mutLBSgeneDB

mutLBSgeneDB
mutated Ligand Binding Site gene DataBase

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Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for XPO5
Gene summary
Basic gene Info.Gene symbolXPO5
Gene nameexportin 5
Synonymsexp5
CytomapUCSC genome browser: 6p21.1
Type of geneprotein-coding
RefGenesNM_020750.2,
Descriptionexportin-5ran-binding protein 21
Modification date20141207
dbXrefs MIM : 607845
HGNC : HGNC
Ensembl : ENSG00000124571
HPRD : 06385
Vega : OTTHUMG00000014742
ProteinUniProt: Q9HAV4
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_XPO5
BioGPS: 57510
PathwayNCI Pathway Interaction Database: XPO5
KEGG: XPO5
REACTOME: XPO5
Pathway Commons: XPO5
ContextiHOP: XPO5
ligand binding site mutation search in PubMed: XPO5
UCL Cancer Institute: XPO5
Assigned class in mutLBSgeneDBC: This gene just belongs to mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO TermPubMed ID


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Ligand binding site mutations for XPO5
Lollipop-style diagram of mutations at LBS in amino-acid sequence.
We represented ligand binding site mutations only. (You can see big image via clicking.)
 : non-synonymous mutation on LBS, Circle size denotes number of samples.

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
R893M891LLUSC1
R718R718HUCEC1
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.


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Protein structure related information for XPO5
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
R893M891L-0.8748437
R718R718H-0.6144555
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for XPO5 from PDB

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Differential gene expression and gene-gene network for XPO5
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of XPO5 and the right PPI network was created from samples without mutations in the LBS of XPO5. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


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Phenotype information for XPO5
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

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Pharmacological information for XPO5
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of XPO5 go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS
NUCNucleic Acids3a6pAR718
NUCNucleic Acids3a6pFR718
NUCNucleic Acids3a6pAR893
NUCNucleic Acids3a6pFR893


