mutLBSgeneDB

mutLBSgeneDB
mutated Ligand Binding Site gene DataBase

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Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for RPS6KB1
Gene summary
Basic gene Info.Gene symbolRPS6KB1
Gene nameribosomal protein S6 kinase, 70kDa, polypeptide 1
SynonymsPS6K|S6K|S6K-beta-1|S6K1|STK14A|p70 S6KA|p70(S6K)-alpha|p70-S6K|p70-alpha
CytomapUCSC genome browser: 17q23.1
Type of geneprotein-coding
RefGenesNM_001272042.1,
NM_001272043.1,NM_001272044.1,NM_001272060.1,NM_003161.3,
Descriptionp70 S6 kinase, alpharibosomal protein S6 kinase Iribosomal protein S6 kinase beta-1serine/threonine kinase 14 alphaserine/threonine-protein kinase 14A
Modification date20141222
dbXrefs MIM : 608938
HGNC : HGNC
Ensembl : ENSG00000108443
HPRD : 10202
Vega : OTTHUMG00000150642
ProteinUniProt: P23443
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_RPS6KB1
BioGPS: 6198
PathwayNCI Pathway Interaction Database: RPS6KB1
KEGG: RPS6KB1
REACTOME: RPS6KB1
Pathway Commons: RPS6KB1
ContextiHOP: RPS6KB1
ligand binding site mutation search in PubMed: RPS6KB1
UCL Cancer Institute: RPS6KB1
Assigned class in mutLBSgeneDBB: This gene belongs to targetable_mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO TermPubMed ID
GO:0006468protein phosphorylation19085255
GO:0031929TOR signaling12150926
GO:0071363cellular response to growth factor stimulus17936702


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Ligand binding site mutations for RPS6KB1

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
L97R95WCOAD1
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.


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Protein structure related information for RPS6KB1
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
L97R95W-0.53618787
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for RPS6KB1 from PDB

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Differential gene expression and gene-gene network for RPS6KB1
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of RPS6KB1 and the right PPI network was created from samples without mutations in the LBS of RPS6KB1. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


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Phenotype information for RPS6KB1
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type
umls:C0079744Lymphoma, Large B-Cell, Diffuse2Biomarker
umls:C0333641Atrophy1Biomarker
umls:C2931673Ceroid lipofuscinosis, neuronal 1, infantile1Biomarker
umls:C0020538Hypertension1Biomarker
umls:C0149721Hypertrophy, Left Ventricular1Biomarker

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

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Pharmacological information for RPS6KB1
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.

Gene-centered drug-gene interaction network
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of RPS6KB1 go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS
STUSTAUROSPORINE3a60AL97
STUSTAUROSPORINE3a60BL97
STUSTAUROSPORINE3a61AL97
STUSTAUROSPORINE3a62AL97
FZ84-[4-(1H-BENZIMIDAZOL-2-YL)PIPERIDIN-1-YL]-1H- PYRAZOLO[3,4-D]PYRIMIDINE3wf5AL97
FZ94-[4-(1H-INDOL-3-YL)-3,6-DIHYDROPYRIDIN-1(2H)-YL]-1H- PYRAZOLO[3,4-D]PYRIMIDINE3wf6AL97
FS91-(9H-PURIN-6-YL)-N-[3-(TRIFLUOROMETHYL) PHENYL]PIPERIDINE-4-CARBOXAMIDE3wf7AL97
F762-OXO-2-[(4-SULFAMOYLPHENYL)AMINO]ETHYL 7,8,9,10- TETRAHYDRO-6H-CYCLOHEPTA[B]QUINOLINE-11-CARBOXYLATE3wf8AL97
FS7(2S)-1-OXO-1-[(4-SULFAMOYLPHENYL)AMINO]PROPAN-2-YL (2S)-2-METHYL-1,2,3,4-TETRAHYDROACRIDINE-9-CARBOXYLATE3wf9AL97
3T3(3-FLUORO-9-METHOXYPYRIDO[2,3-A]PYRROLO[3,4- C]CARBAZOLE-5,7(6H,12H)-DIONATO)(1,4,7- TRITHIACYCLODECAN)RUTHENIUM(II)-ISOTHIOCYANATE, EM5[(AMINO-KAPPAN)METHANETHIOLATO](3-FLUORO-9- HYDROXYPYRIDO[2,3-A]PYRROLO[3,4-C]CARBAZOLE-5,7(6H, 12H)-DIONATO-KAPPA~2~N,N')(1,4,7-TRITHIONANE- KAPPA~3~S~1~,S~4~,S~7~)RUTHENIUM4rloAL97
STUSTAUROSPORINE4rloBL97
72B(3-FLUORO-9-METHOXYPYRIDO[2,3-A]PYRROLO[3,4- C]CARBAZOLE-5,7(6H,12H)-DIONATO)(N-METHYL-1,4,7- TRITHIACYCLODECAN-9-AMINE)RUTHENIUM(II)- ISOTHIOCYANATE, FL772[(AMINO-KAPPAN)METHANETHIOLATO](3-FLUORO-9- METHOXYPYRIDO[2,3-A]PYRROLO[3,4-C]CARBAZOLE-5,7(6H, 12H)-DIONATO-KAPPA~2~N,N')(N-METHYL-1,4,7-TRITHIECAN- 9-AMINE-KAPPA~3~S~1~,S~4~,S~7~)RUTHENIUM4rlpAL97


