mutLBSgeneDB

mutLBSgeneDB
mutated Ligand Binding Site gene DataBase

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Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for PPP1CC
Gene summary
Basic gene Info.Gene symbolPPP1CC
Gene nameprotein phosphatase 1, catalytic subunit, gamma isozyme
SynonymsPP-1G|PP1C|PPP1G
CytomapUCSC genome browser: 12q24.1-q24.2
Type of geneprotein-coding
RefGenesNM_001244974.1,
NM_002710.3,
Descriptionprotein phosphatase 1, catalytic subunit, gamma isoformprotein phosphatase 1C catalytic subunitserine/threonine phosphatase 1 gammaserine/threonine-protein phosphatase PP1-gamma catalytic subunit
Modification date20141222
dbXrefs MIM : 176914
HGNC : HGNC
Ensembl : ENSG00000186298
HPRD : 08911
Vega : OTTHUMG00000169531
ProteinUniProt: P36873
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_PPP1CC
BioGPS: 5501
PathwayNCI Pathway Interaction Database: PPP1CC
KEGG: PPP1CC
REACTOME: PPP1CC
Pathway Commons: PPP1CC
ContextiHOP: PPP1CC
ligand binding site mutation search in PubMed: PPP1CC
UCL Cancer Institute: PPP1CC
Assigned class in mutLBSgeneDBC: This gene just belongs to mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO TermPubMed ID


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Ligand binding site mutations for PPP1CC

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
C202,W206L204ICOAD1
S22S22PSTAD1
S129S129ISTAD1
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.


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Protein structure related information for PPP1CC
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
C202L204I-1.2006263
W206L204I-1.2006263
S22S22P-1.040895
S129S129I-0.36269252
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for PPP1CC from PDB

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Differential gene expression and gene-gene network for PPP1CC
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of PPP1CC and the right PPI network was created from samples without mutations in the LBS of PPP1CC. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


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Phenotype information for PPP1CC
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type
umls:C0919267Ovarian Neoplasms1Biomarker

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

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Pharmacological information for PPP1CC
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.

Gene-centered drug-gene interaction network
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure
ExperimentalDB021699,10-Deepithio-9,10-DidehydroacanthifolicinSmall molecule
ExperimentalDB02860Calyculin ASmall molecule
ExperimentalDB04675(2S,5R,8S,11R,12S,15S,18S,19S,E)-8-ISOBUTYL-18-((5S,6S)-6-METHOXY-3,5-DIMETHYL-7-PHENYLHEPTYL)-1,2,5,12,15,19-HEXAMETHYL-3,6,9,13,16,20,25-HEPTAOXO-1,4,7,10,14,17,21-HEPTAAZACYCLOPENTACOS-21-ENE-11,22-DICARBOXYLIC ACIDSmall molecule
ExperimentalDB04738MotuporinSmall molecule

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of PPP1CC go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS
CYUCALYCULIN A1it6AS129 C202 W206
CYUCALYCULIN A1it6BS129 W206
IIIPeptide ligand (ACB,VAL,1ZN,FGA,MDH)2bcdAS129 W206
IIIPeptide ligand (DAL,LEU,ACB,ALA,1ZN,FGA,ALA)2bdxAS129 W206
MNMANGANESE(2+)2bcdAS22


