mutLBSgeneDB

mutLBSgeneDB
mutated Ligand Binding Site gene DataBase

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Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for PPBP
Gene summary
Basic gene Info.Gene symbolPPBP
Gene namepro-platelet basic protein (chemokine (C-X-C motif) ligand 7)
SynonymsB-TG1|Beta-TG|CTAP-III|CTAP3|CTAPIII|CXCL7|LA-PF4|LDGF|MDGF|NAP-2|PBP|SCYB7|TC1|TC2|TGB|TGB1|THBGB|THBGB1
CytomapUCSC genome browser: 4q12-q13
Type of geneprotein-coding
RefGenesNM_002704.3,
DescriptionC-X-C motif chemokine 7CXC chemokine ligand 7beta-thromboglobulinconnective tissue-activating peptide IIIleukocyte-derived growth factorlow-affinity platelet factor IVmacrophage-derived growth factorneutrophil-activating peptide 2neutrophil-activa
Modification date20141207
dbXrefs MIM : 121010
HGNC : HGNC
HPRD : 07171
ProteinUniProt: P02775
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_PPBP
BioGPS: 5473
PathwayNCI Pathway Interaction Database: PPBP
KEGG: PPBP
REACTOME: PPBP
Pathway Commons: PPBP
ContextiHOP: PPBP
ligand binding site mutation search in PubMed: PPBP
UCL Cancer Institute: PPBP
Assigned class in mutLBSgeneDBC: This gene just belongs to mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO TermPubMed ID


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Ligand binding site mutations for PPBP

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
P74P74LBLCA1
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.


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Protein structure related information for PPBP
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
P74P74L-0.73576933
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for PPBP from PDB

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Differential gene expression and gene-gene network for PPBP
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of PPBP and the right PPI network was created from samples without mutations in the LBS of PPBP. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


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Phenotype information for PPBP
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type
umls:C0020538Hypertension2Biomarker

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

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Pharmacological information for PPBP
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.

Gene-centered drug-gene interaction network
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure
ExperimentalDB03635Ethanesulfonic AcidSmall molecule

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of PPBP go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS


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Conservation information for LBS of PPBP
Multiple alignments for P02775 in multiple species
LBSAA sequence# speciesSpecies


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