mutLBSgeneDB |
Gene summary for ADAM33 |
Gene summary |
Basic gene Info. | Gene symbol | ADAM33 |
Gene name | ADAM metallopeptidase domain 33 | |
Synonyms | C20orf153|DJ964F7.1 | |
Cytomap | UCSC genome browser: 20p13 | |
Type of gene | protein-coding | |
RefGenes | NM_001282447.1, NM_025220.3,NM_153202.2, | |
Description | ADAM 33a disintegrin and metalloprotease 33a disintegrin and metalloproteinase domain 33disintegrin and metalloproteinase domain-containing protein 33disintegrin and reprolysin metalloproteinase family protein | |
Modification date | 20141222 | |
dbXrefs | MIM : 607114 | |
HGNC : HGNC | ||
Ensembl : ENSG00000149451 | ||
HPRD : 06173 | ||
Vega : OTTHUMG00000031758 | ||
Protein | UniProt: Q9BZ11 go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_ADAM33 | |
BioGPS: 80332 | ||
Pathway | NCI Pathway Interaction Database: ADAM33 | |
KEGG: ADAM33 | ||
REACTOME: ADAM33 | ||
Pathway Commons: ADAM33 | ||
Context | iHOP: ADAM33 | |
ligand binding site mutation search in PubMed: ADAM33 | ||
UCL Cancer Institute: ADAM33 | ||
Assigned class in mutLBSgeneDB | A: This gene has a literature evidence and it belongs to targetable_mutLBSgenes. | |
References showing study about ligand binding site mutation for ADAM33. | 1. "Zou J, Zhu F, Liu J, Wang W, Zhang R, Garlisi CG, Liu YH, Wang S, Shah H, Wan Y, Umland SP. Catalytic activity of human ADAM33. J Biol Chem. 2004 Mar 12;279(11):9818-30. Epub 2003 Dec 15. PubMed PMID: 14676211." 14676211 |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO Term | PubMed ID |
Top |
Ligand binding site mutations for ADAM33 |
Cancer type specific mutLBS sorted by frequency |
LBS | AAchange of nsSNV | Cancer type | # samples | N407 | A408V | KIRC | 1 | H355 | D356E | SKCM | 1 |
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
Top |
Protein structure related information for ADAM33 |
Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
: nsSNV at non-LBS: nsSNV at LBS |
nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
LBS | AAchange of nsSNV | Relative stability change | N407 | A408V | -0.66940029 | H355 | D356E | -0.50851951 |
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
Structure image for ADAM33 from PDB |
Top |
Differential gene expression and gene-gene network for ADAM33 |
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
Top |
Top |
Phenotype information for ADAM33 |
Gene level disease information (DisGeNet) |
Disease ID | Disease name | # PubMed | Association type |
umls:C0085129 | Bronchial Hyperreactivity | 17 | Biomarker, GeneticVariation |
Mutation level pathogenic information (ClinVar annotation) |
Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
Top |
Pharmacological information for ADAM33 |
Gene-centered drug-gene interaction network |
Drug information targeting mutLBSgene (Approved drugs only) |
Drug status | DrugBank ID | Name | Type | Drug structure |
Gene-centered ligand-gene interaction network |
Ligands binding to mutated ligand binding site of ADAM33 go to BioLip |
Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | ZN | ZINC(2+) | 1r54 | A | H355 | ZN | ZINC(2+) | 1r55 | A | H355 | 097 | MARIMASTAT | 1r55 | A | H355 | CA | CALCIUM(2+) | 1r54 | A | N407 | CA | CALCIUM(2+) | 1r55 | A | N407 |
Top |
Conservation information for LBS of ADAM33 |
Multiple alignments for Q9BZ11 in multiple species |
LBS | AA sequence | # species | Species |
Copyright © 2016-Present - The University of Texas Health Science Center at Houston |