mutLBSgeneDB

mutLBSgeneDB
mutated Ligand Binding Site gene DataBase

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Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for MAPK1
Gene summary
Basic gene Info.Gene symbolMAPK1
Gene namemitogen-activated protein kinase 1
SynonymsERK|ERK-2|ERK2|ERT1|MAPK2|P42MAPK|PRKM1|PRKM2|p38|p40|p41|p41mapk|p42-MAPK
CytomapUCSC genome browser: 22q11.21
Type of geneprotein-coding
RefGenesNM_002745.4,
NM_138957.3,
DescriptionMAP kinase 1MAP kinase 2MAP kinase isoform p42MAPK 2extracellular signal-regulated kinase 2mitogen-activated protein kinase 2protein tyrosine kinase ERK2
Modification date20141222
dbXrefs MIM : 176948
HGNC : HGNC
Ensembl : ENSG00000100030
HPRD : 01496
Vega : OTTHUMG00000030508
ProteinUniProt: P28482
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_MAPK1
BioGPS: 5594
PathwayNCI Pathway Interaction Database: MAPK1
KEGG: MAPK1
REACTOME: MAPK1
Pathway Commons: MAPK1
ContextiHOP: MAPK1
ligand binding site mutation search in PubMed: MAPK1
UCL Cancer Institute: MAPK1
Assigned class in mutLBSgeneDBB: This gene belongs to targetable_mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO TermPubMed ID
GO:0010800positive regulation of peptidyl-threonine phosphorylation16314496
GO:0018105peptidyl-serine phosphorylation15850461
GO:0038127ERBB signaling pathway15133037
GO:0070371ERK1 and ERK2 cascade16314496
GO:0070849response to epidermal growth factor18794356


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Ligand binding site mutations for MAPK1

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
D321E322KHNSC3
E81E81KBRCA1
A52A52SCOAD1
D162D162GLUSC1
D318P319SSKCM1
R135G136ESTAD1
L121L121IUCEC1
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.

Clinical information for MAPK1 from My Cancer Genome.
Mitogen-activated protein kinase 1 (MAPK1) is a gene that encodes a protein that belongs to the MAP kinase family. The protein functions in several cell signaling processes such as proliferation, differentiation, transcriptional regulation, and cellular development. Missense, nonsense, and silent mutations are observed in cancers such as cervical cancer, endometrial cancer, and skin cancer.Related Pathways: MAP kinase signaling.Modified: December 4, 2015

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Protein structure related information for MAPK1
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
D162D162G-1.4118432
D321E322K-1.1910183
D318P319S-1.0692988
E81E81K-1.0424814
L121L121I-0.96090785
A52A52S-0.84470216
R135G136E-0.49767377
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for MAPK1 from PDB
PDB IDPDB titlePDB structure
1TVOThe structure of ERK2 in complex with a small molecule inhibitor

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Differential gene expression and gene-gene network for MAPK1
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of MAPK1 and the right PPI network was created from samples without mutations in the LBS of MAPK1. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


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Phenotype information for MAPK1
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type
umls:C0027627Neoplasm Metastasis31AlteredExpression, Biomarker, PostTranslationalModification
umls:C0007137Carcinoma, Squamous Cell15AlteredExpression, Biomarker, GeneticVariation, PostTranslationalModification
umls:C0024121Lung Neoplasms7AlteredExpression, Biomarker
umls:C0919267Ovarian Neoplasms6AlteredExpression, Biomarker
umls:C0038356Stomach Neoplasms4AlteredExpression, Biomarker, PostTranslationalModification
umls:C0022665Kidney Neoplasms2Biomarker
umls:C0878544Cardiomyopathies2Biomarker, Therapeutic
umls:C0243026Sepsis2Biomarker
umls:C0236736Cocaine-Related Disorders2Biomarker
umls:C0007786Brain Ischemia1Biomarker
umls:C0017639Gliosis1Biomarker
umls:C0017661Glomerulonephritis, IGA1Biomarker
umls:C0018671Head and Neck Neoplasms1Biomarker
umls:C0020429Hyperalgesia1Biomarker
umls:C0020564Hypertrophy1Biomarker
umls:C0021361Infertility, Female1Biomarker
umls:C0027626Neoplasm Invasiveness1Biomarker
umls:C0027746Nerve Degeneration1Biomarker
umls:C0155862Pneumonia, Pneumococcal1Biomarker
umls:C0034531Radiation Injuries, Experimental1Therapeutic
umls:C0038587Substance Withdrawal Syndrome1Biomarker

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

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Pharmacological information for MAPK1
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.

