mutated Ligand Binding Site gene DataBase





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Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for PLA2G10
Gene summary
Basic gene Info.Gene symbolPLA2G10
Gene namephospholipase A2, group X
CytomapUCSC genome browser: 16p13.1-p12
Type of geneprotein-coding
DescriptionGX sPLA2group 10 secretory phospholipase A2group X secretory phospholipase A2phosphatidylcholine 2-acylhydrolase 10sPLA2-X
Modification date20141207
dbXrefs MIM : 603603
Ensembl : ENSG00000069764
HPRD : 04674
Vega : OTTHUMG00000048069
ProteinUniProt: O15496
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_PLA2G10
BioGPS: 8399
PathwayNCI Pathway Interaction Database: PLA2G10
Pathway Commons: PLA2G10
ContextiHOP: PLA2G10
ligand binding site mutation search in PubMed: PLA2G10
UCL Cancer Institute: PLA2G10
Assigned class in mutLBSgeneDBB: This gene belongs to targetable_mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO:0007411axon guidance15927955
GO:0043433negative regulation of sequence-specific DNA binding transcription factor activity20844270
GO:0051977lysophospholipid transport15927955

Ligand binding site mutations for PLA2G10

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.

Protein structure related information for PLA2G10
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for PLA2G10 from PDB

Differential gene expression and gene-gene network for PLA2G10
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of PLA2G10 and the right PPI network was created from samples without mutations in the LBS of PLA2G10. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


Phenotype information for PLA2G10
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

Pharmacological information for PLA2G10
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of PLA2G10 go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS

Conservation information for LBS of PLA2G10
Multiple alignments for O15496 in multiple species
LBSAA sequence# speciesSpecies
A48GLLELAGTLDC2Mus musculus, Rattus norvegicus
A48GILELAGTVGC1Homo sapiens
C85AIDWCCHGHDC1Homo sapiens
C85AIDWCCYHHDC1Mus musculus
C85AIDWCCYYHDC1Rattus norvegicus
D89CCHGHDCCYTR1Homo sapiens
D89CCYHHDCCYSR1Mus musculus
D89CCYYHDCCYSQ1Rattus norvegicus
F68MNYGCYCGLGG2Mus musculus, Rattus norvegicus
F68MKYGCFCGLGG1Homo sapiens
G70YGCYCGLGGHG2Mus musculus, Rattus norvegicus
G70YGCFCGLGGHG1Homo sapiens
G72CYCGLGGHGEP2Mus musculus, Rattus norvegicus
G72CFCGLGGHGQP1Homo sapiens
H88WCCHGHDCCYT1Homo sapiens
H88WCCYHHDCCYS1Mus musculus
H88WCCYYHDCCYS1Rattus norvegicus
I136KCDQEIANCLA1Homo sapiens
I136RCDEELAYCLA1Mus musculus
I136RCDETLAYCLA1Rattus norvegicus
I44VYKRGLLELAG2Mus musculus, Rattus norvegicus
I44VHRRGILELAG1Homo sapiens
L140EIANCLAQTEY1Homo sapiens
L140ELAYCLAGTEY1Mus musculus
L140TLAYCLADTEY1Rattus norvegicus
L47RGLLELAGTLD2Mus musculus, Rattus norvegicus
L47RGILELAGTVG1Homo sapiens
L71GCYCGLGGHGE2Mus musculus, Rattus norvegicus
L71GCFCGLGGHGQ1Homo sapiens
M63SPMAYMNYGCY2Mus musculus, Rattus norvegicus
M63TPIAYMKYGCF1Homo sapiens
P59VGPRSPMAYMN2Mus musculus, Rattus norvegicus
P59VGPRTPIAYMK1Homo sapiens
Y62RSPMAYMNYGC2Mus musculus, Rattus norvegicus
Y62RTPIAYMKYGC1Homo sapiens

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