mutLBSgeneDB

mutLBSgeneDB
mutated Ligand Binding Site gene DataBase

Home

Download

 Statistics

Help

About Us
Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for TUBG1
Gene summary
Basic gene Info.Gene symbolTUBG1
Gene nametubulin, gamma 1
SynonymsCDCBM4|GCP-1|TUBG|TUBGCP1
CytomapUCSC genome browser: 17q21
Type of geneprotein-coding
RefGenesNM_001070.4,
Descriptiongamma-tubulin complex component 1tubulin gamma-1 chaintubulin, gamma polypeptide
Modification date20141207
dbXrefs MIM : 191135
HGNC : HGNC
Ensembl : ENSG00000131462
HPRD : 01853
Vega : OTTHUMG00000180277
ProteinUniProt: P23258
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_TUBG1
BioGPS: 7283
PathwayNCI Pathway Interaction Database: TUBG1
KEGG: TUBG1
REACTOME: TUBG1
Pathway Commons: TUBG1
ContextiHOP: TUBG1
ligand binding site mutation search in PubMed: TUBG1
UCL Cancer Institute: TUBG1
Assigned class in mutLBSgeneDBC: This gene just belongs to mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO TermPubMed ID


Top
Ligand binding site mutations for TUBG1

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
P173P173SHNSC1
F225F225LUCEC1
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.


Top
Protein structure related information for TUBG1
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
P173P173S-1.3582581
F225F225L-0.80205433
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for TUBG1 from PDB

Top
Differential gene expression and gene-gene network for TUBG1
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of TUBG1 and the right PPI network was created from samples without mutations in the LBS of TUBG1. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


Top

Top
Phenotype information for TUBG1
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type
umls:C1955869Malformations of Cortical Development2Biomarker
umls:C3809420CORTICAL DYSPLASIA, COMPLEX, WITH OTHER BRAIN MALFORMATIONS 41GeneticVariation
umls:C0025958Microcephaly1Biomarker

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

Top
Pharmacological information for TUBG1
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.

Gene-centered drug-gene interaction network
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure
ApprovedDB00570VinblastineSmall molecule

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of TUBG1 go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS
GSPGUANOSINE 5'-[GAMMA-THIO]TRIPHOSPHATE1z5vAP173 F225
GTPGTP1z5wAP173 F225
GDPGUANOSINE-5'-DIPHOSPHATE3cb2AP173 F225
GDPGUANOSINE-5'-DIPHOSPHATE3cb2BP173 F225


