mutLBSgeneDB

mutLBSgeneDB
mutated Ligand Binding Site gene DataBase

Home

	Gene Summary
	Ligand Binding Site Mutation Information
	Protein Structure Related Information
	Gene Expression and Gene-Gene Network
	Phenotype Information
	Pharmacological Information
	Conservation Information for LBS

Gene summary for PKM

Gene summary

Basic gene Info.	Gene symbol	PKM
	Gene name	pyruvate kinase, muscle
	Synonyms	CTHBP\|HEL-S-30\|OIP3\|PK3\|PKM2\|TCB\|THBP1
	Cytomap	UCSC genome browser: 15q22
	Type of gene	protein-coding
	RefGenes	NM_001206796.1, NM_001206797.1,NM_001206798.1,NM_001206799.1,NM_002654.4, NM_182470.2,NM_182471.2,
	Description	OIP-3OPA-interacting protein 3PK, muscle typecytosolic thyroid hormone-binding proteinepididymis secretory protein Li 30p58pyruvate kinase 2/3pyruvate kinase PKMpyruvate kinase isozymes M1/M2pyruvate kinase muscle isozymethyroid hormone-binding
	Modification date	20141222
dbXrefs	MIM : 179050
	HGNC : HGNC
	Ensembl : ENSG00000067225
	HPRD : 01529
	Vega : OTTHUMG00000172709
Protein	UniProt: P14618 go to UniProt's Cross Reference DB Table
Expression	CleanEX: HS_PKM
	BioGPS: 5315
Pathway	NCI Pathway Interaction Database: PKM
	KEGG: PKM
	REACTOME: PKM
	Pathway Commons: PKM
Context	iHOP: PKM
	ligand binding site mutation search in PubMed: PKM
	UCL Cancer Institute: PKM
Assigned class in mutLBSgeneDB	B: This gene belongs to targetable_mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez

GO ID	GO Term	PubMed ID
GO:0012501	programmed cell death	17308100

Top

Ligand binding site mutations for PKM

Cancer type specific mutLBS sorted by frequency

LBS	AAchange of nsSNV	Cancer type	# samples
H464,Y466	L465M	BLCA	1
D354	D354N	BLCA	1
N318	C317Y	BRCA	1
H84	A85V	COAD	1
G46	G46V	LUAD	1
H464	H464R	LUSC	1
R73	R73H	LUSC	1
H464	Q462K	SKCM	1
Y83	H81N	SKCM	1
T50	C49F	STAD	1
G468,Y466	R467S	STAD	1
M30	R32S	STAD	1
E118	P117L	UCEC	1
R516	R516C	UCEC	1

cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.

Top

Protein structure related information for PKM

Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
(ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)

: nsSNV at non-LBS

: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.

LBS	AAchange of nsSNV	Relative stability change
Y83	H81N	0.13145158
R73	R73H	-1.5328766
M30	R32S	-1.445316
R516	R516C	-0.92268596
G468	R467S	-0.91338671
Y466	R467S	-0.91338671
Y466	L465M	-0.89584126
H464	L465M	-0.89584126
T50	C49F	-0.74391708
D354	D354N	-0.5539049
E118	P117L	-0.52379208
H84	A85V	-0.40285128
G46	G46V	-0.26670335
H464	H464R	-0.26280306
H464	Q462K	-0.13300824
N318	C317Y	-0.019136536

(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for PKM from PDB

Top

Differential gene expression and gene-gene network for PKM

Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)

* Left PPI network was created from samples with mutations in the LBS of PKM and the right PPI network was created from samples without mutations in the LBS of PKM. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.

Top

Phenotype information for PKM

Gene level disease information (DisGeNet)

Disease ID	Disease name	# PubMed	Association type
umls:C2239176	Carcinoma, Hepatocellular	7	Biomarker
umls:C0007097	Carcinoma	3	Biomarker
umls:C0027626	Neoplasm Invasiveness	2	Biomarker
umls:C0024667	Mammary Neoplasms, Animal	1	Biomarker
umls:C0024668	Mammary Neoplasms, Experimental	1	Biomarker
umls:C0029456	Osteoporosis	1	Biomarker

Mutation level pathogenic information (ClinVar annotation)

Allele ID

AA change

Clinical significance

Origin

Phenotype IDs

Top

Pharmacological information for PKM

Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.

Gene-centered drug-gene interaction network

Drug information targeting mutLBSgene (Approved drugs only)

Drug status	DrugBank ID	Name	Type	Drug structure
Approved\|nutraceutical	DB00119	Pyruvic acid	Small molecule
Experimental	DB01733	L-Phospholactate	Small molecule
Experimental	DB02726	2-Phosphoglycolic Acid	Small molecule
Experimental	DB07628	6-(2-fluorobenzyl)-2,4-dimethyl-4,6-dihydro-5H-thieno[2',3':4,5]pyrrolo[2,3-d]pyridazin-5-one	Small molecule
Experimental	DB07692	1-[(2,6-difluorophenyl)sulfonyl]-4-(2,3-dihydro-1,4-benzodioxin-6-ylsulfonyl)piperazine	Small molecule
Experimental	DB07697	1-(2,3-dihydro-1,4-benzodioxin-6-ylsulfonyl)-4-[(4-methoxyphenyl)sulfonyl]piperazine	Small molecule

