mutated Ligand Binding Site gene DataBase





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Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for POLK
Gene summary
Basic gene Info.Gene symbolPOLK
Gene namepolymerase (DNA directed) kappa
CytomapUCSC genome browser: 5q13
Type of geneprotein-coding
DescriptionDNA polymerase kappa
Modification date20141207
dbXrefs MIM : 605650
Ensembl : ENSG00000122008
HPRD : 09291
Vega : OTTHUMG00000102107
ProteinUniProt: Q9UBT6
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_POLK
BioGPS: 51426
PathwayNCI Pathway Interaction Database: POLK
Pathway Commons: POLK
ContextiHOP: POLK
ligand binding site mutation search in PubMed: POLK
UCL Cancer Institute: POLK
Assigned class in mutLBSgeneDBC: This gene just belongs to mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez

Ligand binding site mutations for POLK
Lollipop-style diagram of mutations at LBS in amino-acid sequence.
We represented ligand binding site mutations only. (You can see big image via clicking.)
: non-synonymous mutation on LBS, Circle size denotes number of samples.

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.

Protein structure related information for POLK
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for POLK from PDB

Differential gene expression and gene-gene network for POLK
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of POLK and the right PPI network was created from samples without mutations in the LBS of POLK. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


Phenotype information for POLK
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

Pharmacological information for POLK

Gene-centered drug-gene interaction network
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure
ExperimentalDB074351,2,3-TRIHYDROXY-1,2,3,4-TETRAHYDROBENZO[A]PYRENESmall molecule
ExperimentalDB082372'-deoxy-N-(naphthalen-1-ylmethyl)guanosine 5'-(dihydrogen phosphate)Small molecule

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of POLK go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS
TTPDTTP2oh2AD109 R144 K328
TTPDTTP2oh2BD109 R144 K328
DTPDATP(4-)2w7pAD109 R144 K328
ATPATP3in5AD109 R144 K328
DTPDATP(4-)3pzpAD109 R144 K328
NUCNucleic Acids2w7pBF49 M133 P153 F155
NUCNucleic Acids2w7oBF49 M133 P153 F155 L508
NUCNucleic Acids2oh2BF49 P153 F155
NUCNucleic Acids3in5AF49 P153 F155
NUCNucleic Acids3pzpBF49 P153 F155
NUCNucleic Acids2w7oAF49 P153 F155 R512
NUCNucleic Acids2w7pAF49 P153 F155 R512
NUCNucleic Acids2oh2AF49 P153 L508
NUCNucleic Acids3in5BF49 P153 L508 R512
DTPDATP(4-)2w7pBR144 K328
ATPATP3in5BR144 K328
DTPDATP(4-)3pzpBR144 K328
MGMAGNESIUM(2+)3in5AR352 V354
MGMAGNESIUM(2+)3in5BR352 V354
MGMAGNESIUM(2+)3pzpAR352 V354
MGMAGNESIUM(2+)3pzpBR352 V354
NUCNucleic Acids3pzpAS47 F49 P153 F155 L508
NUCNucleic Acids2w7oBV354
NUCNucleic Acids2w7pAV354
NUCNucleic Acids2w7pBV354

