mutLBSgeneDB

mutLBSgeneDB
mutated Ligand Binding Site gene DataBase

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Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for HAT1
Gene summary
Basic gene Info.Gene symbolHAT1
Gene namehistone acetyltransferase 1
SynonymsKAT1
CytomapUCSC genome browser: 2q31.2-q33.1
Type of geneprotein-coding
RefGenesNM_003642.3,
NR_027862.1,NM_001033085.1,
Descriptionhistone acetyltransferase type B catalytic subunit
Modification date20141207
dbXrefs MIM : 603053
HGNC : HGNC
Ensembl : ENSG00000128708
HPRD : 04339
Vega : OTTHUMG00000132282
ProteinUniProt: O14929
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_HAT1
BioGPS: 8520
PathwayNCI Pathway Interaction Database: HAT1
KEGG: HAT1
REACTOME: HAT1
Pathway Commons: HAT1
ContextiHOP: HAT1
ligand binding site mutation search in PubMed: HAT1
UCL Cancer Institute: HAT1
Assigned class in mutLBSgeneDBC: This gene just belongs to mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO TermPubMed ID
GO:0006335DNA replication-dependent nucleosome assembly14718166
GO:0006336DNA replication-independent nucleosome assembly14718166
GO:0043967histone H4 acetylation22615379


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Ligand binding site mutations for HAT1
Lollipop-style diagram of mutations at LBS in amino-acid sequence.
We represented ligand binding site mutations only. (You can see big image via clicking.)
 : non-synonymous mutation on LBS, Circle size denotes number of samples.

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
S190S190TCOAD1
G253G253DCOAD1
E54P53LSKCM1
G253,G251H252RSTAD1
F288D287EUCEC1
F185W184RUCEC1
F185F185CUCEC1
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.


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Protein structure related information for HAT1
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
G253G253D0.11552916
G251H252R0.09627268
G253H252R0.09627268
F185F185C-1.1265936
S190S190T-0.91809321
F185W184R-0.86617474
F288D287E-0.44800558
E54P53L-0.23080518
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for HAT1 from PDB

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Differential gene expression and gene-gene network for HAT1
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of HAT1 and the right PPI network was created from samples without mutations in the LBS of HAT1. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


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Phenotype information for HAT1
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

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Pharmacological information for HAT1
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of HAT1 go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS
IIIPeptide ligand (LYS,GLY,GLY,LYS,GLY,LEU,GLY,LYS,GLY,GLY,ALA,LYS,ARG,HIS,ARG)2p0wAE54 S190
IIIPeptide ligand (GLY,GLY,LYS,GLY,LEU,GLY,LYS,GLY,GLY,ALA,LYS,ARG,HIS,ARG)2p0wBE54 S190
ACOACETYL COENZYME *A2p0wAF185 G251 G253 F288
ACOACETYL COENZYME *A2p0wBF185 G251 G253 F288