Gene-centered drug-gene interaction network
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure
ApprovedDB01064IsoprenalineSmall molecule
Approved|investigationalDB01169Arsenic trioxideSmall molecule
ExperimentalDB02116OlomoucineSmall molecule
ExperimentalDB02482PhosphonothreonineSmall molecule
ExperimentalDB02733PurvalanolSmall molecule
ExperimentalDB04338SB220025Small molecule
ExperimentalDB06877N,N-DIMETHYL-4-(4-PHENYL-1H-PYRAZOL-3-YL)-1H-PYRROLE-2-CARBOXAMIDESmall molecule
ExperimentalDB07010N-BENZYL-4-[4-(3-CHLOROPHENYL)-1H-PYRAZOL-3-YL]-1H-PYRROLE-2-CARBOXAMIDESmall molecule
ExperimentalDB07264(S)-N-(1-(3-CHLORO-4-FLUOROPHENYL)-2-HYDROXYETHYL)-4-(4-(3-CHLOROPHENYL)-1H-PYRAZOL-3-YL)-1H-PYRROLE-2-CARBOXAMIDESmall molecule
ExperimentalDB07788(3R,5Z,8S,9S,11E)-8,9,16-TRIHYDROXY-14-METHOXY-3-METHYL-3,4,9,10-TETRAHYDRO-1H-2-BENZOXACYCLOTETRADECINE-1,7(8H)-DIONESmall molecule
ExperimentalDB077945-(2-PHENYLPYRAZOLO[1,5-A]PYRIDIN-3-YL)-1H-PYRAZOLO[3,4-C]PYRIDAZIN-3-AMINESmall molecule
ExperimentalDB07905(1aR,8S,13S,14S,15aR)-5,13,14-trihydroxy-3-methoxy-8-methyl-8,9,13,14,15,15a-hexahydro-6H-oxireno[k][2]benzoxacyclotetradecine-6,12(1aH)-dioneSmall molecule
ExperimentalDB08513[4-({5-(AMINOCARBONYL)-4-[(3-METHYLPHENYL)AMINO]PYRIMIDIN-2-YL}AMINO)PHENYL]ACETIC ACIDSmall molecule
ExperimentalDB085214-[5-(4-FLUORO-PHENYL)-2-(4-METHANESULFINYL-PHENYL)-3H-IMIDAZOL-4-YL]-PYRIDINESmall molecule

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of MAPK1 go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS
SB24-[5-(4-FLUORO-PHENYL)-2-(4-METHANESULFINYL-PHENYL)-3H-IMIDAZOL-4-YL]-PYRIDINE1pmeAA52
FRZ5-(2-PHENYLPYRAZOLO[1,5-A]PYRIDIN-3-YL)-1H-PYRAZOLO[3,4-C]PYRIDAZIN-3-AMINE1tvoAA52
F29FR2961101wzyAA52
ANPAMP-PNP2y9qAA52
NRANORATHYRIOL3sa0AA52
ANPAMP-PNP3teiAA52
1FM(5Z)-7-OXOZEAENOL(3S,5Z,8S,9S,11E)-8,9,16-TRIHYDROXY-14-METHOXY-3- METHYL-3,4,9,10-TETRAHYDRO-1H-2- BENZOXACYCLOTETRADECINE-1,7(8H)-DIONE3w55AA52
ANPAMP-PNP4fmqAA52
ANPAMP-PNP4h3pAA52
ANPAMP-PNP4h3pDA52
ANPAMP-PNP4h3qAA52
ADPADP4iz5AA52
ADPADP4iz5BA52
ADPADP4iz5CA52
ADPADP4iz5DA52
2SHN-[(1S)-1-(3-CHLORO-4-FLUOROPHENYL)-2-HYDROXYETHYL]-2- (TETRAHYDRO-2H-PYRAN-4-YLAMINO)-5,8-DIHYDROPYRIDO[3,4- D]PYRIMIDINE-7(6H)-CARBOXAMIDE4o6eAA52
38Z(3R)-1-(2-OXO-2-{4-[4-(PYRIMIDIN-2-YL)PHENYL]PIPERAZIN- 1-YL}ETHYL)-N-[3-(PYRIDIN-4-YL)-2H-INDAZOL-5- YL]PYRROLIDINE-3-CARBOXAMIDE4qtaAA52
3904-{2-[(2-CHLORO-4-FLUOROPHENYL)AMINO]-5- METHYLPYRIMIDIN-4-YL}-N-[(1S)-1-(3-CHLOROPHENYL)-2- HYDROXYETHYL]-1H-PYRROLE-2-CARBOXAMIDE4qteAA52
DHCCAFFEIC ACID4n0sAA52
ANPAMP-PNP4nifBA52
ANPAMP-PNP4nifEA52
CQ67-ETHYLSULFONYL-N-(OXAN-4-YL)-6,8-DIHYDRO-5H- PYRIDO[3,4-D]PYRIMIDIN-2-AMINE4zzmAA52
CQ3N-[2-[[5-CHLORANYL-2-(OXAN-4-YLAMINO) PYRIMIDIN-4-YL]AMINO]PHENYL]PROPANAMIDE4zzoAA52
41B1-[(1S)-1-(4-CHLORO-3-FLUOROPHENYL)-2-HYDROXYETHYL]-4- [2-(TETRAHYDRO-2H-PYRAN-4-YLAMINO)PYRIMIDIN-4- YL]PYRIDIN-2(1H)-ONE4xj0AA52
