|
mutLBSgeneDB |
| |
| |
| |
| |
| |
| |
|
| Gene summary for SESN2 |
 Gene summary |
| Basic gene Info. | Gene symbol | SESN2 |
| Gene name | sestrin 2 | |
| Synonyms | HI95|SES2|SEST2 | |
| Cytomap | UCSC genome browser: 1p35.3 | |
| Type of gene | protein-coding | |
| RefGenes | NM_031459.4, | |
| Description | hypoxia induced gene 95sestrin-2 | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 607767 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000130766 | ||
| HPRD : 06378 | ||
| Vega : OTTHUMG00000003532 | ||
| Protein | UniProt: P58004 go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_SESN2 | |
| BioGPS: 83667 | ||
| Pathway | NCI Pathway Interaction Database: SESN2 | |
| KEGG: SESN2 | ||
| REACTOME: SESN2 | ||
| Pathway Commons: SESN2 | ||
| Context | iHOP: SESN2 | |
| ligand binding site mutation search in PubMed: SESN2 | ||
| UCL Cancer Institute: SESN2 | ||
| Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. | |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO Term | PubMed ID |
| Top |
| Ligand binding site mutations for SESN2 |
| Lollipop-style diagram of mutations at LBS in amino-acid sequence. We represented ligand binding site mutations only. (You can see big image via clicking.)  : non-synonymous mutation on LBS, Circle size denotes number of samples. |
 |
| Cancer type specific mutLBS sorted by frequency |
| LBS | AAchange of nsSNV | Cancer type | # samples | H454 | H454Y | SKCM | 1 |
| cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
| Top |
| Protein structure related information for SESN2 |
| Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
 : nsSNV at non-LBS : nsSNV at LBS |
 |
| nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
| LBS | AAchange of nsSNV | Relative stability change | H454 | H454Y | -0.54877617 |
| (MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
| Structure image for SESN2 from PDB |
| Top |
| Differential gene expression and gene-gene network for SESN2 |
| Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
| Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
| Top |
| Top |
| Phenotype information for SESN2 |
| Gene level disease information (DisGeNet) |
| Disease ID | Disease name | # PubMed | Association type |
| Mutation level pathogenic information (ClinVar annotation) |
| Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
| Top |
| Pharmacological information for SESN2 |
| Drug information targeting mutLBSgene (Approved drugs only) |
| Drug status | DrugBank ID | Name | Type | Drug structure |
| Gene-centered ligand-gene interaction network |
 |
| Ligands binding to mutated ligand binding site of SESN2 go to BioLip |
| Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | LEU | L-LEUCINE | 5dj4 | A | H454 | LEU | L-LEUCINE | 5dj4 | B | H454 | LEU | L-LEUCINE | 5dj4 | C | H454 | LEU | L-LEUCINE | 5dj4 | D | H454 | LEU | L-LEUCINE | 5dj4 | E | H454 |
| Top |
| Conservation information for LBS of SESN2 |
| Multiple alignments for P58004 in multiple species |
| LBS | AA sequence | # species | Species | E451 | HFRHSEKVHVN | 3 | Homo sapiens, Mus musculus, Bos taurus | H454 | HSEKVHVNLLL | 3 | Homo sapiens, Mus musculus, Bos taurus | N376 | YSLTYNTIAMH | 2 | Homo sapiens, Bos taurus | N376 | CSLTYNTIAMH | 1 | Mus musculus | R390 | DTSVLRRAIWN | 2 | Homo sapiens, Bos taurus | R390 | DTSMLRRAIWN | 1 | Mus musculus | T374 | AAYSLTYNTIA | 2 | Homo sapiens, Bos taurus | T374 | VACSLTYNTIA | 1 | Mus musculus | T377 | SLTYNTIAMHS | 3 | Homo sapiens, Mus musculus, Bos taurus | T386 | HSGVDTSVLRR | 2 | Homo sapiens, Bos taurus | T386 | HSGVDTSMLRR | 1 | Mus musculus | Y375 | AYSLTYNTIAM | 2 | Homo sapiens, Bos taurus | Y375 | ACSLTYNTIAM | 1 | Mus musculus |
 |
Copyright © 2016-Present - The University of Texas Health Science Center at Houston |