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mutLBSgeneDB |
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| Gene summary for PRKAB2 |
 Gene summary |
| Basic gene Info. | Gene symbol | PRKAB2 |
| Gene name | protein kinase, AMP-activated, beta 2 non-catalytic subunit | |
| Synonyms | - | |
| Cytomap | UCSC genome browser: 1q21.1 | |
| Type of gene | protein-coding | |
| RefGenes | NM_005399.4, NR_103870.1,NR_103871.1, | |
| Description | 5'-AMP-activated protein kinase subunit beta-25'-AMP-activated protein kinase, beta-2 subunitAMP-activated protein kinase beta 2 non-catalytic subunitAMPK beta 2AMPK beta-2 chainAMPK subunit beta-2 | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 602741 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000131791 | ||
| HPRD : 04117 | ||
| Vega : OTTHUMG00000014032 | ||
| Protein | UniProt: O43741 go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_PRKAB2 | |
| BioGPS: 5565 | ||
| Pathway | NCI Pathway Interaction Database: PRKAB2 | |
| KEGG: PRKAB2 | ||
| REACTOME: PRKAB2 | ||
| Pathway Commons: PRKAB2 | ||
| Context | iHOP: PRKAB2 | |
| ligand binding site mutation search in PubMed: PRKAB2 | ||
| UCL Cancer Institute: PRKAB2 | ||
| Assigned class in mutLBSgeneDB | B: This gene belongs to targetable_mutLBSgenes. | |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO Term | PubMed ID | GO:0006468 | protein phosphorylation | 21399626 |
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| Ligand binding site mutations for PRKAB2 |
| Cancer type specific mutLBS sorted by frequency |
| LBS | AAchange of nsSNV | Cancer type | # samples | M251,L253 | V252F | COAD | 1 |
| cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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| Protein structure related information for PRKAB2 |
| Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
 : nsSNV at non-LBS : nsSNV at LBS |
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| nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
| LBS | AAchange of nsSNV | Relative stability change | M251 | V252F | -0.5817996 | L253 | V252F | -0.5817996 |
| (MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
| Structure image for PRKAB2 from PDB |
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| Differential gene expression and gene-gene network for PRKAB2 |
| Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
| Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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| Phenotype information for PRKAB2 |
| Gene level disease information (DisGeNet) |
| Disease ID | Disease name | # PubMed | Association type |
| Mutation level pathogenic information (ClinVar annotation) |
| Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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| Pharmacological information for PRKAB2 |
| Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
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| Gene-centered drug-gene interaction network |
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| Drug information targeting mutLBSgene (Approved drugs only) |
| Drug status | DrugBank ID | Name | Type | Drug structure |
| Approved|nutraceutical | DB00131 | Adenosine monophosphate | Small molecule |  |
| Gene-centered ligand-gene interaction network |
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| Ligands binding to mutated ligand binding site of PRKAB2 go to BioLip |
| Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | III | Peptide ligand (VAL,ALA,PRO,ARG,PRO,GLY,SER,HIS,THR,ILE,GLU,PHE,PHE,GLU,MET,CYS,ALA,ASN,LEU,ILE,LYS,ILE,LEU,ALA,GLN) | 2y94 | B | M251 L253 | III | Peptide ligand (PRO,GLY,SER,HIS,THR,ILE,GLU,PHE,PHE,GLU,MET,CYS,ALA,ASN,LEU,ILE,LYS,ILE,LEU,ALA,GLN) | 4cfh | B | M251 L253 |
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| Conservation information for LBS of PRKAB2 |
| Multiple alignments for O43741 in multiple species |
| LBS | AA sequence | # species | Species | A255 | VMVLSATHRYK | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | A255 | IVALGLTHRFE | 1 | Arabidopsis thaliana | A255 | TLCVASIVRYK | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | H257 | VLSATHRYKKK | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | H257 | ALGLTHRFESK | 1 | Arabidopsis thaliana | H257 | CVASIVRYKQK | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | I35 | -KEHKIMVGST | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | I35 | -ARSRHRRPSS | 1 | Arabidopsis thaliana | I35 | KKKSTLLLRDE | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | K126 | GEHQYKFFVDG | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | K126 | GIYHYKVIVDG | 1 | Arabidopsis thaliana | K126 | GTHRFRFIVDN | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | K270 | TTLLYKPI--- | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | K270 | TVVLYKPLTR- | 1 | Arabidopsis thaliana | K270 | TQILYTPIESS | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | K71 | LEDSVKPTQQA | 1 | Homo sapiens | K71 | QRVFDNPPEQG | 1 | Arabidopsis thaliana | K71 | RSGHSSPREEG | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | K71 | LDDSVKPAQQA | 1 | Mus musculus | K71 | LDDSVKPTQQA | 1 | Rattus norvegicus | L146 | VVTSQLGTINN | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | L146 | FVADEVGNVCN | 1 | Arabidopsis thaliana | L146 | TATDQMGNFVN | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | L241 | VMLNHLYALS- | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | L241 | VVLNHVFIEQG | 1 | Arabidopsis thaliana | L241 | VVLNHLVTSS- | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | L253 | DSVMVLSATHR | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | L253 | QSIVALGLTHR | 1 | Arabidopsis thaliana | L253 | HNTLCVASIVR | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | L268 | YVTTLLYKPI- | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | L268 | YITVVLYKPLT | 1 | Arabidopsis thaliana | L268 | YVTQILYTPIE | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | M251 | IKDSVMVLSAT | 2 | Homo sapiens, Mus musculus | M251 | TPQSIVALGLT | 1 | Arabidopsis thaliana | M251 | IKHNTLCVASI | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | M251 | TKDSVMVLSAT | 1 | Rattus norvegicus | N150 | QLGTINNLIHV | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | N150 | EVGNVCNILDV | 1 | Arabidopsis thaliana | N150 | QMGNFVNYIEV | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | N239 | NHVMLNHLYAL | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | N239 | QHVVLNHVFIE | 1 | Arabidopsis thaliana | N239 | NHVVLNHLVTS | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | Q145 | PVVTSQLGTIN | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | Q145 | PFVADEVGNVC | 1 | Arabidopsis thaliana | Q145 | PTATDQMGNFV | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | S254 | SVMVLSATHRY | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | S254 | SIVALGLTHRF | 1 | Arabidopsis thaliana | S254 | NTLCVASIVRY | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | T148 | TSQLGTINNLI | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | T148 | ADEVGNVCNIL | 1 | Arabidopsis thaliana | T148 | TDQMGNFVNYI | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | T266 | KKYVTTLLYKP | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | T266 | SKYITVVLYKP | 1 | Arabidopsis thaliana | T266 | QKYVTQILYTP | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | W133 | FVDGQWVHDPS | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | W133 | IVDGESKYIPD | 1 | Arabidopsis thaliana | W133 | IVDNELRVSDF | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | W99 | GSFNNWSTKIP | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | W99 | GSWDNWRSRKK | 1 | Arabidopsis thaliana | W99 | GSFTKWRKMIG | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) |
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