mutLBSgeneDB

mutLBSgeneDB
mutated Ligand Binding Site gene DataBase

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Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for ADAM33
Gene summary
Basic gene Info.Gene symbolADAM33
Gene nameADAM metallopeptidase domain 33
SynonymsC20orf153|DJ964F7.1
CytomapUCSC genome browser: 20p13
Type of geneprotein-coding
RefGenesNM_001282447.1,
NM_025220.3,NM_153202.2,
DescriptionADAM 33a disintegrin and metalloprotease 33a disintegrin and metalloproteinase domain 33disintegrin and metalloproteinase domain-containing protein 33disintegrin and reprolysin metalloproteinase family protein
Modification date20141222
dbXrefs MIM : 607114
HGNC : HGNC
Ensembl : ENSG00000149451
HPRD : 06173
Vega : OTTHUMG00000031758
ProteinUniProt: Q9BZ11
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_ADAM33
BioGPS: 80332
PathwayNCI Pathway Interaction Database: ADAM33
KEGG: ADAM33
REACTOME: ADAM33
Pathway Commons: ADAM33
ContextiHOP: ADAM33
ligand binding site mutation search in PubMed: ADAM33
UCL Cancer Institute: ADAM33
Assigned class in mutLBSgeneDBA: This gene has a literature evidence and it belongs to targetable_mutLBSgenes.
References showing study about ligand binding site mutation for ADAM33.1. "Zou J, Zhu F, Liu J, Wang W, Zhang R, Garlisi CG, Liu YH, Wang S, Shah H, Wan Y, Umland SP. Catalytic activity of human ADAM33. J Biol Chem. 2004 Mar 12;279(11):9818-30. Epub 2003 Dec 15. PubMed PMID: 14676211." 14676211

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO TermPubMed ID


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Ligand binding site mutations for ADAM33

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
N407A408VKIRC1
H355D356ESKCM1
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.


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Protein structure related information for ADAM33
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
N407A408V-0.66940029
H355D356E-0.50851951
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for ADAM33 from PDB

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Differential gene expression and gene-gene network for ADAM33
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of ADAM33 and the right PPI network was created from samples without mutations in the LBS of ADAM33. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


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Phenotype information for ADAM33
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type
umls:C0085129Bronchial Hyperreactivity17Biomarker, GeneticVariation

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

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Pharmacological information for ADAM33

Gene-centered drug-gene interaction network
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of ADAM33 go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS
ZNZINC(2+)1r54AH355
ZNZINC(2+)1r55AH355
097MARIMASTAT1r55AH355
CACALCIUM(2+)1r54AN407
CACALCIUM(2+)1r55AN407


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Conservation information for LBS of ADAM33
Multiple alignments for Q9BZ11 in multiple species
LBSAA sequence# speciesSpecies


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