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of PKM go to BioLip

Ligand ID	Ligand short name	Ligand long name	PDB ID	PDB name	mutLBS
3SZ		3-{[4-(2,3-DIHYDRO-1,4-BENZODIOXIN-6-YLSULFONYL)-1,4-DIAZEPAN-1-YL]SULFONYL}ANILINE	3me3	C	D354
07T		6-(3-AMINOBENZYL)-4-METHYL-2-METHYLSULFINYL-4,6- DIHYDRO-5H-THIENO[2',3':4,5]PYRROLO[2,3-D]PYRIDAZIN-5- ONE	3u2z	B	D354
07T		6-(3-AMINOBENZYL)-4-METHYL-2-METHYLSULFINYL-4,6- DIHYDRO-5H-THIENO[2',3':4,5]PYRROLO[2,3-D]PYRIDAZIN-5- ONE	3u2z	D	D354
NZT		N-(4-{[4-(PYRAZIN-2-YL)PIPERAZIN-1-YL]CARBONYL}PHENYL) QUINOLINE-8-SULFONAMIDE	4g1n	C	D354
MG		MAGNESIUM(2+)	4qg9	B	E118
PRO		L-PROLINE	4qg6	B	G46 H464
PRO		L-PROLINE	4qg6	D	G46 H464
SER		L-SERINE	4b2d	A	H464
SER		L-SERINE	4b2d	B	H464
SER		L-SERINE	4b2d	C	H464
SER		L-SERINE	4b2d	D	H464
PHE		L-PHENYLALANINE	4fxj	A	H464 G468
PHE		L-PHENYLALANINE	4fxj	B	H464 G468
PHE		L-PHENYLALANINE	4fxj	C	H464 G468
PHE		L-PHENYLALANINE	4fxj	D	H464 G468
PRO		L-PROLINE	4qg6	A	H464 Y466
PRO		L-PROLINE	4qg6	C	H464 Y466
DYY		1-[(2,6-DIFLUOROPHENYL)SULFONYL]-4-(2,3-DIHYDRO-1,4-BENZODIOXIN-6-YLSULFONYL)PIPERAZINE	3gr4	C	M30
07T		6-(3-AMINOBENZYL)-4-METHYL-2-METHYLSULFINYL-4,6- DIHYDRO-5H-THIENO[2',3':4,5]PYRROLO[2,3-D]PYRIDAZIN-5- ONE	3u2z	A	M30
07T		6-(3-AMINOBENZYL)-4-METHYL-2-METHYLSULFINYL-4,6- DIHYDRO-5H-THIENO[2',3':4,5]PYRROLO[2,3-D]PYRIDAZIN-5- ONE	3u2z	C	M30
3SZ		3-{[4-(2,3-DIHYDRO-1,4-BENZODIOXIN-6-YLSULFONYL)-1,4-DIAZEPAN-1-YL]SULFONYL}ANILINE	3me3	B	M30 D354
NZT		N-(4-{[4-(PYRAZIN-2-YL)PIPERAZIN-1-YL]CARBONYL}PHENYL) QUINOLINE-8-SULFONAMIDE	4g1n	A	M30 D354
NZT		N-(4-{[4-(PYRAZIN-2-YL)PIPERAZIN-1-YL]CARBONYL}PHENYL) QUINOLINE-8-SULFONAMIDE	4g1n	B	M30 D354
NZT		N-(4-{[4-(PYRAZIN-2-YL)PIPERAZIN-1-YL]CARBONYL}PHENYL) QUINOLINE-8-SULFONAMIDE	4g1n	D	M30 D354
DZG		1-(2,3-DIHYDRO-1,4-BENZODIOXIN-6-YLSULFONYL)-4-[(4-METHOXYPHENYL)SULFONYL]PIPERAZINE	3gqy	A	M30 N318 D354
DZG		1-(2,3-DIHYDRO-1,4-BENZODIOXIN-6-YLSULFONYL)-4-[(4-METHOXYPHENYL)SULFONYL]PIPERAZINE	3gqy	B	M30 N318 D354
DZG		1-(2,3-DIHYDRO-1,4-BENZODIOXIN-6-YLSULFONYL)-4-[(4-METHOXYPHENYL)SULFONYL]PIPERAZINE	3gqy	C	M30 N318 D354
DZG		1-(2,3-DIHYDRO-1,4-BENZODIOXIN-6-YLSULFONYL)-4-[(4-METHOXYPHENYL)SULFONYL]PIPERAZINE	3gqy	D	M30 N318 D354
DYY		1-[(2,6-DIFLUOROPHENYL)SULFONYL]-4-(2,3-DIHYDRO-1,4-BENZODIOXIN-6-YLSULFONYL)PIPERAZINE	3gr4	B	M30 N318 D354
