mutLBSgeneDB

mutLBSgeneDB
mutated Ligand Binding Site gene DataBase

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Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for CAMK1D
Gene summary
Basic gene Info.Gene symbolCAMK1D
Gene namecalcium/calmodulin-dependent protein kinase ID
SynonymsCKLiK|CaM-K1|CaMKID
CytomapUCSC genome browser: 10p13
Type of geneprotein-coding
RefGenesNM_020397.2,
NM_153498.2,
DescriptionCaM kinase IDCamKI-like protein kinasecaM kinase I deltacaM-KI deltacaMKI deltacalcium/calmodulin-dependent protein kinase type 1D
Modification date20141207
dbXrefs MIM : 607957
HGNC : HGNC
Ensembl : ENSG00000183049
HPRD : 06409
Vega : OTTHUMG00000017683
ProteinUniProt: Q8IU85
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_CAMK1D
BioGPS: 57118
PathwayNCI Pathway Interaction Database: CAMK1D
KEGG: CAMK1D
REACTOME: CAMK1D
Pathway Commons: CAMK1D
ContextiHOP: CAMK1D
ligand binding site mutation search in PubMed: CAMK1D
UCL Cancer Institute: CAMK1D
Assigned class in mutLBSgeneDBB: This gene belongs to targetable_mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO TermPubMed ID
GO:0032793positive regulation of CREB transcription factor activity16324104


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Ligand binding site mutations for CAMK1D

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
V101G103SGBM1
A309Q308EHNSC1
V101S102TSKCM1
G30G32EUCEC1
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.


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Protein structure related information for CAMK1D
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
G30G32E0.024918417
V101S102T-0.78149676
A309Q308E-0.47167579
V101G103S-0.054166346
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for CAMK1D from PDB

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Differential gene expression and gene-gene network for CAMK1D
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of CAMK1D and the right PPI network was created from samples without mutations in the LBS of CAMK1D. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


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Phenotype information for CAMK1D
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

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Pharmacological information for CAMK1D
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.

Gene-centered drug-gene interaction network
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure
ExperimentalDB08454N-(5-METHYL-1H-PYRAZOL-3-YL)-2-PHENYLQUINAZOLIN-4-AMINESmall molecule

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of CAMK1D go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS
QPP5,6-DIHYDRO-BENZO[H]CINNOLIN-3-YLAMINE2jc6AG30 V101 A309
QPP5,6-DIHYDRO-BENZO[H]CINNOLIN-3-YLAMINE2jc6CG30 V101 A309


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Conservation information for LBS of CAMK1D
Multiple alignments for Q8IU85 in multiple species
LBSAA sequence# speciesSpecies
A309--WRQAF----2Homo sapiens, Mus musculus
A309AGLKEMFKMID1Arabidopsis thaliana
A309--LRDLYLEQT1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
A50TGKLFAVKCIP2Homo sapiens, Mus musculus
A50TGKEFACKTIA1Arabidopsis thaliana
A50TGEDVAVKILI1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
G30FKETLGTGAFS2Homo sapiens, Mus musculus
G30VGRKLGQGQFG1Arabidopsis thaliana
G30FGKTLGAGTFG1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
L100YLVMQLVSGGE2Homo sapiens, Mus musculus
L100HVVMEICAGGE1Arabidopsis thaliana
L100YIITQLAKGGE1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
L29EFKETLGTGAF2Homo sapiens, Mus musculus
L29SVGRKLGQGQF1Arabidopsis thaliana
L29VFGKTLGAGTF1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
M98HLYLVMQLVSG2Homo sapiens, Mus musculus
M98AVHVVMEICAG1Arabidopsis thaliana
M98KFYIITQLAKG1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Q99LYLVMQLVSGG2Homo sapiens, Mus musculus
Q99VHVVMEICAGG1Arabidopsis thaliana
Q99FYIITQLAKGG1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
V101LVMQLVSGGEL2Homo sapiens, Mus musculus
V101VVMEICAGGEL1Arabidopsis thaliana
V101IITQLAKGGEL1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
W306SK---WRQAF-2Homo sapiens, Mus musculus
W306EEIAGLKEMFK1Arabidopsis thaliana
W306QK---LRDLYL1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)


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