mutLBSgeneDB

mutLBSgeneDB
mutated Ligand Binding Site gene DataBase

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Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for POLG
Gene summary
Basic gene Info.Gene symbolPOLG
Gene namepolymerase (DNA directed), gamma
SynonymsMDP1|MIRAS|MTDPS4A|MTDPS4B|PEO|POLG1|POLGA|SANDO|SCAE
CytomapUCSC genome browser: 15q25
Type of geneprotein-coding
RefGenesNM_001126131.1,
NM_002693.2,
DescriptionDNA polymerase subunit gamma-1PolG-alphamitochondrial DNA polymerase catalytic subunit
Modification date20141222
dbXrefs MIM : 174763
HGNC : HGNC
Ensembl : ENSG00000140521
HPRD : 01438
Vega : OTTHUMG00000149646
ProteinUniProt: P54098
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_POLG
BioGPS: 5428
PathwayNCI Pathway Interaction Database: POLG
KEGG: POLG
REACTOME: POLG
Pathway Commons: POLG
ContextiHOP: POLG
ligand binding site mutation search in PubMed: POLG
UCL Cancer Institute: POLG
Assigned class in mutLBSgeneDBC: This gene just belongs to mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO TermPubMed ID
GO:0006287base-excision repair, gap-filling15177179
GO:0071897DNA biosynthetic process15164064


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Ligand binding site mutations for POLG

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
K496K496NBRCA1
R309R309LSKCM1
K561P560TSKCM1
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.


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Protein structure related information for POLG
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
K561P560T-1.1664386
K496K496N-0.9968976
R309R309L-0.22509303
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for POLG from PDB

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Differential gene expression and gene-gene network for POLG
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of POLG and the right PPI network was created from samples without mutations in the LBS of POLG. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


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Phenotype information for POLG
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type
umls:C0751651Mitochondrial Diseases37Biomarker, GeneticVariation
umls:C0162674Ophthalmoplegia, Chronic Progressive External32Biomarker, GeneticVariation
umls:C0205710Alpers' disease31Biomarker, GeneticVariation
umls:C0007795Diffuse Cerebral Sclerosis of Schilder28Biomarker, GeneticVariation
umls:C0242422Parkinsonian Disorders17Biomarker, GeneticVariation
umls:C0021364Infertility, Male12Biomarker, GeneticVariation
umls:C0014544Epilepsy12Biomarker
umls:C0036572Seizures6Biomarker, GeneticVariation
umls:C1843851Sensory ataxic neuropathy, dysarthria, and ophthalmoparesis3Biomarker, GeneticVariation
umls:C0031117Peripheral Nervous System Diseases3Biomarker, GeneticVariation
umls:C1850303Progressive External Ophthalmoplegia with Mitochondrial DNA Deletions, Autosomal Recessive2Biomarker, GeneticVariation
umls:C0860207Drug-Induced Liver Injury2Biomarker
umls:C0023264Leigh Disease1Biomarker, GeneticVariation
umls:C0007959Charcot-Marie-Tooth Disease1Biomarker, GeneticVariation

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

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Pharmacological information for POLG
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of POLG go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS
NUCNucleic Acids4ztuAR309 K496 K561
NUCNucleic Acids4ztzAR309 K496 K561