Conservation information for LBS of POLK
Multiple alignments for Q9UBT6 in multiple species
LBSAA sequence# speciesSpecies
A110HIDMDAFYAAV1Homo sapiens
A110HVDCDAFYASI1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
A110HVDMDAFYAAV1Mus musculus
A110CIDMDAYFAAV1Caenorhabditis elegans
A150RFGVRAAMPGF2Homo sapiens, Mus musculus
A150KFGVRSAMPEF1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
A150RFGVRAGMPGF1Caenorhabditis elegans
A151FGVRAAMPGFI2Homo sapiens, Mus musculus
A151FGVRSAMPEFI1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
A151FGVRAGMPGFI1Caenorhabditis elegans
A26----KAGMEGL2Homo sapiens, Mus musculus
A26PSVLKSGQENV1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
A26----KAGMNGL1Caenorhabditis elegans
A471EVKTRASTVSS1Homo sapiens
A471QVHTKQKSIGQ1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
A471EVKTRASTVPA1Mus musculus
A471DVLTRSLTPSD1Caenorhabditis elegans
D107TIVHIDMDAFY1Homo sapiens
D107IIVHVDCDAFY1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
D107TIVHVDMDAFY1Mus musculus
D107DCVCIDMDAYF1Caenorhabditis elegans
D109VHIDMDAFYAA1Homo sapiens
D109VHVDCDAFYAS1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
D109VHVDMDAFYAA1Mus musculus
D109VCIDMDAYFAA1Caenorhabditis elegans
D198MAMSLDEAYLN2Homo sapiens, Mus musculus
D198CPASIDEFYMN1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
D198GMMSLDEAFID1Caenorhabditis elegans
D325AKVCSDKNKPN2Homo sapiens, Mus musculus
D325AKIASNKRKPN1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
D325AKICSDLNKPN1Caenorhabditis elegans
E199AMSLDEAYLNI2Homo sapiens, Mus musculus
E199PASIDEFYMNL1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
E199MMSLDEAFIDL1Caenorhabditis elegans
E419KSMSVERTFSE2Homo sapiens, Mus musculus
E419KTIGSEATFSS1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
E419KSISVERTFSP1Caenorhabditis elegans
F111IDMDAFYAAVE1Homo sapiens
F111VDCDAFYASIE1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
F111VDMDAFYAAVE1Mus musculus
F111IDMDAYFAAVE1Caenorhabditis elegans
F155AAMPGFIAKRL2Homo sapiens, Mus musculus
F155SAMPEFIARKI1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
F155AGMPGFISNKL1Caenorhabditis elegans
F422SVERTFSE-IN1Homo sapiens
F422GSEATFSSNLS1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
F422SVERTFSE-IS1Mus musculus
F422SVERTFSP-TS1Caenorhabditis elegans
F465LKNVNFEVKTR2Homo sapiens, Mus musculus
F465YKTSEFQVHTK1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
F465LKLSSFDVLTR1Caenorhabditis elegans
F49TKGSRFYGNEL2Homo sapiens, Mus musculus
F49SKGSKFFEAEQ1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
F49TSAS-YSSFSK1Caenorhabditis elegans
G356IRKVSGIGKVT2Homo sapiens, Mus musculus
G356VREVSGIGRVL1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G356IRKVGGIGRVC1Caenorhabditis elegans
G358KVSGIGKVTEK2Homo sapiens, Mus musculus
G358EVSGIGRVLEQ1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G358KVGGIGRVCEA1Caenorhabditis elegans
H105SNTIVHIDMDA1Homo sapiens
H105TQIIVHVDCDA1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
H105NNTIVHVDMDA1Mus musculus
H105SRDCVCIDMDA1Caenorhabditis elegans
I156AMPGFIAKRLC2Homo sapiens, Mus musculus
I156AMPEFIARKIC1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
I156GMPGFISNKLC1Caenorhabditis elegans
I357RKVSGIGKVTE2Homo sapiens, Mus musculus
I357REVSGIGRVLE1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
I357RKVGGIGRVCE1Caenorhabditis elegans
K321NTMLAKVCSDK2Homo sapiens, Mus musculus
K321NKLLAKIASNK1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
K321NFMLAKICSDL1Caenorhabditis elegans
K328CSDKNKPNGQY2Homo sapiens, Mus musculus
K328ASNKRKPNNQF1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
K328CSDLNKPNGQY1Caenorhabditis elegans
