mutLBSgeneDB |
Gene summary for S100A10 |
Gene summary |
Basic gene Info. | Gene symbol | S100A10 |
Gene name | S100 calcium binding protein A10 | |
Synonyms | 42C|ANX2L|ANX2LG|CAL1L|CLP11|Ca[1]|GP11|P11|p10 | |
Cytomap | UCSC genome browser: 1q21 | |
Type of gene | protein-coding | |
RefGenes | NM_002966.2, | |
Description | S100 calcium binding protein A10 (annexin II ligand, calpactin I, light polypeptide (p11))S100 calcium-binding protein A10 (annexin II ligand, calpactin I, light polypeptide (p11))annexin II ligand, calpactin I, light polypeptideannexin II tetramer (AI | |
Modification date | 20141207 | |
dbXrefs | MIM : 114085 | |
HGNC : HGNC | ||
Ensembl : ENSG00000197747 | ||
HPRD : 00232 | ||
Vega : OTTHUMG00000013068 | ||
Protein | UniProt: P60903 go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_S100A10 | |
BioGPS: 6281 | ||
Pathway | NCI Pathway Interaction Database: S100A10 | |
KEGG: S100A10 | ||
REACTOME: S100A10 | ||
Pathway Commons: S100A10 | ||
Context | iHOP: S100A10 | |
ligand binding site mutation search in PubMed: S100A10 | ||
UCL Cancer Institute: S100A10 | ||
Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO Term | PubMed ID | GO:0001765 | membrane raft assembly | 23861394 | GO:0006900 | membrane budding | 23861394 | GO:0051290 | protein heterotetramerization | 23091277 | GO:0090002 | establishment of protein localization to plasma membrane | 12198146 |
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Ligand binding site mutations for S100A10 |
Cancer type specific mutLBS sorted by frequency |
LBS | AAchange of nsSNV | Cancer type | # samples | Q61 | Q61H | HNSC | 1 | N45,L43 | E44K | SKCM | 1 | P2 | P2L | SKCM | 1 | P2 | M1I | SKCM | 1 | Q70 | S71G | UCEC | 1 |
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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Protein structure related information for S100A10 |
Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
: nsSNV at non-LBS: nsSNV at LBS |
nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
LBS | AAchange of nsSNV | Relative stability change | Q70 | S71G | -1.1475523 | Q61 | Q61H | -1.0643721 | N45 | E44K | -0.82446072 | L43 | E44K | -0.82446072 | P2 | M1I | -0.50923928 | P2 | P2L | -0.17671985 |
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
Structure image for S100A10 from PDB |
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Differential gene expression and gene-gene network for S100A10 |
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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Phenotype information for S100A10 |
Gene level disease information (DisGeNet) |
Disease ID | Disease name | # PubMed | Association type |
umls:C0025149 | Medulloblastoma | 1 | Biomarker |
umls:C0022548 | Keloid | 1 | Biomarker |
umls:C0023467 | Leukemia, Myeloid, Acute | 1 | Biomarker |
Mutation level pathogenic information (ClinVar annotation) |
Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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Pharmacological information for S100A10 |
Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
Drug information targeting mutLBSgene (Approved drugs only) |
Drug status | DrugBank ID | Name | Type | Drug structure |
Gene-centered ligand-gene interaction network |
Ligands binding to mutated ligand binding site of S100A10 go to BioLip |
Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS |
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Conservation information for LBS of S100A10 |
Multiple alignments for P60903 in multiple species |
LBS | AA sequence | # species | Species | A51 | QKDPLAVDKIM | 5 | Homo sapiens, Macaca mulatta, Bos taurus, Mus musculus, Rattus norvegicus | A51 | QRDPMALDKIM | 1 | Gallus gallus | A77 | FFSLIAGLTIA | 3 | Homo sapiens, Macaca mulatta, Bos taurus | A77 | FFSLVAGLTIA | 1 | Gallus gallus | A77 | FLSLVAGLTIA | 1 | Mus musculus | A77 | FLSLVAGLIIA | 1 | Rattus norvegicus | A82 | AGLTIACNDYF | 5 | Homo sapiens, Gallus gallus, Macaca mulatta, Bos taurus, Mus musculus | A82 | AGLIIACNDYF | 1 | Rattus norvegicus | C83 | GLTIACNDYFV | 5 | Homo sapiens, Gallus gallus, Macaca mulatta, Bos taurus, Mus musculus | C83 | GLIIACNDYFV | 1 | Rattus norvegicus | D58 | DKIMKDLDQCR | 6 | Homo