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Conservation information for LBS of POLG
Multiple alignments for P54098 in multiple species
LBSAA sequence# speciesSpecies
A862PTWLTASNARP2Homo sapiens, Rattus norvegicus
A862PTWMTASNSRP1Drosophila melanogaster
A862NAWLTASNAKA1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
A862NTWLTASNSKK1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
A862RTWLTASNAKK1Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
D1135CISIHDEVRYL2Homo sapiens, Rattus norvegicus
D1135CLSFHDELRYL1Drosophila melanogaster
D1135CISIHDEIRFL1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
D1135SLTVHDEVRYL1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
D1135AITVHDEIRYL1Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
D769SPFAKDFLPKM2Homo sapiens, Rattus norvegicus
D769NPLSKDFLNKF1Drosophila melanogaster
D769NLLTKSYNHFF1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
D769SPLSKSYQRYF1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
D769NPMAKGYLPYF1Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
D890TLVGADVDSQE1Homo sapiens
D890RLVGADVDSQE1Drosophila melanogaster
D890VLVGADVDSQE1Rattus norvegicus
D890CFVGADVDSEE1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
D890TFVGADVDSEE1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
D890VFVGADVDSEE1Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
D892VGADVDSQELW3Homo sapiens, Drosophila melanogaster, Rattus norvegicus
D892VGADVDSEELW3Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Schizosaccharomyces pombe (strain 972 / ATCC 24843), Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
E895DVDSQELWIAA2Homo sapiens, Rattus norvegicus
E895DVDSEELWIAS2Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
E895DVDSQELWIAS1Drosophila melanogaster
E895DVDSEELWIVA1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
F961GAGQPFAERLL1Homo sapiens
F961GAGQLFAETLL1Drosophila melanogaster
F961GAGQSFAERLL1Rattus norvegicus
F961GAGAKFASQLL1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
F961GAGLKHTTLLL1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
F961GAGLKFASQLL1Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
G952KIFNYGRIYGA2Homo sapiens, Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
G952KVFNYGRIYGA2Rattus norvegicus, Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
G952KVINYARIYGA1Drosophila melanogaster
G952KVFNYGRLYGA1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G956YGRIYGAGQPF1Homo sapiens
G956YARIYGAGQLF1Drosophila melanogaster
G956YGRIYGAGQSF1Rattus norvegicus
G956YGRIYGAGAKF1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
G956YGRLYGAGLKH1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G956YGRIYGAGLKF1Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
G958RIYGAGQPFAE1Homo sapiens
G958RIYGAGQLFAE1Drosophila melanogaster
G958RIYGAGQSFAE1Rattus norvegicus
G958RIYGAGAKFAS1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
G958RLYGAGLKHTT1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G958RIYGAGLKFAS1Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
H1134FCISIHDEVRY2Homo sapiens, Rattus norvegicus
H1134FCLSFHDELRY1Drosophila melanogaster
H1134LCISIHDEIRF1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
H1134LSLTVHDEVRY1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
H1134LAITVHDEIRY1Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
H932RGTDLHSKTAT1Homo sapiens
H932NGSDMHSITAK1Drosophila melanogaster
H932RGTDLHSKTAA1Rattus norvegicus
H932EGTDLHTKTAQ1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
H932EGTDLHSKTAA1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
H932QGTDLHSRTAS1Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
I850VTAGTITRRAV2Homo sapiens, Rattus norvegicus
I850VACGTLTRRAM1Drosophila melanogaster
I850VPMGTITRRAV1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
I850IPMGTVTRRAV1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
I850IPMGTITRRAV1Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
K496DLQEFKQKKAK2Homo sapiens, Rattus norvegicus
K496SVQELKLKQPP1Drosophila melanogaster
K496TTKPLRLTK--1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
K496TPCNLYRK---1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
K496SGQEIKMAKPK1Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
K498QEFKQKKAKKV2Homo sapiens, Rattus norvegicus
K498QELKLKQPPKR1Drosophila melanogaster
K498KPLRLTK----1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
K498CNLYRK-----1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
K498QEIKMAKPKK-1Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
K561TELLPKRPQHL1Homo sapiens
K561QALLPARRPLL1Drosophila melanogaster
