mutLBSgeneDB

mutLBSgeneDB
mutated Ligand Binding Site gene DataBase

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Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for RPS28
Gene summary
Basic gene Info.Gene symbolRPS28
Gene nameribosomal protein S28
SynonymsS28
CytomapUCSC genome browser: 19p13.2
Type of geneprotein-coding
RefGenesNM_001031.4,
Description40S ribosomal protein S28
Modification date20141207
dbXrefs MIM : 603685
HGNC : HGNC
HPRD : 04731
ProteinUniProt: P62857
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_RPS28
BioGPS: 6234
PathwayNCI Pathway Interaction Database: RPS28
KEGG: RPS28
REACTOME: RPS28
Pathway Commons: RPS28
ContextiHOP: RPS28
ligand binding site mutation search in PubMed: RPS28
UCL Cancer Institute: RPS28
Assigned class in mutLBSgeneDBC: This gene just belongs to mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO TermPubMed ID


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Ligand binding site mutations for RPS28

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
R40R40QCOAD1
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.


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Protein structure related information for RPS28
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
R40R40Q-1.0017852
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for RPS28 from PDB

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Differential gene expression and gene-gene network for RPS28
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of RPS28 and the right PPI network was created from samples without mutations in the LBS of RPS28. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


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Phenotype information for RPS28
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type
umls:C0043094Weight Gain1Biomarker

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

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Pharmacological information for RPS28
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of RPS28 go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS
NUCNucleic Acids5flxcR40