DYY		1-[(2,6-DIFLUOROPHENYL)SULFONYL]-4-(2,3-DIHYDRO-1,4-BENZODIOXIN-6-YLSULFONYL)PIPERAZINE	3gr4	D	M30 N318 D354
3SZ		3-{[4-(2,3-DIHYDRO-1,4-BENZODIOXIN-6-YLSULFONYL)-1,4-DIAZEPAN-1-YL]SULFONYL}ANILINE	3me3	A	N318 D354
3SZ		3-{[4-(2,3-DIHYDRO-1,4-BENZODIOXIN-6-YLSULFONYL)-1,4-DIAZEPAN-1-YL]SULFONYL}ANILINE	3me3	D	N318 D354
FBP		FRUCTOSE 1,6-BISPHOSPHATE	1t5a	A	R516
FBP		FRUCTOSE 1,6-BISPHOSPHATE	1t5a	B	R516
FBP		FRUCTOSE 1,6-BISPHOSPHATE	1t5a	C	R516
FBP		FRUCTOSE 1,6-BISPHOSPHATE	1t5a	D	R516
FBP		FRUCTOSE 1,6-BISPHOSPHATE	3bjf	A	R516
FBP		FRUCTOSE 1,6-BISPHOSPHATE	3bjf	B	R516
FBP		FRUCTOSE 1,6-BISPHOSPHATE	3bjf	C	R516
FBP		FRUCTOSE 1,6-BISPHOSPHATE	3bjf	D	R516
FBP		FRUCTOSE 1,6-BISPHOSPHATE	3gqy	A	R516
FBP		FRUCTOSE 1,6-BISPHOSPHATE	3gqy	B	R516
FBP		FRUCTOSE 1,6-BISPHOSPHATE	3gqy	D	R516
FBP		FRUCTOSE 1,6-BISPHOSPHATE	3gr4	A	R516
FBP		FRUCTOSE 1,6-BISPHOSPHATE	3gr4	B	R516
FBP		FRUCTOSE 1,6-BISPHOSPHATE	3gr4	D	R516
FBP		FRUCTOSE 1,6-BISPHOSPHATE	3h6o	A	R516
FBP		FRUCTOSE 1,6-BISPHOSPHATE	3h6o	B	R516
FBP		FRUCTOSE 1,6-BISPHOSPHATE	3h6o	C	R516
FBP		FRUCTOSE 1,6-BISPHOSPHATE	3h6o	D	R516
FBP		FRUCTOSE 1,6-BISPHOSPHATE	3me3	A	R516
FBP		FRUCTOSE 1,6-BISPHOSPHATE	3me3	B	R516
FBP		FRUCTOSE 1,6-BISPHOSPHATE	3me3	C	R516
FBP		FRUCTOSE 1,6-BISPHOSPHATE	3me3	D	R516
FBP		FRUCTOSE 1,6-BISPHOSPHATE	3srd	A	R516
FBP		FRUCTOSE 1,6-BISPHOSPHATE	3srd	B	R516
FBP		FRUCTOSE 1,6-BISPHOSPHATE	3srd	C	R516
FBP		FRUCTOSE 1,6-BISPHOSPHATE	3srd	D	R516
FBP		FRUCTOSE 1,6-BISPHOSPHATE	3u2z	A	R516
FBP		FRUCTOSE 1,6-BISPHOSPHATE	3u2z	B	R516
FBP		FRUCTOSE 1,6-BISPHOSPHATE	3u2z	C	R516
FBP		FRUCTOSE 1,6-BISPHOSPHATE	3u2z	D	R516
FBP		FRUCTOSE 1,6-BISPHOSPHATE	4b2d	A	R516
FBP		FRUCTOSE 1,6-BISPHOSPHATE	4b2d	B	R516
FBP		FRUCTOSE 1,6-BISPHOSPHATE	4b2d	C	R516
FBP		FRUCTOSE 1,6-BISPHOSPHATE	4b2d	D	R516
FBP		FRUCTOSE 1,6-BISPHOSPHATE	4fxf	A	R516
FBP		FRUCTOSE 1,6-BISPHOSPHATE	4fxf	C	R516
FBP		FRUCTOSE 1,6-BISPHOSPHATE	4fxf	B	R516
FBP		FRUCTOSE 1,6-BISPHOSPHATE	4jpg	A	R516
FBP		FRUCTOSE 1,6-BISPHOSPHATE	4jpg	B	R516
FBP		FRUCTOSE 1,6-BISPHOSPHATE	4jpg	C	R516
FBP		FRUCTOSE 1,6-BISPHOSPHATE	4jpg	D	R516
FBP		FRUCTOSE 1,6-BISPHOSPHATE	4rpp	B	R516
FBP		FRUCTOSE 1,6-BISPHOSPHATE	4rpp	D	R516
FBP		FRUCTOSE 1,6-BISPHOSPHATE	4wj8	A	R516
FBP		FRUCTOSE 1,6-BISPHOSPHATE	4wj8	C	R516
ADP		ADP	3gr4	A	R73
ATP		ATP	4fxf	D	T50 R73 Y83 H84
ATP		ATP	4fxf	B	T50 R73 Y83 H84

