mutLBSgeneDB

mutLBSgeneDB
mutated Ligand Binding Site gene DataBase

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Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for SARS
Gene summary
Basic gene Info.Gene symbolSARS
Gene nameseryl-tRNA synthetase
SynonymsSERRS|SERS
CytomapUCSC genome browser: 1p13.3
Type of geneprotein-coding
RefGenesNM_006513.3,
NR_034072.1,NR_034073.1,
DescriptionSeryl-tRNA Ser/Sec synthetaseserine tRNA ligase 1, cytoplasmicserine--tRNA ligase, cytoplasmicseryl-tRNA synthetase, cytoplasmicseryl-tRNA(Ser/Sec) synthetase
Modification date20141207
dbXrefs MIM : 607529
HGNC : HGNC
Ensembl : ENSG00000031698
HPRD : 09605
Vega : OTTHUMG00000011726
ProteinUniProt: P49591
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_SARS
BioGPS: 6301
PathwayNCI Pathway Interaction Database: SARS
KEGG: SARS
REACTOME: SARS
Pathway Commons: SARS
ContextiHOP: SARS
ligand binding site mutation search in PubMed: SARS
UCL Cancer Institute: SARS
Assigned class in mutLBSgeneDBC: This gene just belongs to mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO TermPubMed ID


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Ligand binding site mutations for SARS

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
W43E42QBLCA1
D378D378YBRCA1
E246D244VBRCA1
F48R47SLUAD1
R44R45QLUSC1
R44R45QOV1
A432A432TSTAD1
N58K57NUCEC1
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.


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Protein structure related information for SARS
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
E246D244V0.18401516
R44R45Q-0.92539706
A432A432T-0.88080958
N58K57N-0.81133723
W43E42Q-0.79543364
F48R47S-0.79300174
D378D378Y-0.46856392
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for SARS from PDB

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Differential gene expression and gene-gene network for SARS
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of SARS and the right PPI network was created from samples without mutations in the LBS of SARS. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


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Phenotype information for SARS
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

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Pharmacological information for SARS
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.

Gene-centered drug-gene interaction network
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure
Approved|nutraceuticalDB00133L-SerineSmall molecule

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of SARS go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS
SSA5'-O-(N-(L-SERYL)-SULFAMOYL)ADENOSINE4l87AA432
ANPAMP-PNP4rqeAA432
ANPAMP-PNP4rqeCA432
ANPAMP-PNP4rqfAA432
ANPAMP-PNP4rqfBA432
MGMAGNESIUM(2+)4l87AD378
MGMAGNESIUM(2+)4l87AE246
NUCNucleic Acids4rqeCR44 F48 N58
NUCNucleic Acids4rqeAR44 N58
NUCNucleic Acids4rqfAW43 R44 F48 N58


