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mutLBSgeneDB |
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| Gene summary for RPS27 |
 Gene summary |
| Basic gene Info. | Gene symbol | RPS27 |
| Gene name | ribosomal protein S27 | |
| Synonyms | MPS-1|MPS1|S27 | |
| Cytomap | UCSC genome browser: 1q21 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001030.4, | |
| Description | 40S ribosomal protein S27metallopan-stimulin 1metallopanstimulin 1 | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 603702 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000177954 | ||
| HPRD : 04744 | ||
| Vega : OTTHUMG00000036591 | ||
| Protein | UniProt: P42677 go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_RPS27 | |
| BioGPS: 6232 | ||
| Pathway | NCI Pathway Interaction Database: RPS27 | |
| KEGG: RPS27 | ||
| REACTOME: RPS27 | ||
| Pathway Commons: RPS27 | ||
| Context | iHOP: RPS27 | |
| ligand binding site mutation search in PubMed: RPS27 | ||
| UCL Cancer Institute: RPS27 | ||
| Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. | |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO Term | PubMed ID |
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| Ligand binding site mutations for RPS27 |
| Cancer type specific mutLBS sorted by frequency |
| LBS | AAchange of nsSNV | Cancer type | # samples | F79 | S78F | SKCM | 1 | D34 | F32V | STAD | 1 | I43 | T44A | UCEC | 1 |
| cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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| Protein structure related information for RPS27 |
| Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
 : nsSNV at non-LBS : nsSNV at LBS |
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| nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
| LBS | AAchange of nsSNV | Relative stability change | F79 | S78F | 0.07097047 | D34 | F32V | -1.3014019 | I43 | T44A | -1.1528008 |
| (MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
| Structure image for RPS27 from PDB |
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| Differential gene expression and gene-gene network for RPS27 |
| Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
| Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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| Phenotype information for RPS27 |
| Gene level disease information (DisGeNet) |
| Disease ID | Disease name | # PubMed | Association type |
| Mutation level pathogenic information (ClinVar annotation) |
| Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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| Pharmacological information for RPS27 |
| Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
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| Drug information targeting mutLBSgene (Approved drugs only) |
| Drug status | DrugBank ID | Name | Type | Drug structure |
| Gene-centered ligand-gene interaction network |
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| Ligands binding to mutated ligand binding site of RPS27 go to BioLip |
| Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | NUC | Nucleic Acids | 5a2q | b | D34 I43 F79 | NUC | Nucleic Acids | 5flx | b | D34 I43 F79 |
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| Conservation information for LBS of RPS27 |
| Multiple alignments for P42677 in multiple species |
| LBS | AA sequence | # species | Species | C40 | VKCPGCYKITT | 3 | Homo sapiens, Bos taurus, Rattus norvegicus | C40 | VKCQGCFNITT | 3 | Arabidopsis thaliana, Arabidopsis thaliana, Arabidopsis thaliana | C40 | VKCPGCLNITT | 2 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | C40 | VKCPGCFNITT | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | C40 | VKCPGCFTITT | 1 | Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) | C40 | VKCSGCFKIST | 1 | Caenorhabditis elegans | D34 | NSYFMDVKCPG | 3 | Homo sapiens, Bos taurus, Rattus norvegicus | D34 | NSFFMDVKCQG | 3 | Arabidopsis thaliana, Arabidopsis thaliana, Arabidopsis thaliana | D34 | RSYFLDVKCPG | 2 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | D34 | RSFFMDVKCPG | 2 | Schizosaccharomyces pombe (strain 972 / ATCC 24843), Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) | D34 | NSYFMDVKCSG | 1 | Caenorhabditis elegans | F79 | TEGCSFRRKQH | 3 | Homo sapiens, Bos taurus, Rattus norvegicus | F79 | SEGTSFRRK-- | 2 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | F79 | QEGCSFRKK-- | 1 | Arabidopsis thaliana | F79 | TEGCSFRRKGD | 1 | Arabidopsis thaliana | F79 | TEGCSFRKK-- | 1 | Arabidopsis thaliana | F79 | MEGCSFRRKN- | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | F79 | TEGCSFRRK-- | 1 | Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) | F79 | TEGCSFRKKQ- | 1 | Caenorhabditis elegans | I43 | PGCYKITTVFS | 3 | Homo sapiens, Bos taurus, Rattus norvegicus | I43 | QGCFNITTVFS | 3 | Arabidopsis thaliana, Arabidopsis thaliana, Arabidopsis thaliana | I43 | PGCLNITTVFS | 2 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | I43 | PGCFNITTVFS | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | I43 | PGCFTITTVFS | 1 | Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) | I43 | SGCFKISTVFS | 1 | Caenorhabditis elegans | K36 | YFMDVKCPGCY | 3 | Homo sapiens, Bos taurus, Rattus norvegicus | K36 | FFMDVKCQGCF | 3 | Arabidopsis thaliana, Arabidopsis thaliana, Arabidopsis thaliana | K36 | YFLDVKCPGCL | 2 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | K36 | FFMDVKCPGCF | 2 | Schizosaccharomyces pombe (strain 972 / ATCC 24843), Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) | K36 | YFMDVKCSGCF | 1 | Caenorhabditis elegans | K42 | CPGCYKITTVF | 3 | Homo sapiens, Bos taurus, Rattus norvegicus | K42 | CQGCFNITTVF | 3 | Arabidopsis thaliana, Arabidopsis thaliana, Arabidopsis thaliana | K42 | CPGCLNITTVF | 2 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | K42 | CPGCFNITTVF | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | K42 | CPGCFTITTVF | 1 | Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) | K42 | CSGCFKISTVF | 1 | Caenorhabditis elegans | K82 | CSFRRKQH | 3 | Homo sapiens, Bos taurus, Rattus norvegicus | K82 | TSFRRK-- | 2 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | K82 | CSFRKK-- | 2 | Arabidopsis thaliana, Arabidopsis thaliana | K82 | CSFRRKGD | 1 | Arabidopsis thaliana | K82 | CSFRRKN- | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | K82 | CSFRRK-- | 1 | Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) | K82 | CSFRKKQ- | 1 | Caenorhabditis elegans | R80 | EGCSFRRKQH | 3 | Homo sapiens, Bos taurus, Rattus norvegicus | R80 | EGTSFRRK-- | 2 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | R80 | EGCSFRKK-- | 2 | Arabidopsis thaliana, Arabidopsis thaliana | R80 | EGCSFRRKGD | 1 | Arabidopsis thaliana | R80 | EGCSFRRKN- | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | R80 | EGCSFRRK-- | 1 | Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) | R80 | EGCSFRKKQ- | 1 | Caenorhabditis elegans | Y41 | KCPGCYKITTV | 3 | Homo sapiens, Bos taurus, Rattus norvegicus | Y41 | KCQGCFNITTV | 3 | Arabidopsis thaliana, Arabidopsis thaliana, Arabidopsis thaliana | Y41 | KCPGCLNITTV | 2 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | Y41 | KCPGCFNITTV | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | Y41 | KCPGCFTITTV | 1 | Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) | Y41 | KCSGCFKISTV | 1 | Caenorhabditis elegans |
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