Top

Conservation information for LBS of PKM

Multiple alignments for P14618 in multiple species

LBS	AA sequence	# species	Species
A293	DGIMVARGDLG	6	Homo sapiens, Drosophila melanogaster, Gallus gallus, Rattus norvegicus, Mus musculus, Schizosaccharomyces pombe (strain 972 / ATCC 24843)
A293	DGVMVARGDLG	3	Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37), Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
A366	LSGETAKGDYP	4	Homo sapiens, Gallus gallus, Rattus norvegicus, Mus musculus
A366	LSGETAKGNYP	2	Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
A366	LSGETAKGEYP	1	Drosophila melanogaster
A366	LSGETTKGSYP	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
A366	LSGETAKGIYP	1	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
A388	REAEAAIYHLQ	2	Homo sapiens, Mus musculus
A388	KEAEAALWHQN	1	Drosophila melanogaster
A388	REAEAAMFHRQ	1	Gallus gallus
A388	REAEAAVFHRL	1	Rattus norvegicus
A388	RVAEASIPYGS	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
A388	VIAEQAIAYLP	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
A388	LIAEQAIPYIP	1	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
A388	LIAEQAIPYVP	1	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
D113	LAIALDTKGPE	4	Schizosaccharomyces pombe (strain 972 / ATCC 24843), Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37), Ashbya gossypii (strain ATCC 10895 / CBS 109.51 /
D113	VAVALDTKGPE	3	Homo sapiens, Rattus norvegicus, Mus musculus
D113	VAIALDTKGPE	2	Drosophila melanogaster, Gallus gallus
D178	KIYVDDGLISL	4	Homo sapiens, Gallus gallus, Rattus norvegicus, Mus musculus
D178	IIYVDDGVLSF	2	Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
D178	RVFVDDGLISL	1	Drosophila melanogaster
D178	IIYVDDGILSF	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
D178	VIYVDDGVLSF	1	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
D296	MVARGDLGIEI	9	Homo sapiens, Drosophila melanogaster, Gallus gallus, Rattus norvegicus, Mus musculus, Schizosaccharomyces pombe (strain 972 / ATCC 24843), Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 7079
D354	ANAVLDGADCI	4	Homo sapiens, Gallus gallus, Rattus norvegicus, Mus musculus
D354	GNAVLDGADCV	2	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37), Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
D354	ANAVLDGADCV	1	Drosophila melanogaster
D354	GNAVLDGADLV	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
D354	GNAILDGADCV	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
E118	DTKGPEIRTGL	6	Homo sapiens, Drosophila melanogaster, Gallus gallus, Rattus norvegicus, Mus musculus, Schizosaccharomyces pombe (strain 972 / ATCC 24843)
E118	DTKGPEIRTGT	3	Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37), Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
E272	IISKIENHEGV	4	Homo sapiens, Gallus gallus, Rattus norvegicus, Mus musculus
E272	IIVKIENQQGV	2	Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
E272	IISKIENQQGM	1	Drosophila melanogaster
E272	IICKIENQQGV	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
E272	IIAKIENQQGV	1	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
E397	LQLFEELRRLA	2	Homo sapiens, Mus musculus
E397	QNLFNDLVR-G	1	Drosophila melanogaster
E397	RQQFEEILRHS	1	Gallus gallus
E397	RLLFEELARAS	1	Rattus norvegicus
E397	GSLYQEMFGLV	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
E397	LPNYDDMRNCT	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
E397	IPTYDDLRNLT	1	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
E397	VPTYDDLRNLT	1	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
F26	AMADTFLEHMC	4	Homo sapiens, Gallus gallus, Rattus norvegicus, Mus musculus
F26	--MESRLGWLT	2	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37), Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
F26	AGADTQLEHMC	1	Drosophila melanogaster
F26	SSAVSPKQWVA	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
F26	---MSRLERLT	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
F470	LYRGIFPVLCK	3	Homo sapiens, Rattus norvegicus, Mus musculus
F470	LYRGLVPLIYK	1	Drosophila melanogaster
F470	LYRGVFPVLCK	1	Gallus gallus
F470	LNRGVYPVIYE	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
F470	LYRGVFPFVFE	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
F470	LYRGVFPFVYD	1	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
F470	LHRGVFPFVYE	1	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
F502	GKARGFFKKGD	3	Homo sapiens, Rattus norvegicus, Mus musculus
F502	GKKNGFIKTGD	1	Drosophila melanogaster
F502	GKARGFFKTGD	1	Gallus gallus
F502	AYKMNILKKGD	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
F502	AKEFGILKKGD	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
F502	AKEFGILVDGD	1	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
F502	SKELGILSEGD	1	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
F521	RPGSGFTNTMR	3	Homo sapiens, Rattus norvegicus, Mus musculus
F521	KQGSGFTNTIR	1	Drosophila melanogaster
F521	RPGSGYTNTMR	1	Gallus gallus
F521	VGGKGHTSIFR	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
F521	KAGAGHSNTLQ	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
F521	AAGVGNSNTLR	1	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
F521	ASGVGHSNTLR	1	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
G295	IMVARGDLGIE	6	Homo sapiens, Drosophila melanogaster, Gallus gallus, Rattus norvegicus, Mus musculus, Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G295	VMVARGDLGIE	3	Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37), Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
G363	CIMLSGETAKG	4	Homo sapiens, Gallus gallus, Rattus norvegicus, Mus musculus
