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mutLBSgeneDB |
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| Gene summary for CAMK1 |
 Gene summary |
| Basic gene Info. | Gene symbol | CAMK1 |
| Gene name | calcium/calmodulin-dependent protein kinase I | |
| Synonyms | CAMKI | |
| Cytomap | UCSC genome browser: 3p25.3 | |
| Type of gene | protein-coding | |
| RefGenes | NM_003656.4, | |
| Description | caM kinase I alphacaM-KIcaMKI-alphacalcium/calmodulin-dependent protein kinase type 1 | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 604998 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000134072 | ||
| HPRD : 05412 | ||
| Vega : OTTHUMG00000128419 | ||
| Protein | UniProt: Q14012 go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_CAMK1 | |
| BioGPS: 8536 | ||
| Pathway | NCI Pathway Interaction Database: CAMK1 | |
| KEGG: CAMK1 | ||
| REACTOME: CAMK1 | ||
| Pathway Commons: CAMK1 | ||
| Context | iHOP: CAMK1 | |
| ligand binding site mutation search in PubMed: CAMK1 | ||
| UCL Cancer Institute: CAMK1 | ||
| Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. | |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO Term | PubMed ID | GO:0006468 | protein phosphorylation | 11114197 | GO:0010976 | positive regulation of neuron projection development | 17442826 | GO:0032880 | regulation of protein localization | 11114197 | GO:0043393 | regulation of protein binding | 11114197 | GO:0051147 | regulation of muscle cell differentiation | 11114197 | GO:0071902 | positive regulation of protein serine/threonine kinase activity | 17442826 |
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| Ligand binding site mutations for CAMK1 |
| Cancer type specific mutLBS sorted by frequency |
| LBS | AAchange of nsSNV | Cancer type | # samples | E145 | E145K | BRCA | 1 | E145 | E145D | COAD | 1 |
| cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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| Protein structure related information for CAMK1 |
| Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
 : nsSNV at non-LBS : nsSNV at LBS |
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| nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
| LBS | AAchange of nsSNV | Relative stability change | E145 | E145D | -0.68837452 | E145 | E145K | -0.64736076 |
| (MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
| Structure image for CAMK1 from PDB |
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| Differential gene expression and gene-gene network for CAMK1 |
| Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
| Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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| Phenotype information for CAMK1 |
| Gene level disease information (DisGeNet) |
| Disease ID | Disease name | # PubMed | Association type |
| Mutation level pathogenic information (ClinVar annotation) |
| Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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| Pharmacological information for CAMK1 |
| Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
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| Gene-centered drug-gene interaction network |
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| Drug information targeting mutLBSgene (Approved drugs only) |
| Drug status | DrugBank ID | Name | Type | Drug structure |
| Gene-centered ligand-gene interaction network |
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| Ligands binding to mutated ligand binding site of CAMK1 go to BioLip |
| Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | ATP | ATP | 4fg8 | A | E145 | ATP | ATP | 4fg9 | A | E145 |
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| Conservation information for LBS of CAMK1 |
| Multiple alignments for Q14012 in multiple species |
| LBS | AA sequence | # species | Species | A30 | VLGTGAFSEVI | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | A30 | KLGQGQFGTTF | 2 | Arabidopsis thaliana, Arabidopsis thaliana | A30 | TLGAGSFGVVR | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | A47 | TQKLVAIKCIA | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | A47 | TNEDVAIKILL | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | A47 | TGNEYACKSIS | 1 | Arabidopsis thaliana | A47 | TGKEFACKSIA | 1 | Arabidopsis thaliana | D162 | KIMISDFGLSK | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | D162 | LLKTIDFGLSM | 2 | Arabidopsis thaliana, Arabidopsis thaliana | D162 | PLVIADFGIAK | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | E102 | LVSGGELFDRI | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | E102 | LATGGELFDRI | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | E102 | LCSGGELFDRI | 1 | Arabidopsis thaliana | E102 | CCAGGELFDRI | 1 | Arabidopsis thaliana | E145 | RDLKPENLLYY | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | E145 | RDLKPENFLFV | 2 | Arabidopsis thaliana, Arabidopsis thaliana | E145 | RDLKPENVLYV | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | F31 | LGTGAFSEVIL | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | F31 | LGQGQFGTTFL | 2 | Arabidopsis thaliana, Arabidopsis thaliana | F31 | LGAGSFGVVRQ | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | G27 | FRDVLGTGAFS | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | G27 | LGRKLGQGQFG | 2 | Arabidopsis thaliana, Arabidopsis thaliana | G27 | FGRTLGAGSFG | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | G29 | DVLGTGAFSEV | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | G29 | RKLGQGQFGTT | 2 | Arabidopsis thaliana, Arabidopsis thaliana | G29 | RTLGAGSFGVV | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | K143 | VHRDLKPENLL | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | K143 | MHRDLKPENFL | 2 | Arabidopsis thaliana, Arabidopsis thaliana | K143 | VHRDLKPENVL | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | K49 | KLVAIKCIAKK | 2 | Mus musculus, Rattus norvegicus | K49 | KLVAIKCIAKE | 1 | Homo sapiens | K49 | EDVAIKILLKK | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | K49 | NEYACKSISKR | 1 | Arabidopsis thaliana | K49 | KEFACKSIAKR | 1 | Arabidopsis thaliana | L148 | KPENLLYYSLD | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | L148 | KPENVLYVDKS | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | L148 | KPENFLFVSRE | 1 | Arabidopsis thaliana | L148 | KPENFLFVSKH | 1 | Arabidopsis thaliana | L26 | DFRDVLGTGAF | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | L26 | SLGRKLGQGQF | 2 | Arabidopsis thaliana, Arabidopsis thaliana | L26 | IFGRTLGAGSF | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | L97 | YLIMQLVSGGE | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | L97 | YIVTQLATGGE | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | L97 | HLVMELCSGGE | 1 | Arabidopsis thaliana | L97 | HLVMECCAGGE | 1 | Arabidopsis thaliana | N146 | DLKPENLLYYS | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | N146 | DLKPENFLFVS | 2 | Arabidopsis thaliana, Arabidopsis thaliana | N146 | DLKPENVLYVD | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | Q96 | LYLIMQLVSGG | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | Q96 | FYIVTQLATGG | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | Q96 | VHLVMELCSGG | 1 | Arabidopsis thaliana | Q96 | VHLVMECCAGG | 1 | Arabidopsis thaliana | S32 | GTGAFSEVILA | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | S32 | GQGQFGTTFLC | 2 | Arabidopsis thaliana, Arabidopsis thaliana | S32 | GAGSFGVVRQA | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | T28 | RDVLGTGAFSE | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | T28 | GRKLGQGQFGT | 2 | Arabidopsis thaliana, Arabidopsis thaliana | T28 | GRTLGAGSFGV | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | V34 | GAFSEVILAED | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | V34 | GSFGVVRQARK | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | V34 | GQFGTTFLCLE | 1 | Arabidopsis thaliana | V34 | GQFGTTFLCVE | 1 | Arabidopsis thaliana | V79 | -HPNIVALDDI | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | V79 | GHPNVISIKGA | 2 | Arabidopsis thaliana, Arabidopsis thaliana | V79 | -HPNIVSFKDW | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | V98 | LIMQLVSGGEL | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | V98 | IVTQLATGGEL | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | V98 | LVMELCSGGEL | 1 | Arabidopsis thaliana | V98 | LVMECCAGGEL | 1 | Arabidopsis thaliana |
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