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mutLBSgeneDB |
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| Gene summary for PIM1 |
 Gene summary |
| Basic gene Info. | Gene symbol | PIM1 |
| Gene name | Pim-1 proto-oncogene, serine/threonine kinase | |
| Synonyms | PIM | |
| Cytomap | UCSC genome browser: 6p21.2 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001243186.1, NM_002648.3, | |
| Description | Oncogene PIM1pim-1 kinase 44 kDa isoformpim-1 oncogene (proviral integration site 1)proto-oncogene serine/threonine-protein kinase pim-1serine/threonine-protein kinase pim-1 | |
| Modification date | 20141222 | |
| dbXrefs | MIM : 164960 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000137193 | ||
| HPRD : 01292 | ||
| Vega : OTTHUMG00000016426 | ||
| Protein | UniProt: P11309 go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_PIM1 | |
| BioGPS: 5292 | ||
| Pathway | NCI Pathway Interaction Database: PIM1 | |
| KEGG: PIM1 | ||
| REACTOME: PIM1 | ||
| Pathway Commons: PIM1 | ||
| Context | iHOP: PIM1 | |
| ligand binding site mutation search in PubMed: PIM1 | ||
| UCL Cancer Institute: PIM1 | ||
| Assigned class in mutLBSgeneDB | A: This gene has a literature evidence and it belongs to targetable_mutLBSgenes. | |
| References showing study about ligand binding site mutation for PIM1. | 1. Kim, O., Jiang, T., Xie, Y., Guo, Z., Chen, H., & Qiu, Y. (2004). Synergism of cytoplasmic kinases in IL6-induced ligand-independent activation of androgen receptor in prostate cancer cells. Oncogene, 23(10), 1838-1844. 14981536 | |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO Term | PubMed ID | GO:0006468 | protein phosphorylation | 16266891 | GO:0008283 | cell proliferation | 16186805 | GO:0031659 | positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle | 18593906 | GO:0043066 | negative regulation of apoptotic process | 16186805 | GO:0043433 | negative regulation of sequence-specific DNA binding transcription factor activity | 18593906 | GO:0046777 | protein autophosphorylation | 16266891 |
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| Ligand binding site mutations for PIM1 |
| Lollipop-style diagram of mutations at LBS in amino-acid sequence. We represented ligand binding site mutations only. (You can see big image via clicking.)  : non-synonymous mutation on LBS, Circle size denotes number of samples. |
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| Cancer type specific mutLBS sorted by frequency |
| LBS | AAchange of nsSNV | Cancer type | # samples | T295,V297 | R296Q | COAD | 1 | E338 | E337K | COAD | 1 | E338 | E337K | HNSC | 1 | E338 | E337K | UCEC | 1 |
| cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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| Protein structure related information for PIM1 |
| Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
 : nsSNV at non-LBS : nsSNV at LBS |
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| nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
| LBS | AAchange of nsSNV | Relative stability change | E338 | E337K | -1.0475713 | T295 | R296Q | -0.49083401 | V297 | R296Q | -0.49083401 |
| (MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
| Structure image for PIM1 from PDB |
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| Differential gene expression and gene-gene network for PIM1 |
| Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
| Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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| Phenotype information for PIM1 |
| Gene level disease information (DisGeNet) |
| Disease ID | Disease name | # PubMed | Association type |
| umls:C0282612 | Prostatic Intraepithelial Neoplasia | 2 | AlteredExpression, Biomarker |
| umls:C0017636 | Glioblastoma | 2 | Biomarker |
| umls:C1458155 | Breast Neoplasms | 2 | Biomarker |
| umls:C0034186 | Pyelonephritis | 1 | Biomarker |
| umls:C0007621 | Cell Transformation, Neoplastic | 1 | Biomarker |
| umls:C0162820 | Dermatitis, Allergic Contact | 1 | Biomarker |
| Mutation level pathogenic information (ClinVar annotation) |
| Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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| Pharmacological information for PIM1 |
| Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
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| Gene-centered drug-gene interaction network |
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| Drug information targeting mutLBSgene (Approved drugs only) |
| Drug status | DrugBank ID | Name | Type | Drug structure |
| Approved|nutraceutical | DB00131 | Adenosine monophosphate | Small molecule |  |
| Experimental | DB01754 | 3,4-Dihydroxy-1-Methylquinolin-2(1h)-One | Small molecule |  |
| Experimental | DB02010 | Staurosporine | Small molecule |  |
| Experimental | DB02656 | 2-(4-Morpholinyl)-8-Phenyl-4h-1-Benzopyran-4-One | Small molecule |  |
| Experimental | DB03650 | (3e)-3-[(4-Hydroxyphenyl)Imino]-1h-Indol-2(3h)-One | Small molecule |  |
| Experimental | DB03777 | Rbt205 Inhibitor | Small molecule |  |
| Experimental | DB04216 | Quercetin | Small molecule |  |
| Experimental | DB04395 | Phosphoaminophosphonic Acid-Adenylate Ester | Small molecule |  |
| Experimental | DB04522 | Phosphonoserine | Small molecule |  |
| Experimental | DB04530 | S,S-(2-Hydroxyethyl)Thiocysteine | Small molecule |  |
| Experimental | DB04715 | IMIDAZOPYRIDAZIN 1 | Small molecule |  |
| Experimental | DB07151 | 4-(4-hydroxy-3-methylphenyl)-6-phenylpyrimidin-2(5H)-one | Small molecule |  |
| Experimental | DB07242 | (4R)-7,8-dichloro-1',9-dimethyl-1-oxo-1,2,4,9-tetrahydrospiro[beta-carboline-3,4'-piperidine]-4-carbonitrile | Small molecule |  |
| Experimental | DB07524 | N-phenyl-1H-pyrrolo[2,3-b]pyridin-3-amine | Small molecule |  |
| Experimental | DB08022 | (2S)-1,3-benzothiazol-2-yl{2-[(2-pyridin-3-ylethyl)amino]pyrimidin-4-yl}ethanenitrile | Small molecule |  |
| Experimental | DB08166 | (4R)-7-chloro-9-methyl-1-oxo-1,2,4,9-tetrahydrospiro[beta-carboline-3,4'-piperidine]-4-carbonitrile | Small molecule |  |
| Experimental | DB08230 | 5,7-DIHYDROXY-2-(3,4,5-TRIHYDROXYPHENYL)-4H-CHROMEN-4-ONE | Small molecule |  |
| Experimental | DB08705 | 6-(5-BROMO-2-HYDROXYPHENYL)-2-OXO-4-PHENYL-1,2-DIHYDROPYRIDINE-3-CARBONITRILE | Small molecule |  |
| Experimental | DB08707 | 4-[3-(4-chlorophenyl)-2,1-benzisoxazol-5-yl]pyrimidin-2-amine | Small molecule |  |
| Experimental | DB08708 | N-cyclohexyl-3-[3-(trifluoromethyl)phenyl][1,2,4]triazolo[4,3-b]pyridazin-6-amine | Small molecule |  |
| Experimental | DB08709 | 2,3-diphenyl-1H-indole-7-carboxylic acid | Small molecule |  |
| Gene-centered ligand-gene interaction network |