G363	CVMLSGETAKG	4	Drosophila melanogaster, Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37), Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
G363	LVMLSGETTKG	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G46	TARNTGIICTI	3	Homo sapiens, Rattus norvegicus, Mus musculus
G46	HVRLSGIVCTI	1	Drosophila melanogaster
G46	IARNTGIICTI	1	Gallus gallus
G46	VNRRTSIICTI	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G46	DLRRTSIIGTI	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
G46	NLRRTSIICTI	1	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
G46	ALRRTSIIGTI	1	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
G468	AHLYRGIFPVL	3	Homo sapiens, Rattus norvegicus, Mus musculus
G468	SHLYRGVFPFV	2	Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
G468	AHLYRGLVPLI	1	Drosophila melanogaster
G468	AHLYRGVFPVL	1	Gallus gallus
G468	SHLNRGVYPVI	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G468	CHLHRGVFPFV	1	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
G514	VIVLTGWRPGS	4	Homo sapiens, Gallus gallus, Rattus norvegicus, Mus musculus
G514	VVVVTGWKQGS	1	Drosophila melanogaster
G514	IIVLQGAVGGK	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G514	YVSIQGFKAGA	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
G514	IVTIQGFAAGV	1	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
G514	IVTIQGFASGV	1	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
G518	TGWRPGSGFTN	3	Homo sapiens, Rattus norvegicus, Mus musculus
G518	TGWKQGSGFTN	1	Drosophila melanogaster
G518	TGWRPGSGYTN	1	Gallus gallus
G518	QGAVGGKGHTS	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G518	QGFKAGAGHSN	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
G518	QGFAAGVGNSN	1	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
G518	QGFASGVGHSN	1	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
G52	IICTIGPASRS	4	Homo sapiens, Gallus gallus, Rattus norvegicus, Mus musculus
G52	IIGTIGPKTNN	2	Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
G52	IVCTIGPASSS	1	Drosophila melanogaster
G52	IICTIGPKSNN	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G52	IICTIGPKTNN	1	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
G520	WRPGSGFTNTM	3	Homo sapiens, Rattus norvegicus, Mus musculus
G520	WKQGSGFTNTI	1	Drosophila melanogaster
G520	WRPGSGYTNTM	1	Gallus gallus
G520	AVGGKGHTSIF	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G520	FKAGAGHSNTL	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
G520	FAAGVGNSNTL	1	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
G520	FASGVGHSNTL	1	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
H29	DTFLEHMCRLD	4	Homo sapiens, Gallus gallus, Rattus norvegicus, Mus musculus
H29	DTQLEHMCRLQ	1	Drosophila melanogaster
H29	VSPKQWVAGLN	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
H29	MSRLERLTSLN	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
H29	ESRLGWLTDLS	1	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
H29	ESRLGWLTRLN	1	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
H464	TARQAHLYRGI	3	Homo sapiens, Rattus norvegicus, Mus musculus
H464	AARFSHLYRGV	2	Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
H464	TARQAHLYRGL	1	Drosophila melanogaster
H464	TARQAHLYRGV	1	Gallus gallus
H464	RARQSHLNRGV	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
H464	AARYCHLHRGV	1	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
H78	RLNFSHGTHEY	4	Homo sapiens, Gallus gallus, Rattus norvegicus, Mus musculus
H78	RMNFSHGSYEY	4	Schizosaccharomyces pombe (strain 972 / ATCC 24843), Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37), Ashbya gossypii (strain ATCC 10895 / CBS 109.51 /
H78	RMNFSHGSHEY	1	Drosophila melanogaster
H84	GTHEYHAETIK	3	Homo sapiens, Rattus norvegicus, Mus musculus
H84	GSYEYHQSVID	3	Schizosaccharomyces pombe (strain 972 / ATCC 24843), Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37), Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
H84	GSHEYHAATVA	1	Drosophila melanogaster
H84	GTHEYHEGTIK	1	Gallus gallus
H84	GSYEYHKSVID	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
I389	EAEAAIYHLQL	2	Homo sapiens, Mus musculus
I389	EAEAALWHQNL	1	Drosophila melanogaster
I389	EAEAAMFHRQQ	1	Gallus gallus
I389	EAEAAVFHRLL	1	Rattus norvegicus
I389	VAEASIPYGSL	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
I389	IAEQAIAYLPN	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
I389	IAEQAIPYIPT	1	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
I389	IAEQAIPYVPT	1	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
I469	HLYRGIFPVLC	3	Homo sapiens, Rattus norvegicus, Mus musculus
I469	HLYRGLVPLIY	1	Drosophila melanogaster
I469	HLYRGVFPVLC	1	Gallus gallus
I469	HLNRGVYPVIY	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
I469	HLYRGVFPFVF	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
I469	HLYRGVFPFVY	1	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
I469	HLHRGVFPFVY	1	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
K207	SLGSKKGVNLP	3	Homo sapiens, Rattus norvegicus, Mus musculus
K207	KICSHKGVNLP	3	Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37), Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
K207	SLGSRKGVNLP	1	Drosophila melanogaster
K207	MLGSKKGVNLP	1	Gallus gallus
K207	KISSKKGVNLP	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
K270	IKIISKIENHE	4	Homo sapiens, Gallus gallus, Rattus norvegicus, Mus musculus
K270	IKIISKIENQQ	1	Drosophila melanogaster
K270	IKIICKIENQQ	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
K270	VKIIVKIENQQ	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
K270	IKIIVKIENQQ	1	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
K270	IKIIAKIENQQ	1	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
