mutLBSgeneDB

mutLBSgeneDB
mutated Ligand Binding Site gene DataBase

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Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for PLK1
Gene summary
Basic gene Info.Gene symbolPLK1
Gene namepolo-like kinase 1
SynonymsPLK|STPK13
CytomapUCSC genome browser: 16p12.2
Type of geneprotein-coding
RefGenesNM_005030.3,
DescriptionPLK-1cell cycle regulated protein kinasepolo (Drosophia)-like kinasepolo like kinaseserine/threonine-protein kinase 13serine/threonine-protein kinase PLK1
Modification date20141222
dbXrefs MIM : 602098
HGNC : HGNC
Ensembl : ENSG00000166851
HPRD : 03652
Vega : OTTHUMG00000096984
ProteinUniProt: P53350
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_PLK1
BioGPS: 5347
PathwayNCI Pathway Interaction Database: PLK1
KEGG: PLK1
REACTOME: PLK1
Pathway Commons: PLK1
ContextiHOP: PLK1
ligand binding site mutation search in PubMed: PLK1
UCL Cancer Institute: PLK1
Assigned class in mutLBSgeneDBA: This gene has a literature evidence and it belongs to targetable_mutLBSgenes.
References showing study about ligand binding site mutation for PLK1.1. "Sengupta D, Linstedt AD. Mitotic inhibition of GRASP65 organelle tethering involves Polo-like kinase 1 (PLK1) phosphorylation proximate to an internal PDZ ligand. J Biol Chem. 2010 Dec 17;285(51):39994-40003. doi: 10.1074/jbc.M110.189449. Epub 2010 Oct 11." 20937827

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO TermPubMed ID
GO:0000086G2/M transition of mitotic cell cycle19160488
GO:0000281mitotic cytokinesis19468302
GO:0000910cytokinesis17351640
GO:0001578microtubule bundle formation12939256
GO:0006468protein phosphorylation19468300
GO:0007067mitotic nuclear division18615013
GO:0007092activation of mitotic anaphase-promoting complex activity15148369
GO:0016567protein ubiquitination16885022
GO:0018105peptidyl-serine phosphorylation16885022
GO:0031572G2 DNA damage checkpoint18662541
GO:0031648protein destabilization16885022
GO:0045862positive regulation of proteolysis16885022
GO:0071168protein localization to chromatin21111234


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Ligand binding site mutations for PLK1
Lollipop-style diagram of mutations at LBS in amino-acid sequence.
We represented ligand binding site mutations only. (You can see big image via clicking.)
 : non-synonymous mutation on LBS, Circle size denotes number of samples.

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
L197T199ICOAD2
Y421G422RCOAD1
L508P509SCOAD1
Y417,D419S418ALUAD1
H489H489QOV1
L508P509SSKCM1
R584M586VSTAD1
K82V84ASTAD1
Y582Y582CSTAD1
F535N533SSTAD1
S519A520TUCEC1
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.

Clinical information for PLK1 from My Cancer Genome.
Polo-like kinase 1 (PLK1) is a gene that encodes a protein that functions as a serine/threonine protein kinase. The protein regulates several processes involved in the cell cycle, including centrosome maturation, spindle assembly, cohesion removal, the inactivation of anaphase-promoting complex/cyclosome inhibitors, and cytokinesis. Missense mutations, nonsense mutations, silent mutations, and frameshift deletions and insertions are observed in cancers such as endometrial cancer, intestinal cancer, and stomach cancer.Modified: July 1, 2015

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Protein structure related information for PLK1
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
K82V84A-1.8458011
D419S418A-1.6678063
Y417S418A-1.6678063
L508P509S-1.0048697
L197T199I-0.88335753
F535N533S-0.82244468
Y421G422R-0.7867268
S519A520T-0.67265818
R584M586V-0.59509293
Y582Y582C-0.52323724
H489H489Q-0.46927782
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for PLK1 from PDB
PDB IDPDB titlePDB structure
1UMWSTRUCTURE OF A HUMAN PLK1 POLO-BOX DOMAIN/PHOSPHOPEPTIDE COMPLEX

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Differential gene expression and gene-gene network for PLK1
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of PLK1 and the right PPI network was created from samples without mutations in the LBS of PLK1. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


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Phenotype information for PLK1
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type
umls:C0017638Glioma3Biomarker

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

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Pharmacological information for PLK1
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.

Gene-centered drug-gene interaction network
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure
ExperimentalDB068973-[3-chloro-5-(5-{[(1S)-1-phenylethyl]amino}isoxazolo[5,4-c]pyridin-3-yl)phenyl]propan-1-olSmall molecule
ExperimentalDB069633-[3-(3-methyl-6-{[(1S)-1-phenylethyl]amino}-1H-pyrazolo[4,3-c]pyridin-1-yl)phenyl]propanamideSmall molecule
ExperimentalDB071864-(4-METHYLPIPERAZIN-1-YL)-N-[5-(2-THIENYLACETYL)-1,5-DIHYDROPYRROLO[3,4-C]PYRAZOL-3-YL]BENZAMIDESmall molecule
ExperimentalDB077891-[5-methyl-2-(trifluoromethyl)furan-3-yl]-3-[(2Z)-5-(2-{[6-(1H-1,2,4-triazol-3-ylamino)pyrimidin-4-yl]amino}ethyl)-1,3-thiazol-2(3H)-ylidene]ureaSmall molecule
ExperimentalDB08059(1S,6BR,9AS,11R,11BR)-9A,11B-DIMETHYL-1-[(METHYLOXY)METHYL]-3,6,9-TRIOXO-1,6,6B,7,8,9,9A,10,11,11B-DECAHYDRO-3H-FURO[4,3,2-DE]INDENO[4,5-H][2]BENZOPYRAN-11-YL ACETATESmall molecule