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Conservation information for LBS of HAT1
Multiple alignments for O14929 in multiple species
LBSAA sequence# speciesSpecies
A254GQGHGAQLLET3Homo sapiens, Mus musculus, Rattus norvegicus
A254GKGLGSYLMEV1Arabidopsis thaliana
A254GEGHGLRLLET1Oryza sativa subsp. japonica
A254QKGLGSRLYSI1Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
A254HQGHGSQLYNA1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
A254NKGHGSCLYEA1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
A254GHGHGKRLYQA1Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
A254SKSHGSHLYSA1Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
D193TASFIDVDDE-3Homo sapiens, Mus musculus, Rattus norvegicus
D193GSNPIDVTDP-1Arabidopsis thaliana
D193GSTPIDITEH-1Oryza sativa subsp. japonica
D193GGTPIDMEDPD1Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
D193GGSFIDLNDP-1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
D193AANYIDETDP-1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
D193SASYIDENDS-1Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
D193AASYIDEDDS-1Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
D277DITAEDPSKSY2Homo sapiens, Rattus norvegicus
D277DLTVEEPSEKF1Arabidopsis thaliana
D277DVTIEDPSDYL1Oryza sativa subsp. japonica
D277DITAEDPSRSY1Mus musculus
D277ELTVEDPNEAF1Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
D277DFTVEDASEAF1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
D277EITVEDPNEAF1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
D277EITVEDPNESF1Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
D277EVTVEDPNEAF1Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
D62HQLFGDDETAF3Homo sapiens, Mus musculus, Rattus norvegicus
D62NDFFDGDGKIY1Arabidopsis thaliana
D62NHFFGEDGKIY1Oryza sativa subsp. japonica
D62NNIFGEKEQIF1Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
D62YAIFGDAEVIY1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
D62YPIYGDSEKIY1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
D62YPIYGDSEQIF1Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
D62YPIFGQAEQLF1Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
E187LMWFIETASFI3Homo sapiens, Mus musculus, Rattus norvegicus
E187VLLFVDGSNPI1Arabidopsis thaliana
E187ILLLVEGSTPI1Oryza sativa subsp. japonica
E187VPFFVDGGTPI1Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
E187SLFFIEGGSFI1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
E187SLLFIEAANYI1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
E187TLLFIESASYI1Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
E187TLLFIEAASYI1Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
E276LDITAEDPSKS2Homo sapiens, Rattus norvegicus
E276YDLTVEEPSEK1Arabidopsis thaliana
E276YDVTIEDPSDY1Oryza sativa subsp. japonica
E276LDITAEDPSRS1Mus musculus
E276IELTVEDPNEA1Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
E276LDFTVEDASEA1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
E276TEITVEDPNEA1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
E276VEITVEDPNES1Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
E276SEVTVEDPNEA1Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
E54RTFFPEYTHQL3Homo sapiens, Mus musculus, Rattus norvegicus
E54SSVKPVDLNDF1Arabidopsis thaliana
E54TSLQPFDLNHF1Oryza sativa subsp. japonica
E54DTFHPEYTNNI1Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
E54CQYHPSNTYAI1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
E54VQFSPLFTYPI1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
E54VNFKPTFTYPI1Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
E54VQFSPIFTYPI1Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
E64LFGDDETAFGY3Homo sapiens, Mus musculus, Rattus norvegicus
E64FFDGDGKIYGY1Arabidopsis thaliana
E64FFGEDGKIYGY1Oryza sativa subsp. japonica
E64IFGEKEQIFGY1Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
E64IFGDAEVIYGY1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
E64IYGDSEKIYGY1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
E64IYGDSEQIFGY1Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
E64IFGQAEQLFGY1Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
F185TFLMWFIETAS3Homo sapiens, Mus musculus, Rattus norvegicus
F185PLVLLFVDGSN1Arabidopsis thaliana
F185PLILLLVEGST1Oryza sativa subsp. japonica
F185ILVPFFVDGGT1Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
F185IFSLFFIEGGS1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
F185IFSLLFIEAAN1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
F185IFTLLFIESAS1Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
