mutated Ligand Binding Site gene DataBase





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Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for MRPS18A
Gene summary
Basic gene Info.Gene symbolMRPS18A
Gene namemitochondrial ribosomal protein S18A
CytomapUCSC genome browser: 6p21.3
Type of geneprotein-coding
Description28S ribosomal protein S18-3, mitochondrial28S ribosomal protein S18a, mitochondrialMRP-S18-aS18mt-amitochondrial ribosomal protein S18-3
Modification date20141207
dbXrefs MIM : 611981
Ensembl : ENSG00000096080
HPRD : 14780
Vega : OTTHUMG00000014750
ProteinUniProt: Q9NVS2
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_MRPS18A
BioGPS: 55168
PathwayNCI Pathway Interaction Database: MRPS18A
Pathway Commons: MRPS18A
ContextiHOP: MRPS18A
ligand binding site mutation search in PubMed: MRPS18A
UCL Cancer Institute: MRPS18A
Assigned class in mutLBSgeneDBC: This gene just belongs to mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez

Ligand binding site mutations for MRPS18A

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.

Protein structure related information for MRPS18A
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for MRPS18A from PDB

Differential gene expression and gene-gene network for MRPS18A
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of MRPS18A and the right PPI network was created from samples without mutations in the LBS of MRPS18A. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


Phenotype information for MRPS18A
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

Pharmacological information for MRPS18A
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of MRPS18A go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS
NUCNucleic Acids3j7yrH112 K160

Conservation information for LBS of MRPS18A
Multiple alignments for Q9NVS2 in multiple species
LBSAA sequence# speciesSpecies
A155YLTRWAPGSVK1Homo sapiens
A155YLTRWAPKSVK1Mus musculus
A155YLTRWSPRSVK1Bos taurus
C108KITGLCQEEHR1Homo sapiens
C108RVTGLCREEHR1Mus musculus
C108SITGLCQEEHR1Bos taurus
C70NPSGQCPICRW3Homo sapiens, Mus musculus, Bos taurus
C73GQCPICRWNLK3Homo sapiens, Mus musculus, Bos taurus
D84HKYNYDDVLLL1Homo sapiens
D84HKYTYEDVLLL1Mus musculus
E116EHRKIEECVKM3Homo sapiens, Mus musculus, Bos taurus
G157TRWAPGSVKPI1Homo sapiens
G157TRWAPKSVKPI1Mus musculus
G157TRWSPRSVKPI1Bos taurus
G166PIYKKGPRWNR1Homo sapiens
G166PIYKKGHRWNK1Mus musculus
G166PIYNKGHRWNK1Bos taurus
G98IRPHGGMLPRK1Homo sapiens
G98IRPYGGMLPRR1Mus musculus
H112LCQEEHRKIEE2Homo sapiens, Bos taurus
H112LCREEHRKIEE1Mus musculus
H123CVKMAHRAGLL3Homo sapiens, Mus musculus, Bos taurus
H79RWNLKHKYNYD1Homo sapiens
H79RWNLKHKYTYE1Mus musculus
H96QFIRPHGGMLP2Homo sapiens, Bos taurus
H96QFIRPYGGMLP1Mus musculus
K120IEECVKMAHRA3Homo sapiens, Mus musculus, Bos taurus
K160APGSVKPIYKK1Homo sapiens
K160APKSVKPIYKK1Mus musculus
K160SPRSVKPIYNK1Bos taurus
K165KPIYKKGPRWN1Homo sapiens
K165KPIYKKGHRWN1Mus musculus
K165KPIYNKGHRWN1Bos taurus
K193SRTPWKLYH1Homo sapiens
K193SRRPLKMMH1Mus musculus
K193TGRPLVLYH1Bos taurus
L100PHGGMLPRKIT1Homo sapiens
L100PYGGMLPRRVT1Mus musculus
L100PHGGMLPRSIT1Bos taurus
L151QLNRYLTRWAP1Homo sapiens
L151KLNRYLTRWAP1Mus musculus
L151RLNRYLTRWSP1Bos taurus
L194RTPWKLYH1Homo sapiens
L194RRPLKMMH1Mus musculus
L194GRPLVLYH1Bos taurus
M99RPHGGMLPRKI1Homo sapiens
M99RPYGGMLPRRV1Mus musculus
N82LKHKYNYDDVL1Homo sapiens
N82LKHKYTYEDVL1Mus musculus
P101HGGMLPRKITG1Homo sapiens
P101YGGMLPRRVTG1Mus musculus
P101HGGMLPRSITG1Bos taurus
P179MAVGSPLLKDN2Mus musculus, Bos taurus
P179MPVGSPLLRDN1Homo sapiens
R102GGMLPRKITGL1Homo sapiens
R102GGMLPRRVTGL1Mus musculus
R102GGMLPRSITGL1Bos taurus
R124VKMAHRAGLLP3Homo sapiens, Mus musculus, Bos taurus
R153NRYLTRWAPGS1Homo sapiens
R153NRYLTRWAPKS1Mus musculus
R153NRYLTRWSPRS1Bos taurus
R168YKKGPRWNRVR1Homo sapiens
R168YKKGHRWNKVG1Mus musculus
R168YNKGHRWNKVR1Bos taurus
R171GPRWNRVRMPV1Homo sapiens
R171GHRWNKVGMAV1Mus musculus
R171GHRWNKVRMAV1Bos taurus
R173RWNRVRMPVGS1Homo sapiens
R173RWNKVGMAVGS1Mus musculus
R173RWNKVRMAVGS1Bos taurus
R182GSPLLRDNVCY1Homo sapiens
R182GSPLLKDNVCY1Mus musculus
R182GSPLLKDNVSY1Bos taurus
R189NVCYSRTPWKL1Homo sapiens
R189NVCYSRRPLKM1Mus musculus
R189NVSYTGRPLVL1Bos taurus
R94LSQFIRPHGGM2Homo sapiens, Bos taurus
R94LSQFIRPYGGM1Mus musculus
S158RWAPGSVKPIY1Homo sapiens
S158RWAPKSVKPIY1Mus musculus
S158RWSPRSVKPIY1Bos taurus
S188DNVCYSRTPWK1Homo sapiens
S188DNVCYSRRPLK1Mus musculus
S188DNVSYTGRPLV1Bos taurus
W154RYLTRWAPGSV1Homo sapiens
W154RYLTRWAPKSV1Mus musculus
W154RYLTRWSPRSV1Bos taurus
W169KKGPRWNRVRM1Homo sapiens
W169KKGHRWNKVGM1Mus musculus
W169NKGHRWNKVRM1Bos taurus
W192YSRTPWKLYH1Homo sapiens
W192YSRRPLKMMH1Mus musculus
W192YTGRPLVLYH1Bos taurus
Y150PQLNRYLTRWA1Homo sapiens
Y150PKLNRYLTRWA1Mus musculus
Y150PRLNRYLTRWS1Bos taurus
Y195TPWKLYH1Homo sapiens
Y195RPLKMMH1Mus musculus
Y195RPLVLYH1Bos taurus

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