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mutLBSgeneDB |
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| Gene summary for DUSP22 |
 Gene summary |
| Basic gene Info. | Gene symbol | DUSP22 |
| Gene name | dual specificity phosphatase 22 | |
| Synonyms | JKAP|JSP-1|JSP1|LMW-DSP2|LMWDSP2|MKP-x|MKPX|VHX | |
| Cytomap | UCSC genome browser: 6p25.3 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001286555.1, NM_020185.4,NR_104473.1,NR_104474.1,NR_104475.1, | |
| Description | JNK-stimulating phosphatase 1JNK-stimulatory phosphatase-1MAP kinase phosphatase xdual specificity protein phosphatase 22homolog of mouse dual specificity phosphatase LMW-DSP2low molecular weight dual specificity phosphatase 2mitogen-activated prote | |
| Modification date | 20141207 | |
| dbXrefs | HGNC : HGNC | |
| Ensembl : ENSG00000112679 | ||
| HPRD : 13255 | ||
| Vega : OTTHUMG00000014113 | ||
| Protein | UniProt: Q9NRW4 go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_DUSP22 | |
| BioGPS: 56940 | ||
| Pathway | NCI Pathway Interaction Database: DUSP22 | |
| KEGG: DUSP22 | ||
| REACTOME: DUSP22 | ||
| Pathway Commons: DUSP22 | ||
| Context | iHOP: DUSP22 | |
| ligand binding site mutation search in PubMed: DUSP22 | ||
| UCL Cancer Institute: DUSP22 | ||
| Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. | |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO Term | PubMed ID |
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| Ligand binding site mutations for DUSP22 |
| Cancer type specific mutLBS sorted by frequency |
| LBS | AAchange of nsSNV | Cancer type | # samples | R94 | V96M | COAD | 1 | G91 | G91W | LUAD | 1 | R94 | R94M | LUAD | 1 | D57 | S58L | SKCM | 1 | D57 | A56V | STAD | 1 | D57 | A56V | UCEC | 1 |
| cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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| Protein structure related information for DUSP22 |
| Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
 : nsSNV at non-LBS : nsSNV at LBS |
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| nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
| LBS | AAchange of nsSNV | Relative stability change | D57 | S58L | 0.43814693 | D57 | A56V | -0.73598359 | G91 | G91W | -0.68763427 | R94 | R94M | -0.51285894 | R94 | V96M | -0.30137163 |
| (MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
| Structure image for DUSP22 from PDB |
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| Differential gene expression and gene-gene network for DUSP22 |
| Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
| Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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| Phenotype information for DUSP22 |
| Gene level disease information (DisGeNet) |
| Disease ID | Disease name | # PubMed | Association type |
| Mutation level pathogenic information (ClinVar annotation) |
| Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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| Pharmacological information for DUSP22 |
| Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
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| Drug information targeting mutLBSgene (Approved drugs only) |
| Drug status | DrugBank ID | Name | Type | Drug structure |
| Gene-centered ligand-gene interaction network |
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| Ligands binding to mutated ligand binding site of DUSP22 go to BioLip |
| Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | 4NP | 4-NITROPHENYL PHOSPHATE(2-) | 4woh | A | D57 G91 R94 |
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| Conservation information for LBS of DUSP22 |
| Multiple alignments for Q9NRW4 in multiple species |
| LBS | AA sequence | # species | Species | A90 | LVHCLAGVSRS | 4 | Homo sapiens, Danio rerio, Xenopus tropicalis, Mus musculus | D57 | CIPAADSPSQN | 1 | Homo sapiens | D57 | CIAAADSPTQN | 1 | Danio rerio | D57 | CIPASDSPSQN | 1 | Xenopus tropicalis | D57 | CIPAADTPSQN | 1 | Mus musculus | G91 | VHCLAGVSRSV | 4 | Homo sapiens, Danio rerio, Xenopus tropicalis, Mus musculus | L89 | CLVHCLAGVSR | 4 | Homo sapiens, Danio rerio, Xenopus tropicalis, Mus musculus | R94 | LAGVSRSVTLV | 4 | Homo sapiens, Danio rerio, Xenopus tropicalis, Mus musculus | S93 | CLAGVSRSVTL | 4 | Homo sapiens, Danio rerio, Xenopus tropicalis, Mus musculus | V92 | HCLAGVSRSVT | 4 | Homo sapiens, Danio rerio, Xenopus tropicalis, Mus musculus |
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