F185IFTLLFIEAAS1Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
F288VKLRDFVLVKL2Homo sapiens, Rattus norvegicus
F288QHIRTCIDINR1Arabidopsis thaliana
F288QYIRSSIDCLR1Oryza sativa subsp. japonica
F288LKLRDFVLVKF1Mus musculus
F288DDMRDLADLAF1Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
F288DSLRDHCDYKR1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
F288DDLRDRNDIQR1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
F288DDLRDRCDFER1Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
F288DDLRDRCDFMR1Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
G249LTPFQGQGHGA3Homo sapiens, Mus musculus, Rattus norvegicus
G249LPSFQGKGLGS1Arabidopsis thaliana
G249LPPYQGEGHGL1Oryza sativa subsp. japonica
G249IPPFQQKGLGS1Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
G249LPPFQHQGHGS1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G249FPPYQNKGHGS1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
G249MPPYQGHGHGK1Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
G249FPPYQSKSHGS1Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
G251PFQGQGHGAQL3Homo sapiens, Mus musculus, Rattus norvegicus
G251SFQGKGLGSYL1Arabidopsis thaliana
G251PYQGEGHGLRL1Oryza sativa subsp. japonica
G251PFQQKGLGSRL1Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
G251PFQHQGHGSQL1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G251PYQNKGHGSCL1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
G251PYQGHGHGKRL1Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
G251PYQSKSHGSHL1Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
G253QGQGHGAQLLE3Homo sapiens, Mus musculus, Rattus norvegicus
G253QGKGLGSYLME1Arabidopsis thaliana
G253QGEGHGLRLLE1Oryza sativa subsp. japonica
G253QQKGLGSRLYS1Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
G253QHQGHGSQLYN1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G253QNKGHGSCLYE1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
G253QGHGHGKRLYQ1Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
G253QSKSHGSHLYS1Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
H57FPEYTHQLFGD3Homo sapiens, Mus musculus, Rattus norvegicus
H57KPVDLNDFFDG1Arabidopsis thaliana
H57QPFDLNHFFGE1Oryza sativa subsp. japonica
H57HPEYTNNIFGE1Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
H57HPSNTYAIFGD1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
H57SPLFTYPIYGD1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
H57KPTFTYPIYGD1Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
H57SPIFTYPIFGQ1Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
I186FLMWFIETASF3Homo sapiens, Mus musculus, Rattus norvegicus
I186LVLLFVDGSNP1Arabidopsis thaliana
I186LILLLVEGSTP1Oryza sativa subsp. japonica
I186LVPFFVDGGTP1Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
I186FSLFFIEGGSF1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
I186FSLLFIEAANY1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
I186FTLLFIESASY1Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
I186FTLLFIEAASY1Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
I192ETASFIDVDDE3Homo sapiens, Mus musculus, Rattus norvegicus
I192DGSNPIDVTDP1Arabidopsis thaliana
I192EGSTPIDITEH1Oryza sativa subsp. japonica
I192DGGTPIDMEDP1Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
I192EGGSFIDLNDP1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
I192EAANYIDETDP1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
I192ESASYIDENDS1Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
I192EAASYIDEDDS1Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
I243VSQMLILTPFQ3Homo sapiens, Mus musculus, Rattus norvegicus
I243LSQILVLPSFQ1Arabidopsis thaliana
I243ISQILVLPPYQ1Oryza sativa subsp. japonica
I243ISQFIIIPPFQ1Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
I243ISQFVILPPFQ1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
I243ISQFLIFPPYQ1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
I243ISQFLIMPPYQ1Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
I243ISQFIIFPPYQ1Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
K284SKSYVKLRDFV2Homo sapiens, Rattus norvegicus
K284SEKFQHIRTCI1Arabidopsis thaliana
K284SDYLQYIRSSI1Oryza sativa subsp. japonica
K284SRSYLKLRDFV1Mus musculus
K284NEAFDDMRDLA1Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
K284SEAFDSLRDHC1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
K284NEAFDDLRDRN1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
K284NESFDDLRDRC1Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
K284NEAFDDLRDRC1Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
L242RVSQMLILTPF3Homo sapiens, Mus musculus, Rattus norvegicus
L242RLSQILVLPSF1Arabidopsis thaliana
