mutLBSgeneDB |
Gene summary for ACP1 |
Gene summary |
Basic gene Info. | Gene symbol | ACP1 |
Gene name | acid phosphatase 1, soluble | |
Synonyms | HAAP | |
Cytomap | UCSC genome browser: 2p25 | |
Type of gene | protein-coding | |
RefGenes | NM_001040649.2, NM_004300.3,NM_007099.3,NR_024080.1,NM_177554.1, | |
Description | LMW-PTPLMW-PTPaseacid phosphatase of erythrocyteadipocyte acid phosphatasecytoplasmic phosphotyrosyl protein phosphataselow molecular weight cytosolic acid phosphataselow molecular weight phosphotyrosine protein phosphataseprotein tyrosine phosphat | |
Modification date | 20141207 | |
dbXrefs | MIM : 171500 | |
HGNC : HGNC | ||
Ensembl : ENSG00000143727 | ||
HPRD : 08881 | ||
Vega : OTTHUMG00000086933 | ||
Protein | UniProt: P24666 go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_ACP1 | |
BioGPS: 52 | ||
Pathway | NCI Pathway Interaction Database: ACP1 | |
KEGG: ACP1 | ||
REACTOME: ACP1 | ||
Pathway Commons: ACP1 | ||
Context | iHOP: ACP1 | |
ligand binding site mutation search in PubMed: ACP1 | ||
UCL Cancer Institute: ACP1 | ||
Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO Term | PubMed ID |
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Ligand binding site mutations for ACP1 |
Cancer type specific mutLBS sorted by frequency |
LBS | AAchange of nsSNV | Cancer type | # samples | R19 | R19Q | COAD | 1 | R19 | S20L | HNSC | 1 | L14 | L14V | KIRC | 1 | D130 | D130E | UCEC | 1 |
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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Protein structure related information for ACP1 |
Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
: nsSNV at non-LBS: nsSNV at LBS |
nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
LBS | AAchange of nsSNV | Relative stability change | R19 | S20L | 0.22113383 | R19 | R19Q | -1.4669835 | L14 | L14V | -1.0494685 | D130 | D130E | -0.71901117 |
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
Structure image for ACP1 from PDB |
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Differential gene expression and gene-gene network for ACP1 |
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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Phenotype information for ACP1 |
Gene level disease information (DisGeNet) |
Disease ID | Disease name | # PubMed | Association type |
Mutation level pathogenic information (ClinVar annotation) |
Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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Pharmacological information for ACP1 |
Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
Gene-centered drug-gene interaction network |
Drug information targeting mutLBSgene (Approved drugs only) |
Drug status | DrugBank ID | Name | Type | Drug structure |
Approved|nutraceutical | DB00173 | Adenine | Small molecule | |
Experimental | DB04214 | 4-Nitrophenyl Phosphate | Small molecule |
Gene-centered ligand-gene interaction network |
Ligands binding to mutated ligand binding site of ACP1 go to BioLip |
Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS |
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Conservation information for LBS of ACP1 |
Multiple alignments for P24666 in multiple species |
LBS | AA sequence | # species | Species | C13 | SVLFVCLGNIC | 3 | Homo sapiens, Gallus gallus, Mus musculus | C13 | KVLMICLGNIC | 1 | Drosophila melanogaster | C18 | CLGNICRSPIA | 4 | Homo sapiens, Drosophila melanogaster, Gallus gallus, Mus musculus | D130 | QLIIEDPYYGN | 3 | Homo sapiens, Gallus gallus, Mus musculus | D130 | NRIIEDPYYER | 1 | Drosophila melanogaster | E51 | ATSGYEIGNPP | 1 | Homo sapiens | E51 | AIGGWHVGNRA | 1 | Drosophila melanogaster | E51 | ATSTYEIGNPP | 1 | Gallus gallus | E51 | ATSTYEVGNPP | 1 | Mus musculus | F83 | ITKEDFATFDY | 2 | Homo sapiens, Mus musculus | F83 | IRKQDFSEFDY | 1 | Drosophila melanogaster | F83 | VTKDDFQTFDY | 1 | Gallus gallus | G15 | LFVCLGNICRS | 3 | Homo sapiens, Gallus gallus, Mus musculus | G15 | LMICLGNICRS | 1 | Drosophila melanogaster | I17 | VCLGNICRSPI | 3 | Homo sapiens, Gallus gallus, Mus musculus | I17 | ICLGNICRSPI | 1 | Drosophila melanogaster | I78 | HVARQITKEDF | 1 | Homo sapiens | I78 | HIVRQIRKQDF | 1 | Drosophila melanogaster | I78 | HIARQVTKDDF | 1 | Gallus gallus | I78 | HIARQITKEDF | 1 | Mus musculus | K103 | RDLNRKSNQVK | 2 | Homo sapiens, Mus musculus | K103 | SELRRLAP--K | 1 | Drosophila melanogaster | K103 | RDLKRKSNQVK | 1 | Gallus gallus | K80 | ARQITKEDFAT | 2 | Homo sapiens, Mus musculus | K80 | VRQIRKQDFSE | 1 | Drosophila melanogaster | K80 | ARQVTKDDFQT | 1 | Gallus gallus | L14 | VLFVCLGNICR | 3 | Homo sapiens, Gallus gallus, Mus musculus | L14 | VLMICLGNICR | 1 | Drosophila melanogaster | N16 | FVCLGNICRSP | 3 | Homo sapiens, Gallus gallus, Mus musculus | N16 | MICLGNICRSP | 1 | Drosophila melanogaster | Q77 | SHVARQITKED | 1 | Homo sapiens | Q77 | THIVRQIRKQD | 1 | Drosophila melanogaster | Q77 | NHIARQVTKDD | 1 | Gallus gallus | Q77 | QHIARQITKED | 1 | Mus musculus | R102 | LRDLNRKSNQV | 2 | Homo sapiens, Mus musculus | R102 | MSELRRLAP-- | 1 | Drosophila melanogaster | R102 | LRDLKRKSNQV | 1 | Gallus gallus | R19 | LGNICRSPIAE | 4 | Homo sapiens, Drosophila melanogaster, Gallus gallus, Mus musculus | T79 | VARQITKEDFA | 1 | Homo sapiens | T79 | IVRQIRKQDFS | 1 | Drosophila melanogaster | T79 | IARQVTKDDFQ | 1 | Gallus gallus | T79 | IARQITKEDFA | 1 | Mus musculus | Y132 | IIEDPYYGNDS | 2 | Homo sapiens, Mus musculus | Y132 | IIEDPYYERGA | 1 | Drosophila melanogaster | Y132 | IIEDPYYGNEK | 1 | Gallus gallus |
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