mutated Ligand Binding Site gene DataBase





About Us

Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for SPARC
Gene summary
Basic gene Info.Gene symbolSPARC
Gene namesecreted protein, acidic, cysteine-rich (osteonectin)
CytomapUCSC genome browser: 5q31.3-q32
Type of geneprotein-coding
DescriptionBM-40basement-membrane protein 40cysteine-rich proteinosteonectinsecreted protein acidic and rich in cysteine
Modification date20141222
dbXrefs MIM : 182120
Ensembl : ENSG00000113140
HPRD : 01631
Vega : OTTHUMG00000130122
ProteinUniProt: P09486
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_SPARC
BioGPS: 6678
PathwayNCI Pathway Interaction Database: SPARC
Pathway Commons: SPARC
ContextiHOP: SPARC
ligand binding site mutation search in PubMed: SPARC
UCL Cancer Institute: SPARC
Assigned class in mutLBSgeneDBC: This gene just belongs to mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO:0001937negative regulation of endothelial cell proliferation12867428
GO:0010595positive regulation of endothelial cell migration12867428
GO:0016525negative regulation of angiogenesis12867428
GO:0022604regulation of cell morphogenesis15389586

Ligand binding site mutations for SPARC

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.

Protein structure related information for SPARC
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for SPARC from PDB

Differential gene expression and gene-gene network for SPARC
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of SPARC and the right PPI network was created from samples without mutations in the LBS of SPARC. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


Phenotype information for SPARC
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type
umls:C0022658Kidney Diseases3Biomarker
umls:C0023467Leukemia, Myeloid, Acute3Biomarker
umls:C0023893Liver Cirrhosis, Experimental2Biomarker, Therapeutic
umls:C0919267Ovarian Neoplasms2AlteredExpression, Biomarker
umls:C0158266Intervertebral Disc Degeneration2Biomarker
umls:C0026764Multiple Myeloma2Biomarker
umls:C0029434Osteogenesis Imperfecta2Biomarker
umls:C0009375Colonic Neoplasms1Biomarker, PostTranslationalModification
umls:C0206686Adrenocortical Carcinoma1Biomarker
umls:C0009404Colorectal Neoplasms1Biomarker
umls:C0023890Liver Cirrhosis1Biomarker
umls:C0024031Low Back Pain1Biomarker
umls:C0151744Myocardial Ischemia1Biomarker
umls:C0027659Neoplasms, Experimental1Therapeutic
umls:C0043094Weight Gain1Biomarker

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

Pharmacological information for SPARC
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of SPARC go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS

Conservation information for LBS of SPARC
Multiple alignments for P09486 in multiple species
LBSAA sequence# speciesSpecies
D239QFGQLDQHPID5Homo sapiens, Gallus gallus, Bos taurus, Mus musculus, Rattus norvegicus
D244DQHPIDGYLSH5Homo sapiens, Gallus gallus, Bos taurus, Mus musculus, Rattus norvegicus
D274FFETCDLDNDK4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
D274FFEACDLDFDK1Gallus gallus
D276ETCDLDNDKYI4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
D276EACDLDFDKYI1Gallus gallus
D278CDLDNDKYIAL4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
D278CDLDFDKYIAL1Gallus gallus
E251YLSHTELAPLR5Homo sapiens, Gallus gallus, Bos taurus, Mus musculus, Rattus norvegicus
E263PLIPMEHCTTR5Homo sapiens, Gallus gallus, Bos taurus, Mus musculus, Rattus norvegicus
E285YIALDEWAGCF2Homo sapiens, Bos taurus
E285YIALEEWAGCF2Mus musculus, Rattus norvegicus
E285YIALEEWASCF1Gallus gallus
H241GQLDQHPIDGY5Homo sapiens, Gallus gallus, Bos taurus, Mus musculus, Rattus norvegicus
I260LRAPLIPMEHC5Homo sapiens, Gallus gallus, Bos taurus, Mus musculus, Rattus norvegicus
L259PLRAPLIPMEH5Homo sapiens, Gallus gallus, Bos taurus, Mus musculus, Rattus norvegicus
P242QLDQHPIDGYL5Homo sapiens, Gallus gallus, Bos taurus, Mus musculus, Rattus norvegicus
P258APLRAPLIPME5Homo sapiens, Gallus gallus, Bos taurus, Mus musculus, Rattus norvegicus
Q240FGQLDQHPIDG5Homo sapiens, Gallus gallus, Bos taurus, Mus musculus, Rattus norvegicus
Y246HPIDGYLSHTE5Homo sapiens, Gallus gallus, Bos taurus, Mus musculus, Rattus norvegicus
Y280LDNDKYIALDE2Homo sapiens, Bos taurus
Y280LDNDKYIALEE2Mus musculus, Rattus norvegicus
Y280LDFDKYIALEE1Gallus gallus

Copyright © 2016-Present - The University of Texas Health Science Center at Houston
Site Policies | State of Texas