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| Ligands binding to mutated ligand binding site of PIM1 go to BioLip |
| Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS |
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| Conservation information for LBS of PIM1 |
| Multiple alignments for P11309 in multiple species |
| LBS | AA sequence | # species | Species | A156 | DNLPVAIKHVE | 3 | Homo sapiens, Rattus norvegicus, Bos taurus | A156 | DNALVAVKFIE | 1 | Caenorhabditis elegans | D219 | PEPVQDLFDFI | 3 | Homo sapiens, Rattus norvegicus, Bos taurus | D219 | PYPCIDMFDFI | 1 | Caenorhabditis elegans | D222 | VQDLFDFITER | 3 | Homo sapiens, Rattus norvegicus, Bos taurus | D222 | CIDMFDFIKGQ | 1 | Caenorhabditis elegans | D258 | GVLHRDIKDEN | 3 | Homo sapiens, Rattus norvegicus, Bos taurus | D258 | RVLHRDLKDEN | 1 | Caenorhabditis elegans | D261 | HRDIKDENILI | 3 | Homo sapiens, Rattus norvegicus, Bos taurus | D261 | HRDLKDENIVI | 1 | Caenorhabditis elegans | D277 | ELKLIDFGSGA | 3 | Homo sapiens, Rattus norvegicus, Bos taurus | D277 | STKLIDFGAAT | 1 | Caenorhabditis elegans | D293 | VYTDFDGTRVY | 3 | Homo sapiens, Rattus norvegicus, Bos taurus | D293 | QYSDFQGTRLY | 1 | Caenorhabditis elegans | D325 | GILLYDMVCGD | 3 | Homo sapiens, Rattus norvegicus, Bos taurus | D325 | GVLLYNSLNGR | 1 | Caenorhabditis elegans | D330 | DMVCGDIPFEH | 3 | Homo sapiens, Rattus norvegicus, Bos taurus | D330 | NSLNGRLPFRN | 1 | Caenorhabditis elegans | E180 | TRVPMEVVLLK | 3 | Homo sapiens, Rattus norvegicus, Bos taurus | E180 | EQVPMEICMLA | 1 | Caenorhabditis elegans | E212 | FVLILERPEPV | 3 | Homo sapiens, Rattus norvegicus, Bos taurus | E212 | FLIVMERPYPC | 1 | Caenorhabditis elegans | E262 | RDIKDENILID | 3 | Homo sapiens, Rattus norvegicus, Bos taurus | E262 | RDLKDENIVID | 1 | Caenorhabditis elegans | E334 | GDIPFEHDEEI | 3 | Homo sapiens, Rattus norvegicus, Bos taurus | E334 | GRLPFRNEKDI | 1 | Caenorhabditis elegans | E338 | FEHDEEIIRGQ | 1 | Homo sapiens | E338 | FRNEKDICTAH | 1 | Caenorhabditis elegans | E338 | FEHDEEIVKGQ | 1 | Rattus norvegicus | E338 | FEHDEEIVRGQ | 1 | Bos taurus | F140 | LGSGGFGSVYS | 3 | Homo sapiens, Rattus norvegicus, Bos taurus | F140 | LGRGGFGVVYR | 1 | Caenorhabditis elegans | F221 | PVQDLFDFITE | 3 | Homo sapiens, Rattus norvegicus, Bos taurus | F221 | PCIDMFDFIKG | 1 | Caenorhabditis elegans | F278 | LKLIDFGSGAL | 3 | Homo sapiens, Rattus norvegicus, Bos taurus | F278 | TKLIDFGAATV | 1 | Caenorhabditis elegans | F346 | F----FRQRVS | 2 | Homo sapiens, Bos taurus | F346 | LGPLPFFVPVS | 1 | Caenorhabditis elegans | F346 | Y----FRQRVS | 1 | Rattus norvegicus | G136 | VGPLLGSGGFG | 3 | Homo sapiens, Rattus norvegicus, Bos taurus | G136 | LKAELGRGGFG | 1 | Caenorhabditis elegans | G138 | PLLGSGGFGSV | 3 | Homo sapiens, Rattus norvegicus, Bos taurus | G138 | AELGRGGFGVV | 1 | Caenorhabditis elegans | G139 | LLGSGGFGSVY | 3 | Homo sapiens, Rattus norvegicus, Bos taurus | G139 | ELGRGGFGVVY | 1 | Caenorhabditis elegans | G141 | GSGGFGSVYSG | 3 | Homo sapiens, Rattus norvegicus, Bos taurus | G141 | GRGGFGVVYRA | 1 | Caenorhabditis elegans | G294 | YTDFDGTRVYS | 3 | Homo sapiens, Rattus norvegicus, Bos taurus | G294 | YSDFQGTRLYC | 1 | Caenorhabditis elegans | G329 | YDMVCGDIPFE | 3 | Homo sapiens, Rattus norvegicus, Bos taurus | G329 | YNSLNGRLPFR | 1 | Caenorhabditis elegans | I195 | GFSGVIRLLDW | 3 | Homo sapiens, Rattus norvegicus, Bos