Top
Conservation information for LBS of TUBG1
Multiple alignments for P23258 in multiple species
LBSAA sequence# speciesSpecies
A142LCHSIAGGTGS9Homo sapiens, Oryza sativa subsp. japonica, Arabidopsis thaliana, Arabidopsis thaliana, Drosophila melanogaster, Canis lupus familiaris, Bos taurus, Mus musculus, Rattus norvegicus
A142LLHSIAGGTGS1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
C13LQLGQCGNQIG6Homo sapiens, Drosophila melanogaster, Canis lupus familiaris, Bos taurus, Mus musculus, Rattus norvegicus
C13LQVGQCGNQIG2Arabidopsis thaliana, Arabidopsis thaliana
C13LQAGQCGNQIG1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
C13IQVGQCGNQIG1Oryza sativa subsp. japonica
F225IQNPSFSQINQ4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
F225LTNPTFAQTNS2Arabidopsis thaliana, Arabidopsis thaliana
F225TQNPTFHQQNQ1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
F225LANPTFAQTNS1Oryza sativa subsp. japonica
F225IQTPTFTQINN1Drosophila melanogaster
F225IQNPSFFQINQ1Canis lupus familiaris
G101HGGGAGNNWAS9Homo sapiens, Oryza sativa subsp. japonica, Arabidopsis thaliana, Arabidopsis thaliana, Drosophila melanogaster, Canis lupus familiaris, Bos taurus, Mus musculus, Rattus norvegicus
G101NGGGAGNNWAN1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G11ITLQLGQCGNQ6Homo sapiens, Drosophila melanogaster, Canis lupus familiaris, Bos taurus, Mus musculus, Rattus norvegicus
G11ITLQVGQCGNQ2Arabidopsis thaliana, Arabidopsis thaliana
G11ITLQAGQCGNQ1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G11ITIQVGQCGNQ1Oryza sativa subsp. japonica
G143CHSIAGGTGSG9Homo sapiens, Oryza sativa subsp. japonica, Arabidopsis thaliana, Arabidopsis thaliana, Drosophila melanogaster, Canis lupus familiaris, Bos taurus, Mus musculus, Rattus norvegicus
G143LHSIAGGTGSG1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G144HSIAGGTGSGL6Homo sapiens, Schizosaccharomyces pombe (strain 972 / ATCC 24843), Canis lupus familiaris, Bos taurus, Mus musculus, Rattus norvegicus
G144HSIAGGTGSGM4Oryza sativa subsp. japonica, Arabidopsis thaliana, Arabidopsis thaliana, Drosophila melanogaster
G146IAGGTGSGLGS6Homo sapiens, Schizosaccharomyces pombe (strain 972 / ATCC 24843), Canis lupus familiaris, Bos taurus, Mus musculus, Rattus norvegicus
G146IAGGTGSGMGS4Oryza sativa subsp. japonica, Arabidopsis thaliana, Arabidopsis thaliana, Drosophila melanogaster
I228PSFSQINQLVS4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
I228PTFAQTNSLVS3Oryza sativa subsp. japonica, Arabidopsis thaliana, Arabidopsis thaliana
I228PTFHQQNQLVS1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
I228PTFTQINNLVS1Drosophila melanogaster
I228PSFFQINQLVS1Canis lupus familiaris
N102GGGAGNNWASG9Homo sapiens, Oryza sativa subsp. japonica, Arabidopsis thaliana, Arabidopsis thaliana, Drosophila melanogaster, Canis lupus familiaris, Bos taurus, Mus musculus, Rattus norvegicus
N102GGGAGNNWANG1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
N207VVVLDNTALNR5Homo sapiens, Oryza sativa subsp. japonica, Arabidopsis thaliana, Drosophila melanogaster, Bos taurus
N207VVVLDNTALNL2Mus musculus, Rattus norvegicus
N207VVVLDNAALAH1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
N207VVVLDNTALGR1Arabidopsis thaliana
N207VVVLDNTTLNR1Canis lupus familiaris
N229SFSQINQLVST4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
N229TFAQTNSLVST3Oryza sativa subsp. japonica, Arabidopsis thaliana, Arabidopsis thaliana
N229TFHQQNQLVST1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
N229TFTQINNLVST1Drosophila melanogaster
N229SFFQINQLVST1Canis lupus familiaris
P173TYSVFPNQDEM5Homo sapiens, Canis lupus familiaris, Bos taurus, Mus musculus, Rattus norvegicus
P173TYSVFPNQMET3Oryza sativa subsp. japonica, Arabidopsis thaliana, Arabidopsis thaliana
P173TYSVFPNSQSV1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
P173TYSVFPNQDEI1Drosophila melanogaster
Q12TLQLGQCGNQI6Homo sapiens, Drosophila melanogaster, Canis lupus familiaris, Bos taurus, Mus musculus, Rattus norvegicus
Q12TLQVGQCGNQI2Arabidopsis thaliana, Arabidopsis thaliana
Q12TLQAGQCGNQI1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Q12TIQVGQCGNQI1Oryza sativa subsp. japonica
Q16GQCGNQIGFEF6Homo sapiens, Drosophila melanogaster, Canis lupus familiaris, Bos taurus, Mus musculus, Rattus norvegicus
Q16GQCGNQIGMEF3Oryza sativa subsp. japonica, Arabidopsis thaliana, Arabidopsis thaliana
Q16GQCGNQIGSQF1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Q184SDVVVQPYNSL9Homo sapiens, Schizosaccharomyces pombe (strain 972 / ATCC 24843), Oryza sativa subsp. japonica, Arabidopsis thaliana, Arabidopsis thaliana, Canis lupus familiaris, Bos taurus, Mus musculus, Rattus norvegicus
Q184SDVVVQPYNSI1Drosophila melanogaster
S140FVLCHSIAGGT9Homo sapiens, Oryza sativa subsp. japonica, Arabidopsis thaliana, Arabidopsis thaliana, Drosophila melanogaster, Canis lupus familiaris, Bos taurus, Mus musculus, Rattus norvegicus
S140FSLLHSIAGGT1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
T145SIAGGTGSGLG6Homo sapiens, Schizosaccharomyces pombe (strain 972 / ATCC 24843), Canis lupus familiaris, Bos taurus, Mus musculus, Rattus norvegicus
T145SIAGGTGSGMG4Oryza sativa subsp. japonica, Arabidopsis thaliana, Arabidopsis thaliana, Drosophila melanogaster
V171VQTYSVFPNQD5Homo sapiens, Canis lupus familiaris, Bos taurus, Mus musculus, Rattus norvegicus
V171VQTYSVFPNQM3Oryza sativa subsp. japonica, Arabidopsis thaliana, Arabidopsis thaliana
V171IQTYSVFPNSQ1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
V171IQTYSVFPNQD1Drosophila melanogaster


Copyright © 2016-Present - The University of Texas Health Science Center at Houston
Site Policies | State of Texas