mutLBSgeneDB

mutLBSgeneDB
mutated Ligand Binding Site gene DataBase

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Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for TNF
Gene summary
Basic gene Info.Gene symbolTNF
Gene nametumor necrosis factor
SynonymsDIF|TNF-alpha|TNFA|TNFSF2
CytomapUCSC genome browser: 6p21.3
Type of geneprotein-coding
RefGenesNM_000594.3,
DescriptionAPC1 proteinTNF, macrophage-derivedTNF, monocyte-derivedTNF-acachectintumor necrosis factor ligand superfamily member 2tumor necrosis factor-alpha
Modification date20141222
dbXrefs MIM : 191160
HGNC : HGNC
Ensembl : ENSG00000232810
HPRD : 01855
Vega : OTTHUMG00000031194
ProteinUniProt: P01375
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_TNF
BioGPS: 7124
PathwayNCI Pathway Interaction Database: TNF
KEGG: TNF
REACTOME: TNF
Pathway Commons: TNF
ContextiHOP: TNF
ligand binding site mutation search in PubMed: TNF
UCL Cancer Institute: TNF
Assigned class in mutLBSgeneDBA: This gene has a literature evidence and it belongs to targetable_mutLBSgenes.
References showing study about ligand binding site mutation for TNF.1. "Loetscher H, Stueber D, Banner D, Mackay F, Lesslauer W. Human tumor necrosis factor alpha (TNF alpha) mutants with exclusive specificity for the 55-kDa or 75-kDa TNF receptors. J Biol Chem. 1993 Dec 15;268(35):26350-7." 8253759

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO TermPubMed ID
GO:0000060protein import into nucleus, translocation16280327
GO:0000122negative regulation of transcription from RNA polymerase II promoter15345745
GO:0000185activation of MAPKKK activity15310755
GO:0000187activation of MAPK activity10748004
GO:0001819positive regulation of cytokine production17922812
GO:0001934positive regulation of protein phosphorylation10748004
GO:0002740negative regulation of cytokine secretion involved in immune response10443688
GO:0006919activation of cysteine-type endopeptidase activity involved in apoptotic process16723520
GO:0006927transformed cell apoptotic process3883195
GO:0006954inflammatory response10748004
GO:0008625extrinsic apoptotic signaling pathway via death domain receptors10521396
GO:0009615response to virus10490959
GO:0010628positive regulation of gene expression21559518
GO:0010629negative regulation of gene expression15345745
GO:0030730sequestering of triglyceride19032770
GO:0031334positive regulation of protein complex assembly12813029
GO:0031663lipopolysaccharide-mediated signaling pathway21147091
GO:0032715negative regulation of interleukin-6 production10443688
GO:0032722positive regulation of chemokine production10490959
GO:0032800receptor biosynthetic process10443688
GO:0033138positive regulation of peptidyl-serine phosphorylation17389591
GO:0034116positive regulation of heterotypic cell-cell adhesion10604883
GO:0042346positive regulation of NF-kappaB import into nucleus17922812
GO:0043065positive regulation of apoptotic process16723520
GO:0043068positive regulation of programmed cell death16611992
GO:0043122regulation of I-kappaB kinase/NF-kappaB signaling10748004
GO:0043123positive regulation of I-kappaB kinase/NF-kappaB signaling15310755
GO:0043242negative regulation of protein complex disassembly17389591
GO:0043243positive regulation of protein complex disassembly12813029
GO:0043280positive regulation of cysteine-type endopeptidase activity involved in apoptotic process11577081
GO:0043406positive regulation of MAP kinase activity12813029
GO:0043507positive regulation of JUN kinase activity17389591
GO:0045071negative regulation of viral genome replication10490959
GO:0045080positive regulation of chemokine biosynthetic process10490959
GO:0045416positive regulation of interleukin-8 biosynthetic process20551324
GO:0045429positive regulation of nitric oxide biosynthetic process8383325
GO:0045672positive regulation of osteoclast differentiation17888176
GO:0045892negative regulation of transcription, DNA-templated16895791
GO:0045893positive regulation of transcription, DNA-templated10748004
GO:0045944positive regulation of transcription from RNA polymerase II promoter15345745
GO:0048661positive regulation of smooth muscle cell proliferation16518841
GO:0050715positive regulation of cytokine secretion10443688
GO:0050796regulation of insulin secretion8383325
GO:0050901leukocyte tethering or rolling10820279
GO:0050995negative regulation of lipid catabolic process19032770
GO:0051044positive regulation of membrane protein ectodomain proteolysis18373975
GO:0051091positive regulation of sequence-specific DNA binding transcription factor activity10748004
GO:0051092positive regulation of NF-kappaB transcription factor activity10383454
GO:0051222positive regulation of protein transport15310755
GO:0051384response to glucocorticoid10443688
GO:0051533positive regulation of NFAT protein import into nucleus16803872
GO:0060557positive regulation of vitamin D biosynthetic process1690216
GO:0060559positive regulation of calcidiol 1-monooxygenase activity1690216
GO:0061048negative regulation of branching involved in lung morphogenesis17350185
GO:0071316cellular response to nicotine18676776
GO:0071407cellular response to organic cyclic compound21147091
GO:0071803positive regulation of podosome assembly15220135
GO:0097191extrinsic apoptotic signaling pathway11577081
GO:0097527necroptotic signaling pathway11101870
GO:2000010positive regulation of protein localization to cell surface19366699
GO:2000343positive regulation of chemokine (C-X-C motif) ligand 2 production20551324
GO:2001240negative regulation of extrinsic apoptotic signaling pathway in absence of ligand10666185