sapiens, Gallus gallus, Macaca mulatta, Bos taurus, Mus musculus, Rattus norvegicus | D60 | IMKDLDQCRDG | 6 | Homo sapiens, Gallus gallus, Macaca mulatta, Bos taurus, Mus musculus, Rattus norvegicus | D85 | TIACNDYFVVH | 4 | Homo sapiens, Gallus gallus, Macaca mulatta, Bos taurus | D85 | TIACNDYFVVN | 1 | Mus musculus | D85 | IIACNDYFVVH | 1 | Rattus norvegicus | E10 | MEHAMETMMFT | 3 | Homo sapiens, Macaca mulatta, Bos taurus | E10 | MEHAMETMMLT | 2 | Mus musculus, Rattus norvegicus | E10 | MEHAMETLMFT | 1 | Gallus gallus | E6 | MPSQMEHAMET | 6 | Homo sapiens, Gallus gallus, Macaca mulatta, Bos taurus, Mus musculus, Rattus norvegicus | F14 | METMMFTFHKF | 3 | Homo sapiens, Macaca mulatta, Bos taurus | F14 | METMMLTFHRF | 2 | Mus musculus, Rattus norvegicus | F14 | METLMFTFHKY | 1 | Gallus gallus | F39 | LMEKEFPGFLE | 4 | Homo sapiens, Gallus gallus, Macaca mulatta, Bos taurus | F39 | LMEREFPGFLE | 2 | Mus musculus, Rattus norvegicus | F42 | KEFPGFLENQK | 3 | Homo sapiens, Macaca mulatta, Bos taurus | F42 | REFPGFLENQK | 2 | Mus musculus, Rattus norvegicus | F42 | KEFPGFLENQR | 1 | Gallus gallus | F87 | ACNDYFVVHMK | 5 | Homo sapiens, Gallus gallus, Macaca mulatta, Bos taurus, Rattus norvegicus | F87 | ACNDYFVVNMK | 1 | Mus musculus | G41 | EKEFPGFLENQ | 4 | Homo sapiens, Gallus gallus, Macaca mulatta, Bos taurus | G41 | EREFPGFLENQ | 2 | Mus musculus, Rattus norvegicus | G78 | FSLIAGLTIAC | 3 | Homo sapiens, Macaca mulatta, Bos taurus | G78 | FSLVAGLTIAC | 1 | Gallus gallus | G78 | LSLVAGLTIAC | 1 | Mus musculus | G78 | LSLVAGLIIAC | 1 | Rattus norvegicus | H7 | PSQMEHAMETM | 5 | Homo sapiens, Macaca mulatta, Bos taurus, Mus musculus, Rattus norvegicus | H7 | PSQMEHAMETL | 1 | Gallus gallus | I55 | LAVDKIMKDLD | 5 | Homo sapiens, Macaca mulatta, Bos taurus, Mus musculus, Rattus norvegicus | I55 | MALDKIMKDLD | 1 | Gallus gallus | I81 | IAGLTIACNDY | 3 | Homo sapiens, Macaca mulatta, Bos taurus | I81 | VAGLTIACNDY | 2 | Gallus gallus, Mus musculus | I81 | VAGLIIACNDY | 1 | Rattus norvegicus | K54 | PLAVDKIMKDL | 5 | Homo sapiens, Macaca mulatta, Bos taurus, Mus musculus, Rattus norvegicus | K54 | PMALDKIMKDL | 1 | Gallus gallus | L43 | EFPGFLENQKD | 5 | Homo sapiens, Macaca mulatta, Bos taurus, Mus musculus, Rattus norvegicus | L43 | EFPGFLENQRD | 1 | Gallus gallus | L59 | KIMKDLDQCRD | 6 | Homo sapiens, Gallus gallus, Macaca mulatta, Bos taurus, Mus musculus, Rattus norvegicus | L75 | QSFFSLIAGLT | 3 | Homo sapiens, Macaca mulatta, Bos taurus | L75 | QSFFSLVAGLT | 1 | Gallus gallus | L75 | QSFLSLVAGLT | 1 | Mus musculus | L75 | QSFLSLVAGLI | 1 | Rattus norvegicus | L79 | SLIAGLTIACN | 3 | Homo sapiens, Macaca mulatta, Bos taurus | L79 | SLVAGLTIACN | 2 | Gallus gallus, Mus musculus | L79 | SLVAGLIIACN | 1 | Rattus norvegicus | M13 | AMETMMFTFHK | 3 | Homo sapiens, Macaca mulatta, Bos taurus | M13 | AMETMMLTFHR | 2 | Mus musculus, Rattus norvegicus | M13 | AMETLMFTFHK | 1 | Gallus gallus | M56 | AVDKIMKDLDQ | 5 | Homo sapiens, Macaca mulatta, Bos taurus, Mus musculus, Rattus norvegicus | M56 | ALDKIMKDLDQ | 1 | Gallus gallus | M9 | QMEHAMETMMF | 3 | Homo sapiens, Macaca mulatta, Bos taurus | M9 | QMEHAMETMML | 2 | Mus musculus, Rattus norvegicus | M9 | QMEHAMETLMF | 1 | Gallus gallus | N45 | PGFLENQKDPL | 5 | Homo sapiens, Macaca mulatta, Bos taurus, Mus musculus, Rattus norvegicus | N45 | PGFLENQRDPM | 1 | Gallus gallus | P2 | 6 | Homo sapiens, Gallus gallus, Macaca mulatta, Bos taurus, Mus musculus, Rattus norvegicus | Q46 | GFLENQKDPLA | 5 | Homo sapiens, Macaca mulatta, Bos taurus, Mus musculus, Rattus norvegicus | Q46 | GFLENQRDPMA | 1 | Gallus gallus | Q61 | MKDLDQCRDGK | 6 | Homo sapiens, Gallus gallus, Macaca mulatta, Bos taurus, Mus musculus, Rattus norvegicus | Q70 | GKVGFQSFFSL | 4 | Homo sapiens, Gallus gallus, Macaca mulatta, Bos taurus | Q70 | GKVGFQSFLSL | 2 | Mus musculus, Rattus norvegicus | S74 | FQSFFSLIAGL | 3 | Homo sapiens, Macaca mulatta, Bos taurus | S74 | FQSFLSLVAGL | 2 | Mus musculus, Rattus norvegicus | S74 | FQSFFSLVAGL | 1 | Gallus gallus | Y86 | IACNDYFVVHM | 5 | Homo sapiens, Gallus gallus, Macaca mulatta, Bos taurus, Rattus norvegicus | Y86 | IACNDYFVVNM | 1 | Mus musculus |
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