41B1-[(1S)-1-(4-CHLORO-3-FLUOROPHENYL)-2-HYDROXYETHYL]-4- [2-(TETRAHYDRO-2H-PYRAN-4-YLAMINO)PYRIMIDIN-4- YL]PYRIDIN-2(1H)-ONE4xj0BA52
EMUN-BENZYLADENINE4qp1AA52
EMUN-BENZYLADENINE4qp1BA52
36R5-CHLORO-1,3-BENZOXAZOL-2-AMINE4qp2AA52
36Q(2S)-3-PHENYL-2-(9H-PURIN-6-YLAMINO)PROPAN-1-OL4qp3AA52
36Q(2S)-3-PHENYL-2-(9H-PURIN-6-YLAMINO)PROPAN-1-OL4qp3BA52
36ON-CYCLOHEXYL-9H-PURIN-6-AMINE4qp4AA52
36ON-CYCLOHEXYL-9H-PURIN-6-AMINE4qp4BA52
36N5H-PYRROLO[2,3-B]PYRAZINE4qp6AA52
36N5H-PYRROLO[2,3-B]PYRAZINE4qp6BA52
3632-(1H-PYRAZOL-4-YL)-5H-PYRROLO[2,3-B]PYRAZINE4qp7AA52
3632-(1H-PYRAZOL-4-YL)-5H-PYRROLO[2,3-B]PYRAZINE4qp7BA52
3622-(1H-PYRAZOL-4-YL)-7-(PYRIDIN-3-YL)-5H-PYRROLO[2,3- B]PYRAZINE4qp8AA52
3622-(1H-PYRAZOL-4-YL)-7-(PYRIDIN-3-YL)-5H-PYRROLO[2,3- B]PYRAZINE4qp8BA52
35X7-(1-PROPYL-1H-PYRAZOL-4-YL)-2-(PYRIDIN-4-YL)-5H- PYRROLO[2,3-B]PYRAZINE4qp9AA52
IIIPeptide ligand (ARG,ARG,LYS,PRO,VAL,LEU,PRO,ALA,LEU,THR,ILE,ASN)4h3qAE81 D162 D321
IIIPeptide ligand (MET,LYS,LEU,SER,PRO,PRO,SER,LYS,SER,ARG,LEU,ALA,ARG,ARG,ARG,ALA,LEU)2y9qAE81 L121 R135 D162 D318 D321
IIIPeptide ligand (PRO,GLN,LEU,LYS,PRO,ILE,GLU,ALA,SER,ILE,LEU,ALA,ALA,ARG,ARG,VAL)4h3pAE81 L121 R135 D162 D321
IIIPeptide ligand (PRO,GLN,LEU,LYS,PRO,ILE,GLU,SER,SER,ILE,LEU,ALA,GLN,ARG,ARG,VAL,ARG)3teiAE81 R135 D162 D318 D321
IIIPeptide ligand (PRO,GLN,LEU,LYS,PRO,ILE,GLU,ALA,SER,ILE,LEU,ALA,ALA,ARG,ARG,VAL,ARG)4h3pDE81 R135 D162 D318 D321
IIIPeptide ligand (LEU,SER,SER,LEU,ALA,ALA,SER,SER,LEU,ALA,LYS,ARG,ARG,GLN,GLN)4fmqAE81 R135 D162 D321


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Conservation information for LBS of MAPK1
Multiple alignments for P28482 in multiple species
LBSAA sequence# speciesSpecies
A35YIGEGAYGMVC4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
A35PIGKGAYGIVC2Arabidopsis thaliana, Oryza sativa subsp. japonica
A35LIGEGAYGTVC1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
A35YIGEGAYGMVA1Caenorhabditis elegans
A35YIGEGAYGMVV1Drosophila melanogaster
A52NKVRVAIKKIS4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
A52TNESVAIKKIA1Arabidopsis thaliana
A52TGEQVAIKKIA1Oryza sativa subsp. japonica
A52SGIKVAIKKIQ1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
A52TRDRVAIKKIS1Caenorhabditis elegans
A52TNQRVAIKKIS1Drosophila melanogaster
C161LLNTTCDLKIC5Homo sapiens, Caenorhabditis elegans, Mus musculus, Rattus norvegicus, Bos taurus
C161LLNANCDLKIC2Arabidopsis thaliana, Oryza sativa subsp. japonica
C161LLNSNCDLKVC1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
C161LLNKTCDLKIC1Drosophila melanogaster
C166CDLKICDFGLA8Homo sapiens, Arabidopsis thaliana, Oryza sativa subsp. japonica, Caenorhabditis elegans, Drosophila melanogaster, Mus musculus, Rattus norvegicus, Bos taurus
C166CDLKVCDFGLA1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
D106VYIVQDLMETD4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