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Ligand binding site mutations for TNF

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
L133L133RSTAD1
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.


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Protein structure related information for TNF
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
L133L133R-1.0232201
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for TNF from PDB

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Differential gene expression and gene-gene network for TNF
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of TNF and the right PPI network was created from samples without mutations in the LBS of TNF. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


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Phenotype information for TNF
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type
umls:C0003873Arthritis, Rheumatoid485AlteredExpression, Biomarker, GeneticVariation, Therapeutic
umls:C0028754Obesity158Biomarker, GeneticVariation
umls:C0004096Asthma119Biomarker, GeneticVariation
umls:C0011860Diabetes Mellitus, Type 2105AlteredExpression, Biomarker, GeneticVariation
umls:C0010346Crohn Disease104AlteredExpression, Biomarker, GeneticVariation, Therapeutic
umls:C0021390Inflammatory Bowel Diseases96Biomarker, GeneticVariation
umls:C0243026Sepsis95AlteredExpression, Biomarker, GeneticVariation, Therapeutic
umls:C0033860Psoriasis87AlteredExpression, Biomarker, GeneticVariation
umls:C0011854Diabetes Mellitus, Type 180AlteredExpression, Biomarker, GeneticVariation
umls:C0025202Melanoma67AlteredExpression, Biomarker, GeneticVariation, Therapeutic
umls:C0021368Inflammation63AlteredExpression, Biomarker, GeneticVariation
umls:C0004153Atherosclerosis63AlteredExpression, Biomarker, GeneticVariation
umls:C0009324Colitis, Ulcerative60Biomarker, GeneticVariation
umls:C0024117Pulmonary Disease, Chronic Obstructive50AlteredExpression, Biomarker, GeneticVariation
umls:C0017638Glioma50AlteredExpression, Biomarker
umls:C0023903Liver Neoplasms48Biomarker, GeneticVariation
umls:C0027627Neoplasm Metastasis48AlteredExpression, Biomarker, GeneticVariation
umls:C0024530Malaria45Biomarker, GeneticVariation
umls:C0038454Stroke37AlteredExpression, Biomarker, GeneticVariation
umls:C0036341Schizophrenia36Biomarker, GeneticVariation
umls:C0038356Stomach Neoplasms35AlteredExpression, Biomarker, GeneticVariation, Therapeutic
umls:C0018801Heart Failure34AlteredExpression, Biomarker, GeneticVariation, Therapeutic
umls:C0002395Alzheimer Disease33Biomarker, GeneticVariation
umls:C0009319Colitis33Biomarker
umls:C0020538Hypertension32Biomarker, GeneticVariation
umls:C0003872Arthritis, Psoriatic32Biomarker, GeneticVariation
umls:C0027051Myocardial Infarction30AlteredExpression, Biomarker, GeneticVariation
umls:C3714514Infection25AlteredExpression, Biomarker, GeneticVariation
umls:C0023895Liver Diseases25Biomarker, GeneticVariation
umls:C1458155Breast Neoplasms23AlteredExpression, Biomarker, GeneticVariation
umls:C0001418Adenocarcinoma23AlteredExpression, Biomarker, GeneticVariation, Therapeutic
umls:C0006625Cachexia21Biomarker, GeneticVariation
umls:C0002871Anemia20AlteredExpression, Biomarker
umls:C0022661Kidney Failure, Chronic18Biomarker, GeneticVariation
umls:C0032285Pneumonia18Biomarker, GeneticVariation
umls:C0015695Fatty Liver17Biomarker, GeneticVariation
umls:C0021655Insulin Resistance16Biomarker, GeneticVariation
umls:C0017658Glomerulonephritis16Biomarker, GeneticVariation
umls:C1261473Sarcoma16Biomarker, Therapeutic
umls:C0993582Arthritis, Experimental15Biomarker, Therapeutic
umls:C0011633Dermatomyositis15Biomarker, GeneticVariation
umls:C0878544Cardiomyopathies15Biomarker, GeneticVariation
umls:C0024115Lung Diseases14Biomarker, GeneticVariation
umls:C0020429Hyperalgesia14Biomarker
umls:C0162557Liver Failure, Acute13AlteredExpression, Biomarker, GeneticVariation
umls:C0149931Migraine Disorders13Biomarker, GeneticVariation
umls:C0034069Pulmonary Fibrosis13AlteredExpression, Biomarker, GeneticVariation
umls:C0015625Fanconi Anemia12AlteredExpression, Biomarker
umls:C0030567Parkinson Disease11AlteredExpression, Biomarker, GeneticVariation
umls:C0024121Lung Neoplasms11AlteredExpression, Biomarker, GeneticVariation
umls:C0085655Polymyositis11Biomarker, GeneticVariation
umls:C0038358Stomach Ulcer10Biomarker, GeneticVariation
umls:C0019187Hepatitis, Alcoholic10Biomarker, GeneticVariation
umls:C0037274Skin Diseases10Biomarker, GeneticVariation
umls:C0016059Fibrosis9AlteredExpression, Biomarker, GeneticVariation
umls:C0020517Hypersensitivity9Biomarker, GeneticVariation
umls:C0009404Colorectal Neoplasms9Biomarker, GeneticVariation
umls:C0035126Reperfusion Injury9Biomarker, GeneticVariation
umls:C0011853Diabetes Mellitus, Experimental8Biomarker