taurus | I195 | -VRGVIRLLDW | 1 | Caenorhabditis elegans | I224 | DLFDFITERGA | 3 | Homo sapiens, Rattus norvegicus, Bos taurus | I224 | DMFDFIKGQGK | 1 | Caenorhabditis elegans | I276 | GELKLIDFGSG | 3 | Homo sapiens, Rattus norvegicus, Bos taurus | I276 | GSTKLIDFGAA | 1 | Caenorhabditis elegans | I331 | MVCGDIPFEHD | 3 | Homo sapiens, Rattus norvegicus, Bos taurus | I331 | SLNGRLPFRNE | 1 | Caenorhabditis elegans | K158 | LPVAIKHVEKD | 3 | Homo sapiens, Rattus norvegicus, Bos taurus | K158 | ALVAVKFIERS | 1 | Caenorhabditis elegans | K260 | LHRDIKDENIL | 3 | Homo sapiens, Rattus norvegicus, Bos taurus | K260 | LHRDLKDENIV | 1 | Caenorhabditis elegans | L135 | QVGPLLGSGGF | 3 | Homo sapiens, Rattus norvegicus, Bos taurus | L135 | KLKAELGRGGF | 1 | Caenorhabditis elegans | L184 | MEVVLLKKVSS | 3 | Homo sapiens, Rattus norvegicus, Bos taurus | L184 | MEICMLAKCSK | 1 | Caenorhabditis elegans | L211 | SFVLILERPEP | 3 | Homo sapiens, Rattus norvegicus, Bos taurus | L211 | GFLIVMERPYP | 1 | Caenorhabditis elegans | L265 | KDENILIDLNR | 3 | Homo sapiens, Rattus norvegicus, Bos taurus | L265 | KDENIVIDLVT | 1 | Caenorhabditis elegans | N263 | DIKDENILIDL | 3 | Homo sapiens, Rattus norvegicus, Bos taurus | N263 | DLKDENIVIDL | 1 | Caenorhabditis elegans | P214 | LILERPEPVQD | 3 | Homo sapiens, Rattus norvegicus, Bos taurus | P214 | IVMERPYPCID | 1 | Caenorhabditis elegans | P332 | VCGDIPFEHDE | 3 | Homo sapiens, Rattus norvegicus, Bos taurus | P332 | LNGRLPFRNEK | 1 | Caenorhabditis elegans | Q218 | RPEPVQDLFDF | 3 | Homo sapiens, Rattus norvegicus, Bos taurus | Q218 | RPYPCIDMFDF | 1 | Caenorhabditis elegans | Q348 | ---FRQRVSSE | 3 | Homo sapiens, Rattus norvegicus, Bos taurus | Q348 | PLPFFVPVSAE | 1 | Caenorhabditis elegans | Q355 | VSSECQHLIRW | 3 | Homo sapiens, Rattus norvegicus, Bos taurus | Q355 | VSAEVKDLISK | 1 | Caenorhabditis elegans | R213 | VLILERPEPVQ | 3 | Homo sapiens, Rattus norvegicus, Bos taurus | R213 | LIVMERPYPCI | 1 | Caenorhabditis elegans | R347 | ----FRQRVSS | 3 | Homo sapiens, Rattus norvegicus, Bos taurus | R347 | GPLPFFVPVSA | 1 | Caenorhabditis elegans | R349 | --FRQRVSSEC | 3 | Homo sapiens, Rattus norvegicus, Bos taurus | R349 | LPFFVPVSAEV | 1 | Caenorhabditis elegans | S137 | GPLLGSGGFGS | 3 | Homo sapiens, Rattus norvegicus, Bos taurus | S137 | KAELGRGGFGV | 1 | Caenorhabditis elegans | S142 | SGGFGSVYSGI | 3 | Homo sapiens, Rattus norvegicus, Bos taurus | S142 | RGGFGVVYRAV | 1 | Caenorhabditis elegans | T225 | LFDFITERGAL | 3 | Homo sapiens, Rattus norvegicus, Bos taurus | T225 | MFDFIKGQGKI | 1 | Caenorhabditis elegans | T295 | TDFDGTRVYSP | 3 | Homo sapiens, Rattus norvegicus, Bos taurus | T295 | SDFQGTRLYCP | 1 | Caenorhabditis elegans | V143 | GGFGSVYSGIR | 3 | Homo sapiens, Rattus norvegicus, Bos taurus | V143 | GGFGVVYRAVR | 1 | Caenorhabditis elegans | V217 | ERPEPVQDLFD | 3 | Homo sapiens, Rattus norvegicus, Bos taurus | V217 | ERPYPCIDMFD | 1 | Caenorhabditis elegans | V297 | FDGTRVYSPPE | 3 | Homo sapiens, Rattus norvegicus, Bos taurus | V297 | FQGTRLYCPPE | 1 | Caenorhabditis elegans | V350 | -FRQRVSSECQ | 3 | Homo sapiens, Rattus norvegicus, Bos taurus | V350 | PFFVPVSAEVK | 1 | Caenorhabditis elegans | Y298 | DGTRVYSPPEW | 3 | Homo sapiens, Rattus norvegicus, Bos taurus | Y298 | QGTRLYCPPEW | 1 | Caenorhabditis elegans |
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