L242RISQILVLPPY1Oryza sativa subsp. japonica
L242RISQFIIIPPF1Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
L242RISQFVILPPF1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
L242KISQFLIFPPY1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
L242KISQFLIMPPY1Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
L242KISQFIIFPPY1Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
L285KSYVKLRDFVL2Homo sapiens, Rattus norvegicus
L285EKFQHIRTCID1Arabidopsis thaliana
L285DYLQYIRSSID1Oryza sativa subsp. japonica
L285RSYLKLRDFVL1Mus musculus
L285EAFDDMRDLAD1Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
L285EAFDSLRDHCD1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
L285EAFDDLRDRND1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
L285ESFDDLRDRCD1Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
L285EAFDDLRDRCD1Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
M241PRVSQMLILTP3Homo sapiens, Mus musculus, Rattus norvegicus
M241MRLSQILVLPS1Arabidopsis thaliana
M241LRISQILVLPP1Oryza sativa subsp. japonica
M241TRISQFIIIPP1Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
M241ARISQFVILPP1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
M241AKISQFLIFPP1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
M241AKISQFLIMPP1Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
M241AKISQFIIFPP1Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
P278ITAEDPSKSYV2Homo sapiens, Rattus norvegicus
P278LTVEEPSEKFQ1Arabidopsis thaliana
P278VTIEDPSDYLQ1Oryza sativa subsp. japonica
P278ITAEDPSRSYL1Mus musculus
P278LTVEDPNEAFD1Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
P278FTVEDASEAFD1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
P278ITVEDPNEAFD1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
P278ITVEDPNESFD1Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
P278VTVEDPNEAFD1Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
Q240RPRVSQMLILT3Homo sapiens, Mus musculus, Rattus norvegicus
Q240RMRLSQILVLP1Arabidopsis thaliana
Q240RLRISQILVLP1Oryza sativa subsp. japonica
Q240RTRISQFIIIP1Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Q240RARISQFVILP1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Q240RAKISQFLIFP1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Q240RAKISQFLIMP1Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
Q240RAKISQFIIFP1Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
Q248ILTPFQGQGHG3Homo sapiens, Mus musculus, Rattus norvegicus
Q248VLPSFQGKGLG1Arabidopsis thaliana
Q248VLPPYQGEGHG1Oryza sativa subsp. japonica
Q248IIPPFQQKGLG1Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Q248ILPPFQHQGHG1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Q248IFPPYQNKGHG1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Q248IMPPYQGHGHG1Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
Q248IFPPYQSKSHG1Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
Q250TPFQGQGHGAQ3Homo sapiens, Mus musculus, Rattus norvegicus
Q250PSFQGKGLGSY1Arabidopsis thaliana
Q250PPYQGEGHGLR1Oryza sativa subsp. japonica
Q250PPFQQKGLGSR1Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Q250PPFQHQGHGSQ1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Q250PPYQNKGHGSC1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Q250PPYQGHGHGKR1Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
Q250PPYQSKSHGSH1Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
Q58PEYTHQLFGDD3Homo sapiens, Mus musculus, Rattus norvegicus
Q58PVDLNDFFDGD1Arabidopsis thaliana
Q58PFDLNHFFGED1Oryza sativa subsp. japonica
Q58PEYTNNIFGEK1Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Q58PSNTYAIFGDA1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Q58PLFTYPIYGDS1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Q58PTFTYPIYGDS1Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
Q58PIFTYPIFGQA1Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
R237-KTRPRVSQML3Homo sapiens, Mus musculus, Rattus norvegicus
R237-RLRMRLSQIL1Arabidopsis thaliana
R237-STRLRISQIL1Oryza sativa subsp. japonica
R237LPCRTRISQFI1Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
R237-GIRARISQFV1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
R237-KFRAKISQFL1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
R237-KCRAKISQFL1Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
R237-TKRAKISQFI1Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
S190FIETASFIDVD3Homo sapiens, Mus musculus, Rattus norvegicus
S190FVDGSNPIDVT1Arabidopsis thaliana
S190LVEGSTPIDIT1Oryza sativa subsp. japonica
S190FVDGGTPIDME1Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
