mutLBSgeneDB |
Gene summary for AZU1 |
Gene summary |
Basic gene Info. | Gene symbol | AZU1 |
Gene name | azurocidin 1 | |
Synonyms | AZAMP|AZU|CAP37|HBP|HUMAZUR|NAZC | |
Cytomap | UCSC genome browser: 19p13.3 | |
Type of gene | protein-coding | |
RefGenes | NM_001700.3, | |
Description | azurocidincationic antimicrobial protein 37cationic antimicrobial protein CAP37heparin-binding proteinneutrophil azurocidin | |
Modification date | 20141217 | |
dbXrefs | MIM : 162815 | |
HGNC : HGNC | ||
Ensembl : ENSG00000172232 | ||
HPRD : 01221 | ||
Vega : OTTHUMG00000187023 | ||
Protein | UniProt: P20160 go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_AZU1 | |
BioGPS: 566 | ||
Pathway | NCI Pathway Interaction Database: AZU1 | |
KEGG: AZU1 | ||
REACTOME: AZU1 | ||
Pathway Commons: AZU1 | ||
Context | iHOP: AZU1 | |
ligand binding site mutation search in PubMed: AZU1 | ||
UCL Cancer Institute: AZU1 | ||
Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO Term | PubMed ID | GO:0008347 | glial cell migration | 12465046 | GO:0042535 | positive regulation of tumor necrosis factor biosynthetic process | 12465046 | GO:0045785 | positive regulation of cell adhesion | 12826073 | GO:0050725 | positive regulation of interleukin-1 beta biosynthetic process | 12465046 | GO:0050754 | positive regulation of fractalkine biosynthetic process | 12465046 | GO:0050766 | positive regulation of phagocytosis | 12465046 |
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Ligand binding site mutations for AZU1 |
Cancer type specific mutLBS sorted by frequency |
LBS | AAchange of nsSNV | Cancer type | # samples | R123 | R123L | LUAD | 1 | F40 | F40L | LUAD | 1 | R36,F38 | Q37K | LUSC | 1 | S93 | S93F | SKCM | 1 | I196 | G195S | SKCM | 1 | G247 | G247R | SKCM | 1 | R36 | P35S | STAD | 1 | Q179 | R181C | UCEC | 1 | R158 | R158C | UCEC | 1 | T96 | S98Y | UCEC | 1 | R123 | R123L | UCEC | 1 |
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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Protein structure related information for AZU1 |
Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
: nsSNV at non-LBS: nsSNV at LBS |
nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
LBS | AAchange of nsSNV | Relative stability change | I196 | G195S | -1.1803675 | R158 | R158C | -1.1685662 | Q179 | R181C | -0.91201399 | G247 | G247R | -0.89386841 | R36 | P35S | -0.78257523 | R123 | R123L | -0.73996764 | R36 | Q37K | -0.71929003 | F38 | Q37K | -0.71929003 | F40 | F40L | -0.69312707 | T96 | S98Y | -0.66441764 | S93 | S93F | -0.6057846 |
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
Structure image for AZU1 from PDB |
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Differential gene expression and gene-gene network for AZU1 |
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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Phenotype information for AZU1 |
Gene level disease information (DisGeNet) |
Disease ID | Disease name | # PubMed | Association type |
Mutation level pathogenic information (ClinVar annotation) |
Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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Pharmacological information for AZU1 |
Drug information targeting mutLBSgene (Approved drugs only) |
Drug status | DrugBank ID | Name | Type | Drug structure |
Gene-centered ligand-gene interaction network |
Ligands binding to mutated ligand binding site of AZU1 go to BioLip |
Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS |
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Conservation information for LBS of AZU1 |
Multiple alignments for P20160 in multiple species |
LBS | AA sequence | # species | Species |
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