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of PLK1 go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS
IIIPeptide ligand (LEU,LEU,CYS,SER,THR,PRO,ASN)2ojxAF535
IIIPeptide ligand (ACE,PRO,LEU,HIS,SER,THR)3hikAF535
IIIPeptide ligand (ACE,PRO,LEU,HIS,SER,THR,MET,NH2)4lklAF535
IIIPeptide ligand (MET,GLN,SER,THR,PRO,LEU)1q4kCH489
IIIPeptide ligand (LEU,LEU,CYS,SER,THR,PRO,ASN)3bziAH489
IIIPeptide ligand (ACE,LEU,HIS,SER,THR,ALA,NH2)3fvhAH489
IIIPeptide ligand (PRO,PRO,PRO,MET,SER,SER,MET,NH2)3q1iAH489
IIIPeptide ligand (VAL,LEU,SER,THR,LEU,NH2)4o9wAH489
IIIPeptide ligand (MET,GLN,SER,THR,PRO,LEU)1q4kBH489 F535
IIIPeptide ligand (MET,GLN,SER,THR,PRO,LEU)1q4kAH489 F535
IIIPeptide ligand (PRO,MET,GLN,SER,THR,PRO,LEU)1umwAH489 F535
IIIPeptide ligand (PRO,MET,GLN,SER,THR,PRO,LEU)1umwBH489 F535
IIIPeptide ligand (ACE,PRO,LEU,HIS,SER,THR,ALA,NH2)3p2zAH489 F535
IIIPeptide ligand (ACE,MET,GLN,SER,THR,PRO,LEU,NH2)3p34AH489 F535
IIIPeptide ligand (ACE,MET,GLN,SER,SER,PRO,LEU,NH2)3p35AH489 F535
IIIPeptide ligand (ACE,MET,GLN,SER,SER,PRO,LEU,NH2)3p35BH489 F535
IIIPeptide ligand (PRO,PRO,LEU,HIS,SER,THR,ALA,NH2)3p36AH489 F535
IIIPeptide ligand (PRO,PRO,LEU,HIS,SER,THR,ALA,NH2)4e9cAH489 F535
IIIPeptide ligand (PRO,LEU,HIS,SER,THR,MET,NH2)4habAH489 F535
IIIPeptide ligand (PRO,LEU,HIS,SER,THR,MET,NH2)4habBH489 F535
IIIPeptide ligand (1C3,LEU,HIS,SER,THR,MET,NH2)4hy2AH489 F535
IIIPeptide ligand (GLY,PRO,MET,THR,SER,THR,PRO,LYS)4o56AH489 F535
MGMAGNESIUM(2+)2ou7AK82
6264-(4-METHYLPIPERAZIN-1-YL)-N-[5-(2-THIENYLACETYL)-1,5-DIHYDROPYRROLO[3,4-C]PYRAZOL-3-YL]BENZAMIDE2owbAK82
9371-(2-HYDROXYETHYL)-8-[[5-(4-METHYLPIPERAZIN-1-YL)-2-(TRIFLUOROMETHOXY)PHENYL]AMINO]-4,5-DIHYDROPYRIMIDO[5,4-G]INDAZOLE-3-CARBOXAMIDE2yacAK82
0718-{[2-METHOXY-5-(4-METHYLPIPERAZIN-1-YL)PHENYL]AMINO}-1-METHYL-4,5-DIHYDRO-1H-PYRAZOLO[4,3-H]QUINAZOLINE-3-CARBOXAMIDE3kb7AK82
9391-METHYL-5-(2-{[5-(4-METHYLPIPERAZIN-1-YL)-2-(TRIFLUOROMETHOXY)PHENYL]AMINO}PYRIMIDIN-4-YL)-1H-PYRROLE-3-CARBOXAMIDE4a4lAK82
6641-METHYL-2-(2-{[5-(4-METHYLPIPERAZIN-1-YL)-2-(TRIFLUOROMETHOXY)PHENYL]AMINO}PYRIMIDIN-4-YL)-1,5,6,7-TETRAHYDRO-4H-PYRROLO[3,2-C]PYRIDIN-4-ONE4a4oAK82
1J34-{[(7R)-9-CYCLOPENTYL-7-ETHENYL-7-FLUORO-5-METHYL-6- OXO-6,7,8,9-TETRAHYDRO-5H-PYRIMIDO[4,5-B][1, 4]DIAZEPIN-2-YL]AMINO}-3-METHOXY-N-(4-METHYLPIPERAZIN- 1-YL)BENZAMIDE4j52AK82
1J44-[(9-CYCLOPENTYL-7,7-DIFLUORO-5-METHYL-6-OXO-6,7,8,9- TETRAHYDRO-5H-PYRIMIDO[4,5-B][1,4]DIAZEPIN-2-YL) AMINO]-2-FLUORO-5-METHOXY-N-(1-METHYLPIPERIDIN-4-YL) BENZAMIDE4j53AK82
ANPAMP-PNP2ou7AK82 L197
SO4SULFATE3hihAL508
SO4SULFATE3hihBR584
SO4SULFATE3hihAS519 Y582
IIIPeptide ligand (PRO,PRO,HIS,SER,THR)3c5lAY417
LYTBUTAN-1-AMINE4lkmAY417
IIIPeptide ligand (ACE,PHE,ASP,PRO,PRO,LEU,HIS,SER,THR,ALA)3p37AY417 D419 H489
IIIPeptide ligand (ACE,PHE,ASP,PRO,PRO,LEU,HIS,SER,THR,ALA,NH2)3p37BY417 D419 H489
IIIPeptide ligand (HCI,PRO,LEU,HIS,SER,THR,ALA,NH2)4e67AY417 D419 H489
IIIPeptide ligand (0OB,ASP,PRO,PRO,LEU,HIS,SER,THR,ALA)4e9dAY417 D419 Y421
IIIPeptide ligand (ACE,PRO,LEU,HIS,SER,THR,NH2)3rq7AY417 F535
IIIPeptide ligand (ACE,PRO,LEU,HIS,SER,THR,NH2)4mluAY417 F535
IIIPeptide ligand (ACE,PHE,ASP,PRO,PRO,LEU,HIS,SER,THR,ALA)3p37CY417 H489
IIIPeptide ligand (PRO,LEU,HIS,SER,THR,MET,NH2)4habCY417 H489
IIIPeptide ligand (ACE,PRO,LEU,HIS,SER,THR,MET,NH2)4lkmAY417 H489
IIIPeptide ligand (ACE,PRO,LEU,HIS,SER,THR,MET,NH2)4lkmCY417 H489
IIIPeptide ligand (ACE,PRO,LEU,HIS,SER,THR,NH2)4dfwAY417 Y421
IIIPeptide ligand (ACE,HIS,SER,THR,NH2)4rcpAY417 Y421
5PV5-PHENYLVALERIC ACID4lkmAY421