K311	VFLAQKMMIGR	4	Homo sapiens, Gallus gallus, Rattus norvegicus, Mus musculus
K311	VFLAQKAMIAR	1	Drosophila melanogaster
K311	VFVAQKMMIAK	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
K311	VLAVQKKLIAK	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
K311	VFAVQKKLIAK	1	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
K311	VFAVQKMLIAK	1	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
K367	SGETAKGDYPL	4	Homo sapiens, Gallus gallus, Rattus norvegicus, Mus musculus
K367	SGETAKGNYPI	2	Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
K367	SGETAKGEYPL	1	Drosophila melanogaster
K367	SGETTKGSYPV	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
K367	SGETAKGIYPI	1	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
K433	IIVLTKSGRSA	2	Homo sapiens, Mus musculus
K433	IVVITTSGKSA	1	Drosophila melanogaster
K433	LIVMTESGRSA	1	Gallus gallus
K433	LIVLTESGRSA	1	Rattus norvegicus
K433	IVVLSTSGNTA	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
K433	IIVLSTSGTTP	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
K433	LIVLSTTGDTP	1	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
K433	IVVLSTSGDTT	1	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
L27	MADTFLEHMCR	4	Homo sapiens, Gallus gallus, Rattus norvegicus, Mus musculus
L27	GADTQLEHMCR	1	Drosophila melanogaster
L27	SAVSPKQWVAG	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
L27	--MSRLERLTS	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
L27	-MESRLGWLTD	1	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
L27	-MESRLGWLTR	1	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
L353	VANAVLDGADC	5	Homo sapiens, Drosophila melanogaster, Gallus gallus, Rattus norvegicus, Mus musculus
L353	VGNAVLDGADC	2	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37), Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
L353	VGNAVLDGADL	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
L353	VGNAILDGADC	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
L394	IYHLQLFEELR	2	Homo sapiens, Mus musculus
L394	LWHQNLFNDLV	1	Drosophila melanogaster
L394	MFHRQQFEEIL	1	Gallus gallus
L394	VFHRLLFEELA	1	Rattus norvegicus
L394	IPYGSLYQEMF	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
L394	IAYLPNYDDMR	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
L394	IPYIPTYDDLR	1	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
L394	IPYVPTYDDLR	1	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
L431	GAIIVLTKSGR	2	Homo sapiens, Mus musculus
L431	SAIVVITTSGK	1	Drosophila melanogaster
L431	AALIVMTESGR	1	Gallus gallus
L431	AALIVLTESGR	1	Rattus norvegicus
L431	KAIVVLSTSGN	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
L431	KAIIVLSTSGT	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
L431	RALIVLSTTGD	1	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
L431	KAIVVLSTSGD	1	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
M291	ASDGIMVARGD	4	Homo sapiens, Gallus gallus, Rattus norvegicus, Mus musculus
M291	VTDGVMVARGD	3	Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37), Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
M291	AGDGIMVARGD	1	Drosophila melanogaster
M291	VTDGIMVARGD	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
M30	TFLEHMCRLD-	4	Homo sapiens, Gallus gallus, Rattus norvegicus, Mus musculus
M30	TQLEHMCRLQ-	1	Drosophila melanogaster
M30	SPKQWVAGLNS	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
M30	SRLERLTSLN-	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
M30	SRLGWLTDLS-	1	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
M30	SRLGWLTRLN-	1	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
M360	GADCIMLSGET	4	Homo sapiens, Gallus gallus, Rattus norvegicus, Mus musculus
M360	GADCVMLSGET	4	Drosophila melanogaster, Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37), Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
M360	GADLVMLSGET	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
N318	MIGRCNRAGKP	4	Homo sapiens, Gallus gallus, Rattus norvegicus, Mus musculus
N318	LIAKCNLAGKP	2	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37), Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
N318	MIARCNKAGKP	1	Drosophila melanogaster
N318	MIAKCNIAGKP	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
N318	LIAKSNLAGKP	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
N44	PITARNTGIIC	3	Homo sapiens, Rattus norvegicus, Mus musculus
N44	VPHVRLSGIVC	1	Drosophila melanogaster
N44	PTIARNTGIIC	1	Gallus gallus
N44	PAVNRRTSIIC	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
N44	GSDLRRTSIIG	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
N44	GTNLRRTSIIC	1	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
N44	GSALRRTSIIG	1	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
N70	IKSGMNVARLN	4	Homo sapiens, Gallus gallus, Rattus norvegicus, Mus musculus
N70	RKAGLNIVRMN	2	Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
N70	MATGMNIARMN	1	Drosophila melanogaster
N70	RDAGMNIVRMN	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
N70	RKAGMNIVRMN	1	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
N75	NVARLNFSHGT	4	Homo sapiens, Gallus gallus, Rattus norvegicus, Mus musculus
N75	NIVRMNFSHGS	4	Schizosaccharomyces pombe (strain 972 / ATCC 24843), Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37), Ashbya gossypii (strain ATCC 10895 / CBS 109.51 /
N75	NIARMNFSHGS	1	Drosophila melanogaster
P449	YRPRAPIIAVT	4	Homo sapiens, Gallus gallus, Rattus norvegicus, Mus musculus
P449	YKPNVPIVMVT	2	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37), Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
P449	YRPRCPIIAVT	1	Drosophila melanogaster
P449	YRPSIPIVMVT	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
