mutLBSgeneDB |
Gene summary for OPRL1 |
Gene summary |
Basic gene Info. | Gene symbol | OPRL1 |
Gene name | opiate receptor-like 1 | |
Synonyms | KOR-3|NOCIR|OOR|ORL1 | |
Cytomap | UCSC genome browser: 20q13.33 | |
Type of gene | protein-coding | |
RefGenes | NM_000913.4, NM_001200019.1,NM_182647.2, | |
Description | kappa-type 3 opioid receptorkappa3-related opioid receptornociceptin receptororphanin FQ receptor | |
Modification date | 20141207 | |
dbXrefs | MIM : 602548 | |
HGNC : HGNC | ||
Ensembl : ENSG00000125510 | ||
HPRD : 03971 | ||
Vega : OTTHUMG00000033027 | ||
Protein | UniProt: P41146 go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_OPRL1 | |
BioGPS: 4987 | ||
Pathway | NCI Pathway Interaction Database: OPRL1 | |
KEGG: OPRL1 | ||
REACTOME: OPRL1 | ||
Pathway Commons: OPRL1 | ||
Context | iHOP: OPRL1 | |
ligand binding site mutation search in PubMed: OPRL1 | ||
UCL Cancer Institute: OPRL1 | ||
Assigned class in mutLBSgeneDB | B: This gene belongs to targetable_mutLBSgenes. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO Term | PubMed ID | GO:0038003 | opioid receptor signaling pathway | 12568343 |
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Ligand binding site mutations for OPRL1 |
Cancer type specific mutLBS sorted by frequency |
LBS | AAchange of nsSNV | Cancer type | # samples | D130 | D130Y | COAD | 1 |
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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Protein structure related information for OPRL1 |
Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
: nsSNV at non-LBS: nsSNV at LBS |
nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
LBS | AAchange of nsSNV | Relative stability change | D130 | D130Y | -0.45000146 |
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
Structure image for OPRL1 from PDB |
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Differential gene expression and gene-gene network for OPRL1 |
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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Phenotype information for OPRL1 |
Gene level disease information (DisGeNet) |
Disease ID | Disease name | # PubMed | Association type |
umls:C0003811 | Arrhythmias, Cardiac | 1 | Therapeutic |
umls:C0086439 | Hypokinesia | 1 | Biomarker |
umls:C0026552 | Morphine Dependence | 1 | Biomarker |
umls:C0038587 | Substance Withdrawal Syndrome | 1 | Biomarker |
Mutation level pathogenic information (ClinVar annotation) |
Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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Pharmacological information for OPRL1 |
Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
Gene-centered drug-gene interaction network |
Drug information targeting mutLBSgene (Approved drugs only) |
Drug status | DrugBank ID | Name | Type | Drug structure |
Illicit|vet_approved | DB01497 | Etorphine | Small molecule | |
Investigational | DB05492 | Epicept NP-1 | Small molecule |
Gene-centered ligand-gene interaction network |
Ligands binding to mutated ligand binding site of OPRL1 go to BioLip |
Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | 0NN | 1-BENZYL-N-[3-(1'H,3H-SPIRO[2-BENZOFURAN-1,4'-PIPERIDIN]-1'-YL)PROPYL]-D-PROLINAMIDE | 4ea3 | A | D130 | 0NN | 1-BENZYL-N-[3-(1'H,3H-SPIRO[2-BENZOFURAN-1,4'-PIPERIDIN]-1'-YL)PROPYL]-D-PROLINAMIDE | 4ea3 | B | D130 | DGV | 1-BENZYL-N-{3-[4-(2,6-DICHLOROPHENYL)PIPERIDIN-1- YL]PROPYL}-D-PROLINAMIDE | 5dhg | A | D130 | DGV | 1-BENZYL-N-{3-[4-(2,6-DICHLOROPHENYL)PIPERIDIN-1- YL]PROPYL}-D-PROLINAMIDE | 5dhg | B | D130 | DGW | (5S,7S)-7-{[4-(2,6-DICHLOROPHENYL)PIPERIDIN-1- YL]METHYL}-1-METHYL-6,7,8,9-TETRAHYDRO-5H- BENZO[7]ANNULEN-5-OL | 5dhh | A | D130 | DGW | (5S,7S)-7-{[4-(2,6-DICHLOROPHENYL)PIPERIDIN-1- YL]METHYL}-1-METHYL-6,7,8,9-TETRAHYDRO-5H- BENZO[7]ANNULEN-5-OL | 5dhh | B | D130 |
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Conservation information for LBS of OPRL1 |
Multiple alignments for P41146 in multiple species |
LBS | AA sequence | # species | Species | C200 | DEEIECLVEIP | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | D110 | PFQGTDILLGF | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | D130 | TVIAIDYYNMF | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | F135 | DYYNMFTSTFT | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | I127 | LCKTVIAIDYY | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | I219 | VFAICIFLFSF | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | L201 | EEIECLVEIPA | 2 | Mus musculus, Rattus norvegicus | L201 | EEIECLVEIPT | 1 | Homo sapiens | M134 | IDYYNMFTSTF | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | Q107 | LTLPFQGTDIL | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | Q280 | CWTPVQVFVLV | 2 | Mus musculus, Rattus norvegicus | Q280 | CWTPVQVFVLA | 1 | Homo sapiens | S223 | CIFLFSFIIPV | 2 | Mus musculus, Rattus norvegicus | S223 | CIFLFSFIVPV | 1 | Homo sapiens | T305 | ILRFCTALGYV | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | V279 | GCWTPVQVFVL | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | V283 | PVQVFVLVQGL | 2 | Mus musculus, Rattus norvegicus | V283 | PVQVFVLAQGL | 1 | Homo sapiens | W116 | ILLGFWPFGNA | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | W276 | VFVGCWTPVQV | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | Y131 | VIAIDYYNMFT | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | Y309 | CTALGYVNSCL | 3 | Homo sapiens, Mus musculus, Rattus norvegicus |
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