umls:C0030297Pancreatic Neoplasms8AlteredExpression, Biomarker, GeneticVariation, Therapeutic
umls:C0005138Berylliosis8Biomarker, GeneticVariation
umls:C0002895Anemia, Sickle Cell8Biomarker, GeneticVariation
umls:C0151744Myocardial Ischemia8Biomarker, GeneticVariation
umls:C0023891Liver Cirrhosis, Alcoholic8Biomarker, GeneticVariation
umls:C0003165Anthracosis8Biomarker, GeneticVariation
umls:C0023283Leishmaniasis, Cutaneous8Biomarker, GeneticVariation
umls:C0027765Nervous System Diseases8Biomarker, Therapeutic
umls:C0043251Wounds and Injuries7AlteredExpression, Biomarker, GeneticVariation
umls:C0948089Acute Coronary Syndrome7Biomarker, GeneticVariation
umls:C0008149Chlamydia Infections7Biomarker, GeneticVariation
umls:C0027059Myocarditis7Biomarker, GeneticVariation
umls:C0018790Heart Arrest6AlteredExpression, Biomarker, GeneticVariation
umls:C0036983Shock, Septic6AlteredExpression, Biomarker, GeneticVariation
umls:C0007786Brain Ischemia6Biomarker, GeneticVariation
umls:C0026766Multiple Organ Failure6AlteredExpression, Biomarker, GeneticVariation
umls:C0035242Respiratory Tract Diseases6Biomarker, GeneticVariation
umls:C0860207Drug-Induced Liver Injury6Biomarker, GeneticVariation
umls:C0035309Retinal Diseases6Biomarker
umls:C0162820Dermatitis, Allergic Contact5Biomarker, GeneticVariation
umls:C0018995Hemochromatosis5Biomarker, GeneticVariation
umls:C0006434Burns5Biomarker, GeneticVariation
umls:C0029458Osteoporosis, Postmenopausal5Biomarker, GeneticVariation
umls:C0005695Urinary Bladder Neoplasms5Biomarker, GeneticVariation, Therapeutic
umls:C0023281Leishmaniasis5Biomarker
umls:C0042373Vascular Diseases5Biomarker, GeneticVariation
umls:C0009375Colonic Neoplasms5Biomarker, Therapeutic
umls:C0027626Neoplasm Invasiveness5Biomarker, GeneticVariation
umls:C0001925Albuminuria4Biomarker, GeneticVariation
umls:C0013182Drug Hypersensitivity4Biomarker, GeneticVariation
umls:C0042109Urticaria4Biomarker, GeneticVariation
umls:C0015967Fever4Biomarker, GeneticVariation
umls:C0020437Hypercalcemia4Biomarker
umls:C0023290Leishmaniasis, Visceral4Biomarker
umls:C0038220Status Epilepticus3Biomarker
umls:C0948480Coronary Restenosis3Biomarker, GeneticVariation
umls:C0040053Thrombosis3Biomarker, GeneticVariation
umls:C0221204Osteolysis3Biomarker, GeneticVariation
umls:C0006267Bronchiectasis3Biomarker
umls:C0023860Listeriosis3Biomarker
umls:C0027796Neuralgia3Biomarker
umls:C0036420Scleroderma, Localized3Biomarker
umls:C0008370Cholestasis3Biomarker
umls:C0030193Pain3Biomarker
umls:C2609414Acute Kidney Injury3Biomarker
umls:C0018800Cardiomegaly3Biomarker
umls:C0027540Necrosis3Biomarker
umls:C0027659Neoplasms, Experimental3Therapeutic
umls:C0600467Neurogenic Inflammation2Biomarker
umls:C0032231Pleurisy2Biomarker
umls:C0002893Anemia, Refractory2Biomarker, GeneticVariation
umls:C0029172Oral Submucous Fibrosis2Biomarker, GeneticVariation
umls:C0013604Edema2Biomarker, GeneticVariation
umls:C0035228Respiratory Hypersensitivity2Biomarker, GeneticVariation
umls:C1861172Venous Thromboembolism2Biomarker, GeneticVariation
umls:C0340288Angina, Stable2Biomarker
umls:C0003869Arthritis, Infectious2Biomarker
umls:C0007138Carcinoma, Transitional Cell2Biomarker, Therapeutic
umls:C0343755HIV Wasting Syndrome2Biomarker
umls:C0268318Intrahepatic Cholestasis of Pregnancy2Biomarker
umls:C0031117Peripheral Nervous System Diseases2Biomarker
umls:C0270611Brain Injuries2Biomarker
umls:C0019151Hepatic Encephalopathy2Biomarker
umls:C0020649Hypotension2Biomarker
umls:C0027746Nerve Degeneration2Biomarker, Therapeutic
umls:C0037579Soft Tissue Neoplasms2Therapeutic
umls:C0242973Ventricular Dysfunction2Biomarker
umls:C0043094Weight Gain1Biomarker, GeneticVariation
umls:C1862939Amyotrophic lateral sclerosis 11Biomarker
umls:C0003469Anxiety Disorders1Biomarker
umls:C0311375Arsenic Poisoning1Biomarker
umls:C0206617Cardiovirus Infections1Biomarker
umls:C0853897Diabetic Cardiomyopathies1Biomarker
umls:C0079218Fibromatosis, Aggressive1Therapeutic
umls:C0018843Heat Stroke1Biomarker
umls:C0019061Hemolytic-Uremic Syndrome1Biomarker
umls:C0019284Hernia, Diaphragmatic1Biomarker
umls:C0020433Hyperbilirubinemia1Biomarker
umls:C0598608Hyperhomocysteinemia1Biomarker
umls:C0020615Hypoglycemia1Biomarker
umls:C0020672Hypothermia1Biomarker
umls:C0023893Liver Cirrhosis, Experimental1Biomarker
umls:C0677050Manganese Poisoning1Biomarker
umls:C0162670Mitochondrial Myopathies1Biomarker
umls:C0206146Myocardial Stunning1Biomarker
umls:C0027497Nausea1Biomarker
umls:C0032045Placenta Diseases1Biomarker
umls:C0032963Pregnancy Complications, Cardiovascular1Biomarker
umls:C0034063Pulmonary Edema1Therapeutic
umls:C0034531Radiation Injuries, Experimental1Biomarker
umls:C0036982Shock, Hemorrhagic1Biomarker
umls:C0037926Spinal Cord Compression1Biomarker
umls:C0039231Tachycardia1Biomarker
umls:C0178324Vascular System Injuries1Biomarker

