mutLBSgeneDB |
Gene summary for CAMK2A |
Gene summary |
Basic gene Info. | Gene symbol | CAMK2A |
Gene name | calcium/calmodulin-dependent protein kinase II alpha | |
Synonyms | CAMKA | |
Cytomap | UCSC genome browser: 5q32 | |
Type of gene | protein-coding | |
RefGenes | NM_015981.3, NM_171825.2, | |
Description | CaM kinase II alpha subunitCaM-kinase II alpha chainCaMK-II alpha subunitCaMKIINalphacaM kinase II subunit alphacaMK-II subunit alphacalcium/calmodulin-dependent protein kinase (CaM kinase) II alphacalcium/calmodulin-dependent protein kinase II alp | |
Modification date | 20141207 | |
dbXrefs | MIM : 114078 | |
HGNC : HGNC | ||
Ensembl : ENSG00000070808 | ||
HPRD : 06532 | ||
Vega : OTTHUMG00000134281 | ||
Protein | UniProt: Q9UQM7 go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_CAMK2A | |
BioGPS: 815 | ||
Pathway | NCI Pathway Interaction Database: CAMK2A | |
KEGG: CAMK2A | ||
REACTOME: CAMK2A | ||
Pathway Commons: CAMK2A | ||
Context | iHOP: CAMK2A | |
ligand binding site mutation search in PubMed: CAMK2A | ||
UCL Cancer Institute: CAMK2A | ||
Assigned class in mutLBSgeneDB | B: This gene belongs to targetable_mutLBSgenes. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO Term | PubMed ID | GO:0006468 | protein phosphorylation | 17052756 |
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Ligand binding site mutations for CAMK2A |
Cancer type specific mutLBS sorted by frequency |
LBS | AAchange of nsSNV | Cancer type | # samples | D90 | D90N | BRCA | 1 | V27 | S25L | COAD | 1 | G20 | G22V | SKCM | 1 | L19 | E17K | UCEC | 1 |
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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Protein structure related information for CAMK2A |
Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
: nsSNV at non-LBS: nsSNV at LBS |
nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
LBS | AAchange of nsSNV | Relative stability change | G20 | G22V | 0.045975988 | D90 | D90N | -1.4518402 | L19 | E17K | -0.58478735 | V27 | S25L | -0.003823637 |
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
Structure image for CAMK2A from PDB |
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Differential gene expression and gene-gene network for CAMK2A |
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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Phenotype information for CAMK2A |
Gene level disease information (DisGeNet) |
Disease ID | Disease name | # PubMed | Association type |
umls:C0236736 | Cocaine-Related Disorders | 1 | Biomarker |
umls:C0020429 | Hyperalgesia | 1 | Biomarker |
Mutation level pathogenic information (ClinVar annotation) |
Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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Pharmacological information for CAMK2A |
Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
Gene-centered drug-gene interaction network |
Drug information targeting mutLBSgene (Approved drugs only) |
Drug status | DrugBank ID | Name | Type | Drug structure |
Experimental | DB04119 | Hexatantalum Dodecabromide | Small molecule | |
Experimental | DB04447 | 1,4-Dithiothreitol | Small molecule | |
Experimental | DB07766 | (2Z,3E)-2,3'-BIINDOLE-2',3(1H,1'H)-DIONE 3-{O-[(3R)-3,4-DIHYDROXYBUTYL]OXIME} | Small molecule |
Gene-centered ligand-gene interaction network |
Ligands binding to mutated ligand binding site of CAMK2A go to BioLip |
Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | FEF | INDIRUBIN DERIVATIVE E804 | 2vz6 | A | L19 G20 D90 | FEF | INDIRUBIN DERIVATIVE E804 | 2vz6 | B | L19 G20 D90 | DB8 | BOSUTINIB | 3soa | A | L19 V27 |
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Conservation information for LBS of CAMK2A |
Multiple alignments for Q9UQM7 in multiple species |
LBS | AA sequence | # species | Species |
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