mutLBSgeneDB |
Gene summary for SUV39H2 |
Gene summary |
Basic gene Info. | Gene symbol | SUV39H2 |
Gene name | suppressor of variegation 3-9 homolog 2 (Drosophila) | |
Synonyms | KMT1B | |
Cytomap | UCSC genome browser: 10p13 | |
Type of gene | protein-coding | |
RefGenes | NM_001193424.1, NM_001193425.1,NM_001193426.1,NM_001193427.1,NM_024670.3, NR_034181.1, | |
Description | H3-K9-HMTase 2histone H3-K9 methyltransferase 2histone-lysine N-methyltransferase SUV39H2lysine N-methyltransferase 1Bsu(var)3-9 homolog 2 | |
Modification date | 20141207 | |
dbXrefs | MIM : 606503 | |
HGNC : HGNC | ||
Ensembl : ENSG00000152455 | ||
HPRD : 07580 | ||
Vega : OTTHUMG00000017718 | ||
Protein | UniProt: Q9H5I1 go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_SUV39H2 | |
BioGPS: 79723 | ||
Pathway | NCI Pathway Interaction Database: SUV39H2 | |
KEGG: SUV39H2 | ||
REACTOME: SUV39H2 | ||
Pathway Commons: SUV39H2 | ||
Context | iHOP: SUV39H2 | |
ligand binding site mutation search in PubMed: SUV39H2 | ||
UCL Cancer Institute: SUV39H2 | ||
Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO Term | PubMed ID | GO:0006338 | chromatin remodeling | 10949293 | GO:0071456 | cellular response to hypoxia | 21402781 |
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Ligand binding site mutations for SUV39H2 |
Cancer type specific mutLBS sorted by frequency |
LBS | AAchange of nsSNV | Cancer type | # samples | K300 | D298N | KIRC | 1 | K300 | D298E | KIRC | 1 | N330 | N330S | KIRC | 1 | D195 | D195G | LUAD | 1 | K300 | K300M | LUAD | 1 | H331 | H331Y | STAD | 1 | Y372 | D371Y | UCEC | 1 |
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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Protein structure related information for SUV39H2 |
Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
: nsSNV at non-LBS: nsSNV at LBS |
nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
LBS | AAchange of nsSNV | Relative stability change | K300 | D298N | -1.0317719 | Y372 | D371Y | -1.0272086 | D195 | D195G | -0.81107958 | K300 | D298E | -0.66894599 | H331 | H331Y | -0.63378017 | N330 | N330S | -0.35330364 | K300 | K300M | -0.32384372 |
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
Structure image for SUV39H2 from PDB |
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Differential gene expression and gene-gene network for SUV39H2 |
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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Phenotype information for SUV39H2 |
Gene level disease information (DisGeNet) |
Disease ID | Disease name | # PubMed | Association type |
Mutation level pathogenic information (ClinVar annotation) |
Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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Pharmacological information for SUV39H2 |
Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
Drug information targeting mutLBSgene (Approved drugs only) |
Drug status | DrugBank ID | Name | Type | Drug structure |
Gene-centered ligand-gene interaction network |
Ligands binding to mutated ligand binding site of SUV39H2 go to BioLip |
Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS |
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Conservation information for LBS of SUV39H2 |
Multiple alignments for Q9H5I1 in multiple species |
