mutLBSgeneDB |
Gene summary for ZFAND3 |
Gene summary |
Basic gene Info. | Gene symbol | ZFAND3 |
Gene name | zinc finger, AN1-type domain 3 | |
Synonyms | TEX27 | |
Cytomap | UCSC genome browser: 6p21.2 | |
Type of gene | protein-coding | |
RefGenes | NM_021943.2, | |
Description | AN1-type zinc finger protein 3testis expressed sequence 27 | |
Modification date | 20141217 | |
dbXrefs | MIM : 607455 | |
HGNC : HGNC | ||
Ensembl : ENSG00000156639 | ||
HPRD : 12121 | ||
Vega : OTTHUMG00000014629 | ||
Protein | UniProt: Q9H8U3 go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_ZFAND3 | |
BioGPS: 60685 | ||
Pathway | NCI Pathway Interaction Database: ZFAND3 | |
KEGG: ZFAND3 | ||
REACTOME: ZFAND3 | ||
Pathway Commons: ZFAND3 | ||
Context | iHOP: ZFAND3 | |
ligand binding site mutation search in PubMed: ZFAND3 | ||
UCL Cancer Institute: ZFAND3 | ||
Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO Term | PubMed ID |
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Ligand binding site mutations for ZFAND3 |
Cancer type specific mutLBS sorted by frequency |
LBS | AAchange of nsSNV | Cancer type | # samples | C157 | R156W | COAD | 1 | C157 | R156L | COAD | 1 | H184 | R185H | STAD | 1 | H190 | H190Y | STAD | 1 |
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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Protein structure related information for ZFAND3 |
Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
: nsSNV at non-LBS: nsSNV at LBS |
nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
LBS | AAchange of nsSNV | Relative stability change | H184 | R185H | -0.91650893 | H190 | H190Y | -0.87025679 | C157 | R156W | -0.76665998 | C157 | R156L | -0.4789124 |
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
Structure image for ZFAND3 from PDB |
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Differential gene expression and gene-gene network for ZFAND3 |
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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Phenotype information for ZFAND3 |
Gene level disease information (DisGeNet) |
Disease ID | Disease name | # PubMed | Association type |
umls:C0011860 | Diabetes Mellitus, Type 2 | 1 | Biomarker, GeneticVariation |
Mutation level pathogenic information (ClinVar annotation) |
Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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Pharmacological information for ZFAND3 |
Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
Drug information targeting mutLBSgene (Approved drugs only) |
Drug status | DrugBank ID | Name | Type | Drug structure |
Gene-centered ligand-gene interaction network |
Ligands binding to mutated ligand binding site of ZFAND3 go to BioLip |
Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS |
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Conservation information for LBS of ZFAND3 |
Multiple alignments for Q9H8U3 in multiple species |
LBS | AA sequence | # species | Species | C157 | KSRRRCFQCQT | 3 | Homo sapiens, Rattus norvegicus, Mus musculus | C160 | RRCFQCQTKLE | 3 | Homo sapiens, Rattus norvegicus, Mus musculus | C174 | QELGSCRCGYV | 3 | Homo sapiens, Rattus norvegicus, Mus musculus | C176 | LGSCRCGYVFC | 3 | Homo sapiens, Rattus norvegicus, Mus musculus | C181 | CGYVFCMLHRL | 3 | Homo sapiens, Rattus norvegicus, Mus musculus | C192 | PEQHDCTFDHM | 3 | Homo sapiens, Rattus norvegicus, Mus musculus | H184 | VFCMLHRLPEQ | 3 | Homo sapiens, Rattus norvegicus, Mus musculus | H190 | RLPEQHDCTFD | 3 | Homo sapiens, Rattus norvegicus, Mus musculus |
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