mutLBSgeneDB |
Gene summary for PRSS8 |
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Basic gene Info. | Gene symbol | PRSS8 |
Gene name | protease, serine, 8 | |
Synonyms | CAP1|PROSTASIN | |
Cytomap | UCSC genome browser: 16p11.2 | |
Type of gene | protein-coding | |
RefGenes | NM_002773.3, | |
Description | channel-activating protease 1prostasinserine protease 8 | |
Modification date | 20141207 | |
dbXrefs | MIM : 600823 | |
HGNC : HGNC | ||
Ensembl : ENSG00000052344 | ||
HPRD : 02895 | ||
Vega : OTTHUMG00000176750 | ||
Protein | UniProt: Q16651 go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_PRSS8 | |
BioGPS: 5652 | ||
Pathway | NCI Pathway Interaction Database: PRSS8 | |
KEGG: PRSS8 | ||
REACTOME: PRSS8 | ||
Pathway Commons: PRSS8 | ||
Context | iHOP: PRSS8 | |
ligand binding site mutation search in PubMed: PRSS8 | ||
UCL Cancer Institute: PRSS8 | ||
Assigned class in mutLBSgeneDB | B: This gene belongs to targetable_mutLBSgenes. |
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GO ID | GO Term | PubMed ID |
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Ligand binding site mutations for PRSS8 |
![]() We represented ligand binding site mutations only. (You can see big image via clicking.) ![]() |
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LBS | AAchange of nsSNV | Cancer type | # samples | M221 | V222G | BRCA | 1 | R267,G269 | P268S | COAD | 1 | A233 | A233T | UCEC | 1 |
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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Protein structure related information for PRSS8 |
![]() Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
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![]() Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
LBS | AAchange of nsSNV | Relative stability change | M221 | V222G | -1.6649508 | G269 | P268S | -0.98451044 | R267 | P268S | -0.98451044 | A233 | A233T | -0.93688001 |
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
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Differential gene expression and gene-gene network for PRSS8 |
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Phenotype information for PRSS8 |
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Disease ID | Disease name | # PubMed | Association type |
umls:C0015929 | Fetal Diseases | 1 | Biomarker |
umls:C0027794 | Neural Tube Defects | 1 | Therapeutic |
umls:C0032045 | Placenta Diseases | 1 | Therapeutic |
umls:C0086468 | Prenatal Injuries | 1 | Therapeutic |
umls:C0033578 | Prostatic Neoplasms | 1 | Biomarker |
umls:C0037274 | Skin Diseases | 1 | Biomarker |
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Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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Pharmacological information for PRSS8 |
![]() Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
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Drug status | DrugBank ID | Name | Type | Drug structure |
Experimental | DB06900 | 1-[4-(hydroxymethyl)phenyl]guanidine | Small molecule | ![]() |
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Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | GBS | 4-GUANIDINOBENZOIC ACID | 3dfl | A | A233 R267 G269 |
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Conservation information for LBS of PRSS8 |
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LBS | AA sequence | # species | Species |
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