mutLBSgeneDB

mutLBSgeneDB
mutated Ligand Binding Site gene DataBase

Home

	Gene Summary
	Ligand Binding Site Mutation Information
	Protein Structure Related Information
	Gene Expression and Gene-Gene Network
	Phenotype Information
	Pharmacological Information
	Conservation Information for LBS

Gene summary for ULBP3

Gene summary

Basic gene Info.	Gene symbol	ULBP3
	Gene name	UL16 binding protein 3
	Synonyms	RAET1N
	Cytomap	UCSC genome browser: 6q25
	Type of gene	protein-coding
	RefGenes	NM_024518.1,
	Description	ALCAN-gammaN2DL-3NKG2D ligand 3NKG2DL3UL16-binding protein 3retinoic acid early transcript 1N
	Modification date	20141207
dbXrefs	MIM : 605699
	HGNC : HGNC
	Ensembl : ENSG00000131019
	HPRD : 16144
	Vega : OTTHUMG00000015811
Protein	UniProt: Q9BZM4 go to UniProt's Cross Reference DB Table
Expression	CleanEX: HS_ULBP3
	BioGPS: 79465
Pathway	NCI Pathway Interaction Database: ULBP3
	KEGG: ULBP3
	REACTOME: ULBP3
	Pathway Commons: ULBP3
Context	iHOP: ULBP3
	ligand binding site mutation search in PubMed: ULBP3
	UCL Cancer Institute: ULBP3
Assigned class in mutLBSgeneDB	C: This gene just belongs to mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez

GO ID	GO Term	PubMed ID
GO:0030101	natural killer cell activation	11239445
GO:0042267	natural killer cell mediated cytotoxicity	11239445

Top

Ligand binding site mutations for ULBP3

Cancer type specific mutLBS sorted by frequency

LBS	AAchange of nsSNV	Cancer type	# samples
M200	R202W	COAD	1
L195,L199	D197G	KIRC	1
H32	H32R	UCEC	1

cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.

Top

Protein structure related information for ULBP3

Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
(ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)

: nsSNV at non-LBS

: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.

LBS	AAchange of nsSNV	Relative stability change
M200	R202W	-1.2506942
H32	H32R	-0.55255333
L199	D197G	-0.35664922
L195	D197G	-0.35664922

(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for ULBP3 from PDB

Top

Differential gene expression and gene-gene network for ULBP3

Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)

* Left PPI network was created from samples with mutations in the LBS of ULBP3 and the right PPI network was created from samples without mutations in the LBS of ULBP3. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.

Top

Phenotype information for ULBP3

Gene level disease information (DisGeNet)