LBS | AA sequence | # species | Species | C196 | CSCTDCFFQKC | 1 | Homo sapiens | C196 | CDCSDCFKGKC | 1 | Xenopus tropicalis | C196 | CECSDCPAEKC | 1 | Gallus gallus | C196 | CSCTDCFFDKC | 1 | Mus musculus | C196 | CSCTDCFFEKC | 1 | Bos taurus | C239 | QCGPDCPNRIV | 2 | Homo sapiens, Bos taurus | C239 | KCGPDCPNRVV | 1 | Xenopus tropicalis | C239 | RCGPDCPNRIV | 1 | Gallus gallus | C239 | RCGPECPNRIV | 1 | Mus musculus | C333 | FVNHSCDPNLQ | 5 | Homo sapiens, Xenopus tropicalis, Gallus gallus, Mus musculus, Bos taurus | C398 | RVRTVCKCGAV | 1 | Homo sapiens | C398 | RVRIACKCGAA | 1 | Xenopus tropicalis | C398 | RIRTVCKCGAV | 1 | Gallus gallus | C398 | RVRTQCKCGAE | 1 | Mus musculus | C398 | RARTVCKCGAV | 1 | Bos taurus | C400 | RTVCKCGAVTC | 2 | Homo sapiens, Bos taurus | C400 | RIACKCGAATC | 1 | Xenopus tropicalis | C400 | RTVCKCGAVCC | 1 | Gallus gallus | C400 | RTQCKCGAETC | 1 | Mus musculus | C405 | CGAVTCRGYLN | 2 | Homo sapiens, Bos taurus | C405 | CGAATCRGYLN | 1 | Xenopus tropicalis | C405 | CGAVCCRGYLN | 1 | Gallus gallus | C405 | CGAETCRGYLN | 1 | Mus musculus | D195 | GCSCTDCFFQK | 1 | Homo sapiens | D195 | GCDCSDCFKGK | 1 | Xenopus tropicalis | D195 | GCECSDCPAEK | 1 | Gallus gallus | D195 | GCSCTDCFFDK | 1 | Mus musculus | D195 | GCSCTDCFFEK | 1 | Bos taurus | F328 | GNVSHFVNHSC | 5 | Homo sapiens, Xenopus tropicalis, Gallus gallus, Mus musculus, Bos taurus | G236 | SRCQCGPDCPN | 2 | Homo sapiens, Bos taurus | G236 | SRCKCGPDCPN | 1 | Xenopus tropicalis | G236 | SFCRCGPDCPN | 1 | Gallus gallus | G236 | SRCRCGPECPN | 1 | Mus musculus | G262 | TSNGCGWGVKT | 2 | Mus musculus, Bos taurus | G262 | TSNGRGWGVKT | 1 | Homo sapiens | G262 | TDNGRGWGVKT | 1 | Xenopus tropicalis | G262 | TNNGRGWGVKT | 1 | Gallus gallus | H327 | YGNVSHFVNHS | 5 | Homo sapiens, Xenopus tropicalis, Gallus gallus, Mus musculus, Bos taurus | H331 | SHFVNHSCDPN | 5 | Homo sapiens, Xenopus tropicalis, Gallus gallus, Mus musculus, Bos taurus | K300 | QFYDNKGITYL | 2 | Homo sapiens, Mus musculus | K300 | QQYDSRGITYL | 1 | Xenopus tropicalis | K300 | QFYDNQGNTYL | 1 | Gallus gallus | K300 | QLYDNKGITYL | 1 | Bos taurus | K399 | VRTVCKCGAVT | 1 | Homo sapiens | K399 | VRIACKCGAAT | 1 | Xenopus tropicalis | K399 | IRTVCKCGAVC | 1 | Gallus gallus | K399 | VRTQCKCGAET | 1 | Mus musculus | K399 | ARTVCKCGAVT | 1 | Bos taurus | L44 | ITKRNLNNYEV | 3 | Homo sapiens, Mus musculus, Bos taurus | L44 | ITRKNLNNYEV | 1 | Xenopus tropicalis | L44 | ITNKSLKSYEV | 1 | Gallus gallus | N330 | VSHFVNHSCDP | 5 | Homo sapiens, Xenopus tropicalis, Gallus gallus, Mus musculus, Bos taurus | R261 | RTSNGRGWGVK | 1 | Homo sapiens | R261 | RTDNGRGWGVK | 1 | Xenopus tropicalis | R261 | RTNNGRGWGVK | 1 | Gallus gallus | R261 | KTSNGCGWGVK | 1 | Mus musculus | R261 | RTSNGCGWGVK | 1 | Bos taurus | T194 | FGCSCTDCFFQ | 1 | Homo sapiens | T194 | VGCDCSDCFKG | 1 | Xenopus tropicalis | T194 | TGCECSDCPAE | 1 | Gallus gallus | T194 | FGCSCTDCFFD | 1 | Mus musculus | T194 | FGCSCTDCFFE | 1 | Bos taurus | T303 | DNKGITYLFDL | 3 | Homo sapiens, Mus musculus, Bos taurus | T303 | DSRGITYLFDL | 1 | Xenopus tropicalis | T303 | DNQGNTYLFDL | 1 | Gallus gallus | V329 | NVSHFVNHSCD | 5 | Homo sapiens, Xenopus tropicalis, Gallus gallus, Mus musculus, Bos taurus | V397 | KRVRTVCKCGA | 1 | Homo sapiens | V397 | KRVRIACKCGA | 1 | Xenopus tropicalis | V397 | KRIRTVCKCGA | 1 | Gallus gallus | V397 | KRVRTQCKCGA | 1 | Mus musculus | V397 | KRARTVCKCGA | 1 | Bos taurus | W263 | SNGCGWGVKTL | 2 | Mus musculus, Bos taurus | W263 | SNGRGWGVKTL | 1 | Homo sapiens | W263 | DNGRGWGVKTL | 1 | Xenopus tropicalis | W263 | NNGRGWGVKTL | 1 | Gallus gallus | Y304 | NKGITYLFDLD | 3 | Homo sapiens, Mus musculus, Bos taurus | Y304 | SRGITYLFDLD | 1 | Xenopus tropicalis | Y304 | NQGNTYLFDLD | 1 | Gallus gallus | Y372 | ELTFDYQMKGS | 5 | Homo sapiens, Xenopus tropicalis, Gallus gallus, Mus musculus, Bos taurus |
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