mutLBSgeneDB |
Gene summary for PLA2G10 |
Gene summary |
Basic gene Info. | Gene symbol | PLA2G10 |
Gene name | phospholipase A2, group X | |
Synonyms | GXPLA2|GXSPLA2|SPLA2 | |
Cytomap | UCSC genome browser: 16p13.1-p12 | |
Type of gene | protein-coding | |
RefGenes | NM_003561.1, | |
Description | GX sPLA2group 10 secretory phospholipase A2group X secretory phospholipase A2phosphatidylcholine 2-acylhydrolase 10sPLA2-X | |
Modification date | 20141207 | |
dbXrefs | MIM : 603603 | |
HGNC : HGNC | ||
Ensembl : ENSG00000069764 | ||
HPRD : 04674 | ||
Vega : OTTHUMG00000048069 | ||
Protein | UniProt: O15496 go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_PLA2G10 | |
BioGPS: 8399 | ||
Pathway | NCI Pathway Interaction Database: PLA2G10 | |
KEGG: PLA2G10 | ||
REACTOME: PLA2G10 | ||
Pathway Commons: PLA2G10 | ||
Context | iHOP: PLA2G10 | |
ligand binding site mutation search in PubMed: PLA2G10 | ||
UCL Cancer Institute: PLA2G10 | ||
Assigned class in mutLBSgeneDB | B: This gene belongs to targetable_mutLBSgenes. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO Term | PubMed ID | GO:0007411 | axon guidance | 15927955 | GO:0043433 | negative regulation of sequence-specific DNA binding transcription factor activity | 20844270 | GO:0051977 | lysophospholipid transport | 15927955 |
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Ligand binding site mutations for PLA2G10 |
Cancer type specific mutLBS sorted by frequency |
LBS | AAchange of nsSNV | Cancer type | # samples | L140 | Q142K | LUAD | 1 | I136 | Q134H | STAD | 1 |
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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Protein structure related information for PLA2G10 |
Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
: nsSNV at non-LBS: nsSNV at LBS |
nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
LBS | AAchange of nsSNV | Relative stability change | L140 | Q142K | -0.88458404 | I136 | Q134H | -0.45714113 |
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
Structure image for PLA2G10 from PDB |
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Differential gene expression and gene-gene network for PLA2G10 |
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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Phenotype information for PLA2G10 |
Gene level disease information (DisGeNet) |
Disease ID | Disease name | # PubMed | Association type |
Mutation level pathogenic information (ClinVar annotation) |
Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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Pharmacological information for PLA2G10 |
Drug information targeting mutLBSgene (Approved drugs only) |
Drug status | DrugBank ID | Name | Type | Drug structure |
Gene-centered ligand-gene interaction network |
Ligands binding to mutated ligand binding site of PLA2G10 go to BioLip |
Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS |
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Conservation information for LBS of PLA2G10 |
Multiple alignments for O15496 in multiple species |
LBS | AA sequence | # species | Species | A48 | GLLELAGTLDC | 2 | Mus musculus, Rattus norvegicus | A48 | GILELAGTVGC | 1 | Homo sapiens | C85 | AIDWCCHGHDC | 1 | Homo sapiens | C85 | AIDWCCYHHDC | 1 | Mus musculus | C85 | AIDWCCYYHDC | 1 | Rattus norvegicus | D89 | CCHGHDCCYTR | 1 | Homo sapiens | D89 | CCYHHDCCYSR | 1 | Mus musculus | D89 | CCYYHDCCYSQ | 1 | Rattus norvegicus | F68 | MNYGCYCGLGG | 2 | Mus musculus, Rattus norvegicus | F68 | MKYGCFCGLGG | 1 | Homo sapiens | G70 | YGCYCGLGGHG | 2 | Mus musculus, Rattus norvegicus | G70 | YGCFCGLGGHG | 1 | Homo sapiens | G72 | CYCGLGGHGEP | 2 | Mus musculus, Rattus norvegicus | G72 | CFCGLGGHGQP | 1 | Homo sapiens | H88 | WCCHGHDCCYT | 1 | Homo sapiens | H88 | WCCYHHDCCYS | 1 | Mus musculus | H88 | WCCYYHDCCYS | 1 | Rattus norvegicus | I136 | KCDQEIANCLA | 1 | Homo sapiens | I136 | RCDEELAYCLA | 1 | Mus musculus | I136 | RCDETLAYCLA | 1 | Rattus norvegicus | I44 | VYKRGLLELAG | 2 | Mus musculus, Rattus norvegicus | I44 | VHRRGILELAG | 1 | Homo sapiens | L140 | EIANCLAQTEY | 1 | Homo sapiens | L140 | ELAYCLAGTEY | 1 | Mus musculus | L140 | TLAYCLADTEY | 1 | Rattus norvegicus | L47 | RGLLELAGTLD | 2 | Mus musculus, Rattus norvegicus | L47 | RGILELAGTVG | 1 | Homo sapiens | L71 | GCYCGLGGHGE | 2 | Mus musculus, Rattus norvegicus | L71 | GCFCGLGGHGQ | 1 | Homo sapiens | M63 | SPMAYMNYGCY | 2 | Mus musculus, Rattus norvegicus | M63 | TPIAYMKYGCF | 1 | Homo sapiens | P59 | VGPRSPMAYMN | 2 | Mus musculus, Rattus norvegicus | P59 | VGPRTPIAYMK | 1 | Homo sapiens | Y62 | RSPMAYMNYGC | 2 | Mus musculus, Rattus norvegicus | Y62 | RTPIAYMKYGC | 1 | Homo sapiens |
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