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Conservation information for LBS of PPP1CC
Multiple alignments for P36873 in multiple species
LBSAA sequence# speciesSpecies
A259GYEFFAKRQLV7Homo sapiens, Canis lupus familiaris, Bos taurus, Mus musculus, Xenopus tropicalis, Drosophila melanogaster, Drosophila melanogaster
A259GYEFFADRQLV2Arabidopsis thaliana, Oryza sativa subsp. japonica
A259GYEFFGKRQLV1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
A259GYEFFAKRMLV1Drosophila melanogaster
C202DQGLLCDLLWS8Homo sapiens, Canis lupus familiaris, Bos taurus, Mus musculus, Xenopus tropicalis, Drosophila melanogaster, Drosophila melanogaster, Drosophila melanogaster
C202DTGLLCDLLWS2Arabidopsis thaliana, Oryza sativa subsp. japonica
C202DTGLLCDLVWS1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
C273SAPNYCGEFDN11Homo sapiens, Schizosaccharomyces pombe (strain 972 / ATCC 24843), Canis lupus familiaris, Bos taurus, Mus musculus, Xenopus tropicalis, Drosophila melanogaster, Drosophila melanogaster, Drosophila melanogaster, Arabidopsis thaliana, Oryza sativa subsp. j
D197PTDVPDQGLLC8Homo sapiens, Canis lupus familiaris, Bos taurus, Mus musculus, Xenopus tropicalis, Drosophila melanogaster, Drosophila melanogaster, Drosophila melanogaster
D197PTDIPDTGLLC1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
D197PTMIPDTGLLC1Arabidopsis thaliana
D197PTDVPDTGLLC1Oryza sativa subsp. japonica
D208DLLWSDPDKDV5Homo sapiens, Canis lupus familiaris, Bos taurus, Mus musculus, Xenopus tropicalis
D208DLLWSDPDKDT3Drosophila melanogaster, Drosophila melanogaster, Drosophila melanogaster
D208DLLWSDPGKDV2Arabidopsis thaliana, Oryza sativa subsp. japonica
D208DLVWSDPEKDL1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
D210LWSDPDKDVLG5Homo sapiens, Canis lupus familiaris, Bos taurus, Mus musculus, Xenopus tropicalis
D210LWSDPDKDTMG2Drosophila melanogaster, Drosophila melanogaster
D210VWSDPEKDLTG1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
D210LWSDPDKDTIG1Drosophila melanogaster
D210LWSDPGKDVKG1Arabidopsis thaliana
D210LWSDPGKDVQG1Oryza sativa subsp. japonica
D220GWGENDRGVSF7Homo sapiens, Bos taurus, Mus musculus, Xenopus tropicalis, Drosophila melanogaster, Drosophila melanogaster, Drosophila melanogaster
D220GWGMNDRGVSY2Arabidopsis thaliana, Oryza sativa subsp. japonica
D220GWGENDRGVSY1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
D220GWGETDRGVSF1Canis lupus familiaris
D64LKICGDIHGQY9Homo sapiens, Schizosaccharomyces pombe (strain 972 / ATCC 24843), Canis lupus familiaris, Bos taurus, Mus musculus, Xenopus tropicalis, Drosophila melanogaster, Drosophila melanogaster, Drosophila melanogaster
D64IKICGDIHGQY2Arabidopsis thaliana, Oryza sativa subsp. japonica
D92YLFLGDYVDRG11Homo sapiens, Schizosaccharomyces pombe (strain 972 / ATCC 24843), Canis lupus familiaris, Bos taurus, Mus musculus, Xenopus tropicalis, Drosophila melanogaster, Drosophila melanogaster, Drosophila melanogaster, Arabidopsis thaliana, Oryza sativa subsp. j
E252AHQVVEDGYEF11Homo sapiens, Schizosaccharomyces pombe (strain 972 / ATCC 24843), Canis lupus familiaris, Bos taurus, Mus musculus, Xenopus tropicalis, Drosophila melanogaster, Drosophila melanogaster, Drosophila melanogaster, Arabidopsis thaliana, Oryza sativa subsp. j
