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mutLBSgeneDB |
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| Gene summary for RALB |
 Gene summary |
| Basic gene Info. | Gene symbol | RALB |
| Gene name | v-ral simian leukemia viral oncogene homolog B | |
| Synonyms | - | |
| Cytomap | UCSC genome browser: 2q14.2 | |
| Type of gene | protein-coding | |
| RefGenes | NM_002881.2, | |
| Description | RAS-like protein Bras related GTP binding protein Bras-related protein Ral-Bv-ral simian leukemia viral oncogene homolog B (ras related; GTP binding protein) | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 179551 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000144118 | ||
| HPRD : 01550 | ||
| Vega : OTTHUMG00000131435 | ||
| Protein | UniProt: P11234 go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_RALB | |
| BioGPS: 5899 | ||
| Pathway | NCI Pathway Interaction Database: RALB | |
| KEGG: RALB | ||
| REACTOME: RALB | ||
| Pathway Commons: RALB | ||
| Context | iHOP: RALB | |
| ligand binding site mutation search in PubMed: RALB | ||
| UCL Cancer Institute: RALB | ||
| Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. | |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO Term | PubMed ID | GO:0000910 | cytokinesis | 18756269 |
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| Ligand binding site mutations for RALB |
| Lollipop-style diagram of mutations at LBS in amino-acid sequence. We represented ligand binding site mutations only. (You can see big image via clicking.)  : non-synonymous mutation on LBS, Circle size denotes number of samples. |
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| Cancer type specific mutLBS sorted by frequency |
| LBS | AAchange of nsSNV | Cancer type | # samples | G24 | G23V | COAD | 1 | G24 | G24C | COAD | 1 | G24 | G23A | KIRC | 1 |
| cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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| Protein structure related information for RALB |
| Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
 : nsSNV at non-LBS : nsSNV at LBS |
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| nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
| LBS | AAchange of nsSNV | Relative stability change | G24 | G23V | 0.31350972 | G24 | G24C | -0.74066523 | G24 | G23A | -0.13120804 |
| (MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
| Structure image for RALB from PDB |
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| Differential gene expression and gene-gene network for RALB |
| Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
| Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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| Phenotype information for RALB |
| Gene level disease information (DisGeNet) |
| Disease ID | Disease name | # PubMed | Association type |
| Mutation level pathogenic information (ClinVar annotation) |
| Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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| Pharmacological information for RALB |
| Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
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| Drug information targeting mutLBSgene (Approved drugs only) |
| Drug status | DrugBank ID | Name | Type | Drug structure |
| Gene-centered ligand-gene interaction network |
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| Ligands binding to mutated ligand binding site of RALB go to BioLip |
| Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | GNP | PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER | 2kwi | A | G24 |
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| Conservation information for LBS of RALB |
| Multiple alignments for P11234 in multiple species |
| LBS | AA sequence | # species | Species | A159 | YVETSAKTRAN | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | A29 | GVGKSALTLQF | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | D131 | VGNKSDLEERR | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | E41 | YDEFVEDYEPT | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | E44 | FVEDYEPTKAD | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | F39 | FMYDEFVEDYE | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | G24 | MVGSGGVGKSA | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | G26 | GSGGVGKSALT | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | K129 | LVVGNKSDLEE | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | K160 | VETSAKTRANV | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | K27 | SGGVGKSALTL | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | N128 | LLVVGNKSDLE | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | P45 | VEDYEPTKADS | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | S158 | QYVETSAKTRA | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | S28 | GGVGKSALTLQ | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | T46 | EDYEPTKADSY | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | V25 | VGSGGVGKSAL | 3 | Homo sapiens, Mus musculus, Rattus norvegicus |
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