K561TDLLPKRPQHL1Rattus norvegicus
K561---VPAKCQKL1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
K561---LKKATQEV1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
K561VER-PALNQKL1Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
K768GSPFAKDFLPK2Homo sapiens, Rattus norvegicus
K768GNPLSKDFLNK1Drosophila melanogaster
K768TNLLTKSYNHF1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
K768GSPLSKSYQRY1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
K768VNPMAKGYLPY1Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
K947SREHAKIFNYG1Homo sapiens
K947SRDHAKVINYA1Drosophila melanogaster
K947SREHAKVFNYG1Rattus norvegicus
K947SRNEAKIFNYG1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
K947SRDSAKVFNYG1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
K947TRNDAKVFNYG1Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
L860VEPTWLTASNA2Homo sapiens, Rattus norvegicus
L860MEPTWMTASNS1Drosophila melanogaster
L860VENAWLTASNA1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
L860VENTWLTASNS1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
L860VERTWLTASNA1Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
M1093E---FMTSRVN2Homo sapiens, Rattus norvegicus
M1093QEQRFLPTRIN1Drosophila melanogaster
M1093NS--FLPSRIN1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
M1093NS--FMTSRVN1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
M1093GG--FLTSRIN1Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
M596LLSLQMRVTPK2Homo sapiens, Rattus norvegicus
M596EISTGMQIAPK1Drosophila melanogaster
M596KITIKSRIIPI1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
M596VITAKSRLAPI1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
M596NLTVRSRIAPL1Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
N1098MTSRVNWVVQS2Homo sapiens, Rattus norvegicus
N1098LPTRINWVVQS1Drosophila melanogaster
N1098LPSRINWAIQS1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
N1098MTSRVNWAIQS1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
N1098LTSRINWAIQS1Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
N803ISFWRNAHKRI2Homo sapiens, Rattus norvegicus
N803MSYWRNNRDRI1Drosophila melanogaster
N803GSYWMSARERI1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
N803CSYWSSARDRI1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
N803CSYWISARERI1Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
N864WLTASNARPDR2Homo sapiens, Rattus norvegicus
N864WMTASNSRPDR1Drosophila melanogaster
N864WLTASNAKANR1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
N864WLTASNSKKNR1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
N864WLTASNAKKNR1Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
P765CNVGSPFAKDF1Homo sapiens
P765FRVGNPLSKDF1Drosophila melanogaster
P765YNVGSPFAKDF1Rattus norvegicus
P765FNCTNLLTKSY1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
P765ARCGSPLSKSY1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
P765ARCVNPMAKGY1Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
P857RRAVEPTWLTA2Homo sapiens, Rattus norvegicus
P857RRAMEPTWMTA1Drosophila melanogaster
P857RRAVENAWLTA1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
P857RRAVENTWLTA1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
P857RRAVERTWLTA1Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Q1102VNWVVQSSAVD2Homo sapiens, Rattus norvegicus
Q1102INWAIQSSGVD2Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Q1102INWVVQSGAVD1Drosophila melanogaster
Q1102VNWAIQSSAVD1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Q595SLLSLQMRVTP2Homo sapiens, Rattus norvegicus
Q595SEISTGMQIAP1Drosophila melanogaster
Q595PKITIKSRIIP1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Q595-VITAKSRLAP1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Q595INLTVRSRIAP1Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Q894ADVDSQELWIA3Homo sapiens, Drosophila melanogaster, Rattus norvegicus
Q894ADVDSEELWIA2Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Q894ADVDSEELWIV1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
R309LSSFQRSLWIA1Homo sapiens
R309VTSYQRAML--1Drosophila melanogaster
R309LSSFQRSLWMG1Rattus norvegicus
R309LCSRQRPMFMK1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
R309MCSRQKPTWFK1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
R309MCSQQRPTWMK1Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
R579RKLCPRLDDPA2Homo sapiens, Rattus norvegicus
R579RKLCRKPPAKR1Drosophila melanogaster
R579RQLFPSKDTVE1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
R579KKAYCKTEKRA1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
R579KDLFVKVPKEL1Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
R597LSLQMRVTPKL2Homo sapiens, Rattus norvegicus
R597ISTGMQIAPKL1Drosophila melanogaster
