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mutLBSgeneDB |
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| Gene summary for ROS1 |
 Gene summary |
| Basic gene Info. | Gene symbol | ROS1 |
| Gene name | ROS proto-oncogene 1 , receptor tyrosine kinase | |
| Synonyms | MCF3|ROS|c-ros-1 | |
| Cytomap | UCSC genome browser: 6q22 | |
| Type of gene | protein-coding | |
| RefGenes | NM_002944.2, | |
| Description | c-ros oncogene 1 , receptor tyrosine kinaseproto-oncogene c-Ros-1proto-oncogene tyrosine-protein kinase ROStransmembrane tyrosine-specific protein kinasev-ros avian UR2 sarcoma virus oncogene homolog 1 | |
| Modification date | 20141222 | |
| dbXrefs | MIM : 165020 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000047936 | ||
| HPRD : 01295 | ||
| Vega : OTTHUMG00000016188 | ||
| Protein | UniProt: P08922 go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_ROS1 | |
| BioGPS: 6098 | ||
| Pathway | NCI Pathway Interaction Database: ROS1 | |
| KEGG: ROS1 | ||
| REACTOME: ROS1 | ||
| Pathway Commons: ROS1 | ||
| Context | iHOP: ROS1 | |
| ligand binding site mutation search in PubMed: ROS1 | ||
| UCL Cancer Institute: ROS1 | ||
| Assigned class in mutLBSgeneDB | B: This gene belongs to targetable_mutLBSgenes. | |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO Term | PubMed ID | GO:0006468 | protein phosphorylation | 16885344 | GO:0016049 | cell growth | 16885344 | GO:0018108 | peptidyl-tyrosine phosphorylation | 16885344 | GO:0032006 | regulation of TOR signaling | 16885344 |
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| Ligand binding site mutations for ROS1 |
| Lollipop-style diagram of mutations at LBS in amino-acid sequence. We represented ligand binding site mutations only. (You can see big image via clicking.)  : non-synonymous mutation on LBS, Circle size denotes number of samples. |
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| Cancer type specific mutLBS sorted by frequency |
| LBS | AAchange of nsSNV | Cancer type | # samples | R2083 | A2081E | KIRC | 1 | L2010 | N2008S | SKCM | 1 | L2086 | S2088F | SKCM | 1 | V1959 | Y1960H | UCEC | 1 | R2083 | A2081T | UCEC | 1 | L1951 | L1951M | UCEC | 1 |
| cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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| Protein structure related information for ROS1 |
| Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
 : nsSNV at non-LBS : nsSNV at LBS |
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| nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
| LBS | AAchange of nsSNV | Relative stability change | L2086 | S2088F | -0.8443144 | V1959 | Y1960H | -0.77941834 | R2083 | A2081T | -0.76341274 | L1951 | L1951M | -0.61334098 | R2083 | A2081E | -0.48083838 | L2010 | N2008S | -0.29797447 |
| (MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
| Structure image for ROS1 from PDB |
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| Differential gene expression and gene-gene network for ROS1 |
| Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
| Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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| Phenotype information for ROS1 |
| Gene level disease information (DisGeNet) |
| Disease ID | Disease name | # PubMed | Association type |
| umls:C0007131 | Carcinoma, Non-Small-Cell Lung | 20 | Biomarker |
| umls:C0152013 | Adenocarcinoma of lung | 4 | Biomarker |
| umls:C0017638 | Glioma | 2 | Biomarker |
| umls:C0025202 | Melanoma | 1 | Biomarker |
| Mutation level pathogenic information (ClinVar annotation) |
| Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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| Pharmacological information for ROS1 |
| Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
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| Gene-centered drug-gene interaction network |
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| Drug information targeting mutLBSgene (Approved drugs only) |
| Drug status | DrugBank ID | Name | Type | Drug structure |
| Gene-centered ligand-gene interaction network |
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| Ligands binding to mutated ligand binding site of ROS1 go to BioLip |
| Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | VGH | CRIZOTINIB | 3zbf | A | L1951 L2010 R2083 L2086 | 5P8 | (10R)-7-AMINO-12-FLUORO-2,10,16-TRIMETHYL-15- OXO-10,15,16,17-TETRAHYDRO-2H-8,4-(METHENO) PYRAZOLO[4,3-H][2,5,11] BENZOXADIAZACYCLOTETRADECINE-3-CARBONITRILE | 4uxl | A | L1951 V1959 R2083 L2086 |
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| Conservation information for LBS of ROS1 |
| Multiple alignments for P08922 in multiple species |
| LBS | AA sequence | # species | Species | A1978 | --IKVAVKTLK | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | A1978 | EPQRVAIKSLR | 1 | Drosophila melanogaster | D2033 | LMEGGDLLSYL | 2 | Mus musculus, Rattus norvegicus | D2033 | LMEGGDLLTYL | 1 | Homo sapiens | D2033 | HMEAGDLLSYL | 1 | Drosophila melanogaster | D2102 | VVKIGDFGLAR | 2 | Mus musculus, Rattus norvegicus | D2102 | IVKIGDFGLAR | 1 | Homo sapiens | D2102 | TVKIGDFGLAR | 1 | Drosophila melanogaster | E2027 | QYIILELMEGG | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | E2027 | ISLIMEHMEAG | 1 | Drosophila melanogaster | E2030 | ILELMEGGDLL | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | E2030 | IMEHMEAGDLL | 1 | Drosophila melanogaster | G2032 | ELMEGGDLLSY | 2 | Mus musculus, Rattus norvegicus | G2032 | ELMEGGDLLTY | 1 | Homo sapiens | G2032 | EHMEAGDLLSY | 1 | Drosophila melanogaster | G2101 | RVVKIGDFGLA | 2 | Mus musculus, Rattus norvegicus | G2101 | RIVKIGDFGLA | 1 | Homo sapiens | G2101 | RTVKIGDFGLA | 1 | Drosophila melanogaster | L1951 | SLRLLLGSGAF | 2 | Mus musculus, Rattus norvegicus | L1951 | TLRLLLGSGAF | 1 | Homo sapiens | L1951 | KLLRFLGSGAF | 1 | Drosophila melanogaster | L2010 | NHPNILKQLGV | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | L2010 | KHENIVCLVGI | 1 | Drosophila melanogaster | L2026 | PQYIILELMEG | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | L2026 | SISLIMEHMEA | 1 | Drosophila melanogaster | L2028 | YIILELMEGGD | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | L2028 | SLIMEHMEAGD | 1 | Drosophila melanogaster | L2086 | AARNCLV--SV | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | L2086 | ACRNCLVTEST | 1 | Drosophila melanogaster | M2029 | IILELMEGGDL | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | M2029 | LIMEHMEAGDL | 1 | Drosophila melanogaster | N2084 | DLAARNCLV-- | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | N2084 | DLACRNCLVTE | 1 | Drosophila melanogaster | R2083 | RDLAARNCLV- | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | R2083 | RDLACRNCLVT | 1 | Drosophila melanogaster | V1959 | GAFGEVYEGTA | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | V1959 | GAFGEVYEGQ- | 1 | Drosophila melanogaster |
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