D106VYIAYELMDTD2Arabidopsis thaliana, Oryza sativa subsp. japonica
D106VYLVEELMETD1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
D106IYIVQCLMETD1Caenorhabditis elegans
D106VYIVQCLMETD1Drosophila melanogaster
D111DLMETDLYKLL4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
D111ELMDTDLHQII2Arabidopsis thaliana, Oryza sativa subsp. japonica
D111CLMETDLYKLL2Caenorhabditis elegans, Drosophila melanogaster
D111ELMETDLQKVI1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
D124--LSNDHICYF5Homo sapiens, Drosophila melanogaster, Mus musculus, Rattus norvegicus, Bos taurus
D124--LSEEHCQYF2Arabidopsis thaliana, Oryza sativa subsp. japonica
D124STLSDDHVQYF1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
D124--LSNDHVCYF1Caenorhabditis elegans
D162LNTTCDLKICD5Homo sapiens, Caenorhabditis elegans, Mus musculus, Rattus norvegicus, Bos taurus
D162LNANCDLKICD2Arabidopsis thaliana, Oryza sativa subsp. japonica
D162LNSNCDLKVCD1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
D162LNKTCDLKICD1Drosophila melanogaster
D167DLKICDFGLAR8Homo sapiens, Arabidopsis thaliana, Oryza sativa subsp. japonica, Caenorhabditis elegans, Drosophila melanogaster, Mus musculus, Rattus norvegicus, Bos taurus
D167DLKVCDFGLAR1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
D318LEQYYDPSDEP4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
D318LEQYYDPGDEP2Caenorhabditis elegans, Drosophila melanogaster
D318LNSLHDISDEP1Arabidopsis thaliana
D318LASLHDISDEP1Oryza sativa subsp. japonica
D318LAMYHDPSDEP1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
D321YYDPSDEPIAE3Homo sapiens, Mus musculus, Rattus norvegicus
D321LHDISDEPECT1Arabidopsis thaliana
D321LHDISDEPVCS1Oryza sativa subsp. japonica
D321YHDPSDEPEYP1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
D321YYDPGDEPVCE1Caenorhabditis elegans
D321YYDPGDEPVAE1Drosophila melanogaster
D321YYDPSDEPVAE1Bos taurus
E109VQDLMETDLYK4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
E109AYELMDTDLHQ2Arabidopsis thaliana, Oryza sativa subsp. japonica
E109VQCLMETDLYK2Caenorhabditis elegans, Drosophila melanogaster
E109VEELMETDLQK1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
E33LSYIGEGAYGM5Homo sapiens, Caenorhabditis elegans, Mus musculus, Rattus norvegicus, Bos taurus
E33IMPIGKGAYGI1Arabidopsis thaliana
E33ILPIGKGAYGI1Oryza sativa subsp. japonica
E33VDLIGEGAYGT1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
E33LAYIGEGAYGM1Drosophila melanogaster
E71QRTLREIKILL4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
E71KRTLREIKLLR2Arabidopsis thaliana, Oryza sativa subsp. japonica
E71TRTIREIKLLR1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
E71QRTLREIKILN1Caenorhabditis elegans
E71QRTLREITILT1Drosophila melanogaster
E81RFR-HENIIGI4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
E81HMD-HENIVAI2Arabidopsis thaliana, Oryza sativa subsp. japonica