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Conservation information for LBS of PLK1
Multiple alignments for P53350 in multiple species
LBSAA sequence# speciesSpecies
A493EHLLKAGA-NI5Homo sapiens, Xenopus tropicalis, Mus musculus, Rattus norvegicus, Bos taurus
A493ANLSRVSTFGR1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
A493EHLVKAGA-NN1Drosophila melanogaster
A493DHLVKAGE-GS1Caenorhabditis elegans
A493DHLLQAGQ-QV1Caenorhabditis elegans
A65GKGGFAKCFEI4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
A65GKGGFAKCYEI2Drosophila melanogaster, Xenopus tropicalis
A65GKGGFAHCYEL2Caenorhabditis elegans, Caenorhabditis elegans
A65GEGGFARCFQI1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
A80TKEVFAGKIVP3Homo sapiens, Mus musculus, Bos taurus
A80SGEIFAAKTVA1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
A80TDDVFAGKIVS1Drosophila melanogaster
A80SREVFAGKIVP1Xenopus tropicalis
A80TKEVFPGKIVP1Rattus norvegicus
A80TREVVAGKVVP1Caenorhabditis elegans
A80TGELFAGKVVP1Caenorhabditis elegans
C133VVLELCRRRSL5Homo sapiens, Xenopus tropicalis, Mus musculus, Rattus norvegicus, Bos taurus
C133ILLEICPNGSL1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
C133IVLELCKKRSM1Drosophila melanogaster
C133ITLELCARRSL1Caenorhabditis elegans
C133ITLELCPRRSL1Caenorhabditis elegans
C212RKKTLCGTPNY8Homo sapiens, Drosophila melanogaster, Xenopus tropicalis, Mus musculus, Rattus norvegicus, Bos taurus, Caenorhabditis elegans, Caenorhabditis elegans
C212RKYTICGTPNY1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
C67GGFAKCFEISD4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
C67GGFARCFQIKD1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
C67GGFAKCYEIID1Drosophila melanogaster
C67GGFAKCYEITD1Xenopus tropicalis
C67GGFAHCYELTN1Caenorhabditis elegans
C67GGFAHCYELRN1Caenorhabditis elegans
D194EVKIGDFGLAT5Homo sapiens, Xenopus tropicalis, Mus musculus, Rattus norvegicus, Bos taurus
D194NLKIGDFGLAA1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
D194HVKIGDFGLAT1Drosophila melanogaster
D194VVKIGDFGLAT1Caenorhabditis elegans
D194QVKIGDFGLAT1Caenorhabditis elegans
D416VSKWVDYSDKY5Homo sapiens, Xenopus tropicalis, Mus musculus, Rattus norvegicus, Bos taurus
D416ISKWVDYSDKY3Drosophila melanogaster, Caenorhabditis elegans, Caenorhabditis elegans
D416VTKWVDYSNKH1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
D419WVDYSDKYGLG5Homo sapiens, Xenopus tropicalis, Mus musculus, Rattus norvegicus, Bos taurus
D419WVDYSDKYGIG2Caenorhabditis elegans, Caenorhabditis elegans
D419WVDYSNKHGFS1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
D419WVDYSDKYGFG1Drosophila melanogaster
D438GVLFNDSTRLI5Homo sapiens, Xenopus tropicalis, Mus musculus, Rattus norvegicus, Bos taurus
D438GVLFNDNSRIM2Caenorhabditis elegans, Caenorhabditis elegans
D438GVLFNNGTTVL1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
D438GVMFNDTTKLI1Drosophila melanogaster
E101EKMSME-ISIH4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
E101KKLLSE-IQIH1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
E101EKTAQE-ITIH1Drosophila melanogaster
E101DKMTME-IAIQ1Xenopus tropicalis
E101DKVDNERILIH1Caenorhabditis elegans
E101DKMAQE-VQIH1Caenorhabditis elegans
E131VFVVLELCRRR4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
E131VYILLEICPNG1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
E131IYIVLELCKKR1Drosophila melanogaster
E131VYVVLELCRRR1Xenopus tropicalis
E131VYITLELCARR1Caenorhabditis elegans
E131VYITLELCPRR1Caenorhabditis elegans
E140RRSLLELHKRR5Homo sapiens, Xenopus tropicalis, Mus musculus, Rattus norvegicus, Bos taurus
E140RRSLMELHKRR2Caenorhabditis elegans, Caenorhabditis elegans
E140NGSLMELLKRR1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
