mutLBSgeneDB |
Gene summary for RAB14 |
Gene summary |
Basic gene Info. | Gene symbol | RAB14 |
Gene name | RAB14, member RAS oncogene family | |
Synonyms | FBP|RAB-14 | |
Cytomap | UCSC genome browser: 9q32-q34.11 | |
Type of gene | protein-coding | |
RefGenes | NM_016322.3, | |
Description | F protein-binding protein 1bA165P4.3 (member RAS oncogene family)ras-related protein Rab-14small GTP binding protein RAB14 | |
Modification date | 20141207 | |
dbXrefs | MIM : 612673 | |
HGNC : HGNC | ||
Ensembl : ENSG00000119396 | ||
HPRD : 06693 | ||
Vega : OTTHUMG00000020582 | ||
Protein | UniProt: P61106 go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_RAB14 | |
BioGPS: 51552 | ||
Pathway | NCI Pathway Interaction Database: RAB14 | |
KEGG: RAB14 | ||
REACTOME: RAB14 | ||
Pathway Commons: RAB14 | ||
Context | iHOP: RAB14 | |
ligand binding site mutation search in PubMed: RAB14 | ||
UCL Cancer Institute: RAB14 | ||
Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO Term | PubMed ID | GO:0006184 | GTP catabolic process | 17562788 | GO:0032456 | endocytic recycling | 22595670 | GO:0032880 | regulation of protein localization | 22595670 |
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Ligand binding site mutations for RAB14 |
Lollipop-style diagram of mutations at LBS in amino-acid sequence. We represented ligand binding site mutations only. (You can see big image via clicking.) : non-synonymous mutation on LBS, Circle size denotes number of samples. |
Cancer type specific mutLBS sorted by frequency |
LBS | AAchange of nsSNV | Cancer type | # samples | D66 | T67M | UCEC | 1 | T43 | I44L | UCEC | 1 |
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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Protein structure related information for RAB14 |
Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
: nsSNV at non-LBS: nsSNV at LBS |
nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
LBS | AAchange of nsSNV | Relative stability change | T43 | I44L | -0.50299898 | D66 | T67M | -0.42166103 |
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
Structure image for RAB14 from PDB |
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Differential gene expression and gene-gene network for RAB14 |
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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Phenotype information for RAB14 |
Gene level disease information (DisGeNet) |
Disease ID | Disease name | # PubMed | Association type |
Mutation level pathogenic information (ClinVar annotation) |
Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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Pharmacological information for RAB14 |
Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
Drug information targeting mutLBSgene (Approved drugs only) |
Drug status | DrugBank ID | Name | Type | Drug structure |
Gene-centered ligand-gene interaction network |
Ligands binding to mutated ligand binding site of RAB14 go to BioLip |
Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | MG | MAGNESIUM(2+) | 1z0f | A | D66 | CA | CALCIUM(2+) | 4drz | A | D66 | GTP | GTP | 4d0g | A | T43 | MG | MAGNESIUM(2+) | 4d0g | A | T43 |
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Conservation information for LBS of RAB14 |
Multiple alignments for P61106 in multiple species |
LBS | AA sequence | # species | Species | A155 | FLEASAKTGEN | 4 | Homo sapiens, Mus musculus, Gallus gallus, Rattus norvegicus | A38 | EKKFMADCPHT | 4 | Homo sapiens, Mus musculus, Gallus gallus, Rattus norvegicus | C26 | GVGKSCLLHQF | 4 | Homo sapiens, Mus musculus, Gallus gallus, Rattus norvegicus | C40 | KFMADCPHTIG | 4 | Homo sapiens, Mus musculus, Gallus gallus, Rattus norvegicus | D127 | IGNKADLEAQR | 4 | Homo sapiens, Mus musculus, Gallus gallus, Rattus norvegicus | D39 | KKFMADCPHTI | 4 | Homo sapiens, Mus musculus, Gallus gallus, Rattus norvegicus | D66 | KLQIWDTAGQE | 4 | Homo sapiens, Mus musculus, Gallus gallus, Rattus norvegicus | F36 | FTEKKFMADCP | 4 | Homo sapiens, Mus musculus, Gallus gallus, Rattus norvegicus | G21 | IIGDMGVGKSC | 4 | Homo sapiens, Mus musculus, Gallus gallus, Rattus norvegicus | G23 | GDMGVGKSCLL | 4 | Homo sapiens, Mus musculus, Gallus gallus, Rattus norvegicus | H42 | MADCPHTIGVE | 4 | Homo sapiens, Mus musculus, Gallus gallus, Rattus norvegicus | K125 | ILIGNKADLEA | 4 | Homo sapiens, Mus musculus, Gallus gallus, Rattus norvegicus | K156 | LEASAKTGENV | 4 | Homo sapiens, Mus musculus, Gallus gallus, Rattus norvegicus | K24 | DMGVGKSCLLH | 4 | Homo sapiens, Mus musculus, Gallus gallus, Rattus norvegicus | L128 | GNKADLEAQRD | 4 | Homo sapiens, Mus musculus, Gallus gallus, Rattus norvegicus | M20 | IIIGDMGVGKS | 4 | Homo sapiens, Mus musculus, Gallus gallus, Rattus norvegicus | N124 | IILIGNKADLE | 4 | Homo sapiens, Mus musculus, Gallus gallus, Rattus norvegicus | S154 | LFLEASAKTGE | 4 | Homo sapiens, Mus musculus, Gallus gallus, Rattus norvegicus | S25 | MGVGKSCLLHQ | 4 | Homo sapiens, Mus musculus, Gallus gallus, Rattus norvegicus | T43 | ADCPHTIGVEF | 4 | Homo sapiens, Mus musculus, Gallus gallus, Rattus norvegicus | V22 | IGDMGVGKSCL | 4 | Homo sapiens, Mus musculus, Gallus gallus, Rattus norvegicus |
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