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

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Pharmacological information for TNF
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.

Gene-centered drug-gene interaction network
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure
Approved|investigationalDB00005EtanerceptBiotech
ApprovedDB00051AdalimumabBiotech
ApprovedDB00065InfliximabBiotech
Approved|vet_approvedDB00608ChloroquineSmall molecule
Approved|vet_approvedDB00668EpinephrineSmall molecule
ApprovedDB00852PseudoephedrineSmall molecule
Approved|investigational|withdrawnDB01041ThalidomideSmall molecule
ApprovedDB01296GlucosamineSmall molecule
Approved|vet_approvedDB01407ClenbuterolSmall molecule
ApprovedDB01411PranlukastSmall molecule
ApprovedDB01427AmrinoneSmall molecule
ApprovedDB02325Isopropyl AlcoholSmall molecule
InvestigationalDB04956AfelimomabBiotech
InvestigationalDB05017YSIL6Small molecule
InvestigationalDB05066AV411Small molecule
InvestigationalDB05207SD118Small molecule
InvestigationalDB05218PN0621Biotech
InvestigationalDB05250681323Small molecule
InvestigationalDB05303OMS-103HPSmall molecule
InvestigationalDB05412SCIO-469Small molecule
InvestigationalDB05470VX-702Small molecule
Approved|investigationalDB05676ApremilastSmall molecule
InvestigationalDB05744CRx-139Small molecule
InvestigationalDB05758CYT007-TNFQbBiotech
InvestigationalDB05767HMPL-004Small molecule
InvestigationalDB05869CTI-01Small molecule
InvestigationalDB05879AME-527Biotech
ApprovedDB06674golimumabBiotech
ApprovedDB08904Certolizumab pegolBiotech
ApprovedDB08910PomalidomideSmall molecule