K359VSGIGKVTEKM2Homo sapiens, Mus musculus
K359VSGIGRVLEQQ1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
K359VGGIGRVCEAQ1Caenorhabditis elegans
K414-DGERKSMSVE2Homo sapiens, Mus musculus
K414GESKRKTIGSE1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
K414-DPRRKSISVE1Caenorhabditis elegans
K461VTIKLKNVNFE2Homo sapiens, Mus musculus
K461IAIKYKTSEFQ1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
K461VTLKLKLSSFD1Caenorhabditis elegans
K468VNFEVKTRAST2Homo sapiens, Mus musculus
K468SEFQVHTKQKS1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
K468SSFDVLTRSLT1Caenorhabditis elegans
K56GNELKKEKQVN2Homo sapiens, Mus musculus
K56EAEQKRDRELR1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
K56SFSKKQQSRIE1Caenorhabditis elegans
L508PLRLRLMGVRI1Homo sapiens
L508PMTIRLLGVRA1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
L508PLRLRLMGVRM1Mus musculus
L508GKEIRLLGVRL1Caenorhabditis elegans
M108IVHIDMDAFYA1Homo sapiens
M108IVHVDCDAFYA1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
M108IVHVDMDAFYA1Mus musculus
M108CVCIDMDAYFA1Caenorhabditis elegans
M133IAVGSMSMLST1Homo sapiens
M133MAVGK-SVLCT1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
M133IAVGSMSMLAT1Mus musculus
M133MAVGSSAMLST1Caenorhabditis elegans
M135VGSMSMLSTSN1Homo sapiens
M135VGK-SVLCTAN1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
M135VGSMSMLATSN1Mus musculus
M135VGSSAMLSTSN1Caenorhabditis elegans
M416GERKSMSVERT2Homo sapiens, Mus musculus
M416SKRKTIGSEAT1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
M416PRRKSISVERT1Caenorhabditis elegans
P153VRAAMPGFIAK2Homo sapiens, Mus musculus
P153VRSAMPEFIAR1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
P153VRAGMPGFISN1Caenorhabditis elegans
R144SNYHARRFGVR2Homo sapiens, Mus musculus
R144ANYVARKFGVR1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
R144SNYLARRFGVR1Caenorhabditis elegans
R352KDLPIRKVSGI2Homo sapiens, Mus musculus
R352NDLPVREVSGI1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
R352KDLPIRKVGGI1Caenorhabditis elegans
R413--DGERKSMSV2Homo sapiens, Mus musculus
R413YGESKRKTIGS1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
R413--DPRRKSISV1Caenorhabditis elegans
R420SMSVERTFSE-2Homo sapiens, Mus musculus
R420TIGSEATFSSN1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
R420SISVERTFSP-1Caenorhabditis elegans
R454RLK-GRTVTIK1Homo sapiens
R454GLV-TNSIAIK1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
R454GLK-GRTVTIK1Mus musculus
R454GIVGGKTVTLK1Caenorhabditis elegans
R470FEVKTRASTVS1Homo sapiens
R470FQVHTKQKSIG1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
R470FEVKTRASTVP1Mus musculus
R470FDVLTRSLTPS1Caenorhabditis elegans
R507HPLRLRLMGVR2Homo sapiens, Mus musculus
R507YPMTIRLLGVR1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
R507KGKEIRLLGVR1Caenorhabditis elegans
R512RLMGVRISSFP1Homo sapiens
R512RLLGVRATKLV1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
R512RLMGVRMSTFS1Mus musculus
R512RLLGVRLSQLI1Caenorhabditis elegans
R63KQVNQRIENMM2Homo sapiens, Mus musculus
R63RELRLRIEKVQ1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
R63SRIEEKVLEIK1Caenorhabditis elegans
S134AVGSMSMLSTS1Homo sapiens
S134AVGK-SVLCTA1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
S134AVGSMSMLATS1Mus musculus
S134AVGSSAMLSTS1Caenorhabditis elegans
S137SMSMLSTSNYH1Homo sapiens
S137K-SVLCTANYV1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
S137SMSMLATSNYH1Mus musculus
S137SSAMLSTSNYL1Caenorhabditis elegans
S196NFMAMSLDEAY2Homo sapiens, Mus musculus
S196NLCPASIDEFY1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
S196DVGMMSLDEAF1Caenorhabditis elegans
S324LAKVCSDKNKP2Homo sapiens, Mus musculus