E140KRSMMELHKRR1Drosophila melanogaster
E488RNYMSEHLLKA5Homo sapiens, Xenopus tropicalis, Mus musculus, Rattus norvegicus, Bos taurus
E488AKYMKANLSRV1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
E488KRYMIEHLVKA1Drosophila melanogaster
E488RSYMNDHLVKA1Caenorhabditis elegans
E488RSYMNDHLLQA1Caenorhabditis elegans
E69FAKCFEISDAD3Homo sapiens, Mus musculus, Bos taurus
E69FARCFQIKD-D1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
E69FAKCYEIIDVE1Drosophila melanogaster
E69FAKCYEITDLE1Xenopus tropicalis
E69FAKCFEISDSD1Rattus norvegicus
E69FAHCYELTNRA1Caenorhabditis elegans
E69FAHCYELRNKS1Caenorhabditis elegans
F183KLGNLFLNEDL4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
F183KLGNIFFDSNY1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
F183KLGNLFLNDLL1Drosophila melanogaster
F183KLGNLFLNDEM1Xenopus tropicalis
F183KLGNLFLNDDL1Caenorhabditis elegans
F183KLGNLFLNDEL1Caenorhabditis elegans
F436SVGVLFNDSTR5Homo sapiens, Xenopus tropicalis, Mus musculus, Rattus norvegicus, Bos taurus
F436SVGVLFNDNSR2Caenorhabditis elegans, Caenorhabditis elegans
F436DIGVLFNNGTT1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
F436GIGVMFNDTTK1Drosophila melanogaster
F482TLLKYFRNYMS3Homo sapiens, Xenopus tropicalis, Bos taurus
F482TLLNYFRNYMS2Mus musculus, Rattus norvegicus
F482TLLKYFRSYMN2Caenorhabditis elegans, Caenorhabditis elegans
F482EVVDFFAKYMK1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
F482KLLSYFKRYMI1Drosophila melanogaster
F535VQINFFQDHTK5Homo sapiens, Xenopus tropicalis, Mus musculus, Rattus norvegicus, Bos taurus
F535FQFN-FKDHHK1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
F535VQLN-FSDHMK1Drosophila melanogaster
F535VQINFFNDHVK1Caenorhabditis elegans
F535VQINFFNDHIK1Caenorhabditis elegans
F58YVRGRFLGKGG3Homo sapiens, Mus musculus, Rattus norvegicus
F58YLRGRFLGKGG2Xenopus tropicalis, Bos taurus
F58YHRGHFLGEGG1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
F58YKRMRFFGKGG1Drosophila melanogaster
F58YEKGRFLGKGG1Caenorhabditis elegans
F58YEKGKFLGKGG1Caenorhabditis elegans
G180RDLKLGNLFLN7Homo sapiens, Drosophila melanogaster, Xenopus tropicalis, Mus musculus, Rattus norvegicus, Bos taurus, Caenorhabditis elegans
G180RDLKLGNIFFD1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
G180RDMKLGNLFLN1Caenorhabditis elegans
G193LEVKIGDFGLA4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
G193YNLKIGDFGLA1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
G193LHVKIGDFGLA1Drosophila melanogaster
G193MEVKIGDFGLA1Xenopus tropicalis
G193LVVKIGDFGLA1Caenorhabditis elegans
G193LQVKIGDFGLA1Caenorhabditis elegans
G196KIGDFGLATKV5Homo sapiens, Xenopus tropicalis, Mus musculus, Rattus norvegicus, Bos taurus
G196KIGDFGLAAVL1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
G196KIGDFGLATRI1Drosophila melanogaster
G196KIGDFGLATTV1Caenorhabditis elegans
G196KIGDFGLATTC1Caenorhabditis elegans
G448ILYNDGDSLQY3Homo sapiens, Mus musculus, Rattus norvegicus
G448LRLADAEEFWY1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
G448ILLPNQINVHF1Drosophila melanogaster
G448IMYNDGDSLQY1Xenopus tropicalis
G448ILYSDGDSLQY1Bos taurus
G448MLDQAGNELTY1Caenorhabditis elegans
G448MLDTAGTQLTY1Caenorhabditis elegans
G60RGRFLGKGGFA5Homo sapiens, Xenopus tropicalis, Mus musculus, Rattus norvegicus, Bos taurus
G60RGHFLGEGGFA1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
G60RMRFFGKGGFA1Drosophila melanogaster
G60KGRFLGKGGFA1Caenorhabditis elegans
G60KGKFLGKGGFA1Caenorhabditis elegans
G62RFLGKGGFAKC5Homo sapiens, Xenopus tropicalis, Mus musculus, Rattus norvegicus, Bos taurus
G62HFLGEGGFARC1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
G62RFFGKGGFAKC1Drosophila melanogaster