P449	YRPNCPIILVT	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
P471	YRGIFPVLCKD	3	Homo sapiens, Rattus norvegicus, Mus musculus
P471	YRGLVPLIYKE	1	Drosophila melanogaster
P471	YRGVFPVLCKQ	1	Gallus gallus
P471	NRGVYPVIYEK	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
P471	YRGVFPFVFEK	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
P471	YRGVFPFVYDE	1	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
P471	HRGVFPFVYEQ	1	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
P517	LTGWRPGSGFT	3	Homo sapiens, Rattus norvegicus, Mus musculus
P517	VTGWKQGSGFT	1	Drosophila melanogaster
P517	LTGWRPGSGYT	1	Gallus gallus
P517	LQGAVGGKGHT	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
P517	IQGFKAGAGHS	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
P517	IQGFAAGVGNS	1	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
P517	IQGFASGVGHS	1	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
P53	ICTIGPASRSV	4	Homo sapiens, Gallus gallus, Rattus norvegicus, Mus musculus
P53	IGTIGPKTNNP	2	Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
P53	VCTIGPASSSV	1	Drosophila melanogaster
P53	ICTIGPKSNNV	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
P53	ICTIGPKTNNP	1	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
Q393	AIYHLQLFEEL	2	Homo sapiens, Mus musculus
Q393	ALWHQNLFNDL	1	Drosophila melanogaster
Q393	AMFHRQQFEEI	1	Gallus gallus
Q393	AVFHRLLFEEL	1	Rattus norvegicus
Q393	SIPYGSLYQEM	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Q393	AIAYLPNYDDM	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Q393	AIPYIPTYDDL	1	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
Q393	AIPYVPTYDDL	1	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
R106	DPILYRPVAVA	3	Homo sapiens, Rattus norvegicus, Mus musculus
R106	-----RPLAIA	3	Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37), Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
R106	KLGYEHPVAIA	1	Drosophila melanogaster
R106	DPITYRPVAIA	1	Gallus gallus
R106	-----FPLAIA	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
R120	KGPEIRTGLIK	4	Homo sapiens, Gallus gallus, Rattus norvegicus, Mus musculus
R120	KGPEIRTGTT-	3	Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37), Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
R120	KGPEIRTGLIG	1	Drosophila melanogaster
R120	KGPEIRTGLT-	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
R294	GIMVARGDLGI	6	Homo sapiens, Drosophila melanogaster, Gallus gallus, Rattus norvegicus, Mus musculus, Schizosaccharomyces pombe (strain 972 / ATCC 24843)
R294	GVMVARGDLGI	3	Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37), Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
R43	APITARNTGII	2	Rattus norvegicus, Mus musculus
R43	PPITARNTGII	1	Homo sapiens
R43	PVPHVRLSGIV	1	Drosophila melanogaster
R43	EPTIARNTGII	1	Gallus gallus
R43	-PAVNRRTSII	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
R43	-GSDLRRTSII	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
R43	-GTNLRRTSII	1	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
R43	-GSALRRTSII	1	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
R436	LTKSGRSAHQV	2	Homo sapiens, Mus musculus
R436	ITTSGKSAFQV	1	Drosophila melanogaster
R436	MTESGRSAHLV	1	Gallus gallus
R436	LTESGRSAHQV	1	Rattus norvegicus
R436	LSTSGNTARLC	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
R436	LSTSGTTPRLV	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
R436	LSTTGDTPRLV	1	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
R436	LSTSGDTTRLV	1	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
R489	EDVDLRVNLAM	2	Rattus norvegicus, Mus musculus
R489	EDVDLRVNFAM	1	Homo sapiens
R489	KDVDVRVQFGL	1	Drosophila melanogaster
R489	EDVDLRVNLGM	1	Gallus gallus
R489	KDVDARVAYGC	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
R489	DDVEARINFGI	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
R489	VDVEKRINFGV	1	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
R489	DDVEARLNFGV	1	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
R516	VLTGWRPGSGF	3	Homo sapiens, Rattus norvegicus, Mus musculus
R516	VVTGWKQGSGF	1	Drosophila melanogaster
R516	VLTGWRPGSGY	1	Gallus gallus
R516	VLQGAVGGKGH	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
R516	SIQGFKAGAGH	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
R516	TIQGFAAGVGN	1	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
R516	TIQGFASGVGH	1	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
R73	GMNVARLNFSH	4	Homo sapiens, Gallus gallus, Rattus norvegicus, Mus musculus
R73	GMNIVRMNFSH	2	Schizosaccharomyces pombe (strain 972 / ATCC 24843), Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
R73	GLNIVRMNFSH	2	Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
R73	GMNIARMNFSH	1	Drosophila melanogaster
S243	DMVFASFIRKA	4	Homo sapiens, Gallus gallus, Rattus norvegicus, Mus musculus
S243	HMVFASFIRTA	3	Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37), Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
S243	DMIFASFIRNA	1	Drosophila melanogaster
S243	DMIFASFIRRA	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
S362	DCIMLSGETAK	4	Homo sapiens, Gallus gallus, Rattus norvegicus, Mus musculus
S362	DCVMLSGETAK	4	Drosophila melanogaster, Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37), Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
S362	DLVMLSGETTK	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
S434	IVLTKSGRSAH	2	Homo sapiens, Mus musculus
S434	VVITTSGKSAF	1	Drosophila melanogaster
S434	IVMTESGRSAH	1	Gallus gallus
S434	IVLTESGRSAH	1	Rattus norvegicus
S434	VVLSTSGNTAR	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
