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mutLBSgeneDB |
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| Gene summary for CLIP1 |
 Gene summary |
| Basic gene Info. | Gene symbol | CLIP1 |
| Gene name | CAP-GLY domain containing linker protein 1 | |
| Synonyms | CLIP|CLIP-170|CLIP170|CYLN1|RSN | |
| Cytomap | UCSC genome browser: 12q24.3 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001247997.1, NM_002956.2,NM_198240.1, | |
| Description | CAP-Gly domain-containing linker protein 1cytoplasmic linker protein 1cytoplasmic linker protein 170 alpha-2cytoplasmic linker protein CLIP-170restin (Reed-Steinberg cell-expressed intermediate filament-associated protein) | |
| Modification date | 20141222 | |
| dbXrefs | MIM : 179838 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000130779 | ||
| HPRD : 01568 | ||
| Vega : OTTHUMG00000168922 | ||
| Protein | UniProt: P30622 go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_CLIP1 | |
| BioGPS: 6249 | ||
| Pathway | NCI Pathway Interaction Database: CLIP1 | |
| KEGG: CLIP1 | ||
| REACTOME: CLIP1 | ||
| Pathway Commons: CLIP1 | ||
| Context | iHOP: CLIP1 | |
| ligand binding site mutation search in PubMed: CLIP1 | ||
| UCL Cancer Institute: CLIP1 | ||
| Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. | |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO Term | PubMed ID |
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| Ligand binding site mutations for CLIP1 |
| Lollipop-style diagram of mutations at LBS in amino-acid sequence. We represented ligand binding site mutations only. (You can see big image via clicking.)  : non-synonymous mutation on LBS, Circle size denotes number of samples. |
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| Cancer type specific mutLBS sorted by frequency |
| LBS | AAchange of nsSNV | Cancer type | # samples | W87 | W87L | LUAD | 1 | W87 | W87L | LUSC | 1 |
| cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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| Protein structure related information for CLIP1 |
| Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
 : nsSNV at non-LBS : nsSNV at LBS |
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| nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
| LBS | AAchange of nsSNV | Relative stability change | W87 | W87L | -0.47763002 |
| (MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
| Structure image for CLIP1 from PDB |
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| Differential gene expression and gene-gene network for CLIP1 |
| Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
| Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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| Phenotype information for CLIP1 |
| Gene level disease information (DisGeNet) |
| Disease ID | Disease name | # PubMed | Association type |
| Mutation level pathogenic information (ClinVar annotation) |
| Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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| Pharmacological information for CLIP1 |
| Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
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| Drug information targeting mutLBSgene (Approved drugs only) |
| Drug status | DrugBank ID | Name | Type | Drug structure |
| Gene-centered ligand-gene interaction network |
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| Ligands binding to mutated ligand binding site of CLIP1 go to BioLip |
| Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | III | Peptide ligand (ASP,SER,TRP,LYS,ASP,GLY,CYS,TYR) | 3rdv | A | W87 | III | Peptide ligand (ASP,SER,TRP,LYS,ASP,GLY,CYS,TYR) | 3rdv | B | W87 | III | Peptide ligand (SER,TRP,LYS,ASP,GLY,CYS,TYR) | 3rdv | C | W87 | III | Peptide ligand (ASP,SER,TRP,LYS,ASP,GLY,CYS,TYR) | 3rdv | D | W87 |
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| Conservation information for LBS of CLIP1 |
| Multiple alignments for P30622 in multiple species |
| LBS | AA sequence | # species | Species | A273 | KYGLFAPVHKV | 2 | Homo sapiens, Mus musculus | A273 | RYGLFAPVHKV | 1 | Gallus gallus | F118 | PLKGIFTRPSK | 2 | Homo sapiens, Mus musculus | F118 | PLRGIFTRPSK | 1 | Gallus gallus | F236 | LGETDFAKGEW | 3 | Homo sapiens, Gallus gallus, Mus musculus | F272 | PKYGLFAPVHK | 2 | Homo sapiens, Mus musculus | F272 | PRYGLFAPVHK | 1 | Gallus gallus | F82 | LGETQFAPGQW | 3 | Homo sapiens, Gallus gallus, Mus musculus | G97 | LDEPIGKNDGS | 3 | Homo sapiens, Gallus gallus, Mus musculus | I117 | EPLKGIFTRPS | 2 | Homo sapiens, Mus musculus | I117 | EPLRGIFTRPS | 1 | Gallus gallus | I96 | VLDEPIGKNDG | 3 | Homo sapiens, Gallus gallus, Mus musculus | K252 | DEPLGKNDGAV | 3 | Homo sapiens, Gallus gallus, Mus musculus | K277 | FAPVHKVTKIG | 3 | Homo sapiens, Gallus gallus, Mus musculus | K98 | DEPIGKNDGSV | 3 | Homo sapiens, Gallus gallus, Mus musculus | L271 | QPKYGLFAPVH | 2 | Homo sapiens, Mus musculus | L271 | QPRYGLFAPVH | 1 | Gallus gallus | N253 | EPLGKNDGAVA | 3 | Homo sapiens, Gallus gallus, Mus musculus | N67 | ERVWVNGNKPG | 3 | Homo sapiens, Gallus gallus, Mus musculus | N99 | EPIGKNDGSVA | 3 | Homo sapiens, Gallus gallus, Mus musculus | P274 | YGLFAPVHKVT | 3 | Homo sapiens, Gallus gallus, Mus musculus | T119 | LKGIFTRPSKL | 2 | Homo sapiens, Mus musculus | T119 | LRGIFTRPSKL | 1 | Gallus gallus | V66 | GERVWVNGNKP | 3 | Homo sapiens, Gallus gallus, Mus musculus | W241 | FAKGEWCGVEL | 3 | Homo sapiens, Gallus gallus, Mus musculus | W87 | FAPGQWAGIVL | 3 | Homo sapiens, Gallus gallus, Mus musculus |
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