G62RFLGKGGFAHC1Caenorhabditis elegans
G62KFLGKGGFAHC1Caenorhabditis elegans
G81KEVFAGKIVPK3Homo sapiens, Mus musculus, Bos taurus
G81GEIFAAKTVAK1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
G81DDVFAGKIVSK1Drosophila melanogaster
G81REVFAGKIVPK1Xenopus tropicalis
G81KEVFPGKIVPK1Rattus norvegicus
G81REVVAGKVVPK1Caenorhabditis elegans
G81GELFAGKVVPK1Caenorhabditis elegans
H382MLQQLHSVNAS2Homo sapiens, Bos taurus
H382LLQQLTSVNAS2Mus musculus, Rattus norvegicus
H382LIATSTNVIKS1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
H382LYQQLTNLING1Drosophila melanogaster
H382MLQQLTCVNAV1Xenopus tropicalis
H382LFHQVAVLLEQ1Caenorhabditis elegans
H382LLAQVNDLLAT1Caenorhabditis elegans
H489NYMSEHLLKAG5Homo sapiens, Xenopus tropicalis, Mus musculus, Rattus norvegicus, Bos taurus
H489KYMKANLSRVS1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
H489RYMIEHLVKAG1Drosophila melanogaster
H489SYMNDHLVKAG1Caenorhabditis elegans
H489SYMNDHLLQAG1Caenorhabditis elegans
H538NFFQDHTKLIL4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
H538N-FKDHHKMAI1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
H538N-FSDHMKLIL1Drosophila melanogaster
H538NFFQDHTKIIL1Xenopus tropicalis
H538NFFNDHVKMMM1Caenorhabditis elegans
H538NFFNDHIKMVL1Caenorhabditis elegans
H93LLLKPHQKEKM3Mus musculus, Rattus norvegicus, Bos taurus
H93LLLKPHQREKM1Homo sapiens
H93SIKSEKTRKKL1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
H93LMIKHNQKEKT1Drosophila melanogaster
H93MLLKPHQKDKM1Xenopus tropicalis
H93MLVKQYQRDKV1Caenorhabditis elegans
H93LLIKQYQRDKM1Caenorhabditis elegans
K413--WVSKWVDYS5Homo sapiens, Xenopus tropicalis, Mus musculus, Rattus norvegicus, Bos taurus
K413--WISKWVDYS3Drosophila melanogaster, Caenorhabditis elegans, Caenorhabditis elegans
K413PMIVTKWVDYS1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
K492SEHLLKAGA-N5Homo sapiens, Xenopus tropicalis, Mus musculus, Rattus norvegicus, Bos taurus
K492KANLSRVSTFG1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
K492IEHLVKAGA-N1Drosophila melanogaster
K492NDHLVKAGE-G1Caenorhabditis elegans
K492NDHLLQAGQ-Q1Caenorhabditis elegans
K540FQDHTKLILCP4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
K540FKDHHKMAISD1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
K540FSDHMKLILCP1Drosophila melanogaster
K540FQDHTKIILCP1Xenopus tropicalis
K540FNDHVKMMMCP1Caenorhabditis elegans
K540FNDHIKMVLCP1Caenorhabditis elegans
K61GRFLGKGGFAK5Homo sapiens, Xenopus tropicalis, Mus musculus, Rattus norvegicus, Bos taurus
K61GHFLGEGGFAR1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
K61MRFFGKGGFAK1Drosophila melanogaster
K61GRFLGKGGFAH1Caenorhabditis elegans
K61GKFLGKGGFAH1Caenorhabditis elegans
K66KGGFAKCFEIS4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
K66EGGFARCFQIK1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
K66KGGFAKCYEII1Drosophila melanogaster
K66KGGFAKCYEIT1Xenopus tropicalis
K66KGGFAHCYELT1Caenorhabditis elegans
K66KGGFAHCYELR1Caenorhabditis elegans
K82EVFAGKIVPKS3Homo sapiens, Mus musculus, Bos taurus
K82EIFAAKTVAKA1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
K82DVFAGKIVSKK1Drosophila melanogaster
K82EVFAGKIVPKT1Xenopus tropicalis
K82EVFPGKIVPKS1Rattus norvegicus
K82EVVAGKVVPKS1Caenorhabditis elegans
K82ELFAGKVVPKA1Caenorhabditis elegans
L130FVFVVLELCRR4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
L130NVYILLEICPN1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
L130NIYIVLELCKK1Drosophila melanogaster
L130FVYVVLELCRR1Xenopus tropicalis
L130NVYITLELCAR1Caenorhabditis elegans
L130NVYITLELCPR1Caenorhabditis elegans
L132FVVLELCRRRS4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
L132YILLEICPNGS1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