E81YFHEHENIISI1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
E81RFK-HENIINI1Caenorhabditis elegans
E81RFK-HENIIDI1Drosophila melanogaster
F129DHICYFLYQIL5Homo sapiens, Drosophila melanogaster, Mus musculus, Rattus norvegicus, Bos taurus
F129EHCQYFLYQIL2Arabidopsis thaliana, Oryza sativa subsp. japonica
F129DHVQYFTYQIL1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
F129DHVCYFLYQIL1Caenorhabditis elegans
G169KICDFGLARV-6Homo sapiens, Arabidopsis thaliana, Caenorhabditis elegans, Mus musculus, Rattus norvegicus, Bos taurus
G169KICDFGLART-1Oryza sativa subsp. japonica
G169KVCDFGLARCL1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
G169KICDFGLARI-1Drosophila melanogaster
G32-LSYIGEGAYG5Homo sapiens, Caenorhabditis elegans, Mus musculus, Rattus norvegicus, Bos taurus
G32PIMPIGKGAYG1Arabidopsis thaliana
G32PILPIGKGAYG1Oryza sativa subsp. japonica
G32-VDLIGEGAYG1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
G32-LAYIGEGAYG1Drosophila melanogaster
G34SYIGEGAYGMV5Homo sapiens, Caenorhabditis elegans, Mus musculus, Rattus norvegicus, Bos taurus
G34MPIGKGAYGIV1Arabidopsis thaliana
G34LPIGKGAYGIV1Oryza sativa subsp. japonica
G34DLIGEGAYGTV1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
G34AYIGEGAYGMV1Drosophila melanogaster
G37GEGAYGMVCSA4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
G37GKGAYGIVCSA2Arabidopsis thaliana, Oryza sativa subsp. japonica
G37GEGAYGTVCSA1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
G37GEGAYGMVASA1Caenorhabditis elegans
G37GEGAYGMVVSA1Drosophila melanogaster
H125-LSNDHICYFL5Homo sapiens, Drosophila melanogaster, Mus musculus, Rattus norvegicus, Bos taurus
H125-LSEEHCQYFL2Arabidopsis thaliana, Oryza sativa subsp. japonica
H125TLSDDHVQYFT1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
H125-LSNDHVCYFL1Caenorhabditis elegans
I103MKDVYIVQDLM4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
I103FNDVYIAYELM2Arabidopsis thaliana, Oryza sativa subsp. japonica
I103LNAVYLVEELM1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
I103LKDIYIVQCLM1Caenorhabditis elegans
I103MRDVYIVQCLM1Drosophila melanogaster
I31N-LSYIGEGAY5Homo sapiens, Caenorhabditis elegans, Mus musculus, Rattus norvegicus, Bos taurus
I31PPIMPIGKGAY1Arabidopsis thaliana
I31PPILPIGKGAY1Oryza sativa subsp. japonica
I31L-VDLIGEGAY1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
I31K-LAYIGEGAY1Drosophila melanogaster
I53KVRVAIKKISP4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
I53NESVAIKKIAN1Arabidopsis thaliana
I53GEQVAIKKIAN1Oryza sativa subsp. japonica
I53GIKVAIKKIQP1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
I53RDRVAIKKISP1Caenorhabditis elegans
I53NQRVAIKKISP1Drosophila melanogaster
I56VAIKKISP-FE6Homo sapiens, Caenorhabditis elegans, Drosophila melanogaster, Mus musculus, Rattus norvegicus, Bos taurus
I56VAIKKIANAFD2Arabidopsis thaliana, Oryza sativa subsp. japonica
