mutLBSgeneDB |
Gene summary for TXNDC5 |
Gene summary |
Basic gene Info. | Gene symbol | TXNDC5 |
Gene name | thioredoxin domain containing 5 (endoplasmic reticulum) | |
Synonyms | ENDOPDI|ERP46|HCC-2|PDIA15|STRF8|UNQ364 | |
Cytomap | UCSC genome browser: 6p24.3 | |
Type of gene | protein-coding | |
RefGenes | NM_001145549.2, NM_030810.3,NM_022085.3, | |
Description | ER protein 46endoplasmic reticulum protein ERp46endoplasmic reticulum resident protein 46endothelial protein disulphide isomeraseprotein disulfide isomerase family A, member 15thioredoxin domain-containing protein 5thioredoxin related proteinthiore | |
Modification date | 20141207 | |
dbXrefs | HGNC : HGNC | |
Ensembl : ENSG00000239264 | ||
Ensembl : ENSG00000259040 | ||
HPRD : 18249 | ||
Vega : OTTHUMG00000014216 | ||
Protein | UniProt: Q8NBS9 go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_TXNDC5 | |
BioGPS: 81567 | ||
Pathway | NCI Pathway Interaction Database: TXNDC5 | |
KEGG: TXNDC5 | ||
REACTOME: TXNDC5 | ||
Pathway Commons: TXNDC5 | ||
Context | iHOP: TXNDC5 | |
ligand binding site mutation search in PubMed: TXNDC5 | ||
UCL Cancer Institute: TXNDC5 | ||
Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO Term | PubMed ID |
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Ligand binding site mutations for TXNDC5 |
Cancer type specific mutLBS sorted by frequency |
LBS | AAchange of nsSNV | Cancer type | # samples | K280 | K278N | LUAD | 1 | Y262 | R260C | UCEC | 1 |
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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Protein structure related information for TXNDC5 |
Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
: nsSNV at non-LBS: nsSNV at LBS |
nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
LBS | AAchange of nsSNV | Relative stability change | K280 | K278N | -0.67429552 | Y262 | R260C | -0.30639992 |
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
Structure image for TXNDC5 from PDB |
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Differential gene expression and gene-gene network for TXNDC5 |
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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Phenotype information for TXNDC5 |
Gene level disease information (DisGeNet) |
Disease ID | Disease name | # PubMed | Association type |
umls:C0003873 | Arthritis, Rheumatoid | 2 | Biomarker |
umls:C0993582 | Arthritis, Experimental | 1 | Biomarker |
umls:C0033578 | Prostatic Neoplasms | 1 | Biomarker |
Mutation level pathogenic information (ClinVar annotation) |
Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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Pharmacological information for TXNDC5 |
Drug information targeting mutLBSgene (Approved drugs only) |
Drug status | DrugBank ID | Name | Type | Drug structure |
Gene-centered ligand-gene interaction network |
Ligands binding to mutated ligand binding site of TXNDC5 go to BioLip |
Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | III | Peptide ligand (GLY,GLU,VAL,CYS,PRO,ALA) | 3wgx | B | Y262 | III | Peptide ligand (HIS,GLY,GLU,VAL,CYS,PRO,ALA) | 3wgx | A | Y262 K280 |
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Conservation information for LBS of TXNDC5 |
Multiple alignments for Q8NBS9 in multiple species |
LBS | AA sequence | # species | Species |
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