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mutLBSgeneDB |
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| Gene summary for NGB |
 Gene summary |
| Basic gene Info. | Gene symbol | NGB |
| Gene name | neuroglobin | |
| Synonyms | - | |
| Cytomap | UCSC genome browser: 14q24.3 | |
| Type of gene | protein-coding | |
| RefGenes | NM_021257.3, | |
| Description | - | |
| Modification date | 20141222 | |
| dbXrefs | MIM : 605304 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000165553 | ||
| HPRD : 05602 | ||
| Vega : OTTHUMG00000171558 | ||
| Protein | UniProt: Q9NPG2 go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_NGB | |
| BioGPS: 58157 | ||
| Pathway | NCI Pathway Interaction Database: NGB | |
| KEGG: NGB | ||
| REACTOME: NGB | ||
| Pathway Commons: NGB | ||
| Context | iHOP: NGB | |
| ligand binding site mutation search in PubMed: NGB | ||
| UCL Cancer Institute: NGB | ||
| Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. | |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO Term | PubMed ID |
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| Ligand binding site mutations for NGB |
| Lollipop-style diagram of mutations at LBS in amino-acid sequence. We represented ligand binding site mutations only. (You can see big image via clicking.)  : non-synonymous mutation on LBS, Circle size denotes number of samples. |
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| Cancer type specific mutLBS sorted by frequency |
| LBS | AAchange of nsSNV | Cancer type | # samples | F42 | F42S | COAD | 1 | Y88 | E87D | COAD | 1 | L92 | S91I | KIRC | 1 | V109 | T108S | KIRC | 1 |
| cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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| Protein structure related information for NGB |
| Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
 : nsSNV at non-LBS : nsSNV at LBS |
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| nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
| LBS | AAchange of nsSNV | Relative stability change | F42 | F42S | -1.155792 | Y88 | E87D | -0.92694566 | V109 | T108S | -0.76389039 | L92 | S91I | -0.52297801 |
| (MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
| Structure image for NGB from PDB |
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| Differential gene expression and gene-gene network for NGB |
| Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
| Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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| Phenotype information for NGB |
| Gene level disease information (DisGeNet) |
| Disease ID | Disease name | # PubMed | Association type |
| umls:C0751870 | Heredodegenerative Disorders, Nervous System | 1 | Biomarker |
| Mutation level pathogenic information (ClinVar annotation) |
| Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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| Pharmacological information for NGB |
| Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
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| Drug information targeting mutLBSgene (Approved drugs only) |
| Drug status | DrugBank ID | Name | Type | Drug structure |
| Gene-centered ligand-gene interaction network |
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| Ligands binding to mutated ligand binding site of NGB go to BioLip |
| Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | HEM | HEME B | 1oj6 | A | F42 L92 V109 | HEM | HEME B | 1oj6 | C | F42 L92 V109 | HEM | HEME B | 4mpm | A | F42 L92 V109 | HEM | HEME B | 4mpm | B | F42 L92 V109 | HEM | HEME B | 1oj6 | B | F42 Y88 L92 V109 | HEM | HEME B | 1oj6 | D | F42 Y88 L92 V109 |
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| Conservation information for LBS of NGB |
| Multiple alignments for Q9NPG2 in multiple species |