I56VAIKKIQP-FS1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
I84-HENIIGINDI4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
I84-HENIVAIRDI2Arabidopsis thaliana, Oryza sativa subsp. japonica
I84EHENIISILDK1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
I84-HENIINIQEI1Caenorhabditis elegans
I84-HENIIDIRDI1Drosophila melanogaster
K114ETDLYKLLKTQ6Homo sapiens, Caenorhabditis elegans, Drosophila melanogaster, Mus musculus, Rattus norvegicus, Bos taurus
K114DTDLHQIIRSN2Arabidopsis thaliana, Oryza sativa subsp. japonica
K114ETDLQKVINNQ1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
K151LHRDLKPSNLL8Homo sapiens, Arabidopsis thaliana, Oryza sativa subsp. japonica, Caenorhabditis elegans, Drosophila melanogaster, Mus musculus, Rattus norvegicus, Bos taurus
K151IHRDIKPSNLL1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
K54VRVAIKKISP-4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
K54ESVAIKKIANA1Arabidopsis thaliana
K54EQVAIKKIANA1Oryza sativa subsp. japonica
K54IKVAIKKIQP-1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
K54DRVAIKKISP-1Caenorhabditis elegans
K54QRVAIKKISP-1Drosophila melanogaster
K55RVAIKKISP-F6Homo sapiens, Caenorhabditis elegans, Drosophila melanogaster, Mus musculus, Rattus norvegicus, Bos taurus
K55SVAIKKIANAF1Arabidopsis thaliana
K55QVAIKKIANAF1Oryza sativa subsp. japonica
K55KVAIKKIQP-F1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
L107YIVQDLMETDL4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
L107YIAYELMDTDL2Arabidopsis thaliana, Oryza sativa subsp. japonica
L107YIVQCLMETDL2Caenorhabditis elegans, Drosophila melanogaster
L107YLVEELMETDL1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
L115TDLYKLLKTQH4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
L115TDLHQIIRSNQ2Arabidopsis thaliana, Oryza sativa subsp. japonica
L115TDLQKVINNQN1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
L115TDLYKLLKTQK1Caenorhabditis elegans
L115TDLYKLLKTQR1Drosophila melanogaster
L121-----LSNDHI5Homo sapiens, Drosophila melanogaster, Mus musculus, Rattus norvegicus, Bos taurus
L121A----LSEEHC2Arabidopsis thaliana, Oryza sativa subsp. japonica
L121SGFSTLSDDHV1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
L121-----LSNDHV1Caenorhabditis elegans
L156KPSNLLLNTTC5Homo sapiens, Caenorhabditis elegans, Mus musculus, Rattus norvegicus, Bos taurus
L156KPSNLLLNANC2Arabidopsis thaliana, Oryza sativa subsp. japonica
L156KPSNLLLNSNC1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
L156KPSNLLLNKTC1Drosophila melanogaster
L75REIKILLRFR-4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
L75REIKLLRHMD-2Arabidopsis thaliana, Oryza sativa subsp. japonica
L75REIKLLRYFHE1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
L75REIKILNRFK-1Caenorhabditis elegans
L75REITILTRFK-1Drosophila melanogaster
M108IVQDLMETDLY4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
