mutLBSgeneDB

mutLBSgeneDB
mutated Ligand Binding Site gene DataBase

Home

Download

 Statistics

Help

About Us

Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for S100A10
Gene summary
Basic gene Info.Gene symbolS100A10
Gene nameS100 calcium binding protein A10
Synonyms42C|ANX2L|ANX2LG|CAL1L|CLP11|Ca[1]|GP11|P11|p10
CytomapUCSC genome browser: 1q21
Type of geneprotein-coding
RefGenesNM_002966.2,
DescriptionS100 calcium binding protein A10 (annexin II ligand, calpactin I, light polypeptide (p11))S100 calcium-binding protein A10 (annexin II ligand, calpactin I, light polypeptide (p11))annexin II ligand, calpactin I, light polypeptideannexin II tetramer (AI
Modification date20141207
dbXrefs MIM : 114085
HGNC : HGNC
Ensembl : ENSG00000197747
HPRD : 00232
Vega : OTTHUMG00000013068
ProteinUniProt: P60903
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_S100A10
BioGPS: 6281
PathwayNCI Pathway Interaction Database: S100A10
KEGG: S100A10
REACTOME: S100A10
Pathway Commons: S100A10
ContextiHOP: S100A10
ligand binding site mutation search in PubMed: S100A10
UCL Cancer Institute: S100A10
Assigned class in mutLBSgeneDBC: This gene just belongs to mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO TermPubMed ID
GO:0001765membrane raft assembly23861394
GO:0006900membrane budding23861394
GO:0051290protein heterotetramerization23091277
GO:0090002establishment of protein localization to plasma membrane12198146


Top
Ligand binding site mutations for S100A10

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
Q61Q61HHNSC1
N45,L43E44KSKCM1
P2P2LSKCM1
P2M1ISKCM1
Q70S71GUCEC1
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.


Top
Protein structure related information for S100A10
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
Q70S71G-1.1475523
Q61Q61H-1.0643721
N45E44K-0.82446072
L43E44K-0.82446072
P2M1I-0.50923928
P2P2L-0.17671985
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for S100A10 from PDB

Top
Differential gene expression and gene-gene network for S100A10
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of S100A10 and the right PPI network was created from samples without mutations in the LBS of S100A10. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


Top

Top
Phenotype information for S100A10
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type
umls:C0025149Medulloblastoma1Biomarker
umls:C0022548Keloid1Biomarker
umls:C0023467Leukemia, Myeloid, Acute1Biomarker

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

Top
Pharmacological information for S100A10
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of S100A10 go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS


Top
Conservation information for LBS of S100A10
Multiple alignments for P60903 in multiple species
LBSAA sequence# speciesSpecies
A51QKDPLAVDKIM5Homo sapiens, Macaca mulatta, Bos taurus, Mus musculus, Rattus norvegicus
A51QRDPMALDKIM1Gallus gallus
A77FFSLIAGLTIA3Homo sapiens, Macaca mulatta, Bos taurus
A77FFSLVAGLTIA1Gallus gallus
A77FLSLVAGLTIA1Mus musculus
A77FLSLVAGLIIA1Rattus norvegicus
A82AGLTIACNDYF5Homo sapiens, Gallus gallus, Macaca mulatta, Bos taurus, Mus musculus
A82AGLIIACNDYF1Rattus norvegicus
C83GLTIACNDYFV5Homo sapiens, Gallus gallus, Macaca mulatta, Bos taurus, Mus musculus
C83GLIIACNDYFV1Rattus norvegicus
D58DKIMKDLDQCR6Homo sapiens, Gallus gallus, Macaca mulatta, Bos taurus, Mus musculus, Rattus norvegicus
D60IMKDLDQCRDG6Homo sapiens, Gallus gallus, Macaca mulatta, Bos taurus, Mus musculus, Rattus norvegicus
D85TIACNDYFVVH4Homo sapiens, Gallus gallus, Macaca mulatta, Bos taurus
D85TIACNDYFVVN1Mus musculus
D85IIACNDYFVVH1Rattus norvegicus
E10MEHAMETMMFT3Homo sapiens, Macaca mulatta, Bos taurus
E10MEHAMETMMLT2Mus musculus, Rattus norvegicus
E10MEHAMETLMFT1Gallus gallus
E6MPSQMEHAMET6Homo sapiens, Gallus gallus, Macaca mulatta, Bos taurus, Mus musculus, Rattus norvegicus
F14METMMFTFHKF3Homo sapiens, Macaca mulatta, Bos taurus
F14METMMLTFHRF2Mus musculus, Rattus norvegicus
F14METLMFTFHKY1Gallus gallus
F39LMEKEFPGFLE4Homo sapiens, Gallus gallus, Macaca mulatta, Bos taurus
F39LMEREFPGFLE2Mus musculus, Rattus norvegicus
F42KEFPGFLENQK3Homo sapiens, Macaca mulatta, Bos taurus
F42REFPGFLENQK2Mus musculus, Rattus norvegicus
F42KEFPGFLENQR1Gallus gallus
F87ACNDYFVVHMK5Homo sapiens, Gallus gallus, Macaca mulatta, Bos taurus, Rattus norvegicus
F87ACNDYFVVNMK1Mus musculus
G41EKEFPGFLENQ4Homo sapiens, Gallus gallus, Macaca mulatta, Bos taurus
G41EREFPGFLENQ2Mus musculus, Rattus norvegicus
G78FSLIAGLTIAC3Homo sapiens, Macaca mulatta, Bos taurus
G78FSLVAGLTIAC1Gallus gallus
G78LSLVAGLTIAC1Mus musculus
G78LSLVAGLIIAC1Rattus norvegicus
H7PSQMEHAMETM5Homo sapiens, Macaca mulatta, Bos taurus, Mus musculus, Rattus norvegicus
H7PSQMEHAMETL1Gallus gallus
I55LAVDKIMKDLD5Homo sapiens, Macaca mulatta, Bos taurus, Mus musculus, Rattus norvegicus
I55MALDKIMKDLD1Gallus gallus
I81IAGLTIACNDY3Homo sapiens, Macaca mulatta, Bos taurus
I81VAGLTIACNDY2Gallus gallus, Mus musculus
I81VAGLIIACNDY1Rattus norvegicus
K54PLAVDKIMKDL5Homo sapiens, Macaca mulatta, Bos taurus, Mus musculus, Rattus norvegicus
K54PMALDKIMKDL1Gallus gallus
L43EFPGFLENQKD5Homo sapiens, Macaca mulatta, Bos taurus, Mus musculus, Rattus norvegicus
L43EFPGFLENQRD1Gallus gallus
L59KIMKDLDQCRD6Homo sapiens, Gallus gallus, Macaca mulatta, Bos taurus, Mus musculus, Rattus norvegicus
L75QSFFSLIAGLT3Homo sapiens, Macaca mulatta, Bos taurus
L75QSFFSLVAGLT1Gallus gallus
L75QSFLSLVAGLT1Mus musculus
L75QSFLSLVAGLI1Rattus norvegicus
L79SLIAGLTIACN3Homo sapiens, Macaca mulatta, Bos taurus
L79SLVAGLTIACN2Gallus gallus, Mus musculus
L79SLVAGLIIACN1Rattus norvegicus
M13AMETMMFTFHK3Homo sapiens, Macaca mulatta, Bos taurus
M13AMETMMLTFHR2Mus musculus, Rattus norvegicus
M13AMETLMFTFHK1Gallus gallus
M56AVDKIMKDLDQ5Homo sapiens, Macaca mulatta, Bos taurus, Mus musculus, Rattus norvegicus
M56ALDKIMKDLDQ1Gallus gallus
M9QMEHAMETMMF3Homo sapiens, Macaca mulatta, Bos taurus
M9QMEHAMETMML2Mus musculus, Rattus norvegicus
M9QMEHAMETLMF1Gallus gallus
N45PGFLENQKDPL5Homo sapiens, Macaca mulatta, Bos taurus, Mus musculus, Rattus norvegicus
N45PGFLENQRDPM1Gallus gallus
P26Homo sapiens, Gallus gallus, Macaca mulatta, Bos taurus, Mus musculus, Rattus norvegicus
Q46GFLENQKDPLA5Homo sapiens, Macaca mulatta, Bos taurus, Mus musculus, Rattus norvegicus
Q46GFLENQRDPMA1Gallus gallus
Q61MKDLDQCRDGK6Homo sapiens, Gallus gallus, Macaca mulatta, Bos taurus, Mus musculus, Rattus norvegicus
Q70GKVGFQSFFSL4Homo sapiens, Gallus gallus, Macaca mulatta, Bos taurus
Q70GKVGFQSFLSL2Mus musculus, Rattus norvegicus
S74FQSFFSLIAGL3Homo sapiens, Macaca mulatta, Bos taurus
S74FQSFLSLVAGL2Mus musculus, Rattus norvegicus
S74FQSFFSLVAGL1Gallus gallus
Y86IACNDYFVVHM5Homo sapiens, Gallus gallus, Macaca mulatta, Bos taurus, Rattus norvegicus
Y86IACNDYFVVNM1Mus musculus


Copyright © 2016-Present - The University of Texas Health Science Center at Houston
Site Policies | State of Texas