mutLBSgeneDB |
Gene summary for SRP54 |
Gene summary |
Basic gene Info. | Gene symbol | SRP54 |
Gene name | signal recognition particle 54kDa | |
Synonyms | - | |
Cytomap | UCSC genome browser: 14q13.2 | |
Type of gene | protein-coding | |
RefGenes | NM_001146282.1, NM_003136.3, | |
Description | signal recognition particle 54 kDa proteinsignal recognition particle 54kD | |
Modification date | 20141207 | |
dbXrefs | MIM : 604857 | |
HGNC : HGNC | ||
Ensembl : ENSG00000100883 | ||
HPRD : 05330 | ||
Vega : OTTHUMG00000140214 | ||
Protein | UniProt: P61011 go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_SRP54 | |
BioGPS: 6729 | ||
Pathway | NCI Pathway Interaction Database: SRP54 | |
KEGG: SRP54 | ||
REACTOME: SRP54 | ||
Pathway Commons: SRP54 | ||
Context | iHOP: SRP54 | |
ligand binding site mutation search in PubMed: SRP54 | ||
UCL Cancer Institute: SRP54 | ||
Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO Term | PubMed ID | GO:0006184 | GTP catabolic process | 8247130 | GO:0042493 | response to drug | 18089836 |
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Ligand binding site mutations for SRP54 |
Lollipop-style diagram of mutations at LBS in amino-acid sequence. We represented ligand binding site mutations only. (You can see big image via clicking.) : non-synonymous mutation on LBS, Circle size denotes number of samples. |
Cancer type specific mutLBS sorted by frequency |
LBS | AAchange of nsSNV | Cancer type | # samples | D380 | D380A | BRCA | 1 | Q399 | K398E | COAD | 1 |
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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Protein structure related information for SRP54 |
Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
: nsSNV at non-LBS: nsSNV at LBS |
nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
LBS | AAchange of nsSNV | Relative stability change | D380 | D380A | -0.92254235 | Q399 | K398E | -0.14601255 |
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
Structure image for SRP54 from PDB |
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Differential gene expression and gene-gene network for SRP54 |
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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Phenotype information for SRP54 |
Gene level disease information (DisGeNet) |
Disease ID | Disease name | # PubMed | Association type |
Mutation level pathogenic information (ClinVar annotation) |
Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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Pharmacological information for SRP54 |
Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
Drug information targeting mutLBSgene (Approved drugs only) |
Drug status | DrugBank ID | Name | Type | Drug structure |
Gene-centered ligand-gene interaction network |
Ligands binding to mutated ligand binding site of SRP54 go to BioLip |
Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | NUC | Nucleic Acids | 1mfq | C | D380 Q399 |
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Conservation information for LBS of SRP54 |
Multiple alignments for P61011 in multiple species |
LBS | AA sequence | # species | Species | D380 | LMTIMDSMNDQ | 6 | Homo sapiens, Rattus norvegicus, Canis lupus familiaris, Bos taurus, Mus musculus, Mus musculus | D380 | YMTMMDSMTND | 1 | Arabidopsis thaliana | D380 | MVYVLDSMTKE | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | D380 | MLYIVDSMTEQ | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | G401 | FSKQPGRIQRV | 6 | Homo sapiens, Rattus norvegicus, Canis lupus familiaris, Bos taurus, Mus musculus, Mus musculus | G401 | FNE--SRMMRI | 1 | Arabidopsis thaliana | G401 | FIEEPTRMVRV | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | G401 | FVEQPSRVLRV | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | G409 | QRVARGSGVST | 6 | Homo sapiens, Rattus norvegicus, Canis lupus familiaris, Bos taurus, Mus musculus, Mus musculus | G409 | MRIARGSGRQV | 1 | Arabidopsis thaliana | G409 | VRVAKGSGTSV | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | G409 | LRVARGSGTSV | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | G411 | VARGSGVSTRD | 6 | Homo sapiens, Rattus norvegicus, Canis lupus familiaris, Bos taurus, Mus musculus, Mus musculus | G411 | IARGSGRQVRE | 1 | Arabidopsis thaliana | G411 | VAKGSGTSVFE | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | G411 | VARGSGTSVLE | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | M382 | TIMDSMNDQEL | 6 | Homo sapiens, Rattus norvegicus, Canis lupus familiaris, Bos taurus, Mus musculus, Mus musculus | M382 | TMMDSMTNDEL | 1 | Arabidopsis thaliana | M382 | YVLDSMTKEEL | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | M382 | YIVDSMTEQEL | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | N383 | IMDSMNDQELD | 6 | Homo sapiens, Rattus norvegicus, Canis lupus familiaris, Bos taurus, Mus musculus, Mus musculus | N383 | MMDSMTNDELD | 1 | Arabidopsis thaliana | N383 | VLDSMTKEELE | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | N383 | IVDSMTEQELD | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | Q399 | KVFSKQPGRIQ | 6 | Homo sapiens, Rattus norvegicus, Canis lupus familiaris, Bos taurus, Mus musculus, Mus musculus | Q399 | KVFNE--SRMM | 1 | Arabidopsis thaliana | Q399 | RMFIEEPTRMV | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | Q399 | LLFVEQPSRVL | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | R402 | SKQPGRIQRVA | 6 | Homo sapiens, Rattus norvegicus, Canis lupus familiaris, Bos taurus, Mus musculus, Mus musculus | R402 | NE--SRMMRIA | 1 | Arabidopsis thaliana | R402 | IEEPTRMVRVA | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | R402 | VEQPSRVLRVA | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | R405 | PGRIQRVARGS | 6 | Homo sapiens, Rattus norvegicus, Canis lupus familiaris, Bos taurus, Mus musculus, Mus musculus | R405 | -SRMMRIARGS | 1 | Arabidopsis thaliana | R405 | PTRMVRVAKGS | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | R405 | PSRVLRVARGS | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | S381 | MTIMDSMNDQE | 6 | Homo sapiens, Rattus norvegicus, Canis lupus familiaris, Bos taurus, Mus musculus, Mus musculus | S381 | MTMMDSMTNDE | 1 | Arabidopsis thaliana | S381 | VYVLDSMTKEE | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | S381 | LYIVDSMTEQE | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | S410 | RVARGSGVSTR | 6 | Homo sapiens, Rattus norvegicus, Canis lupus familiaris, Bos taurus, Mus musculus, Mus musculus | S410 | RIARGSGRQVR | 1 | Arabidopsis thaliana | S410 | RVAKGSGTSVF | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | S410 | RVARGSGTSVL | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | T377 | LKKLMTIMDSM | 6 | Homo sapiens, Rattus norvegicus, Canis lupus familiaris, Bos taurus, Mus musculus, Mus musculus | T377 | IKRYMTMMDSM | 1 | Arabidopsis thaliana | T377 | MKKMVYVLDSM | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | T377 | MKRMLYIVDSM | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) |
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