M108IAYELMDTDLH2Arabidopsis thaliana, Oryza sativa subsp. japonica
M108IVQCLMETDLY2Caenorhabditis elegans, Drosophila melanogaster
M108LVEELMETDLQ1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
M38EGAYGMVCSAY4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
M38KGAYGIVCSAM1Arabidopsis thaliana
M38KGAYGIVCSAL1Oryza sativa subsp. japonica
M38EGAYGTVCSAI1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
M38EGAYGMVASAL1Caenorhabditis elegans
M38EGAYGMVVSAD1Drosophila melanogaster
N154DLKPSNLLLNT5Homo sapiens, Caenorhabditis elegans, Mus musculus, Rattus norvegicus, Bos taurus
N154DLKPSNLLLNA2Arabidopsis thaliana, Oryza sativa subsp. japonica
N154DIKPSNLLLNS1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
N154DLKPSNLLLNK1Drosophila melanogaster
N158SNLLLNTTCDL5Homo sapiens, Caenorhabditis elegans, Mus musculus, Rattus norvegicus, Bos taurus
N158SNLLLNANCDL2Arabidopsis thaliana, Oryza sativa subsp. japonica
N158SNLLLNSNCDL1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
N158SNLLLNKTCDL1Drosophila melanogaster
Q105DVYIVQDLMET4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
Q105DVYIAYELMDT2Arabidopsis thaliana, Oryza sativa subsp. japonica
Q105AVYLVEELMET1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Q105DIYIVQCLMET1Caenorhabditis elegans
Q105DVYIVQCLMET1Drosophila melanogaster
Q119KLLKTQH----4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
Q119QIIRSNQA---2Arabidopsis thaliana, Oryza sativa subsp. japonica
Q119KVINNQNSGFS1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Q119KLLKTQK----1Caenorhabditis elegans
Q119KLLKTQR----1Drosophila melanogaster
Q132CYFLYQILRGL6Homo sapiens, Caenorhabditis elegans, Drosophila melanogaster, Mus musculus, Rattus norvegicus, Bos taurus
Q132QYFLYQILRGL2Arabidopsis thaliana, Oryza sativa subsp. japonica
Q132QYFTYQILRAL1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Q315HPYLEQYYDPS4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
Q315HPYLEQYYDPG2Caenorhabditis elegans, Drosophila melanogaster
Q315HPYLNSLHDIS1Arabidopsis thaliana
Q315HPYLASLHDIS1Oryza sativa subsp. japonica
Q315HPYLAMYHDPS1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
R135LYQILRGLKYI8Homo sapiens, Arabidopsis thaliana, Oryza sativa subsp. japonica, Caenorhabditis elegans, Drosophila melanogaster, Mus musculus, Rattus norvegicus, Bos taurus
R135TYQILRALKSI1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
R67QTYCQRTLREI5Homo sapiens, Drosophila melanogaster, Mus musculus, Rattus norvegicus, Bos taurus
R67KIDAKRTLREI2Arabidopsis thaliana, Oryza sativa subsp. japonica
R67KLFVTRTIREI1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
R67QTFCQRTLREI1Caenorhabditis elegans
S153RDLKPSNLLLN8Homo sapiens, Arabidopsis thaliana, Oryza sativa subsp. japonica, Caenorhabditis elegans, Drosophila melanogaster, Mus musculus, Rattus norvegicus, Bos taurus