| LBS | AA sequence | # species | Species | F106 | VKLSSFSTVGE | 5 | Homo sapiens, Canis lupus familiaris, Bos taurus, Pan troglodytes, Macaca mulatta | F106 | VRLSSFSTVGE | 2 | Mus musculus, Rattus norvegicus | F106 | VNTQSFALVGE | 1 | Danio rerio | F42 | DLLPLFQYNCR | 5 | Homo sapiens, Canis lupus familiaris, Bos taurus, Pan troglodytes, Macaca mulatta | F42 | SLLPLFQYNGR | 2 | Mus musculus, Rattus norvegicus | F42 | ALLTLFSYSTN | 1 | Danio rerio | H64 | PEFLDHIRKVM | 7 | Homo sapiens, Mus musculus, Rattus norvegicus, Canis lupus familiaris, Bos taurus, Pan troglodytes, Macaca mulatta | H64 | PEFLEHVTKVM | 1 | Danio rerio | H96 | SLGRKHRAVGV | 4 | Homo sapiens, Mus musculus, Pan troglodytes, Macaca mulatta | H96 | NLGRKHQAVGV | 1 | Danio rerio | H96 | TLGRKHRAVGV | 1 | Rattus norvegicus | H96 | GLGKKHRAVGV | 1 | Canis lupus familiaris | H96 | GLGRKHRAVGV | 1 | Bos taurus | K67 | LDHIRKVMLVI | 7 | Homo sapiens, Mus musculus, Rattus norvegicus, Canis lupus familiaris, Bos taurus, Pan troglodytes, Macaca mulatta | K67 | LEHVTKVMLVI | 1 | Danio rerio | K95 | ASLGRKHRAVG | 3 | Homo sapiens, Pan troglodytes, Macaca mulatta | K95 | LNLGRKHQAVG | 1 | Danio rerio | K95 | TSLGRKHRAVG | 1 | Mus musculus | K95 | ATLGRKHRAVG | 1 | Rattus norvegicus | K95 | AGLGKKHRAVG | 1 | Canis lupus familiaris | K95 | AGLGRKHRAVG | 1 | Bos taurus | L31 | VLFARLFALEP | 4 | Homo sapiens, Mus musculus, Pan troglodytes, Macaca mulatta | L31 | VLFARLFDLEP | 2 | Canis lupus familiaris, Bos taurus | L31 | VLFTRLFELDP | 1 | Danio rerio | L31 | VLFSRLFALEP | 1 | Rattus norvegicus | L38 | ALEPDLLPLFQ | 3 | Homo sapiens, Pan troglodytes, Macaca mulatta | L38 | ALEPSLLPLFQ | 2 | Mus musculus, Rattus norvegicus | L38 | DLEPDLLPLFQ | 2 | Canis lupus familiaris, Bos taurus | L38 | ELDPALLTLFS | 1 | Danio rerio | L41 | PDLLPLFQYNC | 5 | Homo sapiens, Canis lupus familiaris, Bos taurus, Pan troglodytes, Macaca mulatta | L41 | PSLLPLFQYNG | 2 | Mus musculus, Rattus norvegicus | L41 | PALLTLFSYST | 1 | Danio rerio | L92 | EYLASLGRKHR | 3 | Homo sapiens, Pan troglodytes, Macaca mulatta | L92 | DFLLNLGRKHQ | 1 | Danio rerio | L92 | EYLTSLGRKHR | 1 | Mus musculus | L92 | EYLATLGRKHR | 1 | Rattus norvegicus | L92 | EYLAGLGKKHR | 1 | Canis lupus familiaris | L92 | EYLAGLGRKHR | 1 | Bos taurus | N45 | PLFQYNCRQFS | 5 | Homo sapiens, Canis lupus familiaris, Bos taurus, Pan troglodytes, Macaca mulatta | N45 | PLFQYNGRQFS | 2 | Mus musculus, Rattus norvegicus | N45 | TLFSYSTNCGD | 1 | Danio rerio | N78 | DAAVTNVEDLS | 6 | Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus, Pan troglodytes, Macaca mulatta | N78 | DAAVSHLDDLH | 1 | Danio rerio | N78 | DTAVTNVEDLS | 1 | Canis lupus familiaris | S105 | GVKLSSFSTVG | 5 | Homo sapiens, Canis lupus familiaris, Bos taurus, Pan troglodytes, Macaca mulatta | S105 | GVRLSSFSTVG | 2 | Mus musculus, Rattus norvegicus | S105 | GVNTQSFALVG | 1 | Danio rerio | T77 | IDAAVTNVEDL | 6 | Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus, Pan troglodytes, Macaca mulatta | T77 | IDAAVSHLDDL | 1 | Danio rerio | T77 | IDTAVTNVEDL | 1 | Canis lupus familiaris | V101 | HRAVGVKLSSF | 5 | Homo sapiens, Canis lupus familiaris, Bos taurus, Pan troglodytes, Macaca mulatta | V101 | HRAVGVRLSSF | 2 | Mus musculus, Rattus norvegicus | V101 | HQAVGVNTQSF | 1 | Danio rerio | V109 | SSFSTVGESLL | 7 | Homo sapiens, Mus musculus, Rattus norvegicus, Canis lupus familiaris, Bos taurus, Pan troglodytes, Macaca mulatta | V109 | QSFALVGESLL | 1 | Danio rerio | V68 | DHIRKVMLVID | 7 | Homo sapiens, Mus musculus, Rattus norvegicus, Canis lupus familiaris, Bos taurus, Pan troglodytes, Macaca mulatta | V68 | EHVTKVMLVID | 1 | Danio rerio | V71 | RKVMLVIDAAV | 6 | Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus, Pan troglodytes, Macaca mulatta | V71 | TKVMLVIDAAV | 1 | Danio rerio | V71 | RKVMLVIDTAV | 1 | Canis lupus familiaris | V99 | RKHRAVGVKLS | 4 | Homo sapiens, Bos taurus, Pan troglodytes, Macaca mulatta | V99 | RKHRAVGVRLS | 2 | Mus musculus, Rattus norvegicus | V99 | RKHQAVGVNTQ | 1 | Danio rerio | V99 | KKHRAVGVKLS | 1 | Canis lupus familiaris | Y88 | SSLEEYLASLG | 3 | Homo sapiens, Pan troglodytes, Macaca mulatta | Y88 | SSLEEYLAGLG | 2 | Canis lupus familiaris, Bos taurus | Y88 | HTLEDFLLNLG | 1 | Danio rerio | Y88 | SSLEEYLTSLG | 1 | Mus musculus | Y88 | SSLEEYLATLG | 1 | Rattus norvegicus |
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