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Conservation information for LBS of RPS28
Multiple alignments for P62857 in multiple species
LBSAA sequence# speciesSpecies
D36RVEFMDD-TSR6Homo sapiens, Schizosaccharomyces pombe (strain 972 / ATCC 24843), Schizosaccharomyces pombe (strain 972 / ATCC 24843), Bos taurus, Mus musculus, Rattus norvegicus
D36RVKFTD--SDR3Arabidopsis thaliana, Arabidopsis thaliana, Arabidopsis thaliana
D36RVEFLED-TSR2Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
D36KVEFLGE-QNR1Drosophila melanogaster
D36RVEFLED-TTR1Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
D36RVEFLDD-TSR1Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
D36RVEFMDD-QTR1Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
D36RVEFINDQNNR1Caenorhabditis elegans
D36RVEFMDD-SNR1Danio rerio
D37VEFMDD-TSRS6Homo sapiens, Schizosaccharomyces pombe (strain 972 / ATCC 24843), Schizosaccharomyces pombe (strain 972 / ATCC 24843), Bos taurus, Mus musculus, Rattus norvegicus
D37VKFTD--SDRY2Arabidopsis thaliana, Arabidopsis thaliana
D37VEFLED-TSRT2Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
D37VKFTD--SDRF1Arabidopsis thaliana
D37VEFLGE-QNRQ1Drosophila melanogaster
D37VEFLED-TTRT1Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
D37VEFLDD-TSRT1Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
D37VEFMDD-QTRS1Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
D37VEFINDQNNRS1Caenorhabditis elegans
D37VEFMDD-SNRS1Danio rerio
E33TQVRVEFMDD-8Homo sapiens, Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987), Schizosaccharomyces pombe (strain 972 / ATCC 24843), Schizosaccharomyces pombe (strain 972 / ATCC 24843), Bos taurus, Mus musculus, Rattus norvegicus, Dan
E33TQVRVKFTD--3Arabidopsis thaliana, Arabidopsis thaliana, Arabidopsis thaliana
E33TQVRVEFLED-3Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37), Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
E33TQVKVEFLGE-1Drosophila melanogaster
E33TQVRVEFLDD-1Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
E33TQVRVEFINDQ1Caenorhabditis elegans
I43TSRSIIRNVKG6Homo sapiens, Schizosaccharomyces pombe (strain 972 / ATCC 24843), Schizosaccharomyces pombe (strain 972 / ATCC 24843), Bos taurus, Mus musculus, Rattus norvegicus
I43TSRTIVRNVKG3Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
I43SDRYIMRNVKG2Arabidopsis thaliana, Arabidopsis thaliana
I43SDRFIMRNVKG1Arabidopsis thaliana
I43QNRQIIRNVKG1Drosophila melanogaster
I43TTRTIVRNVKG1Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
I43QTRSIIRNVKG1Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
I43NNRSIIRNVKG1Caenorhabditis elegans
I43SNRSIIRNVKG1Danio rerio
K16LAKVIKVLGRT6Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37), Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Ashbya gossypii (strain ATCC 10895 / CBS 109.51
K16LARVTKVLGRT5Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus, Danio rerio
K16HAVVVKVMGRT3Arabidopsis thaliana, Arabidopsis thaliana, Arabidopsis thaliana
K16WARVMKVLGRT1Drosophila melanogaster
K16LVKVTRVLGRT1Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
K16LARVTKVIGRT1Caenorhabditis elegans
L18KVIKVLGRTGS6Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37), Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Ashbya gossypii (strain ATCC 10895 / CBS 109.51
L18RVTKVLGRTGS5Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus, Danio rerio
L18VVVKVMGRTGS3Arabidopsis thaliana, Arabidopsis thaliana, Arabidopsis thaliana
L18RVMKVLGRTGS1Drosophila melanogaster
L18KVTRVLGRTGS1Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
L18RVTKVIGRTGS1Caenorhabditis elegans
Q29RGGVTQVRVEF7Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37), Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Ashbya gossypii (strain ATCC 10895 / CBS 109.51
Q29QGQCTQVRVEF6Homo sapiens, Caenorhabditis elegans, Bos taurus, Mus musculus, Rattus norvegicus, Danio rerio
Q29RGQVTQVRVKF3Arabidopsis thaliana, Arabidopsis thaliana, Arabidopsis thaliana
Q29QGQCTQVKVEF1Drosophila melanogaster
R31QCTQVRVEFMD5Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus, Danio rerio
R31QVTQVRVKFTD3Arabidopsis thaliana, Arabidopsis thaliana, Arabidopsis thaliana
R31GVTQVRVEFLE3Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37), Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
R31GVTQVRVEFMD3Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987), Schizosaccharomyces pombe (strain 972 / ATCC 24843), Schizosaccharomyces pombe (strain 972 / ATCC 24843)
R31QCTQVKVEFLG1Drosophila melanogaster
R31GVTQVRVEFLD1Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
R31QCTQVRVEFIN1Caenorhabditis elegans
R40DD-TSRSIIRN6Homo sapiens, Schizosaccharomyces pombe (strain 972 / ATCC 24843), Schizosaccharomyces pombe (strain 972 / ATCC 24843), Bos taurus, Mus musculus, Rattus norvegicus
R40D--SDRYIMRN2Arabidopsis thaliana, Arabidopsis thaliana
R40ED-TSRTIVRN2Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
R40D--SDRFIMRN1Arabidopsis thaliana
R40GE-QNRQIIRN1Drosophila melanogaster
R40ED-TTRTIVRN1Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
R40DD-TSRTIVRN1Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
R40DD-QTRSIIRN1Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
R40NDQNNRSIIRN1Caenorhabditis elegans
R40DD-SNRSIIRN1Danio rerio
R517Homo sapiens, Arabidopsis thaliana, Arabidopsis thaliana, Arabidopsis thaliana, Drosophila melanogaster, Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37), Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
R66SEREARRLR17Homo sapiens, Arabidopsis thaliana, Arabidopsis thaliana, Arabidopsis thaliana, Drosophila melanogaster, Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37), Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
R67EREARRLR17Homo sapiens, Arabidopsis thaliana, Arabidopsis thaliana, Arabidopsis thaliana, Drosophila melanogaster, Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37), Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
S39MDD-TSRSIIR6Homo sapiens, Schizosaccharomyces pombe (strain 972 / ATCC 24843), Schizosaccharomyces pombe (strain 972 / ATCC 24843), Bos taurus, Mus musculus, Rattus norvegicus
S39TD--SDRYIMR2Arabidopsis thaliana, Arabidopsis thaliana
S39LED-TSRTIVR2Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
S39TD--SDRFIMR1Arabidopsis thaliana
S39LGE-QNRQIIR1Drosophila melanogaster
S39LED-TTRTIVR1Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
S39LDD-TSRTIVR1Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
S39MDD-QTRSIIR1Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
S39INDQNNRSIIR1Caenorhabditis elegans
S39MDD-SNRSIIR1Danio rerio
S41D-TSRSIIRNV6Homo sapiens, Schizosaccharomyces pombe (strain 972 / ATCC 24843), Schizosaccharomyces pombe (strain 972 / ATCC 24843), Bos taurus, Mus musculus, Rattus norvegicus
S41D-TSRTIVRNV3Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
S41--SDRYIMRNV2Arabidopsis thaliana, Arabidopsis thaliana
S41--SDRFIMRNV1Arabidopsis thaliana
S41E-QNRQIIRNV1Drosophila melanogaster
S41D-TTRTIVRNV1Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
S41D-QTRSIIRNV1Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
S41DQNNRSIIRNV1Caenorhabditis elegans
S41D-SNRSIIRNV1Danio rerio
T38FMDD-TSRSII6Homo sapiens, Schizosaccharomyces pombe (strain 972 / ATCC 24843), Schizosaccharomyces pombe (strain 972 / ATCC 24843), Bos taurus, Mus musculus, Rattus norvegicus
T38FTD--SDRYIM2Arabidopsis thaliana, Arabidopsis thaliana
T38FLED-TSRTIV2Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
T38FTD--SDRFIM1Arabidopsis thaliana
T38FLGE-QNRQII1Drosophila melanogaster
T38FLED-TTRTIV1Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
T38FLDD-TSRTIV1Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
T38FMDD-QTRSII1Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
T38FINDQNNRSII1Caenorhabditis elegans
T38FMDD-SNRSII1Danio rerio


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