mutated Ligand Binding Site gene DataBase





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Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for RERG
Gene summary
Basic gene Info.Gene symbolRERG
Gene nameRAS-like, estrogen-regulated, growth inhibitor
CytomapUCSC genome browser: 12p12.3
Type of geneprotein-coding
Descriptionras-related and estrogen-regulated growth inhibitor
Modification date20141207
dbXrefs MIM : 612664
Ensembl : ENSG00000134533
HPRD : 15238
Vega : OTTHUMG00000168745
ProteinUniProt: Q96A58
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_RERG
BioGPS: 85004
PathwayNCI Pathway Interaction Database: RERG
Pathway Commons: RERG
ContextiHOP: RERG
ligand binding site mutation search in PubMed: RERG
UCL Cancer Institute: RERG
Assigned class in mutLBSgeneDBC: This gene just belongs to mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO:0008285negative regulation of cell proliferation11533059
GO:0009725response to hormone11533059
GO:0030308negative regulation of cell growth11533059

Ligand binding site mutations for RERG
Lollipop-style diagram of mutations at LBS in amino-acid sequence.
We represented ligand binding site mutations only. (You can see big image via clicking.)
: non-synonymous mutation on LBS, Circle size denotes number of samples.

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.

Protein structure related information for RERG
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for RERG from PDB

Differential gene expression and gene-gene network for RERG
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of RERG and the right PPI network was created from samples without mutations in the LBS of RERG. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


Phenotype information for RERG
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

Pharmacological information for RERG
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of RERG go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS

Conservation information for LBS of RERG
Multiple alignments for Q96A58 in multiple species
LBSAA sequence# speciesSpecies
A149FYECSACTGEG3Homo sapiens, Bos taurus, Mus musculus
A21GVGKSALVVRF2Homo sapiens, Bos taurus
A21GVGKSAIVVRF1Mus musculus
C150YECSACTGEGN3Homo sapiens, Bos taurus, Mus musculus
D121VGNKADLDHSR3Homo sapiens, Bos taurus, Mus musculus
E34KRFIWEYDPTL3Homo sapiens, Bos taurus, Mus musculus
F31FLTKRFIWEYD3Homo sapiens, Bos taurus, Mus musculus
G16IFGRAGVGKSA3Homo sapiens, Bos taurus, Mus musculus
G18GRAGVGKSALV2Homo sapiens, Bos taurus
G18GRAGVGKSAIV1Mus musculus
K119ILVGNKADLDH3Homo sapiens, Bos taurus, Mus musculus
K19RAGVGKSALVV2Homo sapiens, Bos taurus
K19RAGVGKSAIVV1Mus musculus
L122GNKADLDHSRQ3Homo sapiens, Bos taurus, Mus musculus
N118LILVGNKADLD3Homo sapiens, Bos taurus, Mus musculus
S148AFYECSACTGE3Homo sapiens, Bos taurus, Mus musculus
S20AGVGKSALVVR2Homo sapiens, Bos taurus
S20AGVGKSAIVVR1Mus musculus
V17FGRAGVGKSAL2Homo sapiens, Bos taurus
V17FGRAGVGKSAI1Mus musculus

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