S190FIEGGSFIDLN1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
S190FIEAANYIDET1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
S190FIESASYIDEN1Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
S190FIEAASYIDED1Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
S239TRPRVSQMLIL3Homo sapiens, Mus musculus, Rattus norvegicus
S239LRMRLSQILVL1Arabidopsis thaliana
S239TRLRISQILVL1Oryza sativa subsp. japonica
S239CRTRISQFIII1Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
S239IRARISQFVIL1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
S239FRAKISQFLIF1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
S239CRAKISQFLIM1Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
S239KRAKISQFIIF1Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
S279TVEDPNEAFDD3Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987), Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
S279TAEDPSKSYVK2Homo sapiens, Rattus norvegicus
S279TVEEPSEKFQH1Arabidopsis thaliana
S279TIEDPSDYLQY1Oryza sativa subsp. japonica
S279TAEDPSRSYLK1Mus musculus
S279TVEDASEAFDS1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
S279TVEDPNESFDD1Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
S281EDPSKSYVKLR2Homo sapiens, Rattus norvegicus
S281EDPNEAFDDLR2Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
S281EEPSEKFQHIR1Arabidopsis thaliana
S281EDPSDYLQYIR1Oryza sativa subsp. japonica
S281EDPSRSYLKLR1Mus musculus
S281EDPNEAFDDMR1Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
S281EDASEAFDSLR1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
S281EDPNESFDDLR1Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
T188MWFIETASFID3Homo sapiens, Mus musculus, Rattus norvegicus
T188LLFVDGSNPID1Arabidopsis thaliana
T188LLLVEGSTPID1Oryza sativa subsp. japonica
T188PFFVDGGTPID1Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
T188LFFIEGGSFID1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
T188LLFIEAANYID1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
T188LLFIESASYID1Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
T188LLFIEAASYID1Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
W199E---RWHYFLV3Homo sapiens, Mus musculus, Rattus norvegicus
W199P---DWHLYLL1Arabidopsis thaliana
W199H---GWEMLLV1Oryza sativa subsp. japonica
W199PDVDRWTIYFL1Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
W199P---RWMVYLL1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
W199P---SWQIYWL1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
W199S---SWEIFIV1Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
W199S---AWDIFMT1Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
Y225GYMTVYNYYVY3Homo sapiens, Mus musculus, Rattus norvegicus
Y225GFTAIYKFYRY1Arabidopsis thaliana
Y225GFAAVHHFYHY1Oryza sativa subsp. japonica
Y225GYSTLYRYYAF1Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Y225GYCTVYKYYKW1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Y225GFVTTYKYWHY1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Y225GYTTTYQFWKY1Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
Y225GYTTTYKHWRY1Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
Y227MTVYNYYVYPD3Homo sapiens, Mus musculus, Rattus norvegicus
Y227TAIYKFYRYPD1Arabidopsis thaliana
Y227AAVHHFYHYPE1Oryza sativa subsp. japonica
Y227STLYRYYAFQP1Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Y227CTVYKYYKWDK1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Y227VTTYKYWHYLG1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Y227TTTYQFWKYLG1Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
Y227TTTYKHWRYIN1Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
Y282DPSKSYVKLRD2Homo sapiens, Rattus norvegicus
Y282DPNEAFDDLRD2Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
Y282EPSEKFQHIRT1Arabidopsis thaliana
Y282DPSDYLQYIRS1Oryza sativa subsp. japonica
Y282DPSRSYLKLRD1Mus musculus
Y282DPNEAFDDMRD1Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Y282DASEAFDSLRD1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Y282DPNESFDDLRD1Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
Y55TFFPEYTHQLF3Homo sapiens, Mus musculus, Rattus norvegicus
Y55SVKPVDLNDFF1Arabidopsis thaliana
Y55SLQPFDLNHFF1Oryza sativa subsp. japonica
Y55TFHPEYTNNIF1Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Y55QYHPSNTYAIF1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Y55QFSPLFTYPIY1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Y55NFKPTFTYPIY1Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
Y55QFSPIFTYPIF1Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)


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