E275PNYCGEFDNAG10Homo sapiens, Canis lupus familiaris, Bos taurus, Mus musculus, Xenopus tropicalis, Drosophila melanogaster, Drosophila melanogaster, Drosophila melanogaster, Arabidopsis thaliana, Oryza sativa subsp. japonica
E275PNYCGEFDNVG1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
F267QLVTLFSAPNY7Homo sapiens, Canis lupus familiaris, Bos taurus, Mus musculus, Xenopus tropicalis, Drosophila melanogaster, Drosophila melanogaster
F267QLVTIFSAPNY2Schizosaccharomyces pombe (strain 972 / ATCC 24843), Oryza sativa subsp. japonica
F267MLVTLFSAPNY1Drosophila melanogaster
F267QLVTVFSAPNY1Arabidopsis thaliana
F276NYCGEFDNAGA10Homo sapiens, Canis lupus familiaris, Bos taurus, Mus musculus, Xenopus tropicalis, Drosophila melanogaster, Drosophila melanogaster, Drosophila melanogaster, Arabidopsis thaliana, Oryza sativa subsp. japonica
F276NYCGEFDNVGA1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
H125LLRGNHECASI9Homo sapiens, Bos taurus, Mus musculus, Xenopus tropicalis, Drosophila melanogaster, Drosophila melanogaster, Drosophila melanogaster, Arabidopsis thaliana, Oryza sativa subsp. japonica
H125LLRGNHEFASI1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
H125LLRGNHECVSI1Canis lupus familiaris
H173KIFCCHGGLSP8Homo sapiens, Canis lupus familiaris, Bos taurus, Mus musculus, Xenopus tropicalis, Drosophila melanogaster, Drosophila melanogaster, Drosophila melanogaster
H173KILCMHGGLSP2Arabidopsis thaliana, Oryza sativa subsp. japonica
H173KIFCMHGGLSP1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
H248LICRAHQVVED10Homo sapiens, Schizosaccharomyces pombe (strain 972 / ATCC 24843), Canis lupus familiaris, Bos taurus, Mus musculus, Xenopus tropicalis, Drosophila melanogaster, Drosophila melanogaster, Drosophila melanogaster, Oryza sativa subsp. japonica
H248LVCRAHQVVED1Arabidopsis thaliana
H66ICGDIHGQYYD8Homo sapiens, Canis lupus familiaris, Bos taurus, Mus musculus, Xenopus tropicalis, Drosophila melanogaster, Drosophila melanogaster, Drosophila melanogaster
H66ICGDIHGQYSD3Schizosaccharomyces pombe (strain 972 / ATCC 24843), Arabidopsis thaliana, Oryza sativa subsp. japonica
I130HECASINRIYG9Homo sapiens, Bos taurus, Mus musculus, Xenopus tropicalis, Drosophila melanogaster, Drosophila melanogaster, Drosophila melanogaster, Arabidopsis thaliana, Oryza sativa subsp. japonica
I130HEFASINRIYG1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
I130HECVSINRIYG1Canis lupus familiaris
I146KRRYNIKLWKT5Homo sapiens, Canis lupus familiaris, Bos taurus, Mus musculus, Xenopus tropicalis
I146KRRYSIKLWKT2Schizosaccharomyces pombe (strain 972 / ATCC 24843), Drosophila melanogaster
I146KRRYTIKLWKT2Drosophila melanogaster, Drosophila melanogaster
I146KRRFNVRVWKV1Arabidopsis thaliana
I146KRRFNVRLWKV1Oryza sativa subsp. japonica
K23EVRGSKPGKNV5Homo sapiens, Canis lupus familiaris, Bos taurus, Mus musculus, Xenopus tropicalis
K23EVRGARPGKNV3Drosophila melanogaster, Drosophila melanogaster, Drosophila melanogaster
K23KARNGKPSKQV1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
K23EVRLARPGKQV1Arabidopsis thaliana
K23EVRTARPGKQV1Oryza sativa subsp. japonica