L132YIVLELCKKRS1Drosophila melanogaster
L132YVVLELCRRRS1Xenopus tropicalis
L132YITLELCARRS1Caenorhabditis elegans
L132YITLELCPRRS1Caenorhabditis elegans
L139RRRSLLELHKR5Homo sapiens, Xenopus tropicalis, Mus musculus, Rattus norvegicus, Bos taurus
L139PNGSLMELLKR1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
L139KKRSMMELHKR1Drosophila melanogaster
L139ARRSLMELHKR1Caenorhabditis elegans
L139PRRSLMELHKR1Caenorhabditis elegans
L197IGDFGLATKVE5Homo sapiens, Xenopus tropicalis, Mus musculus, Rattus norvegicus, Bos taurus
L197IGDFGLAAVLA1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
L197IGDFGLATRIE1Drosophila melanogaster
L197IGDFGLATTVN1Caenorhabditis elegans
L197IGDFGLATTCD1Caenorhabditis elegans
L444STRLILYNDGD3Homo sapiens, Mus musculus, Rattus norvegicus
L444GTTVLRLADAE1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
L444TTKLILLPNQI1Drosophila melanogaster
L444STRLIMYNDGD1Xenopus tropicalis
L444STRLILYSDGD1Bos taurus
L444NSRIMLDQAGN1Caenorhabditis elegans
L444NSRIMLDTAGT1Caenorhabditis elegans
L463GTESYLTVSS-3Homo sapiens, Mus musculus, Rattus norvegicus
L463DREGWVASHYL1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
L463GKETYMTTTD-1Drosophila melanogaster
L463NSESYLNVRS-1Xenopus tropicalis
L463GSESYLTVSS-1Bos taurus
L463NKEHYFSMHS-1Caenorhabditis elegans
L463EKEHYFDMES-1Caenorhabditis elegans
L478MKKITLLNYFR2Mus musculus, Rattus norvegicus
L478MKKITLLKYFR1Homo sapiens
L478SRHLEVVDFFA1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
L478DKKMKLLSYFK1Drosophila melanogaster
L478TKKITLLKYFR1Xenopus tropicalis
L478IKKITLLKYFR1Bos taurus
L478NKKVTLLKYFR1Caenorhabditis elegans
L478QKKMTLLKYFR1Caenorhabditis elegans
L490YMSEHLLKAGA5Homo sapiens, Xenopus tropicalis, Mus musculus, Rattus norvegicus, Bos taurus
L490YMKANLSRVST1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
L490YMIEHLVKAGA1Drosophila melanogaster
L490YMNDHLVKAGE1Caenorhabditis elegans
L490YMNDHLLQAGQ1Caenorhabditis elegans
L491MSEHLLKAGA-5Homo sapiens, Xenopus tropicalis, Mus musculus, Rattus norvegicus, Bos taurus
L491MKANLSRVSTF1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
L491MIEHLVKAGA-1Drosophila melanogaster
L491MNDHLVKAGE-1Caenorhabditis elegans
L491MNDHLLQAGQ-1Caenorhabditis elegans
L508DELARLPYLRT4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
L508DDLARLPTLRV2Caenorhabditis elegans, Caenorhabditis elegans
L508DDV----FLRR1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
L508DQISRMPHLHS1Drosophila melanogaster
L508DELARLPFLRT1Xenopus tropicalis
L59VRGRFLGKGGF3Homo sapiens, Mus musculus, Rattus norvegicus
L59LRGRFLGKGGF2Xenopus tropicalis, Bos taurus
L59HRGHFLGEGGF1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
L59KRMRFFGKGGF1Drosophila melanogaster
L59EKGRFLGKGGF1Caenorhabditis elegans
L59EKGKFLGKGGF1Caenorhabditis elegans
N385QLHSVNASKPS2Homo sapiens, Bos taurus
N385QLTSVNASKPS2Mus musculus, Rattus norvegicus
N385TSTNVIKSEIS1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
N385QLTNLINGKPR1Drosophila melanogaster
N385QLTCVNAVKPS1Xenopus tropicalis
N385QVAVLLEQRIP1Caenorhabditis elegans
N385QVNDLLATPTA1Caenorhabditis elegans
N430YQLCDNSVGVL7Homo sapiens, Xenopus tropicalis, Mus musculus, Rattus norvegicus, Bos taurus, Caenorhabditis elegans, Caenorhabditis elegans
N430YQLSTEDIGVL1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
N430YQLCDEGIGVM1Drosophila melanogaster
N437VGVLFNDSTRL5Homo sapiens, Xenopus tropicalis, Mus musculus, Rattus norvegicus, Bos taurus
N437VGVLFNDNSRI2Caenorhabditis elegans, Caenorhabditis elegans
N437IGVLFNNGTTV1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
N437IGVMFNDTTKL1Drosophila melanogaster
R134VLELCRRRSLL5Homo sapiens, Xenopus tropicalis, Mus musculus, Rattus norvegicus, Bos taurus
