mutLBSgeneDB

mutLBSgeneDB
mutated Ligand Binding Site gene DataBase

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Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for RAB14
Gene summary
Basic gene Info.Gene symbolRAB14
Gene nameRAB14, member RAS oncogene family
SynonymsFBP|RAB-14
CytomapUCSC genome browser: 9q32-q34.11
Type of geneprotein-coding
RefGenesNM_016322.3,
DescriptionF protein-binding protein 1bA165P4.3 (member RAS oncogene family)ras-related protein Rab-14small GTP binding protein RAB14
Modification date20141207
dbXrefs MIM : 612673
HGNC : HGNC
Ensembl : ENSG00000119396
HPRD : 06693
Vega : OTTHUMG00000020582
ProteinUniProt: P61106
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_RAB14
BioGPS: 51552
PathwayNCI Pathway Interaction Database: RAB14
KEGG: RAB14
REACTOME: RAB14
Pathway Commons: RAB14
ContextiHOP: RAB14
ligand binding site mutation search in PubMed: RAB14
UCL Cancer Institute: RAB14
Assigned class in mutLBSgeneDBC: This gene just belongs to mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO TermPubMed ID
GO:0006184GTP catabolic process17562788
GO:0032456endocytic recycling22595670
GO:0032880regulation of protein localization22595670


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Ligand binding site mutations for RAB14
Lollipop-style diagram of mutations at LBS in amino-acid sequence.
We represented ligand binding site mutations only. (You can see big image via clicking.)
 
: non-synonymous mutation on LBS, Circle size denotes number of samples.

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
D66T67MUCEC1
T43I44LUCEC1
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.


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Protein structure related information for RAB14
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
T43I44L-0.50299898
D66T67M-0.42166103
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for RAB14 from PDB

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Differential gene expression and gene-gene network for RAB14
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of RAB14 and the right PPI network was created from samples without mutations in the LBS of RAB14. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


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Phenotype information for RAB14
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

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Pharmacological information for RAB14
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of RAB14 go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS
MGMAGNESIUM(2+)1z0fAD66
CACALCIUM(2+)4drzAD66
GTPGTP4d0gAT43
MGMAGNESIUM(2+)4d0gAT43


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Conservation information for LBS of RAB14
Multiple alignments for P61106 in multiple species
LBSAA sequence# speciesSpecies
A155FLEASAKTGEN4Homo sapiens, Mus musculus, Gallus gallus, Rattus norvegicus
A38EKKFMADCPHT4Homo sapiens, Mus musculus, Gallus gallus, Rattus norvegicus
C26GVGKSCLLHQF4Homo sapiens, Mus musculus, Gallus gallus, Rattus norvegicus
C40KFMADCPHTIG4Homo sapiens, Mus musculus, Gallus gallus, Rattus norvegicus
D127IGNKADLEAQR4Homo sapiens, Mus musculus, Gallus gallus, Rattus norvegicus
D39KKFMADCPHTI4Homo sapiens, Mus musculus, Gallus gallus, Rattus norvegicus
D66KLQIWDTAGQE4Homo sapiens, Mus musculus, Gallus gallus, Rattus norvegicus
F36FTEKKFMADCP4Homo sapiens, Mus musculus, Gallus gallus, Rattus norvegicus
G21IIGDMGVGKSC4Homo sapiens, Mus musculus, Gallus gallus, Rattus norvegicus
G23GDMGVGKSCLL4Homo sapiens, Mus musculus, Gallus gallus, Rattus norvegicus
H42MADCPHTIGVE4Homo sapiens, Mus musculus, Gallus gallus, Rattus norvegicus
K125ILIGNKADLEA4Homo sapiens, Mus musculus, Gallus gallus, Rattus norvegicus
K156LEASAKTGENV4Homo sapiens, Mus musculus, Gallus gallus, Rattus norvegicus
K24DMGVGKSCLLH4Homo sapiens, Mus musculus, Gallus gallus, Rattus norvegicus
L128GNKADLEAQRD4Homo sapiens, Mus musculus, Gallus gallus, Rattus norvegicus
M20IIIGDMGVGKS4Homo sapiens, Mus musculus, Gallus gallus, Rattus norvegicus
N124IILIGNKADLE4Homo sapiens, Mus musculus, Gallus gallus, Rattus norvegicus
S154LFLEASAKTGE4Homo sapiens, Mus musculus, Gallus gallus, Rattus norvegicus
S25MGVGKSCLLHQ4Homo sapiens, Mus musculus, Gallus gallus, Rattus norvegicus
T43ADCPHTIGVEF4Homo sapiens, Mus musculus, Gallus gallus, Rattus norvegicus
V22IGDMGVGKSCL4Homo sapiens, Mus musculus, Gallus gallus, Rattus norvegicus


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