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mutLBSgeneDB |
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| Gene summary for GALNT10 |
 Gene summary |
| Basic gene Info. | Gene symbol | GALNT10 |
| Gene name | polypeptide N-acetylgalactosaminyltransferase 10 | |
| Synonyms | GALNACT10|PPGALNACT10|PPGANTASE10 | |
| Cytomap | UCSC genome browser: 5q33.2 | |
| Type of gene | protein-coding | |
| RefGenes | NM_198321.3, NM_017540.3,NM_024564.1, | |
| Description | GalNAc transferase 10UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 10UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 10 (GalNAc-T10) | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 608043 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000164574 | ||
| HPRD : 12157 | ||
| Vega : OTTHUMG00000130145 | ||
| Protein | UniProt: Q86SR1 go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_GALNT10 | |
| BioGPS: 55568 | ||
| Pathway | NCI Pathway Interaction Database: GALNT10 | |
| KEGG: GALNT10 | ||
| REACTOME: GALNT10 | ||
| Pathway Commons: GALNT10 | ||
| Context | iHOP: GALNT10 | |
| ligand binding site mutation search in PubMed: GALNT10 | ||
| UCL Cancer Institute: GALNT10 | ||
| Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. | |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO Term | PubMed ID | GO:0006493 | protein O-linked glycosylation | 12417297 | GO:0016266 | O-glycan processing | 18562306 |
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| Ligand binding site mutations for GALNT10 |
| Cancer type specific mutLBS sorted by frequency |
| LBS | AAchange of nsSNV | Cancer type | # samples | Y536 | D537N | BRCA | 1 | G319 | G319C | LUAD | 1 | E156 | E156K | SKCM | 1 | D185 | D184G | UCEC | 1 |
| cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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| Protein structure related information for GALNT10 |
| Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
 : nsSNV at non-LBS : nsSNV at LBS |
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| nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
| LBS | AAchange of nsSNV | Relative stability change | D185 | D184G | -1.4450353 | Y536 | D537N | -1.093244 | E156 | E156K | -0.58916832 | G319 | G319C | -0.13686174 |
| (MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
| Structure image for GALNT10 from PDB |
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| Differential gene expression and gene-gene network for GALNT10 |
| Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
| Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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| Phenotype information for GALNT10 |
| Gene level disease information (DisGeNet) |
| Disease ID | Disease name | # PubMed | Association type |
| Mutation level pathogenic information (ClinVar annotation) |
| Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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| Pharmacological information for GALNT10 |
| Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
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| Drug information targeting mutLBSgene (Approved drugs only) |
| Drug status | DrugBank ID | Name | Type | Drug structure |
| Gene-centered ligand-gene interaction network |
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| Ligands binding to mutated ligand binding site of GALNT10 go to BioLip |
| Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | UDP | URIDINE-DIPHOSPHATE | 2d7i | A | E156 D185 | UDP | URIDINE-DIPHOSPHATE | 2d7r | A | E156 D185 | NGA | N-ACETYL-D-GALACTOSAMINE | 2d7i | A | G319 | NGA | N-ACETYL-D-GALACTOSAMINE | 2d7r | A | G319 | TNR | O-(N-ACETYL-ALPHA-D-GALACTOSAMINYL)-L-SERINE | 2d7r | A | Y536 |
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| Conservation information for LBS of GALNT10 |
| Multiple alignments for Q86SR1 in multiple species |