K260YEFFAKRQLVT7Homo sapiens, Canis lupus familiaris, Bos taurus, Mus musculus, Xenopus tropicalis, Drosophila melanogaster, Drosophila melanogaster
K260YEFFADRQLVT2Arabidopsis thaliana, Oryza sativa subsp. japonica
K260YEFFGKRQLVT1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
K260YEFFAKRMLVT1Drosophila melanogaster
M183PDLQSMEQIRR5Homo sapiens, Canis lupus familiaris, Bos taurus, Mus musculus, Xenopus tropicalis
M183PDLTSMEQIRR2Drosophila melanogaster, Drosophila melanogaster
M183PDLNSLDQIQR1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
M183PDLSSMEQIRR1Drosophila melanogaster
M183PDLDHLDEIRN1Arabidopsis thaliana
M183PDLTHLDEIKS1Oryza sativa subsp. japonica
N124FLLRGNHECAS9Homo sapiens, Bos taurus, Mus musculus, Xenopus tropicalis, Drosophila melanogaster, Drosophila melanogaster, Drosophila melanogaster, Arabidopsis thaliana, Oryza sativa subsp. japonica
N124FLLRGNHEFAS1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
N124FLLRGNHECVS1Canis lupus familiaris
N145CKRRYNIKLWK5Homo sapiens, Canis lupus familiaris, Bos taurus, Mus musculus, Xenopus tropicalis
N145CKRRYSIKLWK2Schizosaccharomyces pombe (strain 972 / ATCC 24843), Drosophila melanogaster
N145CKRRYTIKLWK2Drosophila melanogaster, Drosophila melanogaster
N145CKRRFNVRVWK1Arabidopsis thaliana
N145CKRRFNVRLWK1Oryza sativa subsp. japonica
N219LGWGENDRGVS4Homo sapiens, Bos taurus, Mus musculus, Xenopus tropicalis
N219MGWGENDRGVS2Drosophila melanogaster, Drosophila melanogaster
N219TGWGENDRGVS1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
N219LGWGETDRGVS1Canis lupus familiaris
N219IGWGENDRGVS1Drosophila melanogaster
N219KGWGMNDRGVS1Arabidopsis thaliana
N219QGWGMNDRGVS1Oryza sativa subsp. japonica
P196RPTDVPDQGLL8Homo sapiens, Canis lupus familiaris, Bos taurus, Mus musculus, Xenopus tropicalis, Drosophila melanogaster, Drosophila melanogaster, Drosophila melanogaster
P196RPTDIPDTGLL1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
P196RPTMIPDTGLL1Arabidopsis thaliana
P196RPTDVPDTGLL1Oryza sativa subsp. japonica
P209LLWSDPDKDVL5Homo sapiens, Canis lupus familiaris, Bos taurus, Mus musculus, Xenopus tropicalis
P209LLWSDPDKDTM2Drosophila melanogaster, Drosophila melanogaster
P209LVWSDPEKDLT1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
P209LLWSDPDKDTI1Drosophila melanogaster
P209LLWSDPGKDVK1Arabidopsis thaliana
P209LLWSDPGKDVQ1Oryza sativa subsp. japonica
Q249ICRAHQVVEDG10Homo sapiens, Schizosaccharomyces pombe (strain 972 / ATCC 24843), Canis lupus familiaris, Bos taurus, Mus musculus, Xenopus tropicalis, Drosophila melanogaster, Drosophila melanogaster, Drosophila melanogaster, Oryza sativa subsp. japonica
Q249VCRAHQVVEDG1Arabidopsis thaliana
R221WGENDRGVSFT7Homo sapiens, Bos taurus, Mus musculus, Xenopus tropicalis, Drosophila melanogaster, Drosophila melanogaster, Drosophila melanogaster
R221WGMNDRGVSYT2Arabidopsis thaliana, Oryza sativa subsp. japonica
R221WGENDRGVSYT1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
R221WGETDRGVSFT1Canis lupus familiaris
R96GDYVDRGKQSL11Homo sapiens, Schizosaccharomyces pombe (strain 972 / ATCC 24843), Canis lupus familiaris, Bos taurus, Mus musculus, Xenopus tropicalis, Drosophila melanogaster, Drosophila melanogaster, Drosophila melanogaster, Arabidopsis thaliana, Oryza sativa subsp. j
