mutated Ligand Binding Site gene DataBase





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Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for SUV39H2
Gene summary
Basic gene Info.Gene symbolSUV39H2
Gene namesuppressor of variegation 3-9 homolog 2 (Drosophila)
CytomapUCSC genome browser: 10p13
Type of geneprotein-coding
DescriptionH3-K9-HMTase 2histone H3-K9 methyltransferase 2histone-lysine N-methyltransferase SUV39H2lysine N-methyltransferase 1Bsu(var)3-9 homolog 2
Modification date20141207
dbXrefs MIM : 606503
Ensembl : ENSG00000152455
HPRD : 07580
Vega : OTTHUMG00000017718
ProteinUniProt: Q9H5I1
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_SUV39H2
BioGPS: 79723
PathwayNCI Pathway Interaction Database: SUV39H2
Pathway Commons: SUV39H2
ContextiHOP: SUV39H2
ligand binding site mutation search in PubMed: SUV39H2
UCL Cancer Institute: SUV39H2
Assigned class in mutLBSgeneDBC: This gene just belongs to mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO:0006338chromatin remodeling10949293
GO:0071456cellular response to hypoxia21402781

Ligand binding site mutations for SUV39H2

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.

Protein structure related information for SUV39H2
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for SUV39H2 from PDB

Differential gene expression and gene-gene network for SUV39H2
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of SUV39H2 and the right PPI network was created from samples without mutations in the LBS of SUV39H2. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


Phenotype information for SUV39H2
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

Pharmacological information for SUV39H2
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of SUV39H2 go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS

Conservation information for LBS of SUV39H2
Multiple alignments for Q9H5I1 in multiple species
LBSAA sequence# speciesSpecies
C196CSCTDCFFQKC1Homo sapiens
C196CDCSDCFKGKC1Xenopus tropicalis
C196CECSDCPAEKC1Gallus gallus
C196CSCTDCFFDKC1Mus musculus
C196CSCTDCFFEKC1Bos taurus
C239QCGPDCPNRIV2Homo sapiens, Bos taurus
C239KCGPDCPNRVV1Xenopus tropicalis
C239RCGPDCPNRIV1Gallus gallus
C239RCGPECPNRIV1Mus musculus
C333FVNHSCDPNLQ5Homo sapiens, Xenopus tropicalis, Gallus gallus, Mus musculus, Bos taurus
C398RVRTVCKCGAV1Homo sapiens
C398RVRIACKCGAA1Xenopus tropicalis
C398RIRTVCKCGAV1Gallus gallus
C398RVRTQCKCGAE1Mus musculus
C398RARTVCKCGAV1Bos taurus
C400RTVCKCGAVTC2Homo sapiens, Bos taurus
C400RIACKCGAATC1Xenopus tropicalis
C400RTVCKCGAVCC1Gallus gallus
C400RTQCKCGAETC1Mus musculus
C405CGAVTCRGYLN2Homo sapiens, Bos taurus
C405CGAATCRGYLN1Xenopus tropicalis
C405CGAVCCRGYLN1Gallus gallus
C405CGAETCRGYLN1Mus musculus
D195GCSCTDCFFQK1Homo sapiens
D195GCDCSDCFKGK1Xenopus tropicalis
D195GCECSDCPAEK1Gallus gallus
D195GCSCTDCFFDK1Mus musculus
D195GCSCTDCFFEK1Bos taurus
F328GNVSHFVNHSC5Homo sapiens, Xenopus tropicalis, Gallus gallus, Mus musculus, Bos taurus
G236SRCQCGPDCPN2Homo sapiens, Bos taurus
G236SRCKCGPDCPN1Xenopus tropicalis
G236SFCRCGPDCPN1Gallus gallus
G236SRCRCGPECPN1Mus musculus
G262TSNGCGWGVKT2Mus musculus, Bos taurus
G262TSNGRGWGVKT1Homo sapiens
G262TDNGRGWGVKT1Xenopus tropicalis
G262TNNGRGWGVKT1Gallus gallus
H327YGNVSHFVNHS5Homo sapiens, Xenopus tropicalis, Gallus gallus, Mus musculus, Bos taurus
H331SHFVNHSCDPN5Homo sapiens, Xenopus tropicalis, Gallus gallus, Mus musculus, Bos taurus
K300QFYDNKGITYL2Homo sapiens, Mus musculus
K300QQYDSRGITYL1Xenopus tropicalis
K300QFYDNQGNTYL1Gallus gallus
K300QLYDNKGITYL1Bos taurus
K399VRTVCKCGAVT1Homo sapiens
K399VRIACKCGAAT1Xenopus tropicalis
K399IRTVCKCGAVC1Gallus gallus
K399VRTQCKCGAET1Mus musculus
K399ARTVCKCGAVT1Bos taurus
L44ITKRNLNNYEV3Homo sapiens, Mus musculus, Bos taurus
L44ITRKNLNNYEV1Xenopus tropicalis
L44ITNKSLKSYEV1Gallus gallus
N330VSHFVNHSCDP5Homo sapiens, Xenopus tropicalis, Gallus gallus, Mus musculus, Bos taurus
R261RTSNGRGWGVK1Homo sapiens
R261RTDNGRGWGVK1Xenopus tropicalis
R261RTNNGRGWGVK1Gallus gallus
R261KTSNGCGWGVK1Mus musculus
R261RTSNGCGWGVK1Bos taurus
T194FGCSCTDCFFQ1Homo sapiens
T194VGCDCSDCFKG1Xenopus tropicalis
T194TGCECSDCPAE1Gallus gallus
T194FGCSCTDCFFD1Mus musculus
T194FGCSCTDCFFE1Bos taurus
T303DNKGITYLFDL3Homo sapiens, Mus musculus, Bos taurus
T303DSRGITYLFDL1Xenopus tropicalis
T303DNQGNTYLFDL1Gallus gallus
V329NVSHFVNHSCD5Homo sapiens, Xenopus tropicalis, Gallus gallus, Mus musculus, Bos taurus
V397KRVRTVCKCGA1Homo sapiens
V397KRVRIACKCGA1Xenopus tropicalis
V397KRIRTVCKCGA1Gallus gallus
V397KRVRTQCKCGA1Mus musculus
V397KRARTVCKCGA1Bos taurus
W263SNGCGWGVKTL2Mus musculus, Bos taurus
W263SNGRGWGVKTL1Homo sapiens
W263DNGRGWGVKTL1Xenopus tropicalis
W263NNGRGWGVKTL1Gallus gallus
Y304NKGITYLFDLD3Homo sapiens, Mus musculus, Bos taurus
Y304SRGITYLFDLD1Xenopus tropicalis
Y304NQGNTYLFDLD1Gallus gallus
Y372ELTFDYQMKGS5Homo sapiens, Xenopus tropicalis, Gallus gallus, Mus musculus, Bos taurus

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