mutated Ligand Binding Site gene DataBase





About Us

Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for ACP1
Gene summary
Basic gene Info.Gene symbolACP1
Gene nameacid phosphatase 1, soluble
CytomapUCSC genome browser: 2p25
Type of geneprotein-coding
DescriptionLMW-PTPLMW-PTPaseacid phosphatase of erythrocyteadipocyte acid phosphatasecytoplasmic phosphotyrosyl protein phosphataselow molecular weight cytosolic acid phosphataselow molecular weight phosphotyrosine protein phosphataseprotein tyrosine phosphat
Modification date20141207
dbXrefs MIM : 171500
Ensembl : ENSG00000143727
HPRD : 08881
Vega : OTTHUMG00000086933
ProteinUniProt: P24666
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_ACP1
BioGPS: 52
PathwayNCI Pathway Interaction Database: ACP1
Pathway Commons: ACP1
ContextiHOP: ACP1
ligand binding site mutation search in PubMed: ACP1
UCL Cancer Institute: ACP1
Assigned class in mutLBSgeneDBC: This gene just belongs to mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez

Ligand binding site mutations for ACP1

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.

Protein structure related information for ACP1
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for ACP1 from PDB

Differential gene expression and gene-gene network for ACP1
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of ACP1 and the right PPI network was created from samples without mutations in the LBS of ACP1. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


Phenotype information for ACP1
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

Pharmacological information for ACP1
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.

Gene-centered drug-gene interaction network
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure
Approved|nutraceuticalDB00173AdenineSmall molecule
ExperimentalDB042144-Nitrophenyl PhosphateSmall molecule

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of ACP1 go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS

Conservation information for LBS of ACP1
Multiple alignments for P24666 in multiple species
LBSAA sequence# speciesSpecies
C13SVLFVCLGNIC3Homo sapiens, Gallus gallus, Mus musculus
C13KVLMICLGNIC1Drosophila melanogaster
C18CLGNICRSPIA4Homo sapiens, Drosophila melanogaster, Gallus gallus, Mus musculus
D130QLIIEDPYYGN3Homo sapiens, Gallus gallus, Mus musculus
D130NRIIEDPYYER1Drosophila melanogaster
E51ATSGYEIGNPP1Homo sapiens
E51AIGGWHVGNRA1Drosophila melanogaster
E51ATSTYEIGNPP1Gallus gallus
E51ATSTYEVGNPP1Mus musculus
F83ITKEDFATFDY2Homo sapiens, Mus musculus
F83IRKQDFSEFDY1Drosophila melanogaster
F83VTKDDFQTFDY1Gallus gallus
G15LFVCLGNICRS3Homo sapiens, Gallus gallus, Mus musculus
G15LMICLGNICRS1Drosophila melanogaster
I17VCLGNICRSPI3Homo sapiens, Gallus gallus, Mus musculus
I17ICLGNICRSPI1Drosophila melanogaster
I78HVARQITKEDF1Homo sapiens
I78HIVRQIRKQDF1Drosophila melanogaster
I78HIARQVTKDDF1Gallus gallus
I78HIARQITKEDF1Mus musculus
K103RDLNRKSNQVK2Homo sapiens, Mus musculus
K103SELRRLAP--K1Drosophila melanogaster
K103RDLKRKSNQVK1Gallus gallus
K80ARQITKEDFAT2Homo sapiens, Mus musculus
K80VRQIRKQDFSE1Drosophila melanogaster
K80ARQVTKDDFQT1Gallus gallus
L14VLFVCLGNICR3Homo sapiens, Gallus gallus, Mus musculus
L14VLMICLGNICR1Drosophila melanogaster
N16FVCLGNICRSP3Homo sapiens, Gallus gallus, Mus musculus
N16MICLGNICRSP1Drosophila melanogaster
Q77SHVARQITKED1Homo sapiens
Q77THIVRQIRKQD1Drosophila melanogaster
Q77NHIARQVTKDD1Gallus gallus
Q77QHIARQITKED1Mus musculus
R102LRDLNRKSNQV2Homo sapiens, Mus musculus
R102MSELRRLAP--1Drosophila melanogaster
R102LRDLKRKSNQV1Gallus gallus
R19LGNICRSPIAE4Homo sapiens, Drosophila melanogaster, Gallus gallus, Mus musculus
T79VARQITKEDFA1Homo sapiens
T79IVRQIRKQDFS1Drosophila melanogaster
T79IARQVTKDDFQ1Gallus gallus
T79IARQITKEDFA1Mus musculus
Y132IIEDPYYGNDS2Homo sapiens, Mus musculus
Y132IIEDPYYERGA1Drosophila melanogaster
Y132IIEDPYYGNEK1Gallus gallus

Copyright © 2016-Present - The University of Texas Health Science Center at Houston
Site Policies | State of Texas