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Conservation information for LBS of RPS6KB1
Multiple alignments for P23443 in multiple species
LBSAA sequence# speciesSpecies
A121TGKIFAMKVLK4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
A121TSEIYAMKVMR2Arabidopsis thaliana, Arabidopsis thaliana
A121NGQIFAMKVLQ1Caenorhabditis elegans
C240TDFGLCKESIH4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
C240TDFGLAKE-FE2Arabidopsis thaliana, Arabidopsis thaliana
C240TDFGLCKEEIE1Caenorhabditis elegans
C254VTHTFCGTIEY4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
C254RSNSMCGTTEY2Arabidopsis thaliana, Arabidopsis thaliana
C254KTHTFCGTIEY1Caenorhabditis elegans
D236HVKLTDFGLCK5Homo sapiens, Caenorhabditis elegans, Bos taurus, Mus musculus, Rattus norvegicus
D236HVMLTDFGLAK2Arabidopsis thaliana, Arabidopsis thaliana
E143AHTKAERNILE5Homo sapiens, Caenorhabditis elegans, Bos taurus, Mus musculus, Rattus norvegicus
E143EYMKAERDILT2Arabidopsis thaliana, Arabidopsis thaliana
E173LYLILEYLSGG5Homo sapiens, Caenorhabditis elegans, Bos taurus, Mus musculus, Rattus norvegicus
E173LYLVLDFINGG2Arabidopsis thaliana, Arabidopsis thaliana
E179YLSGGELFMQL4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
E179FINGGHLFFQL2Arabidopsis thaliana, Arabidopsis thaliana
E179YLSGGELFMHL1Caenorhabditis elegans
E222RDLKPENIMLN4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
E222RDLKPENILMD2Arabidopsis thaliana, Arabidopsis thaliana
E222RDLKPENILLD1Caenorhabditis elegans
F237VKLTDFGLCKE5Homo sapiens, Caenorhabditis elegans, Bos taurus, Mus musculus, Rattus norvegicus
F237VMLTDFGLAKE2Arabidopsis thaliana, Arabidopsis thaliana
F382EDVSQFDSKFT4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
F382QCIANFDKCWT2Arabidopsis thaliana, Arabidopsis thaliana
F382EDTSLFDARFT1Caenorhabditis elegans
G100RVLGKGGYGKV4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
G100KVVGQGAFGKV1Arabidopsis thaliana
G100KVVGKGAFGKV1Arabidopsis thaliana
G100KVLGKGGYGKV1Caenorhabditis elegans
G101VLGKGGYGKVF5Homo sapiens, Caenorhabditis elegans, Bos taurus, Mus musculus, Rattus norvegicus
G101VVGQGAFGKVY1Arabidopsis thaliana
G101VVGKGAFGKVY1Arabidopsis thaliana
G103GKGGYGKVFQV5Homo sapiens, Caenorhabditis elegans, Bos taurus, Mus musculus, Rattus norvegicus
G103GQGAFGKVYQV1Arabidopsis thaliana
G103GKGAFGKVYQV1Arabidopsis thaliana
G178EYLSGGELFMQ4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
G178DFINGGHLFFQ2Arabidopsis thaliana, Arabidopsis thaliana
G178EYLSGGELFMH1Caenorhabditis elegans
G98LLRVLGKGGYG4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
G98VLKVVGQGAFG1Arabidopsis thaliana
G98VMKVVGKGAFG1Arabidopsis thaliana
G98LLKVLGKGGYG1Caenorhabditis elegans
H245CKESIHDGTVT4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
H245AKE-FEENTRS2Arabidopsis thaliana, Arabidopsis thaliana
H245CKEEIEGDQKT1Caenorhabditis elegans
H251DGTVTHTFCGT4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
H251ENTRSNSMCGT2Arabidopsis thaliana, Arabidopsis thaliana