| LBS | AA sequence | # species | Species | A318 | ESPVMAGGLFA | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | A318 | KSPIMAGGLFA | 1 | Drosophila melanogaster | A318 | NSPVMAGGYFA | 1 | Caenorhabditis elegans | D185 | IVLVDDFSDRE | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | D185 | IILVDDHSDRE | 1 | Drosophila melanogaster | D185 | IILVDDFSEKP | 1 | Caenorhabditis elegans | D237 | VITFLDSHCEA | 2 | Homo sapiens, Rattus norvegicus | D237 | VLIFLDSHVEA | 1 | Drosophila melanogaster | D237 | ILIFLDAHSEA | 1 | Caenorhabditis elegans | D237 | VVTFLDSHCEA | 1 | Mus musculus | D525 | KKFCFDAVSH- | 2 | Mus musculus, Rattus norvegicus | D525 | KKFCFDAISH- | 1 | Homo sapiens | D525 | KKECLDVQIWD | 1 | Drosophila melanogaster | D525 | RKICFDCSTSV | 1 | Caenorhabditis elegans | E156 | IPFHNEGWSSL | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | E156 | IIFYNEYLSVL | 1 | Drosophila melanogaster | E156 | FPFHEEHNSTL | 1 | Caenorhabditis elegans | E345 | EIWGGEQYEIS | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | E345 | DIWGGEQYELS | 2 | Drosophila melanogaster, Caenorhabditis elegans | F153 | SIIIPFHNEGW | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | F153 | SVIIIFYNEYL | 1 | Drosophila melanogaster | F153 | SVIFPFHEEHN | 1 | Caenorhabditis elegans | G216 | TKKREGLIRTR | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | G216 | LPRRTGLIGAR | 1 | Drosophila melanogaster | G216 | TKKREGLIRGR | 1 | Caenorhabditis elegans | G319 | SPVMAGGLFAV | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | G319 | SPIMAGGLFAI | 1 | Drosophila melanogaster | G319 | SPVMAGGYFAI | 1 | Caenorhabditis elegans | G320 | PVMAGGLFAVD | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | G320 | PIMAGGLFAIS | 1 | Drosophila melanogaster | G320 | PVMAGGYFAIS | 1 | Caenorhabditis elegans | G343 | GLEIWGGEQYE | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | G343 | GLDIWGGEQYE | 2 | Drosophila melanogaster, Caenorhabditis elegans | G543 | CHSMKGNQLWK | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | G543 | CHSQGGNQYWY | 1 | Drosophila melanogaster | G543 | CHSMKGNQLFK | 1 | Caenorhabditis elegans | H154 | IIIPFHNEGWS | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | H154 | VIIIFYNEYLS | 1 | Drosophila melanogaster | H154 | VIFPFHEEHNS | 1 | Caenorhabditis elegans | H239 | TFLDSHCEANV | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | H239 | IFLDSHVEANY | 1 | Drosophila melanogaster | H239 | IFLDAHSEANY | 1 | Caenorhabditis elegans | H370 | CSRVGHIYR-K | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | H370 | CSRIGHIYRGP | 1 | Drosophila melanogaster | H370 | CSRVAHIYRCK | 1 | Caenorhabditis elegans | H539 | TLYDCHSMKGN | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | H539 | WLWDCHSQGGN | 1 | Drosophila melanogaster | H539 | ILFDCHSMKGN | 1 | Caenorhabditis elegans | I341 | DPGLEIWGGEQ | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | I341 | DEGLDIWGGEQ | 2 | Drosophila melanogaster, Caenorhabditis elegans | L217 | KKREGLIRTRM | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | L217 | PRRTGLIGARA | 1 | Drosophila melanogaster | L217 | KKREGLIRGRQ | 1 | Caenorhabditis elegans | N544 | HSMKGNQLWKY | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | N544 | HSQGGNQYWYY | 1 | Drosophila melanogaster | N544 | HSMKGNQLFKY | 1 | Caenorhabditis elegans | P152 | TSIIIPFHNEG | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | P152 | VSVIIIFYNEY | 1 | Drosophila melanogaster | P152 | VSVIFPFHEEH | 1 | Caenorhabditis elegans | R214 | LRTKKREGLIR | 4 | Homo sapiens, Caenorhabditis elegans, Mus musculus, Rattus norvegicus | R214 | VRLPRRTGLIG | 1 | Drosophila melanogaster | R221 | GLIRTRMLGAS | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | R221 | GLIGARAAGAR | 1 | Drosophila melanogaster | R221 | GLIRGRQLGAQ | 1 | Caenorhabditis elegans | R373 | VGHIYR-KYVP | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | R373 | IGHIYRGPRNH | 1 | Drosophila melanogaster | R373 | VAHIYRCKYAP | 1 | Caenorhabditis elegans | S238 | ITFLDSHCEAN | 2 | Homo sapiens, Rattus norvegicus | S238 | LIFLDSHVEAN | 1 | Drosophila melanogaster | S238 | LIFLDAHSEAN | 1 | Caenorhabditis elegans | S238 | VTFLDSHCEAN | 1 | Mus musculus | W342 | PGLEIWGGEQY | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | W342 | EGLDIWGGEQY | 2 | Drosophila melanogaster, Caenorhabditis elegans | Y378 | -KYVPYKVPA- | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | Y378 | GPRNHQPSPRK | 1 | Drosophila melanogaster | Y378 | CKYAPFKNAGM | 1 | Caenorhabditis elegans | Y536 | SPVTLYDCHSM | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | Y536 | APVWLWDCHSQ | 1 | Drosophila melanogaster | Y536 | APVILFDCHSM | 1 | Caenorhabditis elegans |
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