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Conservation information for LBS of XPO5
Multiple alignments for Q9HAV4 in multiple species
LBSAA sequence# speciesSpecies
A1091HDGCMASLVHL2Homo sapiens, Mus musculus
A1091AINS-PDLVNI1Arabidopsis thaliana
A441FNSSRAQQGEV1Homo sapiens
A441----RSKLLEL1Arabidopsis thaliana
A441FNSSRAQHGEV1Mus musculus
D1087MHGQHDGCMAS2Homo sapiens, Mus musculus
D1087MESNAINS-PD1Arabidopsis thaliana
E445RAQQGEVMRLA1Homo sapiens
E445RSKLLELIKLT1Arabidopsis thaliana
E445RAQHGEVVRCV1Mus musculus
E711CDPGLEDPCGL1Homo sapiens
E711----LSDPMGL1Arabidopsis thaliana
E711CDPAVEDPCGL1Mus musculus
F1098LVHLAFQIYEA2Homo sapiens, Mus musculus
F1098LVNICREIFIY1Arabidopsis thaliana
F1129DSLDQFDCKLL1Homo sapiens
F1129NDLHAFE----1Arabidopsis thaliana
F1129ESLDQFDCKLL1Mus musculus
F839ERMQRFFSTLY1Homo sapiens
F839SDIRNWLKGIR1Arabidopsis thaliana
F839ERMQRFFGILY1Mus musculus
G1088HGQHDGCMASL2Homo sapiens, Mus musculus
G1088ESNAINS-PDL1Arabidopsis thaliana
G279AVSRKGKLEDR2Homo sapiens, Mus musculus
G279VCSRKRPSDAS1Arabidopsis thaliana
G715LEDPCGLNR--1Homo sapiens
G715LSDPMGLVRLC1Arabidopsis thaliana
G715VEDPCGLNR--1Mus musculus
H1086QMHGQHDGCMA2Homo sapiens, Mus musculus
H1086GMESNAINS-P1Arabidopsis thaliana
I1118AVMEQIPEIQK1Homo sapiens
I1118QVLLSLPCLTP1Arabidopsis thaliana
I1118AVMEQIPEINK1Mus musculus
I1121EQIPEIQKDSL1Homo sapiens
I1121LSLPCLTPNDL1Arabidopsis thaliana
I1121EQIPEINKESL1Mus musculus
I609ACSSIIKMCRD1Homo sapiens
I609ICTSFIRIAKA1Arabidopsis thaliana
I609ACSSINKMCRD1Mus musculus
K278IAVSRKGKLED2Homo sapiens, Mus musculus
K278LVCSRKRPSDA1Arabidopsis thaliana
K610CSSIIKMCRDY1Homo sapiens
K610CTSFIRIAKAA1Arabidopsis thaliana
K610CSSINKMCRDY1Mus musculus
K830-----KTVLER1Homo sapiens
K830KEGQAEASESD1Arabidopsis thaliana
K830-----RTTLER1Mus musculus
L1042AWKDTLSCQRT1Homo sapiens
L1042TWTDG----EA1Arabidopsis thaliana
L1042TWKDTLSCQRA1Mus musculus
L820GLPQPLLELND1Homo sapiens
L820GEANPKLS-KG1Arabidopsis thaliana
L820GLPQPLLEFND1Mus musculus
M373RSSTQMTWGAL1Homo sapiens
M373HFEALLFWLSL1Arabidopsis thaliana
M373RSSTHMTWGAL1Mus musculus
M643LLLTQMEKCAL2Homo sapiens, Mus musculus
M643TLL-RGEHNIL1Arabidopsis thaliana
Q1045DTLSCQRTTSQ1Homo sapiens
Q1045DG----EATTK1Arabidopsis thaliana
Q1045DTLSCQRATTQ1Mus musculus
Q1050QRTTSQLCW--1Homo sapiens
Q1050-EATTKVCYFC1Arabidopsis thaliana
Q1050QRATTQLCW--1Mus musculus
Q642ELLLTQMEKCA2Homo sapiens, Mus musculus
Q642GTLL-RGEHNI1Arabidopsis thaliana
R1046TLSCQRTTSQL1Homo sapiens
R1046G----EATTKV1Arabidopsis thaliana
R1046TLSCQRATTQL1Mus musculus
R380WGALFRH----2Homo sapiens, Mus musculus
R380WLSLMRDLLPK1Arabidopsis thaliana
R440FFNSSRAQQGE1Homo sapiens
R440Y----RSKLLE1Arabidopsis thaliana
R440FFNSSRAQHGE1Mus musculus
R448QGEVMRLACRL1Homo sapiens
R448LLELIKLTASH1Arabidopsis thaliana
R448HGEVVRCVCRL1Mus musculus
R593ESKAPRTRAVR2Homo sapiens, Mus musculus
R593VVKDPATSTSR1Arabidopsis thaliana
R595KAPRTRAVRNV2Homo sapiens, Mus musculus
R595KDPATSTSRAA1Arabidopsis thaliana
R602VRNVRRHACSS2Homo sapiens, Mus musculus
R602SRAARLQICTS1Arabidopsis thaliana
R718PCGLNR----A2Homo sapiens, Mus musculus
R718PMGLVRLCSNT1Arabidopsis thaliana
R734LGVVKRTCWPT1Homo sapiens
R734VTFFEKALKRS1Arabidopsis thaliana
R734LGVMRRTSWPS1Mus musculus
R835KTVLERMQRFF1Homo sapiens
R835EASESDIRNWL1Arabidopsis thaliana
R835RTTLERMQRFF1Mus musculus
R838LERMQRFFSTL1Homo sapiens
R838ESDIRNWLKGI1Arabidopsis thaliana
R838LERMQRFFGIL1Mus musculus
R893LRPMLRVFVKP1Homo sapiens
R893IRLFIHTFITY1Arabidopsis thaliana
R893LRSMLRVFVKP1Mus musculus
S606RRHACSSIIKM1Homo sapiens
S606RLQICTSFIRI1Arabidopsis thaliana
S606RRHACSSINKM1Mus musculus
T641NELLLTQMEKC2Homo sapiens, Mus musculus
T641EGTLL-RGEHN1Arabidopsis thaliana
Y726MSFCVYSILGV2Homo sapiens, Mus musculus
Y726FMWSIYHTVTF1Arabidopsis thaliana


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