H251GDQKTHTFCGT1Caenorhabditis elegans
K104KGGYGKVFQVR5Homo sapiens, Caenorhabditis elegans, Bos taurus, Mus musculus, Rattus norvegicus
K104QGAFGKVYQVR1Arabidopsis thaliana
K104KGAFGKVYQVR1Arabidopsis thaliana
K123KIFAMKVLKKA4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
K123EIYAMKVMRKD2Arabidopsis thaliana, Arabidopsis thaliana
K123QIFAMKVLQKA1Caenorhabditis elegans
K241DFGLCKESIHD4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
K241DFGLAKE-FEE2Arabidopsis thaliana, Arabidopsis thaliana
K241DFGLCKEEIEG1Caenorhabditis elegans
K99LRVLGKGGYGK4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
K99LKVVGQGAFGK1Arabidopsis thaliana
K99MKVVGKGAFGK1Arabidopsis thaliana
K99LKVLGKGGYGK1Caenorhabditis elegans
L125FAMKVLKKAMI4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
L125YAMKVMRKDKI1Arabidopsis thaliana
L125YAMKVMRKDHI1Arabidopsis thaliana
L125FAMKVLQKATI1Caenorhabditis elegans
L172KLYLILEYLSG5Homo sapiens, Caenorhabditis elegans, Bos taurus, Mus musculus, Rattus norvegicus
L172RLYLVLDFING2Arabidopsis thaliana, Arabidopsis thaliana
L175LILEYLSGGEL5Homo sapiens, Caenorhabditis elegans, Bos taurus, Mus musculus, Rattus norvegicus
L175LVLDFINGGHL2Arabidopsis thaliana, Arabidopsis thaliana
L239LTDFGLCKESI4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
L239LTDFGLAKE-F2Arabidopsis thaliana, Arabidopsis thaliana
L239LTDFGLCKEEI1Caenorhabditis elegans
L97ELLRVLGKGGY4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
L97EVLKVVGQGAF1Arabidopsis thaliana
L97EVMKVVGKGAF1Arabidopsis thaliana
L97QLLKVLGKGGY1Caenorhabditis elegans
M182GGELFMQLERE4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
M182GGHLFFQLYHQ2Arabidopsis thaliana, Arabidopsis thaliana
M182GGELFMHLERE1Caenorhabditis elegans
M225KPENIMLNHQG4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
M225KPENILMDVDG1Arabidopsis thaliana
M225KPENILMDTDG1Arabidopsis thaliana
M225KPENILLDAYG1Caenorhabditis elegans
N223DLKPENIMLNH4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
N223DLKPENILMDV1Arabidopsis thaliana
N223DLKPENILMDT1Arabidopsis thaliana
N223DLKPENILLDA1Caenorhabditis elegans
T235GHVKLTDFGLC5Homo sapiens, Caenorhabditis elegans, Bos taurus, Mus musculus, Rattus norvegicus
T235GHVMLTDFGLA2Arabidopsis thaliana, Arabidopsis thaliana
V105GGYGKVFQVRK5Homo sapiens, Caenorhabditis elegans, Bos taurus, Mus musculus, Rattus norvegicus
V105GAFGKVYQVRK2Arabidopsis thaliana, Arabidopsis thaliana
V156KHPFIVDLIYA4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
V156DHPFIVQLKYS2Arabidopsis thaliana, Arabidopsis thaliana
V156KSPFICDLLYA1Caenorhabditis elegans
Y102LGKGGYGKVFQ5Homo sapiens, Caenorhabditis elegans, Bos taurus, Mus musculus, Rattus norvegicus
Y102VGQGAFGKVYQ1Arabidopsis thaliana
Y102VGKGAFGKVYQ1Arabidopsis thaliana
Y174YLILEYLSGGE5Homo sapiens, Caenorhabditis elegans, Bos taurus, Mus musculus, Rattus norvegicus
Y174YLVLDFINGGH2Arabidopsis thaliana, Arabidopsis thaliana


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