignments for Q09161 in multiple species |
| LBS | AA sequence | # species | Species | K707 | AQSEQKNLFLV | 5 | Homo sapiens, Xenopus tropicalis, Gallus gallus, Mus musculus, Rattus norvegicus | K707 | ALSETEVLLLL | 1 | Arabidopsis thaliana | K707 | GLEESKELLRL | 1 | Oryza sativa subsp. japonica | K707 | NKEKLERMVT- | 1 | Caenorhabditis elegans | K707 | ANVNQKRLFLI | 1 | Drosophila melanogaster | K707 | AYVDQKRLFLI | 1 | Anopheles gambiae | T764 | QQYMVTLENLL | 4 | Homo sapiens, Xenopus tropicalis, Mus musculus, Rattus norvegicus | T764 | WPHMEKLESEV | 1 | Arabidopsis thaliana | T764 | WSHIAMLDQEI | 1 | Oryza sativa subsp. japonica | T764 | LKHSSNIADEV | 1 | Caenorhabditis elegans | T764 | QQYMVTFENLL | 1 | Gallus gallus | T764 | QKYSSTLETLL | 1 | Drosophila melanogaster | T764 | QKYSSTLESLL | 1 | Anopheles gambiae | V763 | IQQYMVTLENL | 4 | Homo sapiens, Xenopus tropicalis, Mus musculus, Rattus norvegicus | V763 | IWPHMEKLESE | 1 | Arabidopsis thaliana | V763 | IWSHIAMLDQE | 1 | Oryza sativa subsp. japonica | V763 | LLKHSSNIADE | 1 | Caenorhabditis elegans | V763 | IQQYMVTFENL | 1 | Gallus gallus | V763 | VQKYSSTLETL | 1 | Drosophila melanogaster | V763 | VQKYSSTLESL | 1 | Anopheles gambiae | Y761 | QIIQQYMVTLE | 3 | Homo sapiens, Xenopus tropicalis, Rattus norvegicus | Y761 | EQVQKYSSTLE | 2 | Drosophila melanogaster, Anopheles gambiae | Y761 | SEIWPHMEKLE | 1 | Arabidopsis thaliana | Y761 | TEIWSHIAMLD | 1 | Oryza sativa subsp. japonica | Y761 | ETLLKHSSNIA | 1 | Caenorhabditis elegans | Y761 | QIIQQYMVTFE | 1 | Gallus gallus | Y761 | QTIQQYMVTLE | 1 | Mus musculus |
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