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Conservation information for LBS of SARS
Multiple alignments for P49591 in multiple species
LBSAA sequence# speciesSpecies
A428VHMLNATMCAT4Homo sapiens, Caenorhabditis elegans, Bos taurus, Rattus norvegicus
A428VHMLNSTLTAT1Arabidopsis thaliana
A428VHCLNSTLAAT1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
A428VHCLNSTLCAT1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
A432NATMCATTRTI3Homo sapiens, Bos taurus, Rattus norvegicus
A432NATMCATTRVI1Caenorhabditis elegans
A432NSTLTATERTI1Arabidopsis thaliana
A432NSTLAATQRAL1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
A432NSTLCATERAL1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
D378ASKKLDLEAWF3Homo sapiens, Bos taurus, Rattus norvegicus
D378AAKKYDLEAWF3Arabidopsis thaliana, Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Schizosaccharomyces pombe (strain 972 / ATCC 24843)
D378AAKKFDLEAWF1Caenorhabditis elegans
D51CRFRADNLNKL3Homo sapiens, Bos taurus, Rattus norvegicus
D51ERFVADQLNRQ1Caenorhabditis elegans
D51RQFEVDSFRKE1Arabidopsis thaliana
D51TRFELDELNKK1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
D51LRFELDNTNKS1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
E246SQFDEELYKVI3Homo sapiens, Bos taurus, Rattus norvegicus
E246SQFDDELYKVS1Caenorhabditis elegans
E246AQFDEELYKVT1Arabidopsis thaliana
E246SEFDEELYKVI1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
E246EQFDEELYKVI1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
E273LIATSEQPIAA4Homo sapiens, Caenorhabditis elegans, Bos taurus, Rattus norvegicus
E273LIATSEQPISA2Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Schizosaccharomyces pombe (strain 972 / ATCC 24843)
E273LIATAEQPLCA1Arabidopsis thaliana
E304TCFRQEVGSHG4Homo sapiens, Caenorhabditis elegans, Bos taurus, Rattus norvegicus
E304SCFRKEAGSHG1Arabidopsis thaliana
E304SCFRREAGSHG1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
E304TCYRREAGSHG1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
E325QFEKIEQFVYS3Homo sapiens, Bos taurus, Rattus norvegicus
E325QFEKIEQFVLC1Caenorhabditis elegans
E325QFEKIEQFCIT1Arabidopsis thaliana
E325AFEKIEQFVIT1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
E325AFEKIEQFVLT1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
E391SGAFRELVSCS3Homo sapiens, Bos taurus, Rattus norvegicus
E391SGAYRELVSCS1Caenorhabditis elegans
E391SETFRELVSCS1Arabidopsis thaliana
E391QKEYKELVSCS1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
E391QGEYKELVSCS1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
F316DTRGIFRVHQF4Homo sapiens, Caenorhabditis elegans, Bos taurus, Rattus norvegicus
F316DTLGIFRVHQF1Arabidopsis thaliana
F316DAWGVFRVHAF1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
F316DAWGIFRVHAF1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
F321FRVHQFEKIEQ5Homo sapiens, Caenorhabditis elegans, Bos taurus, Rattus norvegicus, Arabidopsis thaliana
F321FRVHAFEKIEQ2Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Schizosaccharomyces pombe (strain 972 / ATCC 24843)
F48WRRCRFRADNL3Homo sapiens, Bos taurus, Rattus norvegicus
F48WRKERFVADQL1Caenorhabditis elegans
F48WRQRQFEVDSF1Arabidopsis thaliana
F48WVKTRFELDEL1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
F48WVSLRFELDNT1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
I64LCSKTIGEKMK3Homo sapiens, Bos taurus, Rattus norvegicus
I64AISKAIGEKMK1Caenorhabditis elegans
I64KLNKQVAQLKI1Arabidopsis thaliana
I64KLQKDIGLKFK1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
I64RVQKEIGLKMK1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
K323VHQFEKIEQFV4Homo sapiens, Caenorhabditis elegans, Bos taurus, Rattus norvegicus
K323VHAFEKIEQFV2Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Schizosaccharomyces pombe (strain 972 / ATCC 24843)
K323VHQFEKIEQFC1Arabidopsis thaliana
K376HAASKKLDLEA3Homo sapiens, Bos taurus, Rattus norvegicus
K376NAAAKKYDLEA2Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Schizosaccharomyces pombe (strain 972 / ATCC 24843)
K376NAAAKKFDLEA1Caenorhabditis elegans
K376DAAAKKYDLEA1Arabidopsis thaliana
K55ADNLNKLKNLC3Homo sapiens, Bos taurus, Rattus norvegicus
K55ADQLNRQKNAI1Caenorhabditis elegans
K55VDSFRKEFNKL1Arabidopsis thaliana
K55LDELNKKFNKL1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
K55LDNTNKSINRV1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
L392GAFRELVSCSN3Homo sapiens, Bos taurus, Rattus norvegicus
L392GAYRELVSCSN1Caenorhabditis elegans