S434	IVLSTSGTTPR	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
S434	IVLSTTGDTPR	1	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
S434	VVLSTSGDTTR	1	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
S437	TKSGRSAHQVA	2	Homo sapiens, Mus musculus
S437	TTSGKSAFQVS	1	Drosophila melanogaster
S437	TESGRSAHLVS	1	Gallus gallus
S437	TESGRSAHQVA	1	Rattus norvegicus
S437	STSGNTARLCS	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
S437	STSGTTPRLVS	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
S437	STTGDTPRLVA	1	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
S437	STSGDTTRLVS	1	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
S519	GWRPGSGFTNT	3	Homo sapiens, Rattus norvegicus, Mus musculus
S519	GWKQGSGFTNT	1	Drosophila melanogaster
S519	GWRPGSGYTNT	1	Gallus gallus
S519	GAVGGKGHTSI	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
S519	GFKAGAGHSNT	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
S519	GFAAGVGNSNT	1	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
S519	GFASGVGHSNT	1	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
S77	ARLNFSHGTHE	4	Homo sapiens, Gallus gallus, Rattus norvegicus, Mus musculus
S77	VRMNFSHGSYE	4	Schizosaccharomyces pombe (strain 972 / ATCC 24843), Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37), Ashbya gossypii (strain ATCC 10895 / CBS 109.51 /
S77	ARMNFSHGSHE	1	Drosophila melanogaster
T114	AIALDTKGPEI	6	Drosophila melanogaster, Gallus gallus, Schizosaccharomyces pombe (strain 972 / ATCC 24843), Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37), Ashbya gos
T114	AVALDTKGPEI	3	Homo sapiens, Rattus norvegicus, Mus musculus
T328	PVICATQMLES	7	Homo sapiens, Drosophila melanogaster, Rattus norvegicus, Mus musculus, Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37), Ashbya gossypii (strain ATCC 10
T328	PIICATQMLES	1	Gallus gallus
T328	PVACATQMLES	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
T432	AIIVLTKSGRS	2	Homo sapiens, Mus musculus
T432	AIVVITTSGKS	1	Drosophila melanogaster
T432	ALIVMTESGRS	1	Gallus gallus
T432	ALIVLTESGRS	1	Rattus norvegicus
T432	AIVVLSTSGNT	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
T432	AIIVLSTSGTT	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
T432	ALIVLSTTGDT	1	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
T432	AIVVLSTSGDT	1	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
T45	ITARNTGIICT	3	Homo sapiens, Rattus norvegicus, Mus musculus
T45	PHVRLSGIVCT	1	Drosophila melanogaster
T45	TIARNTGIICT	1	Gallus gallus
T45	AVNRRTSIICT	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
T45	SDLRRTSIIGT	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
T45	TNLRRTSIICT	1	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
T45	SALRRTSIIGT	1	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
T50	TGIICTIGPAS	4	Homo sapiens, Gallus gallus, Rattus norvegicus, Mus musculus
T50	TSIIGTIGPKT	2	Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
T50	SGIVCTIGPAS	1	Drosophila melanogaster
T50	TSIICTIGPKS	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
T50	TSIICTIGPKT	1	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
T513	VVIVLTGWRPG	3	Homo sapiens, Rattus norvegicus, Mus musculus
T513	SVVVVTGWKQG	1	Drosophila melanogaster
T513	LVIVLTGWRPG	1	Gallus gallus
T513	KIIVLQGAVGG	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
T513	TYVSIQGFKAG	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
T513	TIVTIQGFAAG	1	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
T513	TIVTIQGFASG	1	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
T522	PGSGFTNTMRV	3	Homo sapiens, Rattus norvegicus, Mus musculus
T522	QGSGFTNTIRI	1	Drosophila melanogaster
T522	PGSGYTNTMRV	1	Gallus gallus
T522	GGKGHTSIFRL	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
T522	AGAGHSNTLQV	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
T522	AGVGNSNTLRV	1	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
T522	SGVGHSNTLRV	1	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
W482	PVQEAWAEDVD	1	Homo sapiens
W482	PGLGDWLKDVD	1	Drosophila melanogaster
W482	PAHDAWAEDVD	1	Gallus gallus
W482	AVLDAWAEDVD	1	Rattus norvegicus
W482	AVLNAWAEDVD	1	Mus musculus
W482	EPLSDWQKDVD	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
W482	EPVSDWTDDVE	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
W482	SSDSEWTVDVE	1	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
W482	EAADEWTDDVE	1	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
Y390	AEAAIYHLQLF	2	Homo sapiens, Mus musculus
Y390	AEAALWHQNLF	1	Drosophila melanogaster
Y390	AEAAMFHRQQF	1	Gallus gallus
Y390	AEAAVFHRLLF	1	Rattus norvegicus
Y390	AEASIPYGSLY	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Y390	AEQAIAYLPNY	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Y390	AEQAIPYIPTY	1	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
Y390	AEQAIPYVPTY	1	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
Y466	RQAHLYRGIFP	3	Homo sapiens, Rattus norvegicus, Mus musculus
Y466	RFSHLYRGVFP	2	Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
Y466	RQAHLYRGLVP	1	Drosophila melanogaster
Y466	RQAHLYRGVFP	1	Gallus gallus
Y466	RQSHLNRGVYP	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Y466	RYCHLHRGVFP	1	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
Y83	HGTHEYHAETI	3	Homo sapiens, Rattus norvegicus, Mus musculus
Y83	HGSYEYHQSVI	3	Schizosaccharomyces pombe (strain 972 / ATCC 24843), Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37), Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
Y83	HGSHEYHAATV	1	Drosophila melanogaster
Y83	HGTHEYHEGTI	1	Gallus gallus
Y83	HGSYEYHKSVI	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)