R597ITIKSRIIPIL1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
R597ITAKSRLAPIL1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
R597LTVRSRIAPLL1Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
R807RNAHKRISSQM2Homo sapiens, Rattus norvegicus
R807RNNRDRIMGQM1Drosophila melanogaster
R807MSARERIQSQF1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
R807SSARDRIRSQM1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
R807ISARERIKNQM1Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
R853GTITRRAVEPT2Homo sapiens, Rattus norvegicus
R853GTLTRRAMEPT1Drosophila melanogaster
R853GTITRRAVENA1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
R853GTVTRRAVENT1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
R853GTITRRAVERT1Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
R869NARPDRVGSEL2Homo sapiens, Rattus norvegicus
R869NSRPDRLGSEL1Drosophila melanogaster
R869NAKANRIGSEL1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
R869NSKKNRLGSEL1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
R869NAKKNRVGSEL1Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
S1095--FMTSRVNWV2Homo sapiens, Rattus norvegicus
S1095QRFLPTRINWV1Drosophila melanogaster
S1095--FLPSRINWA1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
S1095--FMTSRVNWA1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
S1095--FLTSRINWA1Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
S306ISGLSSFQRSL2Homo sapiens, Rattus norvegicus
S306VSGVTSYQRAM1Drosophila melanogaster
S306SFGLCSRQRPM1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
S306THGMCSRQKPT1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
S306VNGMCSQQRPT1Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
S593GPSLLSLQMRV2Homo sapiens, Rattus norvegicus
S593GASEISTGMQI1Drosophila melanogaster
S593--PKITIKSRI1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
S593---VITAKSRL1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
S593EFINLTVRSRI1Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
S764SCNVGSPFAKD1Homo sapiens
S764SFRVGNPLSKD1Drosophila melanogaster
S764NYNVGSPFAKD1Rattus norvegicus
S764TFNCTNLLTKS1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
S764EARCGSPLSKS1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
S764NARCVNPMAKG1Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
S893GADVDSQELWI3Homo sapiens, Drosophila melanogaster, Rattus norvegicus
S893GADVDSEELWI3Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Schizosaccharomyces pombe (strain 972 / ATCC 24843), Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
T1094---FMTSRVNW2Homo sapiens, Rattus norvegicus
T1094EQRFLPTRINW1Drosophila melanogaster
T1094S--FLPSRINW1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
T1094S--FMTSRVNW1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
T1094G--FLTSRINW1Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
T849VVTAGTITRRA2Homo sapiens, Rattus norvegicus
T849VVACGTLTRRA1Drosophila melanogaster
T849IVPMGTITRRA1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
T849IIPMGTVTRRA1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
T849VIPMGTITRRA1Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
T861EPTWLTASNAR2Homo sapiens, Rattus norvegicus
T861EPTWMTASNSR1Drosophila melanogaster
T861ENAWLTASNAK1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
T861ENTWLTASNSK1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
T861ERTWLTASNAK1Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
V855ITRRAVEPTWL2Homo sapiens, Rattus norvegicus
V855LTRRAMEPTWM1Drosophila melanogaster
V855ITRRAVENAWL1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
V855VTRRAVENTWL1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
V855ITRRAVERTWL1Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
V891LVGADVDSQEL3Homo sapiens, Drosophila melanogaster, Rattus norvegicus
V891FVGADVDSEEL3Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Schizosaccharomyces pombe (strain 972 / ATCC 24843), Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Y951AKIFNYGRIYG2Homo sapiens, Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Y951AKVFNYGRIYG2Rattus norvegicus, Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Y951AKVINYARIYG1Drosophila melanogaster
Y951AKVFNYGRLYG1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Y955NYGRIYGAGQP1Homo sapiens
Y955NYARIYGAGQL1Drosophila melanogaster
Y955NYGRIYGAGQS1Rattus norvegicus
Y955NYGRIYGAGAK1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Y955NYGRLYGAGLK1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Y955NYGRIYGAGLK1Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)


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