L392ETFRELVSCSN1Arabidopsis thaliana
L392KEYKELVSCSN1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
L392GEYKELVSCSN1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
N427FVHMLNATMCA4Homo sapiens, Caenorhabditis elegans, Bos taurus, Rattus norvegicus
N427YVHMLNSTLTA1Arabidopsis thaliana
N427YVHCLNSTLAA1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
N427YVHCLNSTLCA1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
N54RADNLNKLKNL3Homo sapiens, Bos taurus, Rattus norvegicus
N54VADQLNRQKNA1Caenorhabditis elegans
N54EVDSFRKEFNK1Arabidopsis thaliana
N54ELDELNKKFNK1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
N54ELDNTNKSINR1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
N58LNKLKNLCSKT3Homo sapiens, Bos taurus, Rattus norvegicus
N58LNRQKNAISKA1Caenorhabditis elegans
N58FRKEFNKLNKQ1Arabidopsis thaliana
N58LNKKFNKLQKD1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
N58TNKSINRVQKE1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
R302LSTCFRQEVGS2Homo sapiens, Bos taurus
R302VSTCFRQEVGS1Caenorhabditis elegans
R302FSTCFRQEVGS1Rattus norvegicus
R302YSSCFRKEAGS1Arabidopsis thaliana
R302YSSCFRREAGS1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
R302YSTCYRREAGS1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
R317TRGIFRVHQFE4Homo sapiens, Caenorhabditis elegans, Bos taurus, Rattus norvegicus
R317TLGIFRVHQFE1Arabidopsis thaliana
R317AWGVFRVHAFE1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
R317AWGIFRVHAFE1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
R435MCATTRTICAI3Homo sapiens, Bos taurus, Rattus norvegicus
R435MCATTRVICAI1Caenorhabditis elegans
R435LTATERTICCI1Arabidopsis thaliana
R435LAATQRALCCI1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
R435LCATERALCCI1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
R44ADSEWRRCRFR3Homo sapiens, Bos taurus, Rattus norvegicus
R44LDEKWRKERFV1Caenorhabditis elegans
R44LDKEWRQRQFE1Arabidopsis thaliana
R44DYKDWVKTRFE1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
R44MYKEWVSLRFE1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
R9DLDLFRVDKGG3Homo sapiens, Bos taurus, Rattus norvegicus
R9DIDMFRTEKGG1Caenorhabditis elegans
R9DINLFREEKGN1Arabidopsis thaliana
R9DINQFIEDKGG1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
R9DINLFQVEKGG1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
S394FRELVSCSNCT4Homo sapiens, Bos taurus, Rattus norvegicus, Arabidopsis thaliana
S394YKELVSCSNCT2Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Schizosaccharomyces pombe (strain 972 / ATCC 24843)
S394YRELVSCSNCL1Caenorhabditis elegans
S61LKNLCSKTIGE3Homo sapiens, Bos taurus, Rattus norvegicus
S61QKNAISKAIGE1Caenorhabditis elegans
S61EFNKLNKQVAQ1Arabidopsis thaliana
S61KFNKLQKDIGL1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
S61SINRVQKEIGL1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
T271KYLIATSEQPI5Homo sapiens, Caenorhabditis elegans, Bos taurus, Rattus norvegicus, Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
T271KYLIATAEQPL1Arabidopsis thaliana
T271RYLIATSEQPI1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
T429HMLNATMCATT4Homo sapiens, Caenorhabditis elegans, Bos taurus, Rattus norvegicus
T429HMLNSTLTATE1Arabidopsis thaliana
T429HCLNSTLAATQ1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
T429HCLNSTLCATE1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
T434TMCATTRTICA3Homo sapiens, Bos taurus, Rattus norvegicus
T434TMCATTRVICA1Caenorhabditis elegans
T434TLTATERTICC1Arabidopsis thaliana
T434TLAATQRALCC1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
T434TLCATERALCC1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
V318RGIFRVHQFEK4Homo sapiens, Caenorhabditis elegans, Bos taurus, Rattus norvegicus
V318LGIFRVHQFEK1Arabidopsis thaliana
V318WGVFRVHAFEK1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
V318WGIFRVHAFEK1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
V393AFRELVSCSNC3Homo sapiens, Bos taurus, Rattus norvegicus
V393EYKELVSCSNC2Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Schizosaccharomyces pombe (strain 972 / ATCC 24843)
V393AYRELVSCSNC1Caenorhabditis elegans
V393TFRELVSCSNC1Arabidopsis thaliana
W43KADSEWRRCRF3Homo sapiens, Bos taurus, Rattus norvegicus
W43ELDEKWRKERF1Caenorhabditis elegans
W43KLDKEWRQRQF1Arabidopsis thaliana
W43SDYKDWVKTRF1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
W43EMYKEWVSLRF1Schizosaccharomyces pombe (strain 972 / ATCC 24843)


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