mutated Ligand Binding Site gene DataBase





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Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for GALNT10
Gene summary
Basic gene Info.Gene symbolGALNT10
Gene namepolypeptide N-acetylgalactosaminyltransferase 10
CytomapUCSC genome browser: 5q33.2
Type of geneprotein-coding
DescriptionGalNAc transferase 10UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 10UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 10 (GalNAc-T10)
Modification date20141207
dbXrefs MIM : 608043
Ensembl : ENSG00000164574
HPRD : 12157
Vega : OTTHUMG00000130145
ProteinUniProt: Q86SR1
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_GALNT10
BioGPS: 55568
PathwayNCI Pathway Interaction Database: GALNT10
Pathway Commons: GALNT10
ContextiHOP: GALNT10
ligand binding site mutation search in PubMed: GALNT10
UCL Cancer Institute: GALNT10
Assigned class in mutLBSgeneDBC: This gene just belongs to mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO:0006493protein O-linked glycosylation12417297
GO:0016266O-glycan processing18562306

Ligand binding site mutations for GALNT10

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.

Protein structure related information for GALNT10
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for GALNT10 from PDB

Differential gene expression and gene-gene network for GALNT10
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of GALNT10 and the right PPI network was created from samples without mutations in the LBS of GALNT10. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


Phenotype information for GALNT10
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

Pharmacological information for GALNT10
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of GALNT10 go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS

Conservation information for LBS of GALNT10
Multiple alignments for Q86SR1 in multiple species
LBSAA sequence# speciesSpecies
A318ESPVMAGGLFA3Homo sapiens, Mus musculus, Rattus norvegicus
A318KSPIMAGGLFA1Drosophila melanogaster
A318NSPVMAGGYFA1Caenorhabditis elegans
D185IVLVDDFSDRE3Homo sapiens, Mus musculus, Rattus norvegicus
D185IILVDDHSDRE1Drosophila melanogaster
D185IILVDDFSEKP1Caenorhabditis elegans
D237VITFLDSHCEA2Homo sapiens, Rattus norvegicus
D237VLIFLDSHVEA1Drosophila melanogaster
D237ILIFLDAHSEA1Caenorhabditis elegans
D237VVTFLDSHCEA1Mus musculus
D525KKFCFDAVSH-2Mus musculus, Rattus norvegicus
D525KKFCFDAISH-1Homo sapiens
D525KKECLDVQIWD1Drosophila melanogaster
D525RKICFDCSTSV1Caenorhabditis elegans
E156IPFHNEGWSSL3Homo sapiens, Mus musculus, Rattus norvegicus
E156IIFYNEYLSVL1Drosophila melanogaster
E156FPFHEEHNSTL1Caenorhabditis elegans
E345EIWGGEQYEIS3Homo sapiens, Mus musculus, Rattus norvegicus
E345DIWGGEQYELS2Drosophila melanogaster, Caenorhabditis elegans
F153SIIIPFHNEGW3Homo sapiens, Mus musculus, Rattus norvegicus
F153SVIIIFYNEYL1Drosophila melanogaster
F153SVIFPFHEEHN1Caenorhabditis elegans
G216TKKREGLIRTR3Homo sapiens, Mus musculus, Rattus norvegicus
G216LPRRTGLIGAR1Drosophila melanogaster
G216TKKREGLIRGR1Caenorhabditis elegans
G319SPVMAGGLFAV3Homo sapiens, Mus musculus, Rattus norvegicus
G319SPIMAGGLFAI1Drosophila melanogaster
G319SPVMAGGYFAI1Caenorhabditis elegans
G320PVMAGGLFAVD3Homo sapiens, Mus musculus, Rattus norvegicus
G320PIMAGGLFAIS1Drosophila melanogaster
G320PVMAGGYFAIS1Caenorhabditis elegans
G343GLEIWGGEQYE3Homo sapiens, Mus musculus, Rattus norvegicus
G343GLDIWGGEQYE2Drosophila melanogaster, Caenorhabditis elegans
G543CHSMKGNQLWK3Homo sapiens, Mus musculus, Rattus norvegicus
G543CHSQGGNQYWY1Drosophila melanogaster
G543CHSMKGNQLFK1Caenorhabditis elegans
H154IIIPFHNEGWS3Homo sapiens, Mus musculus, Rattus norvegicus
H154VIIIFYNEYLS1Drosophila melanogaster
H154VIFPFHEEHNS1Caenorhabditis elegans
H239TFLDSHCEANV3Homo sapiens, Mus musculus, Rattus norvegicus
H239IFLDSHVEANY1Drosophila melanogaster
H239IFLDAHSEANY1Caenorhabditis elegans
H370CSRVGHIYR-K3Homo sapiens, Mus musculus, Rattus norvegicus
H370CSRIGHIYRGP1Drosophila melanogaster
H370CSRVAHIYRCK1Caenorhabditis elegans
H539TLYDCHSMKGN3Homo sapiens, Mus musculus, Rattus norvegicus
H539WLWDCHSQGGN1Drosophila melanogaster
H539ILFDCHSMKGN1Caenorhabditis elegans
I341DPGLEIWGGEQ3Homo sapiens, Mus musculus, Rattus norvegicus
I341DEGLDIWGGEQ2Drosophila melanogaster, Caenorhabditis elegans
L217KKREGLIRTRM3Homo sapiens, Mus musculus, Rattus norvegicus
L217PRRTGLIGARA1Drosophila melanogaster
L217KKREGLIRGRQ1Caenorhabditis elegans
N544HSMKGNQLWKY3Homo sapiens, Mus musculus, Rattus norvegicus
N544HSQGGNQYWYY1Drosophila melanogaster
N544HSMKGNQLFKY1Caenorhabditis elegans
P152TSIIIPFHNEG3Homo sapiens, Mus musculus, Rattus norvegicus
P152VSVIIIFYNEY1Drosophila melanogaster
P152VSVIFPFHEEH1Caenorhabditis elegans
R214LRTKKREGLIR4Homo sapiens, Caenorhabditis elegans, Mus musculus, Rattus norvegicus
R214VRLPRRTGLIG1Drosophila melanogaster
R221GLIRTRMLGAS3Homo sapiens, Mus musculus, Rattus norvegicus
R221GLIGARAAGAR1Drosophila melanogaster
R221GLIRGRQLGAQ1Caenorhabditis elegans
R373VGHIYR-KYVP3Homo sapiens, Mus musculus, Rattus norvegicus
R373IGHIYRGPRNH1Drosophila melanogaster
R373VAHIYRCKYAP1Caenorhabditis elegans
S238ITFLDSHCEAN2Homo sapiens, Rattus norvegicus
S238LIFLDSHVEAN1Drosophila melanogaster
S238LIFLDAHSEAN1Caenorhabditis elegans
S238VTFLDSHCEAN1Mus musculus
W342PGLEIWGGEQY3Homo sapiens, Mus musculus, Rattus norvegicus
W342EGLDIWGGEQY2Drosophila melanogaster, Caenorhabditis elegans
Y378-KYVPYKVPA-3Homo sapiens, Mus musculus, Rattus norvegicus
Y378GPRNHQPSPRK1Drosophila melanogaster
Y378CKYAPFKNAGM1Caenorhabditis elegans
Y536SPVTLYDCHSM3Homo sapiens, Mus musculus, Rattus norvegicus
Y536APVWLWDCHSQ1Drosophila melanogaster
Y536APVILFDCHSM1Caenorhabditis elegans

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