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of TNF go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS


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Conservation information for LBS of TNF
Multiple alignments for P01375 in multiple species
LBSAA sequence# speciesSpecies
G197EPIYLGGVFQL5Homo sapiens, Mus musculus, Canis lupus familiaris, Macaca mulatta, Pan troglodytes
G197EPIYQGGVFQL1Bos taurus
G197EPMYLGGVFQL1Rattus norvegicus
G198PIYLGGVFQLE5Homo sapiens, Mus musculus, Canis lupus familiaris, Macaca mulatta, Pan troglodytes
G198PIYQGGVFQLE1Bos taurus
G198PMYLGGVFQLE1Rattus norvegicus
G224DFAESGQVYFG5Homo sapiens, Mus musculus, Canis lupus familiaris, Macaca mulatta, Pan troglodytes
G224DYAESGQVYFG1Bos taurus
G224DITESGQVYFG1Rattus norvegicus
H91DKPVAHVVANP4Homo sapiens, Canis lupus familiaris, Macaca mulatta, Pan troglodytes
H91DKPVAHVVANH2Mus musculus, Rattus norvegicus
H91NKPVAHVVADI1Bos taurus
L12IRDVELAEEAL5Homo sapiens, Mus musculus, Rattus norvegicus, Macaca mulatta, Pan troglodytes
L12IRDVELAEEVL1Bos taurus
L12IRDVELAEEPL1Canis lupus familiaris
L133SEGLYLIYSQV3Homo sapiens, Macaca mulatta, Pan troglodytes
L133ADGLYLIYSQV2Bos taurus, Rattus norvegicus
L133ADGLYLVYSQV1Mus musculus
L133SDGLYLIYSQV1Canis lupus familiaris
L196YEPIYLGGVFQ5Homo sapiens, Mus musculus, Canis lupus familiaris, Macaca mulatta, Pan troglodytes
L196YEPIYQGGVFQ1Bos taurus
L196YEPMYLGGVFQ1Rattus norvegicus
Q225FAESGQVYFGI4Homo sapiens, Canis lupus familiaris, Macaca mulatta, Pan troglodytes
Q225YAESGQVYFGI1Bos taurus
Q225FAESGQVYFGV1Mus musculus
Q225ITESGQVYFGV1Rattus norvegicus
S136LYLIYSQVLFK5Homo sapiens, Rattus norvegicus, Canis lupus familiaris, Macaca mulatta, Pan troglodytes
S136LYLIYSQVLFR1Bos taurus
S136LYLVYSQVLFK1Mus musculus
S223LDFAESGQVYF5Homo sapiens, Mus musculus, Canis lupus familiaris, Macaca mulatta, Pan troglodytes
S223LDYAESGQVYF1Bos taurus
S223LDITESGQVYF1Rattus norvegicus
V199IYLGGVFQLEK5Homo sapiens, Mus musculus, Canis lupus familiaris, Macaca mulatta, Pan troglodytes
V199IYQGGVFQLEK1Bos taurus
V199MYLGGVFQLEK1Rattus norvegicus
Y135GLYLIYSQVLF6Homo sapiens, Bos taurus, Rattus norvegicus, Canis lupus familiaris, Macaca mulatta, Pan troglodytes
Y135GLYLVYSQVLF1Mus musculus
Y195WYEPIYLGGVF5Homo sapiens, Mus musculus, Canis lupus familiaris, Macaca mulatta, Pan troglodytes
Y195WYEPIYQGGVF1Bos taurus
Y195WYEPMYLGGVF1Rattus norvegicus
Y227ESGQVYFGIIA5Homo sapiens, Bos taurus, Canis lupus familiaris, Macaca mulatta, Pan troglodytes
Y227ESGQVYFGVIA2Mus musculus, Rattus norvegicus


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