mutLBSgeneDB

mutLBSgeneDB
mutated Ligand Binding Site gene DataBase

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Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for TP73
Gene summary
Basic gene Info.Gene symbolTP73
Gene nametumor protein p73
SynonymsP73
CytomapUCSC genome browser: 1p36.3
Type of geneprotein-coding
RefGenesNM_001126240.2,
NM_001126241.2,NM_001126242.2,NM_001204184.1,NM_001204185.1,
NM_001204186.1,NM_001204187.1,NM_001204188.1,NM_001204189.1,
NM_001204190.1,NM_001204191.1,NM_001204192.1,NM_005427.3,
Descriptionp53-like transcription factorp53-related protein
Modification date20141222
dbXrefs MIM : 601990
HGNC : HGNC
Ensembl : ENSG00000078900
HPRD : 03587
Vega : OTTHUMG00000000610
ProteinUniProt: O15350
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_TP73
BioGPS: 7161
PathwayNCI Pathway Interaction Database: TP73
KEGG: TP73
REACTOME: TP73
Pathway Commons: TP73
ContextiHOP: TP73
ligand binding site mutation search in PubMed: TP73
UCL Cancer Institute: TP73
Assigned class in mutLBSgeneDBB: This gene belongs to targetable_mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO TermPubMed ID
GO:0006974cellular response to DNA damage stimulus18174154
GO:0042771intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator18174154
GO:0045893positive regulation of transcription, DNA-templated15678106
GO:0045944positive regulation of transcription from RNA polymerase II promoter16343436


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Ligand binding site mutations for TP73

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
A296A296TCOAD1
C194P195LLAML1
T354T354MSKCM1
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.


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Protein structure related information for TP73
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
A296A296T-0.67950032
T354T354M-0.57091071
C194P195L-0.55160806
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for TP73 from PDB

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Differential gene expression and gene-gene network for TP73
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of TP73 and the right PPI network was created from samples without mutations in the LBS of TP73. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


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Phenotype information for TP73
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type
umls:C0206655Rhabdomyosarcoma, Alveolar1Biomarker

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

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Pharmacological information for TP73
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of TP73 go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS
NUCNucleic Acids3vd0AA296
NUCNucleic Acids3vd0BA296
NUCNucleic Acids3vd0CA296
NUCNucleic Acids3vd0DA296
NUCNucleic Acids3vd0IA296
NUCNucleic Acids3vd0JA296
NUCNucleic Acids3vd0KA296
NUCNucleic Acids3vd0LA296
NUCNucleic Acids3vd1AA296
NUCNucleic Acids3vd1BA296
NUCNucleic Acids3vd1CA296
NUCNucleic Acids3vd1DA296
NUCNucleic Acids3vd1IA296
NUCNucleic Acids3vd1JA296
NUCNucleic Acids3vd1KA296
NUCNucleic Acids3vd1LA296
NUCNucleic Acids3vd2AA296
NUCNucleic Acids3vd2BA296
NUCNucleic Acids3vd2CA296
NUCNucleic Acids3vd2DA296
NUCNucleic Acids3vd2IA296
NUCNucleic Acids3vd2JA296
NUCNucleic Acids4g82AA296
NUCNucleic Acids4g82BA296
NUCNucleic Acids4g83AA296
NUCNucleic Acids4g83BA296
NUCNucleic Acids4guqAA296
NUCNucleic Acids4guqBA296
NUCNucleic Acids4guoAA296
NUCNucleic Acids4guoBA296
NUCNucleic Acids4guoCA296
NUCNucleic Acids4guoDA296
NUCNucleic Acids4guoIA296
NUCNucleic Acids4guoJA296
NUCNucleic Acids4guoKA296
NUCNucleic Acids4guoLA296
ZNZINC(2+)2xwcAC194
ZNZINC(2+)3vd0AC194
ZNZINC(2+)3vd0BC194
ZNZINC(2+)3vd0CC194
ZNZINC(2+)3vd0DC194
ZNZINC(2+)3vd0IC194
ZNZINC(2+)3vd0JC194
ZNZINC(2+)3vd0KC194
ZNZINC(2+)3vd0LC194
ZNZINC(2+)3vd1AC194
ZNZINC(2+)3vd1BC194
ZNZINC(2+)3vd1CC194
ZNZINC(2+)3vd1DC194
ZNZINC(2+)3vd1IC194
ZNZINC(2+)3vd1JC194
ZNZINC(2+)3vd1KC194
ZNZINC(2+)3vd1LC194
ZNZINC(2+)3vd2AC194
ZNZINC(2+)3vd2BC194
ZNZINC(2+)3vd2CC194
ZNZINC(2+)3vd2DC194
ZNZINC(2+)3vd2IC194
ZNZINC(2+)3vd2JC194
ZNZINC(2+)4a63CC194
ZNZINC(2+)4a63EC194
ZNZINC(2+)4a63GC194
ZNZINC(2+)4a63IC194
ZNZINC(2+)4a63KC194
ZNZINC(2+)4g82AC194
ZNZINC(2+)4g82BC194
ZNZINC(2+)4g83AC194
ZNZINC(2+)4g83BC194
ZNZINC(2+)4guqAC194
ZNZINC(2+)4guqBC194
ZNZINC(2+)4guoAC194
ZNZINC(2+)4guoBC194
ZNZINC(2+)4guoCC194
ZNZINC(2+)4guoDC194
ZNZINC(2+)4guoIC194
ZNZINC(2+)4guoJC194
ZNZINC(2+)4guoKC194
ZNZINC(2+)4guoLC194
IIIPeptide ligand (ASP,THR,TYR,TYR,LEU,GLN,VAL,ARG,GLY,ARG,GLU,ASN,PHE,GLU,ILE,LEU,MET,LYS,LEU,LYS,GLU,SER,LEU,GLU,LEU,MET,GLU,LEU,VAL)2wttNT354


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Conservation information for LBS of TP73
Multiple alignments for O15350 in multiple species
LBSAA sequence# speciesSpecies


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