S324LAKIASNKRKP1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
S324LAKICSDLNKP1Caenorhabditis elegans
S355PIRKVSGIGKV2Homo sapiens, Mus musculus
S355PVREVSGIGRV1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
S355PIRKVGGIGRV1Caenorhabditis elegans
S388LSLLFSETSWH2Homo sapiens, Mus musculus
S388LSYIFLPKSFQ1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
S388YPLCFTPLSQE1Caenorhabditis elegans
S391LFSETSWHYFL2Homo sapiens, Mus musculus
S391IFLPKSFQNLL1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
S391CFTPLSQESFL1Caenorhabditis elegans
S415DGERKSMSVER2Homo sapiens, Mus musculus
S415ESKRKTIGSEA1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
S415DPRRKSISVER1Caenorhabditis elegans
S417ERKSMSVERTF2Homo sapiens, Mus musculus
S417KRKTIGSEATF1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
S417RRKSISVERTF1Caenorhabditis elegans
S423VERTFSE-INK1Homo sapiens
S423SEATFSSNLSS1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
S423VERTFSE-ISK1Mus musculus
S423VERTFSP-TSD1Caenorhabditis elegans
S47EATKGSRFYGN2Homo sapiens, Mus musculus
S47EASKGSKFFEA1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
S47ENTSAS-YSSF1Caenorhabditis elegans
S472VKTRASTVSSV1Homo sapiens
S472VHTKQKSIGQF1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
S472VKTRASTVPAA1Mus musculus
S472VLTRSLTPSDV1Caenorhabditis elegans
T138MSMLSTSNYHA1Homo sapiens
T138-SVLCTANYVA1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
T138MSMLATSNYHA1Mus musculus
T138SAMLSTSNYLA1Caenorhabditis elegans
T361GIGKVTEKMLK1Homo sapiens
T361GIGRVLEQQLL1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
T361GIGKVTEKMLM1Mus musculus
T361GIGRVCEAQLK1Caenorhabditis elegans
T390LLFSETSWHYF2Homo sapiens, Mus musculus
T390YIFLPKSFQNL1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
T390LCFTPLSQESF1Caenorhabditis elegans
T421MSVERTFSE-I2Homo sapiens, Mus musculus
T421IGSEATFSSNL1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
T421ISVERTFSP-T1Caenorhabditis elegans
T44IIMEATKGSRF2Homo sapiens, Mus musculus
T44IIYEASKGSKF1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
T44VIEENTSAS-Y1Caenorhabditis elegans
T455LK-GRTVTIKL2Homo sapiens, Mus musculus
T455LV-TNSIAIKY1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
T455IVGGKTVTLKL1Caenorhabditis elegans
T469NFEVKTRASTV2Homo sapiens, Mus musculus
T469EFQVHTKQKSI1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
T469SFDVLTRSLTP1Caenorhabditis elegans
T473KTRASTVSSVV1Homo sapiens
T473HTKQKSIGQFI1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
T473KTRASTVPAAI1Mus musculus
T473LTRSLTPSDVV1Caenorhabditis elegans
V354LPIRKVSGIGK2Homo sapiens, Mus musculus
V354LPVREVSGIGR1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
V354LPIRKVGGIGR1Caenorhabditis elegans
V360SGIGKVTEKML2Homo sapiens, Mus musculus
V360SGIGRVLEQQL1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
V360GGIGRVCEAQL1Caenorhabditis elegans
V418RKSMSVERTFS2Homo sapiens, Mus musculus
V418RKTIGSEATFS1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
V418RKSISVERTFS1Caenorhabditis elegans
V467NVNFEVKTRAS2Homo sapiens, Mus musculus
V467TSEFQVHTKQK1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
V467LSSFDVLTRSL1Caenorhabditis elegans
V60KKEKQVNQRIE2Homo sapiens, Mus musculus
V60KRDRELRLRIE1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
V60KQQSRIEEKVL1Caenorhabditis elegans
Y112DMDAFYAAVEM2Homo sapiens, Mus musculus
Y112DCDAFYASIEE1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Y112DMDAYFAAVEM1Caenorhabditis elegans
Y141LSTSNYHARRF1Homo sapiens
Y141LCTANYVARKF1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Y141LATSNYHARRF1Mus musculus
Y141LSTSNYLARRF1Caenorhabditis elegans

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