S153RDIKPSNLLLN1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
T110QDLMETDLYKL4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
T110YELMDTDLHQI2Arabidopsis thaliana, Oryza sativa subsp. japonica
T110QCLMETDLYKL2Caenorhabditis elegans, Drosophila melanogaster
T110EELMETDLQKV1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
T159NLLLNTTCDLK5Homo sapiens, Caenorhabditis elegans, Mus musculus, Rattus norvegicus, Bos taurus
T159NLLLNANCDLK2Arabidopsis thaliana, Oryza sativa subsp. japonica
T159NLLLNSNCDLK1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
T159NLLLNKTCDLK1Drosophila melanogaster
T160LLLNTTCDLKI5Homo sapiens, Caenorhabditis elegans, Mus musculus, Rattus norvegicus, Bos taurus
T160LLLNANCDLKI2Arabidopsis thaliana, Oryza sativa subsp. japonica
T160LLLNSNCDLKV1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
T160LLLNKTCDLKI1Drosophila melanogaster
T68TYCQRTLREIK4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
T68IDAKRTLREIK2Arabidopsis thaliana, Oryza sativa subsp. japonica
T68LFVTRTIREIK1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
T68TFCQRTLREIK1Caenorhabditis elegans
T68TYCQRTLREIT1Drosophila melanogaster
V39GAYGMVCSAYD4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
V39GAYGIVCSAMN1Arabidopsis thaliana
V39GAYGIVCSALN1Oryza sativa subsp. japonica
V39GAYGTVCSAIH1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
V39GAYGMVASALD1Caenorhabditis elegans
V39GAYGMVVSADD1Drosophila melanogaster
Y128NDHICYFLYQI5Homo sapiens, Drosophila melanogaster, Mus musculus, Rattus norvegicus, Bos taurus
Y128EEHCQYFLYQI2Arabidopsis thaliana, Oryza sativa subsp. japonica
Y128DDHVQYFTYQI1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Y128NDHVCYFLYQI1Caenorhabditis elegans
Y131ICYFLYQILRG5Homo sapiens, Drosophila melanogaster, Mus musculus, Rattus norvegicus, Bos taurus
Y131CQYFLYQILRG2Arabidopsis thaliana, Oryza sativa subsp. japonica
Y131VQYFTYQILRA1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Y131VCYFLYQILRG1Caenorhabditis elegans
Y316PYLEQYYDPSD4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
Y316PYLEQYYDPGD2Caenorhabditis elegans, Drosophila melanogaster
Y316PYLNSLHDISD1Arabidopsis thaliana
Y316PYLASLHDISD1Oryza sativa subsp. japonica
Y316PYLAMYHDPSD1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Y36IGEGAYGMVCS4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
Y36IGKGAYGIVCS2Arabidopsis thaliana, Oryza sativa subsp. japonica
Y36IGEGAYGTVCS1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Y36IGEGAYGMVAS1Caenorhabditis elegans
Y36IGEGAYGMVVS1Drosophila melanogaster
Y64FEHQTYCQRTL5Homo sapiens, Drosophila melanogaster, Mus musculus, Rattus norvegicus, Bos taurus
Y64FDNKIDAKRTL2Arabidopsis thaliana, Oryza sativa subsp. japonica
Y64FSKKLFVTRTI1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Y64FEHQTFCQRTL1Caenorhabditis elegans


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