|
mutLBSgeneDB |
| |
| |
| |
| |
| |
| |
|
| Gene summary for SPARC |
 Gene summary |
| Basic gene Info. | Gene symbol | SPARC |
| Gene name | secreted protein, acidic, cysteine-rich (osteonectin) | |
| Synonyms | ON | |
| Cytomap | UCSC genome browser: 5q31.3-q32 | |
| Type of gene | protein-coding | |
| RefGenes | NM_003118.3, | |
| Description | BM-40basement-membrane protein 40cysteine-rich proteinosteonectinsecreted protein acidic and rich in cysteine | |
| Modification date | 20141222 | |
| dbXrefs | MIM : 182120 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000113140 | ||
| HPRD : 01631 | ||
| Vega : OTTHUMG00000130122 | ||
| Protein | UniProt: P09486 go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_SPARC | |
| BioGPS: 6678 | ||
| Pathway | NCI Pathway Interaction Database: SPARC | |
| KEGG: SPARC | ||
| REACTOME: SPARC | ||
| Pathway Commons: SPARC | ||
| Context | iHOP: SPARC | |
| ligand binding site mutation search in PubMed: SPARC | ||
| UCL Cancer Institute: SPARC | ||
| Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. | |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO Term | PubMed ID | GO:0001937 | negative regulation of endothelial cell proliferation | 12867428 | GO:0010595 | positive regulation of endothelial cell migration | 12867428 | GO:0016525 | negative regulation of angiogenesis | 12867428 | GO:0022604 | regulation of cell morphogenesis | 15389586 |
| Top |
| Ligand binding site mutations for SPARC |
| Cancer type specific mutLBS sorted by frequency |
| LBS | AAchange of nsSNV | Cancer type | # samples | Y280 | A282T | COAD | 1 | E285 | A287V | COAD | 1 | D274 | D274A | LUAD | 1 | P258 | R256P | LUAD | 1 | E285 | A287V | STAD | 1 | E263 | E263K | STAD | 1 | Y280 | A282T | STAD | 1 |
| cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
| Top |
| Protein structure related information for SPARC |
| Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
 : nsSNV at non-LBS : nsSNV at LBS |
 |
| nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
| LBS | AAchange of nsSNV | Relative stability change | E263 | E263K | -1.4019439 | Y280 | A282T | -0.9686823 | D274 | D274A | -0.76831758 | P258 | R256P | -0.5184732 | E285 | A287V | -0.19124592 |
| (MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
| Structure image for SPARC from PDB |
| Top |
| Differential gene expression and gene-gene network for SPARC |
| Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
| Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
| Top |
| Top |
| Phenotype information for SPARC |
| Gene level disease information (DisGeNet) |
| Disease ID | Disease name | # PubMed | Association type |
| umls:C0022658 | Kidney Diseases | 3 | Biomarker |
| umls:C0023467 | Leukemia, Myeloid, Acute | 3 | Biomarker |
| umls:C0023893 | Liver Cirrhosis, Experimental | 2 | Biomarker, Therapeutic |
| umls:C0919267 | Ovarian Neoplasms | 2 | AlteredExpression, Biomarker |
| umls:C0158266 | Intervertebral Disc Degeneration | 2 | Biomarker |
| umls:C0026764 | Multiple Myeloma | 2 | Biomarker |
| umls:C0029434 | Osteogenesis Imperfecta | 2 | Biomarker |
| umls:C0009375 | Colonic Neoplasms | 1 | Biomarker, PostTranslationalModification |
| umls:C0206686 | Adrenocortical Carcinoma | 1 | Biomarker |
| umls:C0009404 | Colorectal Neoplasms | 1 | Biomarker |
| umls:C0019158 | Hepatitis | 1 | Biomarker |
| umls:C0020429 | Hyperalgesia | 1 | Biomarker |
| umls:C0023890 | Liver Cirrhosis | 1 | Biomarker |
| umls:C0024031 | Low Back Pain | 1 | Biomarker |
| umls:C0151744 | Myocardial Ischemia | 1 | Biomarker |
| umls:C0027540 | Necrosis | 1 | Biomarker |
| umls:C0027659 | Neoplasms, Experimental | 1 | Therapeutic |
| umls:C0041948 | Uremia | 1 | Biomarker |
| umls:C0043094 | Weight Gain | 1 | Biomarker |
| Mutation level pathogenic information (ClinVar annotation) |
| Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
| Top |
| Pharmacological information for SPARC |
| Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
 |
| Drug information targeting mutLBSgene (Approved drugs only) |
| Drug status | DrugBank ID | Name | Type | Drug structure |
| Gene-centered ligand-gene interaction network |
 |
| Ligands binding to mutated ligand binding site of SPARC go to BioLip |
| Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS |
| Top |
| Conservation information for LBS of SPARC |
| Multiple alignments for P09486 in multiple species |
| LBS | AA sequence | # species | Species | D239 | QFGQLDQHPID | 5 | Homo sapiens, Gallus gallus, Bos taurus, Mus musculus, Rattus norvegicus | D244 | DQHPIDGYLSH | 5 | Homo sapiens, Gallus gallus, Bos taurus, Mus musculus, Rattus norvegicus | D274 | FFETCDLDNDK | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | D274 | FFEACDLDFDK | 1 | Gallus gallus | D276 | ETCDLDNDKYI | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | D276 | EACDLDFDKYI | 1 | Gallus gallus | D278 | CDLDNDKYIAL | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | D278 | CDLDFDKYIAL | 1 | Gallus gallus | E251 | YLSHTELAPLR | 5 | Homo sapiens, Gallus gallus, Bos taurus, Mus musculus, Rattus norvegicus | E263 | PLIPMEHCTTR | 5 | Homo sapiens, Gallus gallus, Bos taurus, Mus musculus, Rattus norvegicus | E285 | YIALDEWAGCF | 2 | Homo sapiens, Bos taurus | E285 | YIALEEWAGCF | 2 | Mus musculus, Rattus norvegicus | E285 | YIALEEWASCF | 1 | Gallus gallus | H241 | GQLDQHPIDGY | 5 | Homo sapiens, Gallus gallus, Bos taurus, Mus musculus, Rattus norvegicus | I260 | LRAPLIPMEHC | 5 | Homo sapiens, Gallus gallus, Bos taurus, Mus musculus, Rattus norvegicus | L259 | PLRAPLIPMEH | 5 | Homo sapiens, Gallus gallus, Bos taurus, Mus musculus, Rattus norvegicus | P242 | QLDQHPIDGYL | 5 | Homo sapiens, Gallus gallus, Bos taurus, Mus musculus, Rattus norvegicus | P258 | APLRAPLIPME | 5 | Homo sapiens, Gallus gallus, Bos taurus, Mus musculus, Rattus norvegicus | Q240 | FGQLDQHPIDG | 5 | Homo sapiens, Gallus gallus, Bos taurus, Mus musculus, Rattus norvegicus | Y246 | HPIDGYLSHTE | 5 | Homo sapiens, Gallus gallus, Bos taurus, Mus musculus, Rattus norvegicus | Y280 | LDNDKYIALDE | 2 | Homo sapiens, Bos taurus | Y280 | LDNDKYIALEE | 2 | Mus musculus, Rattus norvegicus | Y280 | LDFDKYIALEE | 1 | Gallus gallus |
 |
Copyright © 2016-Present - The University of Texas Health Science Center at Houston |