S129NHECASINRIY9Homo sapiens, Bos taurus, Mus musculus, Xenopus tropicalis, Drosophila melanogaster, Drosophila melanogaster, Drosophila melanogaster, Arabidopsis thaliana, Oryza sativa subsp. japonica
S129NHEFASINRIY1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
S129NHECVSINRIY1Canis lupus familiaris
S182SPDLQSMEQIR5Homo sapiens, Canis lupus familiaris, Bos taurus, Mus musculus, Xenopus tropicalis
S182SPDLTSMEQIR2Drosophila melanogaster, Drosophila melanogaster
S182SPDLNSLDQIQ1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
S182SPDLSSMEQIR1Drosophila melanogaster
S182SPDLDHLDEIR1Arabidopsis thaliana
S182SPDLTHLDEIK1Oryza sativa subsp. japonica
S22LEVRGSKPGKN5Homo sapiens, Canis lupus familiaris, Bos taurus, Mus musculus, Xenopus tropicalis
S22LEVRGARPGKN3Drosophila melanogaster, Drosophila melanogaster, Drosophila melanogaster
S22VKARNGKPSKQ1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
S22TEVRLARPGKQ1Arabidopsis thaliana
S22LEVRTARPGKQ1Oryza sativa subsp. japonica
T226RGVSFTFGAEV8Homo sapiens, Canis lupus familiaris, Bos taurus, Mus musculus, Xenopus tropicalis, Drosophila melanogaster, Drosophila melanogaster, Drosophila melanogaster
T226RGVSYTFGADV1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
T226RGVSYTFGPDK1Arabidopsis thaliana
T226RGVSYTFGADK1Oryza sativa subsp. japonica
V195MRPTDVPDQGL8Homo sapiens, Canis lupus familiaris, Bos taurus, Mus musculus, Xenopus tropicalis, Drosophila melanogaster, Drosophila melanogaster, Drosophila melanogaster
V195IRPTDIPDTGL1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
V195PRPTMIPDTGL1Arabidopsis thaliana
V195PRPTDVPDTGL1Oryza sativa subsp. japonica
V223ENDRGVSFTFG7Homo sapiens, Bos taurus, Mus musculus, Xenopus tropicalis, Drosophila melanogaster, Drosophila melanogaster, Drosophila melanogaster
V223MNDRGVSYTFG2Arabidopsis thaliana, Oryza sativa subsp. japonica
V223ENDRGVSYTFG1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
V223ETDRGVSFTFG1Canis lupus familiaris
V250CRAHQVVEDGY11Homo sapiens, Schizosaccharomyces pombe (strain 972 / ATCC 24843), Canis lupus familiaris, Bos taurus, Mus musculus, Xenopus tropicalis, Drosophila melanogaster, Drosophila melanogaster, Drosophila melanogaster, Arabidopsis thaliana, Oryza sativa subsp. j
W206LCDLLWSDPDK8Homo sapiens, Canis lupus familiaris, Bos taurus, Mus musculus, Xenopus tropicalis, Drosophila melanogaster, Drosophila melanogaster, Drosophila melanogaster
W206LCDLLWSDPGK2Arabidopsis thaliana, Oryza sativa subsp. japonica
W206LCDLVWSDPEK1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Y134SINRIYGFYDE11Homo sapiens, Schizosaccharomyces pombe (strain 972 / ATCC 24843), Canis lupus familiaris, Bos taurus, Mus musculus, Xenopus tropicalis, Drosophila melanogaster, Drosophila melanogaster, Drosophila melanogaster, Arabidopsis thaliana, Oryza sativa subsp. j
Y272FSAPNYCGEFD11Homo sapiens, Schizosaccharomyces pombe (strain 972 / ATCC 24843), Canis lupus familiaris, Bos taurus, Mus musculus, Xenopus tropicalis, Drosophila melanogaster, Drosophila melanogaster, Drosophila melanogaster, Arabidopsis thaliana, Oryza sativa subsp. j


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