mutLBSgeneDB |
Gene summary for PDE4A |
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Basic gene Info. | Gene symbol | PDE4A |
Gene name | phosphodiesterase 4A, cAMP-specific | |
Synonyms | DPDE2|PDE4|PDE46 | |
Cytomap | UCSC genome browser: 19p13.2 | |
Type of gene | protein-coding | |
RefGenes | NM_001111307.1, NM_001111308.1,NM_001111309.1,NM_001243121.1,NM_006202.2, | |
Description | cAMP-specific 3',5'-cyclic phosphodiesterase 4Aphosphodiesterase 4A, cAMP-specific (duncephosphodiesterase E2 dunce homolog, Drosophilaphosphodiesterase isozyme 4 | |
Modification date | 20141207 | |
dbXrefs | MIM : 600126 | |
HGNC : HGNC | ||
Ensembl : ENSG00000065989 | ||
HPRD : 02527 | ||
Vega : OTTHUMG00000180411 | ||
Protein | UniProt: P27815 go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_PDE4A | |
BioGPS: 5141 | ||
Pathway | NCI Pathway Interaction Database: PDE4A | |
KEGG: PDE4A | ||
REACTOME: PDE4A | ||
Pathway Commons: PDE4A | ||
Context | iHOP: PDE4A | |
ligand binding site mutation search in PubMed: PDE4A | ||
UCL Cancer Institute: PDE4A | ||
Assigned class in mutLBSgeneDB | B: This gene belongs to targetable_mutLBSgenes. |
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GO ID | GO Term | PubMed ID | GO:0006198 | cAMP catabolic process | 17404263 |
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Ligand binding site mutations for PDE4A |
![]() We represented ligand binding site mutations only. (You can see big image via clicking.) ![]() |
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LBS | AAchange of nsSNV | Cancer type | # samples | D591 | A590V | GBM | 1 | D474 | D474N | HNSC | 1 | F613 | Q615H | KIRC | 1 | D474 | V475L | LUAD | 1 | N594 | N594S | STAD | 1 | H473 | A471V | UCEC | 1 |
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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Protein structure related information for PDE4A |
![]() Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
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![]() Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
LBS | AAchange of nsSNV | Relative stability change | F613 | Q615H | -1.0745272 | D474 | V475L | -0.90902103 | N594 | N594S | -0.73330091 | H473 | A471V | -0.4219737 | D474 | D474N | -0.40433243 | D591 | A590V | -0.3834742 |
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
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Differential gene expression and gene-gene network for PDE4A |
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Phenotype information for PDE4A |
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Disease ID | Disease name | # PubMed | Association type |
umls:C0004352 | Autistic Disorder | 1 | Biomarker |
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Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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Pharmacological information for PDE4A |
![]() Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
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Drug status | DrugBank ID | Name | Type | Drug structure |
Approved | DB00277 | Theophylline | Small molecule | ![]() |
Approved | DB00651 | Dyphylline | Small molecule | ![]() |
Approved|investigational | DB00806 | Pentoxifylline | Small molecule | ![]() |
Approved | DB00824 | Enprofylline | Small molecule | ![]() |
Approved | DB00920 | Ketotifen | Small molecule | ![]() |
Approved | DB00975 | Dipyridamole | Small molecule | ![]() |
Approved|investigational | DB01088 | Iloprost | Small molecule | ![]() |
Approved | DB01303 | Oxtriphylline | Small molecule | ![]() |
Approved | DB01656 | Roflumilast | Small molecule | ![]() |
Experimental | DB01791 | Piclamilast | Small molecule | ![]() |
Investigational | DB05219 | AN2728 | Small molecule | ![]() |
Approved|investigational | DB05266 | Ibudilast | Small molecule | ![]() |
Approved|investigational | DB05676 | Apremilast | Small molecule | ![]() |
Investigational | DB05876 | PDE4 | Small molecule | ![]() |
Approved | DB06751 | Drotaverine | Small molecule | ![]() |
Experimental | DB06842 | (4R)-4-(3-butoxy-4-methoxybenzyl)imidazolidin-2-one | Small molecule | ![]() |
Experimental | DB08299 | 4-[8-(3-nitrophenyl)-1,7-naphthyridin-6-yl]benzoic acid | Small molecule | ![]() |
Approved | DB08811 | Tofisopam | Small molecule | ![]() |
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Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS |
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Conservation information for LBS of PDE4A |
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LBS | AA sequence | # species | Species | D429 | DHYHADVAYHN | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | D474 | AAAIHDVDHPG | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | D591 | MVHCADLSNPT | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | F613 | RIMAEFFQQGD | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | F645 | KSQVGFIDYIV | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | H427 | LEDHYHADVAY | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | H433 | ADVAYHNSLHA | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | H437 | YHNSLHAADVL | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | H473 | FAAAIHDVDHP | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | I609 | QWTDRIMAEFF | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | M546 | VLATDMSKHMT | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | M610 | WTDRIMAEFFQ | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | M630 | MEISPMCDKHT | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | N594 | CADLSNPTKPL | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | Q642 | SVEKSQVGFID | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | S641 | ASVEKSQVGFI | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | T544 | DMVLATDMSKH | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | T606 | LYRQWTDRIMA | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | Y432 | HADVAYHNSLH | 3 | Homo sapiens, Mus musculus, Rattus norvegicus |
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