R134LLEICPNGSLM1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
R134VLELCKKRSMM1Drosophila melanogaster
R134TLELCARRSLM1Caenorhabditis elegans
R134TLELCPRRSLM1Caenorhabditis elegans
R136ELCRRRSLLEL5Homo sapiens, Xenopus tropicalis, Mus musculus, Rattus norvegicus, Bos taurus
R136EICPNGSLMEL1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
R136ELCKKRSMMEL1Drosophila melanogaster
R136ELCARRSLMEL1Caenorhabditis elegans
R136ELCPRRSLMEL1Caenorhabditis elegans
R483LLKYFRNYMSE3Homo sapiens, Xenopus tropicalis, Bos taurus
R483LLNYFRNYMSE2Mus musculus, Rattus norvegicus
R483LLKYFRSYMND2Caenorhabditis elegans, Caenorhabditis elegans
R483VVDFFAKYMKA1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
R483LLSYFKRYMIE1Drosophila melanogaster
R507GDELARLPYLR4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
R507GDDLARLPTLR2Caenorhabditis elegans, Caenorhabditis elegans
R507KDDV----FLR1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
R507SDQISRMPHLH1Drosophila melanogaster
R507GDELARLPFLR1Xenopus tropicalis
R516LRTWFRTRSAI5Homo sapiens, Xenopus tropicalis, Mus musculus, Rattus norvegicus, Bos taurus
R516LRVWFRTKSAI2Caenorhabditis elegans, Caenorhabditis elegans
R516LRRYTRYKPFV1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
R516LHSWFRTTCAV1Drosophila melanogaster
R518TWFRTRSAIIL5Homo sapiens, Xenopus tropicalis, Mus musculus, Rattus norvegicus, Bos taurus
R518VWFRTKSAIVL2Caenorhabditis elegans, Caenorhabditis elegans
R518RYTRYKPFVMF1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
R518SWFRTTCAVVM1Drosophila melanogaster
R557YIDEKRDFRTY2Homo sapiens, Bos taurus
R557YISPSHESTTY1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
R557YMDQEKNFRTY1Drosophila melanogaster
R557YIDEKREFHTY1Xenopus tropicalis
R557YINEKRDFQTY1Mus musculus
R557YINEKRDFRTY1Rattus norvegicus
R557FIDQNKRMLTY1Caenorhabditis elegans
R557FIDENKRMFTY1Caenorhabditis elegans
R57RYLRGRFLGKG2Xenopus tropicalis, Bos taurus
R57QYVRGRFLGKG2Mus musculus, Rattus norvegicus
R57RYVRGRFLGKG1Homo sapiens
R57-YHRGHFLGEG1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
R57TYKRMRFFGKG1Drosophila melanogaster
R57YYEKGRFLGKG1Caenorhabditis elegans
R57RYEKGKFLGKG1Caenorhabditis elegans
R584RLRYARTMVDK3Homo sapiens, Mus musculus, Rattus norvegicus
R584NFREKLTLIKE1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
R584KIRYAQEKLRK1Drosophila melanogaster
R584RLRYARTMVEK1Xenopus tropicalis
R584RLRYARAMVDK1Bos taurus
R584RLKYAKTMIER1Caenorhabditis elegans
R584RIQYAKCMIQR1Caenorhabditis elegans
S137LCRRRSLLELH5Homo sapiens, Xenopus tropicalis, Mus musculus, Rattus norvegicus, Bos taurus
S137ICPNGSLMELL1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
S137LCKKRSMMELH1Drosophila melanogaster
S137LCARRSLMELH1Caenorhabditis elegans
S137LCPRRSLMELH1Caenorhabditis elegans
S412---WVSKWVDY5Homo sapiens, Xenopus tropicalis, Mus musculus, Rattus norvegicus, Bos taurus
S412---WISKWVDY3Drosophila melanogaster, Caenorhabditis elegans, Caenorhabditis elegans
S412HPMIVTKWVDY1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
S467YLTVSS--H--4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
S467WVASHYLLSEK1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
S467YMTTTD--Y--1Drosophila melanogaster
S467YLNVRS--Y--1Xenopus tropicalis
S467YFSMHS--GEM1Caenorhabditis elegans
S467YFDMES--A-I1Caenorhabditis elegans
S487FRNYMSEHLLK5Homo sapiens, Xenopus tropicalis, Mus musculus, Rattus norvegicus, Bos taurus
S487FAKYMKANLSR1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
S487FKRYMIEHLVK1Drosophila melanogaster
S487FRSYMNDHLVK1Caenorhabditis elegans
S487FRSYMNDHLLQ1Caenorhabditis elegans
S519WFRTRSAIILH5Homo sapiens, Xenopus tropicalis, Mus musculus, Rattus norvegicus, Bos taurus
S519WFRTKSAIVLH2Caenorhabditis elegans, Caenorhabditis elegans
S519YTRYKPFVMFE1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
S519WFRTTCAVVMH1Drosophila melanogaster
T464TESYLTVSS--3Homo sapiens, Mus musculus, Rattus norvegicus
T464REGWVASHYLL1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
T464KETYMTTTD--1Drosophila melanogaster
T464SESYLNVRS--1Xenopus tropicalis
T464SESYLTVSS--1Bos taurus
T464KEHYFSMHS--1Caenorhabditis elegans
T464KEHYFDMES--1Caenorhabditis elegans
T517RTWFRTRSAII5Homo sapiens, Xenopus tropicalis, Mus musculus, Rattus norvegicus, Bos taurus
T517RVWFRTKSAIV2Caenorhabditis elegans, Caenorhabditis elegans
T517RRYTRYKPFVM1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
T517HSWFRTTCAVV1Drosophila melanogaster
V114AHQHVVGFHGF3Homo sapiens, Rattus norvegicus, Bos taurus
V114SHPNIVQFIDC1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
V114NHPNIVKFHNY1Drosophila melanogaster
V114DHRHVVGFHGF1Xenopus tropicalis
V114AHQHVVGFHDF1Mus musculus
V114GHINIVKLFNF1Caenorhabditis elegans
V114QHRNVVKLYHF1Caenorhabditis elegans
V415WVSKWVDYSDK5Homo sapiens, Xenopus tropicalis, Mus musculus, Rattus norvegicus, Bos taurus
V415WISKWVDYSDK3Drosophila melanogaster, Caenorhabditis elegans, Caenorhabditis elegans
V415IVTKWVDYSNK1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
W414-WVSKWVDYSD5Homo sapiens, Xenopus tropicalis, Mus musculus, Rattus norvegicus, Bos taurus
W414-WISKWVDYSD3Drosophila melanogaster, Caenorhabditis elegans, Caenorhabditis elegans
W414MIVTKWVDYSN1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Y417SKWVDYSDKYG8Homo sapiens, Drosophila melanogaster, Xenopus tropicalis, Mus musculus, Rattus norvegicus, Bos taurus, Caenorhabditis elegans, Caenorhabditis elegans
Y417TKWVDYSNKHG1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Y421DYSDKYGLGYQ5Homo sapiens, Xenopus tropicalis, Mus musculus, Rattus norvegicus, Bos taurus
Y421DYSDKYGIGYQ2Caenorhabditis elegans, Caenorhabditis elegans
Y421DYSNKHGFSYQ1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Y421DYSDKYGFGYQ1Drosophila melanogaster
Y445TRLILYNDGDS3Homo sapiens, Mus musculus, Rattus norvegicus
Y445TTVLRLADAEE1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Y445TKLILLPNQIN1Drosophila melanogaster
Y445TRLIMYNDGDS1Xenopus tropicalis
Y445TRLILYSDGDS1Bos taurus
Y445SRIMLDQAGNE1Caenorhabditis elegans
Y445SRIMLDTAGTQ1Caenorhabditis elegans
Y462DGTESYLTVSS3Homo sapiens, Mus musculus, Rattus norvegicus
Y462DDREGWVASHY1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Y462DGKETYMTTTD1Drosophila melanogaster
Y462NNSESYLNVRS1Xenopus tropicalis
Y462DGSESYLTVSS1Bos taurus
Y462SNKEHYFSMHS1Caenorhabditis elegans
Y462TEKEHYFDMES1Caenorhabditis elegans
Y481ITLLKYFRNYM3Homo sapiens, Xenopus tropicalis, Bos taurus
Y481ITLLNYFRNYM2Mus musculus, Rattus norvegicus
Y481LEVVDFFAKYM1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Y481MKLLSYFKRYM1Drosophila melanogaster
Y481VTLLKYFRSYM1Caenorhabditis elegans
Y481MTLLKYFRSYM1Caenorhabditis elegans
Y485KYFRNYMSEHL3Homo sapiens, Xenopus tropicalis, Bos taurus
Y485NYFRNYMSEHL2Mus musculus, Rattus norvegicus
Y485KYFRSYMNDHL2Caenorhabditis elegans, Caenorhabditis elegans
Y485DFFAKYMKANL1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Y485SYFKRYMIEHL1Drosophila melanogaster
Y582ASRLRYARTMV4Homo sapiens, Xenopus tropicalis, Mus musculus, Rattus norvegicus
Y582ESNFREKLTLI1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Y582YQKIRYAQEKL1Drosophila melanogaster
Y582ASRLRYARAMV1Bos taurus
Y582LHRLKYAKTMI1Caenorhabditis elegans
Y582LHRIQYAKCMI1Caenorhabditis elegans


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